정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

The role of FGF-2 in smoke-induced emphysema and the therapeutic potential of recombinant FGF-2 in patients with COPD

Kim, You-Sun,Hong, Goohyeon,Kim, Doh Hyung,Kim, Young Min,Kim, Yoon-Keun,Oh, Yeon-Mok,Jee, Young-Koo Nature Publishing Group UK 2018 Experimental and molecular medicine Vol.50 No.11

<▼1><P>Although the positive effects of recombinant fibroblast growth factor-2 (rFGF-2) in chronic obstructive pulmonary disease (COPD) have been implicated in previous studies, knowledge of its role in COPD remains limited. The mechanism of FGF2 in a COPD mouse model and the therapeutic potential of rFGF-2 were investigated in COPD. The mechanism and protective effects of rFGF-2 were evaluated in cigarette smoke-exposed or elastase-induced COPD animal models. Inflammation was assessed in alveolar cells and lung tissues from mice. FGF-2 was decreased in the lungs of cigarette smoke-exposed mice. Intranasal use of rFGF-2 significantly reduced macrophage-dominant inflammation and alveolar destruction in the lungs. In the elastase-induced emphysema model, rFGF-2 improved regeneration of the lungs. In humans, plasma FGF-2 was decreased significantly in COPD compared with normal subjects (10 subjects, <I>P</I> <I>=</I> 0.037). The safety and efficacy of inhaled rFGF-2 use was examined in COPD patients, along with changes in respiratory symptoms and pulmonary function. A 2-week treatment with inhaled rFGF-2 in COPD (<I>n</I> = 6) resulted in significantly improved respiratory symptoms compared with baseline levels (<I>P</I> <I><</I> 0.05); however, the results were not significant compared with the placebo. The pulmonary function test results of COPD improved numerically compared with those in the placebo, but the difference was not statistically significant. No serious adverse events occurred during treatment with inhaled rFGF-2. The loss of FGF-2 production is an important mechanism in the development of COPD. Inhaling rFGF-2 may be a new therapeutic option for patients with COPD because rFGF-2 decreases inflammation in lungs exposed to cigarette smoke.</P></▼1><▼2><P><B>Lung disease: Inhaling a protein might help</B></P><P>Studies on the role of the protein ‘fibroblast growth factor-2’ (FGF-2) in chronic obstructive pulmonary disease (COPD) suggest that inhaled FGF-2 could help treat the emphysema linked to smoking. Researchers in South Korea led by Young-Koo Jee at Dankook University, Cheonan, and Yeon-Mok Oh at the University of Ulsan, Seoul, studied the role of the reduced FGF-2 levels found in mice with lung inflammation caused by exposure to cigarette smoke. They also uncovered details of a protective effect of inhaled FGF-2, identifying specific cellular and lung structure changes attributed to the administered FGF-2. Reduced FGF-2 levels were also found in patients with COPD. Initial trials revealed some improvement in patients treated with FGF-2, but not at a statistically significant level. Nevertheless, the authors suggest their results justify further investigation of the protein’s therapeutic potential.</P></▼2>

Gap Junction Contributions to the Goldfish Electroretinogram at the Photopic Illumination Level

Doh-Yeon Kim,Chang-Sub Jung 대한생리학회-대한약리학회 2012 The Korean Journal of Physiology & Pharmacology Vol.16 No.3

