간내 담석과 동반된 간내 담도암에서의 p53과 Ki-ras의 발현

김명환,이성구,서동완,이승규,남승우,박능화,민영일,김연석,심기남,공경엽 대한소화기학회 1997 대한소화기학회지 Vol.30 No.5

Background/Aims: Hepatolithiasis or primary intrahepatic stones may be accompanied later by intrahepatic cholangiocarcinoma. This cancerous lesion is frequently associated with atypical hyperplastic epithelium that was suspected of being precancerous. To investigate the Ki-ras or p53 mutation may play a role in carcinogenesis, and to determine whether atypical hyperplastic epithelium may be precancerous, this study was performed in intrahepatic cholangiocarcinomas associated with hepatolithiasis. Methods: We examined 12 patients with intrahepatic cholangiocarcinomas associated with hepatolithiasis. Ki-ras point mutations were assessed by direct DNA sequencing. Expressions of p53 protein were immunohistochemically assessed. The overexpression of p53 and point mutation of Ki-ras were examined in normal, hyperplastic, atypical hyperplastic, and can- cerous tissues separately. Results: The expressions of p53 protein were detected in 4 (33%) of 12 cholangiocarcinomas and Ki-ras point mutations at codon 12 were found in 2 (17%) of 12 cholangiocarcinomas. In those two carcinoma cases which contained the mutant sequence of Ki-ras, the same point mutation from wild type GGT (glycine) to GAT (aspartic acid) was. found in the associated atypical hyperplastic epithelium. However, none of the normal and hyperplastic epithelium harbored Ki-ras or p53 mutations. Conclusions: The overexpression of p53 may play a part in the carcinogenesis of some intrahepatic cholangiocarcinomas associated with hepatolithiasis, whereas the role of Ki-ras mutations in those cases is dubious. However, Ki-ras point mutation at codon 12 may be responsible for either cancer or atypical hyperplastic epithelium associated with hepatolithiasis in certain cases, suggesting atypical hyperplastic epithelium may give rise to carcinoma.

한중록의 국어학적 고찰

李氣銅(Lee Ki-dong) 고려대학교 한국학연구소 2009 한국학연구 Vol.30 No.-

본 연구의 목적은 『한중록』이라 불리는 작품의 이본인 李氣銅本과 一?本을 국어학적으로 비교하여 李氣銅本의 간행 연대를 추정하는 것이다. 『한중록』은 『한중만록』, 『읍혈록』 등의 명칭으로 불리며 지금까지 21종의 이본을 확인할 수 있다. 그러나 현재까지 원본으로 확정된 것은 없다. 본고에서는 여기에 새로운 1종을 추가하여 李氣銅本이라고 하고 이를 一?本과 비교하여 李氣銅本의 간행 연대를 추정한다. 이를 위해 두 이본 사이에서 관찰되는 연철ㆍ중철ㆍ분철, 합용병서, ‘ㅎ’종성체언, 높임법의 주격 표지, 음운변화 등의 표기 경향을 살폈다. 李氣銅本의 표기는 근대국어의 일반적 표기 경향에 가까우면서도 궁중에서 만들어진 작품이라는 성격 때문에 근대국어 이전의 표기 경향도 반영하는 보수성을 보여주고 있다. 이에 비해 一?本은 근대국어의 표기경향을 따르면서도 근대국어 후기의 성격도 반영하고 있다. 그러므로 두 이본의 비교를 통해 李氣銅本이 적어도 一?本보다 앞선 시기의 작품으로 판단할 수 있다. The purpose of this study is to compare the Lee Ki Dong-version Hanjungrok with the IlSa-version linguistically and to estimate the age of publication. The Hanjungrok has 21 versions and various names such as Hanjungmanrok, Uephyoelrok. But, up to now, there is no version identified as the original. In this paper one version called Lee Ki Dong-version is added to the versions of Hanjungrok and then compared with IlSa-version to estimate age of publication. For that, this paper investigated the notational tendency of both versions. On the one hand the notation of the Lee Ki Dong-version resembles Modem Korean notational tendency, but on the other shows the conservativeness that reflects the notational tendency of Middle Korean because of the particularity as Court literature. In comparison, the IlSa-version reflects the notational tendency of not only Modem Korean but also Late Modem Korean. As a result, the comparison between the Lee Ki Dong-version and the IlSa-version suggests that the former is earlier at least than the latter.

