알쯔하이머형 치매와 혈관성 치매환자에서의 ALDH2와 APOE 유전자의 다형성에 관한 연구

김동홍,김영돈,이창화,엄기춘,김은식,윤경식,김동희 대한생물치료정신의학회 2002 생물치료정신의학 Vol.8 No.2

연구목적: 본 연구는 국내 치매환자들을 대상으로 치매발병의 위험요소가 될 수있는 ALDH2와 APOE 유전자형이 어떤 양상으로 나타나는지 알아보기 위하여 시행되었다. 방 법: 충남 부여군에 위치한 부여노인병원에 입원중인 65세 이상의 알쯔하이머형 치매와 혈관성 또는 혼재성 치매환자 59명(남:19, 녀:40)을 대상으로 ALDH2와 APOE 유전자형을 제한효소법에 의하여 조사하였고 치매유형에 따른 유전자형과 대립유전자의 빈도를 비교하였다. 결 과: 1) 알쯔하이머형 치매환자군에서 혈관성 또는 혼재성 치매환자군보다 ALDH2*(-/2)유전자형의 빈도가 높았으나 통계학적으로 의미있는 차이는 없었다. 2) 알쯔하이머형 치매화자군에서 혈관성 또는 혼재성 치매환자군보다 APOE*(-/ε4) 유전자형의 빈도가 높았으나 통계학적으로 의미있는 차이는 없었다. 3) APOE*ε4와 ALDH2*2를 알쯔하이머병의 균등한 위험대립유전자로 가정하고 각 유전자형의 대립유전자의 수를 점수화하여 각 치매환자군의 위험유전자 전체점수를 비교한 결과 알쯔하이머형 치매환자군에서 점수가 더 높게 나왔으나 통계학적으로 의미있는 차이는 없었다. 결 론: 알쯔하이머형 치매환자군에서 혈관성 또는 혼재성치매치매환자군보다 ALDH2*2와 APOE*ε4 대립유전자의 빈도가 높게 나왔으나 통계학적으로 의미있는 차이는 없었다. A study on gene polymorphism of ALDH2 and APOE in patients with alzheimer's disease and vascular or mixed dementia. Objective : This study was designed to investigate gene polymorphism of ALDH2 and APOE, reported the risk factor of Alzheimer's disease, in korean dementia patients. Method : 59 Patients(male:19, female:40) with dementia, aged 65 and older in Buyeo geriatric hospital located in Buyeo-gun, chungnam, were finally included in this study. gene polymorphism of ALDH2 and APOE was typed with polymerase chain reaction in patients with Alzheimer's desease and vascular or mixed dementia. Results : 1) There was no difference in allelic frequency of ALDH2 gene polymorphism between patients with Alzheimer's disease and vascular or mixed dementia. 2) There was no difference in allelic frequency of APOE gene polymorphism between patients with Alzheimer's disease and vascular or mixed dementia. 3) Supposing APOE*ε4 and ALDH2*2 were equal risk allele of Alzheimer's disease, the sum of score by counting each risk allele was higher in patients with Alzheimer's disease than vascular mixed dementia, however there was no significant difference. Conclusion : The genotype frequency of ALDH2*(-/2) and APOE*(-/ε4) was higher in patients with Alsheimer's disease than vascular or mixed dementia, however there was no significant difference in allelic frequency of gene polymorphism of ALDH2 and APOE between patients with Alzheimer's disease and vascular or mixed dementia.