Understanding how the b-wave of the electroretinogram (ERG) is generated by full-field light stimulation is still a challenge in visual neuroscience. To understand more about the origin of the b-wave, we studied the contributions of gap junctions to the ERG b-wave. Many types of retinal neurons are connected to similar and different neighboring neurons through gap junctions. The photopic (cone-dominated) ERG, stimulated by a small light beam, was recorded from goldfish (Carassius auratus) using a corneal electrode. Data were obtained before and after intravitreal injection of agents into the eye under a photopic illumination level. Several agents were used to affect gap junctions, such as dopamine D1 and D2 receptor agonists and antagonists, a nitric oxide (NO) donor, a nitric oxide synthase (NOS) inhibitor, the gap junction blocker meclofenamic acid (MFA), and mixtures of these agents. The ERG b-waves, which were enhanced by MFA, sodium nitroprusside (SNP), SKF 38393, and sulpiride, remained following application of a further injection of a mixture with MFA. The ERG b-waves decreased following N^G-nitro-L-arginine methyl ester (L-NAME), SCH 23390, and quinpirole administration but were enhanced by further injection of a mixture with MFA. These results indicate that gap junction activity influences b-waves of the ERG related to NO and dopamine actions.

Can Television Program Diversity Be Measured? : Validity of program type model and measurement formula

Doh-Yeon Kim(김도연) 서울대학교 언론정보연구소 1998 언론정보연구 Vol.35 No.-

시청자위원회 제도의 평가와 개선방안

김도연 ( Doh Yeon Kim ) 국민대학교 사회과학연구소 2009 社會科學硏究 Vol.21 No.-

Gap Junction Contributions to the Goldfish Electroretinogram at the Photopic Illumination Level

Kim, Doh-Yeon,Jung, Chang-Sub The Korean Society of Pharmacology 2012 The Korean Journal of Physiology & Pharmacology Vol.16 No.3

Understanding how the b-wave of the electroretinogram (ERG) is generated by full-field light stimulation is still a challenge in visual neuroscience. To understand more about the origin of the b-wave, we studied the contributions of gap junctions to the ERG b-wave. Many types of retinal neurons are connected to similar and different neighboring neurons through gap junctions. The photopic (cone-dominated) ERG, stimulated by a small light beam, was recorded from goldfish (Carassius auratus) using a corneal electrode. Data were obtained before and after intravitreal injection of agents into the eye under a photopic illumination level. Several agents were used to affect gap junctions, such as dopamine D1 and D2 receptor agonists and antagonists, a nitric oxide (NO) donor, a nitric oxide synthase (NOS) inhibitor, the gap junction blocker meclofenamic acid (MFA), and mixtures of these agents. The ERG b-waves, which were enhanced by MFA, sodium nitroprusside (SNP), SKF 38393, and sulpiride, remained following application of a further injection of a mixture with MFA. The ERG b-waves decreased following $N^G$-nitro-L-arginine methyl ester (L-NAME), SCH 23390, and quinpirole administration but were enhanced by further injection of a mixture with MFA. These results indicate that gap junction activity influences b-waves of the ERG related to NO and dopamine actions.

