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Bin Li,Sang-Bin Lee,Kozo Watanabe,Dong-HwanKim,Muyoung Heo,Young-Seuk Park,Tae-Soo Chon 한국응용곤충학회 2016 한국응용곤충학회 학술대회논문집 Vol.2016 No.04
Investigating loci compositions by conventional methods is limited in fully addressing complex gene information. We applied self-organizing map (SOM) to characterize Amplified Fragment Length Polymorphism (AFLP) of aquatic insects in six streams in Japan in responding to environmental variables. Locus band presence patterns were clustered by the trained SOM. Presence and absence data of loci were altered and cluster change through recognition was Subsequently expressed to indicate sensitivity to environmental variables. The outlier loci were determined based on the 90th percentile. Subsequently environmental responsiveness was obtained for each outlier in different species. Outlier loci were overall sensitive to pollutants and feeding material. Poly-loci like responsiveness was detected in adapting to environmental constraints. SOM training combined with recognition could be an efficient means of characterizing loci information without knowledge on population genetics a prior.
Dong-YoonLim,Yong-GyoonLee,Il-HwanKim 대한약학회 2002 Archives of Pharmacal Research Vol.25 No.4
The purpose of this study was to determine whether bromocriptine affects the catecholamines (CA) secretion evoked in isolated perfused rat adrenal glands, by cholinergic stimulation, membrane depolarization and calcium mobilization, and to establish the mechanism of its action. The perfusion of bromocriptine (1~10 mM) into an adrenal vein, for 60 min, produced relatively dose-dependent inhibition in the secretion of catecholamines (CA) evoked by acetylcholine (ACh, 5.32 mM), DMPP (100 mM for 2 min), McN-A-343 (100 mM for 2 min), cyclopiazonic acid (CPA, 10 mM for 4 min) and Bay-K-8644 (10 mM for 4 min). High K+ (56 mM)-evoked CA release was also inhibited, although not in a dose-dependent fashion. Also, in the presence of apomorphine (100 mM), which is also known to be a selective D2 -agonist, the CA secretory responses evoked by ACh, high potassium, DMPP, McN-A-343, Bay-K-8644 and cyclopiazonic acid were also significantly depressed. However, in adrenal glands preloaded with bromocriptine (3 mM) in the presence of metoclopramide (15 mM), a selective D2 -antagonist, the CA secretory responses evoked by ACh, high potassium, DMPP, McN-A-343, Bay-K- 8644 and cyclopiazonic acid considerably recovered as compared to that of bromocriptine only. Taken together, these results suggest that bromocriptine can inhibit the CA secretion evoked by stimulation of cholinergic receptors, as well as by membrane depolarization, in the perfused rat adrenal medulla. It is thought this inhibitory effect of bromocriptine may be mediated by inhibiting the influx of extracellular calcium and the release from intracellular calcium stores, through the activation of dopaminergic D2-receptors located in the rat adrenomedullary chromaffin cells. Furthermore, these findings also suggest that the dopaminergic D2-receptors may play an important role in regulating adrenomedullary CA secretion.
Clinical Experience in Conformal Stereotactic Radiotherapy of Irregularly Shaped Intracranial Tumors
Ki-Hwan Kim,Moon-JuneCho,Dong-WukKim,Jun-SangKim,Seon-HwanKim,Shi-HunSong,Ji-YoungJang,Jae-SungKim,Chang-JoonSong 대한암학회 2003 Cancer Research and Treatment Vol.35 No.1
Purpose: The dosimetric advantages of multiple noncoplanarstationary fields for stereotactic radiotherapyor radiosurgery (SRT/S) are well known. However, thistechnique is not widely used due to the logistical problemsassociated with producing and testing customizedcollimators. We report our experience of SRT/Susing multiple non-coplanar stationary fields (conformalSRT/ S).Materials and Methods: Between August 1997 andFebruary 2002, we performed frameless SRT/S in 63patients. We chose conformal SRT/S when the tumor wasof a very irregular shape or larger than 4 cm. We obtainedthree pieces of information: 1) the couch translationsrequired to bring the target point to the isocenter, 2) thedistance between the stereotaxic markers in the CTstudy, and the distance between the markers determinedfrom orthogonal beam films, taken in the anterior- posteriorand lateral directions, and 3) the rotational movementof thehead position between the CT study and actualtreatment position. W e evaluated two kinds of data:1) the precision of the isocenter setup, and 2) thereproducibility of the head position in the a) translationaland b) rotational components.Results: Twenty-six of the 63 patients receiving stereotactictreatment received conformal SRT/S. The precisionof the isocenter setup for the conformal SRT/S wasx=-0.03±0.26 mm, y=0.19±0.25 mm and z=-0.20 ±0.27mm. The reproducibilities of the head position with theconformal SRT/S were 0.5 mm and less than 1o, for thetranslational and rotational components, in any plane.Conclusion: We were able to apply conformal stereotacticirradiation, which has a dosimetric advantage, toirregularly shaped intracranial tumors, with precision andreproducibility of head position for the isocenter setupnearly equivalent to that of frame-based SRS or multiple-arc SRT/S. (Cancer Res Treat. 2003;35:69-74)