족과관절염좌 환자에 대한 동씨침법과 일반침법의 효과에 대한 비교 연구

안호진,정동화,황규선,윤기붕,김태우,문장혁,백종엽,이상무,Ahn, Ho-jin,Jeong, Dong-hwa,Hwang, Kyu-seon,Yoon, Ki-bung,Kim, Tae-woo,Moon, Jang-huyk,Baek, Jong-yeob,Lee, Sang-moo 대한침구의학회 2003 대한침구의학회지 Vol.20 No.1

Objective: The purpose of this study is to compare the effects of Dong-si acupuncture therapy and General acupuncture therapy for the patients with acute ankle sprain. Methods : This study has been carried out for 60 cases of ankle sprain patients who have visited Dong-Seo Oriental medical Hospital from May 1, 2002 to September 30, 2002. We have treated 30 cases of them by Dong-si acupuncture therapy and the other 30 cases by General acupuncture therapy. And we have compared those two group. Results : 1. There was no significant difference at the treatment period and the number of treatment times in comparing two groups. 2. The number of treatment times for good effect is that : Dong-si took $1.57{\pm}0.85$ times and General acupuncture therapy took $2.15{\pm}0.96$ times. And we have found that the effect of Dong-si acupuncture therapy is faster than the other.

광선각화증, 보웬병, 편평상피세포암에서 Ki-67, Cyclin A, p53, p16의 발현 양상

이효진 ( Hyo Jin Lee ),신동훈 ( Dong Hoon Shin ),최종수 ( Jong Soo Choi ),김기홍 ( Ki Hong Kim ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.4

Background: Actinic keratosis (AK) and bowen`s disease (BD) are pre-cancerous diseases, and are regarded as an early squamous cell carcinoma (SCC). AK and BD can be progressed into SCC. In this process, tumor suppressor and cell proliferative proteins may play important roles. Objective: To investigate the differences of expression patterns of the immunohistochemical (IHC) staining and useful markers for differential diagnosis in AK, BD and SCC. Methods: Biopsy had proven 17 cases of AK, 20 cases of BD and 17 cases of SCC, which were all selected. IHC staining for Ki-67 and cyclin-A, as cell proliferative markers, p53 and p16 as tumor suppressor markers, were performed. Labeling index (LI) and distribution pattern of IHC expressions were measured. Results: LI of Ki-67 in AK, BD and SCC were 30.6%, 60.2% and 54.8%, respectively. LI of cyclin-A in AK, BD and SCC were 9.2%, 24.4% and 24.1%, respectively. LI of p53 in AK, BD and SCC were 20.7%, 37.9%, and 39.9%, respectively. LI of p16 in AK, BD and SCC were 10.6%, 38.3% and 39.9%, respectively. Lower 1/3 was the most frequent distribution pattern in AK in all IHC stains, full thickness lower 2/3 were the most frequent distribution pattern in BD and SCC in all IHC stains. Conclusion: LI and distribution pattern of Ki-67, cyclin-A, and p16, as well as the distribution pattern of p53 may be useful markers to differentiate AK from BD and SCC. Higher degree and full-thickness distribution pattern IHC expressions in all stains may be helpful in the diagnosis of BD, rather than AK. (Korean J Dermatol 2012;50(4):290∼298)

Lightweight Printed Dipole Antenna Array With 3×2 Beamforming Network for Wide UAV Communication Coverage

Dong‑Geun Seo,Jeong‑Soo Park,Gun ‑Ki Lee,Wang‑Sang Lee 대한전기학회 2020 Journal of Electrical Engineering & Technology Vol.15 No.4