치료저항 만성 정신분열증 환자에서 Clozapine과 Haloperidol의 치료효과에 대한 비교

이홍식,김찬형,이희상,남궁기,송동호,이영문,한은선 大韓臨床藥理學會 1993 臨床藥理學會誌 Vol.1 No.2

난치성 만성정신분열증 환자의 생활의 질에 미치는 정신사회치료 프로그램의 효과에 대한 예비연구

송동호,배민진,이종호,이홍식,김선경,서호석,김찬형,전지용 大韓神經精神醫學會 1995 신경정신의학 Vol.34 No.4

Objects : Recent studies of psychosocial adjustment after hospitalization have found that the combination of maintenance antipsychotic drug treatment and psychosocial treatment including psychoeducational program are highly predictive of social rehabilitation and reduction of subsequent relapse. Two groups of patients with refractory chronic schizophrenia were preliminarily compared to determine the effect of a psychosocial treatment program on the quality of life in refractory chronic schizophrenics in an open comparative trial. Methods : One group(N=11) was assigned to approximately six months of the psychosocial treatment program(including psychoeducation program and activity program such as interpersonal relationship program, social skill training, self management program, outings, etc), in a group format, twice a week and a fixed maintenance dosage of clozapine ; while scale(QLS) was used to provide an objective measure of changes in patient's psychosocial functioning and a general assessment of psychopathology was made using the Brief Psychiatric Rating Scale(BPRS). Results : Both BPRS total positive score and the QLS total score, especially in the intrapsychic foundation factor of the scale showed a statistically significant improvement in the psychosocial treatment group. But there was no significant change in both BPRS and QLS scores over a 6-month period in the non-psychosocial treatment group. A significant negative correlation was found between the negative symptom and changes of QLS total, instrumental role and common object and activities scores respectively after receiving a 6-month of the psychosocial treatment program. Conclusion : These results suggest that a psychosocial treatment program including the integration of psychoeducation and a skill training oriented activity program serve as an outpatient treatment modality to improve the quality of the life in refractory chronic schizophrenia. To further clarify the effect of psychosocial treatment in chronic schizophrenia, a randomized trial should be done.

선택적 함구증 환자에서의 Fluoxetine 치험

송동호,박민숙,남수용,육기환,노경선,이홍식 대한소아ㆍ청소년정신의학회 1997 소아청소년정신의학 Vol.8 No.2

한국 및 러시아 한국계 청소년 우울증의 사회심리적 위험요인에 대한 횡문화 비교 연구

송동호,민성기,김지웅,김찬형,이홍식,Kim, Larissa 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.5

연구목적 : 본 연구는 사회문화적 배경이 다른 한국과 러시아, 두 나라의 한국인 청소년을 대상으로 우울증의 유병율을 비교 조사하고, 우울증과 관련된 사회심리적 위험요인들을 알아보고자 하였다. 방 법 : 연구도구의 한국어판을 제작하고 두 나라의 청소년 우울증 환자 40명씩을 대상으로 우울척도의 cut-off 점수를 산정하기 위한 예비연구를 본 연구에 앞서 시행하였다. 한국의 청소년 대상은 서울 소재의 중고등학생 838명이었고, 러시아의 청소년은 우즈베키스탄 공화국의 중고등학생 중 양부모가 모두 한국인인 652명이었다. 연구도구로는 우울증의 사회심리적 요인들과 횡문화적 요인들을 조사하기 위하여 기초자료 설문지 및 Beck 우울척도를 적용하였다. 결 과 : 우울증 환자를 대상으로 시행한 예비연구에서 얻은 Beck 우울척도의 cut-off 점수 19점 이상을 기준으로 하였을 때, 한국 청소년 집단에서 우울증의 유병률은 26.5%인데 반하여 러시아 청소년에서는 7.4%의 유병률을 보였다. 한국인 청소년들은 한국인-러시아 청소년에 비하여 염세주의(pessimism), 실패감(failure), 자살사고, 죄책감 등, 절망감(helplessness)과 관련된 증상들이 유의하게 많이 나타났다. 한국인 청소년과 한국인-러시아 청소년 간에 우울증의 유의한 사회심리적 위험요인들로서 여성, 낮은 학업성적, 부모와의 갈등이 공통적으로 나타났으며, 그외에 친구교제 요인, 만성 신체질환, 형제간이나 친구들과의 갈등이 한국인 청소년에서는 또 다른 위험요인으로 존재하였다. 결 론 : 본 연구를 통하여 한국인 청소년의 우울증 유병율이 한국인-러시아 청소년의 유병률에 비하여 유의하게 높았으며, 한국과 러시아의 한국인 청소년들 간에 우울증의 유의한 사회심리적 위험요인들이 차이가 있음을 시사한다. Objectives : In order to study a cross-cultural epidemiology of the adolescent depressives with Korean ethnicity in Korea and Russia, we compared psychosocial characteristics and risk factors of depressive disorder between two school-based populations in different sociocultural environments. Methods : We measured psychosocial variables of 838 subjects in Korea, and 652 in Russia(Uzbekitan) using Basic Questionnaires and Beck Depression Inventory(BDI). Results : The cut-off point of BDI for adolescent depression in Koreans was 19 points. Higher prevalence of depression was noted in Korean adolescents(26.5%) compared to Korean-Russian adolescents(7.4%). We found signicant risk factors of adolescent depression in two study samples : female, academic failure, meeting friends less frequently, presence of chronic physical illness, interpersonal problems with parents, and same-sex and opposite-sex friends. Conclusions : Our data will provide information on cross-cultural understanding of psychosocial characteristics and risk factors in adolescent depression compared between Koreans and Korean-Russians.