HIP 처리에 의한 알루미나 소결체에서의 잔류기공 소멸

김도연(Doh Yeon Kim),이상호(Sang Ho Lee) 대한금속재료학회 1992 분말야금 Vol.4 No.-

통신,방송의 융합과 정책 방향 : 디지털화를 통한 케이블TV 융합전략과 공정경쟁 규제이슈

김도연 ( Doh Yeon Kim ) 정보통신정책학회 2004 정보통신정책연구 Vol.11 No.3

케이블TV는 사용하는 네트워크와 제공되는 서비스, 그리고 사업자들의 행위 등에서 통신ㆍ방송 융합의 가장 선도적인 산업부문으로 인정되어왔다. 케이블TV 산업은 주요국에서 산업으로 성장하며 일정 규모의 초기가입자와 네트워크 외부성, 그리고 규모와 범위의 경제를 구현하는 산업적 특성을 형성하며 이러한 성격들을 융합산업으로의 변모에 활용하려고 하는 반면에, 국내의 경우 케이블TV 도입 초기의 시행착오를 거쳐 이행기의 어려움을 돌파해 줄 해결책으로 디지털화를 총한 융합 전략을 채택한 면이 크다. 국내 케이블TV 산업계에서는 구체적으로 디지털미디어센터(DMC)의 구축을 통해 트리플 플레이 서비스(TPS)의 제공을 추구하는 것을 융합 전략으로 하고 있다고 하겠다. 그러나 이의 추진과 성공을 위해서는 결합상품에서의 상호보조의 문제와 수평적, 수직적 기업견합에서의 시장지배력에 대한 합리적인 규제기준을 마련하여 새로운 융합 상황에서의 공정경쟁 환경을 조성하는 것이 중요하다고 할 것이다. Cable TV has been recognized as an industry which is the most advanced for convergence in its network, service, and players` conduct. In advanced countries, cable TV grew to be a typical industry, reaching to the critical mass in its early stage, getting network externality, and utilizing the economies of scale and scope, which have led to the transformation into convergence industry. In Korea, however, cable TV has struggled with lot of trials and errors from the beginning, and adopted the strategy of digitalization to overcome them. More concretely, Korean cable TV industry has established the convergence strategies to built digital media centers(DMC) and to provide triple play service(TPS). However, to propel and succeed in the convergence strategies, a proper regulatory scheme is required. Especially, the regulation of cross subsidization in bundling products and the control of market governance execution are important in order to establish fair competition environment in convergence market.

균형성과표(BSC)를 통한 ADS-B 운영성과분석

김도현 ( Doh Yeon Kim ),류종현 ( Jong Hyeon Ryu ) 한국항공운항학회 2010 한국항공운항학회지 Vol.18 No.4

This study is to analyze the performance for ADS-B(Automatic Dependent Surveillance-Broadcast) operations by the Balanced Scorecard(BSC). It is also to collect the opinions of users(pilots, air traffic controllers and ground operators) relating ADS-B and to use the results as data about preparing political measures of aviation safety. For these purpose, BSC model redesigned on 4 different points of view is used for measuring the performance of the ADS-B operation. The proposed perspectives are affairs effectiveness, user orientation, system orientation and the capacity. As the results of this study, it is showed that the continuous development of ADS-B should be required and the users must be involved in the activities, additionally, the relevant authorities should try to be drawn the user-oriented results through the process.

애니메이션의 성공조건

김도연(Doh Yeon Kim) 한국콘텐츠학회 2011 한국콘텐츠학회논문지 Vol.11 No.8

〈뽀로로〉의 기획 및 제작과정을 현재의 성공적 성과와 연결지어 분석하면, 기획단계에서부터 문화적 할인(cultural discount)까지를 고려한 과학적이고 치밀한 기획을 하고 여러 참여사의 장점을 극대화한 협력적 비즈니스 관계를 확립한 것이 여러 창구를 통한 콘텐츠의 지속적 수익창출과 시리즈의 제작, 그리고 캐릭터 판매를 통한 수익 극대화와 해외 판매로까지 이어지는 성공적인 성과를 낳았음을 발견하게 된다. 그러나 흔히들 이야기하는 애니메이션 비즈니스 전략으로서의 OSMU는 기획단계에서부터 의도되었다기보다는 좋은 콘텐츠를 제작한 이후의 비즈니스 과정으로 진행되었다고 하겠다. 그런 점에서 그간 애니메이션산업 연구에서 언급되어온 OSMU전략은 산업현장을 현실을 고려할 때 지나치게 강조된 측면이 있다. 〈뽀로로〉와 같은 성공사례를 더 낳아 국내 애니메이션산업계에 좋은 작품이 계속 생산되는 생태계를 조성하기 위해서는 업계의 노력과 정부의 정책효율성이 함께 증진될 필요가 있다. When the process of planning and production of Pororo is to be analyzed, scientific and meticulous contents planning which considered even cultural discount, and collaborative business partnership which maximized the strength of each participants are found to be the main success factors. Owing to them, Pororo has resulted in continuous profit making through various outlets, the production of series up to 4 seasons, and successful sales in foreign markets. However, OSMU strategy as the key business strategy was not intended from the stage of planning, but was resulted as the business process after good contents were created. In order to have more successful cases like Pororo, and to build a good animation industry ecosystem, efforts by the industry and effective supporting system by the governments should be met.