In this paper, a lightweight printed dipole antenna array with 3×2 beamforming network for wide unmanned aerial vehicle (UAV) communication coverage is presented. The proposed antenna consists of an upper substrate, a lower substrate, and two supports with a microstrip feeding. The upper substrate has a two-element printed dipole antenna array, and the lower substrate includes a beamforming feeding circuit and a ground plane as a refector of the proposed antenna array for gain improvement. For wide beam coverage, the proposed feeding network consists of three RF switches, one Wilkinson power divider, and one 90° hybrid coupler, and generates the wide beam using one broadside beam and two end-fre beams. Measured impedance bandwidth, peak gain, and half-power beamwidth (HPBW) of the proposed array operated from 5.03 to 5.15 GHz are approximately 2 GHz, 4.3 dBi, and 155°, respectively.

여자체조 팀별 상태불안과 기록의 관계

백동기 중앙대학교 스포츠과학연구소 2003 體育硏究 Vol.- No.19

This study aimed at analyzing the competitive state anxiety and record among the woman gymnastics teams and verifying the significance among the countries. The subjects was twenty-eight players; 7 Korean players, 7 Japanese players, 7 Chinese players and 7 Kazakstran players. The tool of this measure was TGCSA(Test of Gymnastics' Competitive State Anxiety)which was developed by Baek Dong ki1994. Before 30 minutes of the game, this test each translated in Korean, Chinese, Japanese and Kazakstran was administered. With the Mean and standard diviation if the measured data and one-way Anova statistical significance is verified. If the significance was found out Newman-Keuls was performed as the after verification. The results were the followings. 1. In cognitive state anxiety, Chinese team(12.29) is lower than the other teams(Korea 20.00, Japan 24.29, Kazakstan 22.14). 2. In somatic state anxiety, There is no significant difference among the countries(Korea 13.43, China 11.14, Japan 17.86, Kazakstan 16.29). 3. In state self-confidence, Chinese team(35.29) is higher than the other teams(Korea 27.71, Japan 26.00, Kazakstan 27.86). 4. In Vault, There is no significant difference among the countries(Korea 9.45, China 9.38, Japan 9.28, Kazakstan 9..28). 5. In Uneven Bar, China team(9.60) is higher than the other teams(Korea 9.31, Japan 9.33, Kazakstan 8.93). 6. In Balance Beam, Chinese team(9.74)is higher than the other teams(Korea 9.41, Japan 9.50, Kazakstan 9.15). 7. In Floor Exercise, There is no significant difference among the countries (Korea 9.43, China 9.40, Japan 9.31, Kazakstan 9.26).

The influence of obesity on pediatric conscious sedation

Park, Ki-Tae,Kim, Ji-Yeon,Park, Sung-Dong 大韓小兒齒科學會 2006 大韓小兒齒科學會誌 Vol.33 No.1

Objective: This study was conducted to investigate as to whether obesity have any effects on conscious sedation outcomes. Methods: Forty children (mean age 30.5 months, mean height and weight were 91.3 cm, 14.3 kg respectively) were sedated with chloral hydrate (60 mg/kg) and hydroxyzine (25 mg). The relative obesity rate of the patients was obtained by the proportion of height to weight and the tonsil size of the patients was classified by Brodsky's scale. The overall sedation outcomes were evaluated by Houpt's scale. The pulse and respiratory rates during sedation were also evaluated. Results: The obesity of the patients had no statistically significant effects on movement, crying during sedation. However, an increase in obesity had negative effects on the overall conscious sedation outcomes. Conclusion: This investigation demonstrated that increased obesity may cause detrimental effects on pediatric conscious sedation outcomes. 본 연구의 목적은 소아의 비만도가 진정요법의 효과에 미치는 영향을 알아보는 것이다. 삼성서울병원 소아치과에 내원한 환자 중 ASA Ⅰ또는Ⅱ에 해당하는 40명의 환아 (평균연령 30.5개월, 평균신장 91.3cm, 평균체중 14.3kg)를 대상으로 chloral hydrate(60mg/kg) 및 hydroxyzine(25mg)을 사용하여 진정요법을 시행하였다. 환아의 체중과 신장을 이용하여 환아 각각의 비만도를 계산하였고 Broadsky's scale을 이용하여 편도선의 크기를 측정하였다. 진정요법에 대한 결과는 Houpt's scale(수면, 움직임, 울음, 전반적인 행동지수)을 이용하여 평가하였다. 환아의 비만도는 진정효과중 움직임과 울음에 대하여는 통계학적으로 유의한 차이를 만들지 않았으나 비만도가 증가 할수록 전반적인 행동지수가 유의하게 나빠지는 결과를 보였다.