韓國에서의 精神治療

이동신 최신의학사 1979 最新醫學 Vol.22 No.9

C-means 알고리즘을 이용한 마이크로 엔드밀의 상태 감시

권동희,정연식,강익수,김전하,김정석 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

Recently, the advanced industries using micro parts are rapidly growing. Micro end milling is one of the prominent technology that has wide spectrum of application field ranging from macro to micro parts. Also, the method of micro-grooving using micro end milling is used widely owing to many merit, but has problems of precision and quality of products due to tool wear and tool fracture. This study deals with condition monitoring using acoustic emission(AE) signal in the micro-grooving. First, the feature extraction of AE signal directly related to machining process is executed. Then, the distinctive micro end mill state according to the each tool condition is classified by using the fuzzy C-means algorithm, which is one of the methods to recognize data patterns. These result is effective monitoring method of micro end mill state by the AE sensing techniques which can be expected to be applicable to micro machining processes in the future.

親和性 크로마토그라피에 의한 大豆β-amylase의 精製 및 特性

金贊植,李東恩,姜順善 제주대학교 1992 논문집 Vol.34 No.-

Soybean β-amyase 〔β-1.4-glucan maltohydrolase EC 3.2.1.2 〕has been purified from defatted soybean meal by fractional precipitation with ammonium sulfate, ion ezchange chromatography on CM-Toyopearl 650M,affinity chromatography on γ-CD-sepharose column,and some physicochemical properties of the enzyme were investigated. The purified enzyme showed 50.5 folds of purification , 1,136unit/mg protein of specific activity and 36% of yield,respectively,compared to the curde extract. The enzyme showed a single band on Sodium Dodecyl Sulfate polyacrylamide gel electrophoresis, and its molecular was estimated to be 58,000 daltons by SDS-PAGE. The prified enzyme was identified as homegenous by HPLC analysis and maltose activity assay. The optimum pH and temperature was 5.6and 55℃ ,respentively. The enzyme was stable below 60℃,but was very labile over 65℃ The enzyme was most stable at pH 5.0~6.0, and was more stable in the acidic region than in neutral region. From the Hanes-Woolf plot,the Km value for soluble starch was calculates as 0.05% and Vmax value was 1.3×10²μmol maltose. min??.mg??

고등학교 축구 지도자의 리더십 행동유형과 선수 만족도의 관계

송광환,정재은,고의석,박윤식,육동원 한국스포츠리서치 2005 한국 스포츠 리서치 Vol.16 No.2

The purpose of this study was to examine behavioral types of efficient soccer coaches by identifying relationship between athletic satisfaction and leadership behavior types of high school soccer coaches. who have an impact on soccer players. The study also took a closer look at the types of leadership behavior shown by soccer players depending on their school level, position and status-whether or not a key player or a bench warmer. A total of 287 high school soccer players were subjected to the study and the Leadership Scale for Sport (LSS) and the Satisfaction Scale for Soccer Players were used to obtain the study results. In terms of leadership behavioral type by school level. good schools were found to hold higher levels of perception on instruction behavior. autocratic behavior. democratic behavior and social support behavior than the relatively poor schools. No significant difference was found in terms of leadership behavior type by position. However, the analysis on the leadership behavior type by players status showed that the key players had a higher perception on instruction and training behaviors than the bench warmers. According to the athletic satisfaction by school level, no significant difference was found in sub-variables. The same was true for both athletic satisfaction by position and athletic satisfaction by players status. In terms of correlation between the leadership behavior type and athletic satisfaction, training and instruction behavior. democratic behavior, social support behavior and positive feedback behavior were found to have a significant correlation with the sub-variables of athletic satisfaction, which are, sport performance satisfaction and psychological satisfaction. Moreover, the leadership behavior type, training and instruction behavior and autocratic behavior were identified as variables that have a significant impact on sport performance satisfaction and psychological satisfaction, which are sub-factors of athletic satisfaction.

상악골 비구개관 낭종의 치험예

이상철,김여갑,류동목,송우식 경희대학교 1989 慶熙醫學 Vol.5 No.2