북한의 방언구획에 대한 고찰

이기동 고려대학교 한국학연구소 2001 한국학연구 Vol.15 No.-

This study centers round dialect division in the realm of dialectology which is studied mainly in North Korea. The study of language which had been worked in North Korea was not pure sense but supplementary means to perform social and political purpose. The such cognition of the study of language shows well from dialectology, and the dialect is understood in North Korea so-called 'what has to be gone in the process of centering round Mun-Hwa Language'. Despite of the such view about dialect, when we analyze the dialectology general, it is not very different from boundary of dialectology itself. It was worked relatively for many dialectologists to study of dialect division in dialectology. The early of dialect division study, it was arrangement stage of the study which is established by native and foreign dialectologists. After this, it was centering round large dialect area. It was a similar tendency in even South Korea, but since then the study in South Korea was converted to the study centering round small dialect area. It is not too much to say that dialect North Korea is Seo-Buk dialect, Dong-Buk dialect and Yukjin dialect. To be remarkable phonological feature in Seo-Buk dialect, there is no palatalization. Vowel 'ㅡ' is very unstable in Seo-Buk dialect, and it is lost of opposition to vowel 'ㅜ'. In Dong-Buk dialect, the important feature is that the inflection of the declinable word which stem ends in consonant 'ㅅ, ㅂ' is regular. In addition, the vowel sometimes nasalizes with falling of nasal consonant. To be the feature related to vowel, there is the 'umlaut' that realizes powerfully, there is a view that Yukjin dialect is regarded as 'isolated island' of Dong-Buk dialect, but it was understood in individual dialect area. Because we can see the distinguished individual system and phonological phenomena between Yukjin dialect and Dong-Buk dialect, though Seo-Buk dialect and Dong-Buk dialect share with some phonological phenomena. Especially, it is quite notable single vowel 〈+〉 that characterized central high vowel in this dialect. The studies of dialect division in North Korea have been working centered around national scale data on the whole, they present a contrast to the tendency centering round small dialect area in South Korea dialectology.

인(仁)문화의 원류와 동이(東夷)와의 관계

이기동 ( Ki Dong Lee ) 한국유교학회 2008 유교사상문화연구 Vol.32 No.-

조기에 재발한 미세낭종성 뇌수막종 -증례보고-

하동원 ( Dong Won Ha ),김세혁 ( Se Hyuk Kim ),신용삼 ( Yong Sam Shin ),안영환 ( Young Hwan Ahn ),윤수한 ( Soo Han Yoon ),조기홍 ( Ki Hong Cho ),조경기 ( Kyung Gi Cho ),임현이 ( Hyun Yee Lim ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2005 대한뇌종양학회지 Vol.4 No.2

We report a case of microcystic meningioma which showed unusual radiological findings resembling malignant tumor. A 44-year-old woman presented with generalized tonic clonic seizure and right hemiparesis. Computed tomography and magnetic resonance images showed a mass at left frontal, parasagittal area with septa-like enhancement and surrounding edema. 201Tl SPECT showed focal uptake in mass lesion which suggests the malignant tumor. The histopathological findings of this tumor revealed to be a microcystic meningioma and Ki-67 labeling index was 3.8. Although the mass was a subtype of meningioma, it showed a early recurrence 10 months after grossly total resection because of high proliferative index. We suggest that the biological behaviour in addition to morphologic classification should be considered in the management of benign brain tumor, such as meningioma.