Histoid Leprosy의 1例

尹在一,金鍾敏,金洪植,金道一 大韓癩學會 1976 癩學 會誌 Vol.10 No.1

자기교시 언어치료전략을 사용한 문장지도 프로그램이 정신지체아동의 언어능력에 미치는 효과

윤선연,권도하 대구대학교 특수교육재활과학연구소 2004 再活科學硏究 Vol.22 No.1

본 연구의 목적은 자기 교시 언어치료 전략을 사용한 문장 지도 프로그램이 정신지체 아동의 언어 능력에 미치는 효과를 증명하는 것이다. 본 실험은 3명의 피험자에게 40분 한 세션으로 일주일에 4회 지도하였다. 실험은 사전, 치료, 유지의 세 단계로 구성되었으며 AB 실험설계를 이용하였다. 의문사 이해력과 구어 표현력 사전, 사후, 유지 단계에서 평가되었다. 그 결과는 다음과 같다. 첫째, 의문사를 이해하는 능력은 모든 피험자들이 향상 되었다. 그리고 계속적으로 의문사 이해능력이 유지되었다. 둘째, 본 실험에서 모든 피험자들의 구어 표현력의 향상되었다. 구어 표현력 또한 지속적으로 유지되었다. 결론적으로 자기 교시 언어치료 전략을 사용한 문장 지도 프로그램이 정신지체 아동의 언어 능력을 향상시키는데 효과적이었다. 본 연구는 자기 교시 언어치료 전략을 사용한 문장 지도 프로그램이 정신지체 아동의 언어 능력에 미치는 효과를 증명하기 위하여, 12~13세 중도(중도)교육가능급 정신지체아동 3명을 대상으로 지도하였다. 실험은 사전평가, 치료, 유지의 세 단계로 구성되었으며 AB설계를 사용하였다. 의문사 이해력과 구어 표현력이 사전, 사후, 유지 단계에서 평가되었다. 실험 결과, 첫째, 의문사를 이해하는 능력이 모든 피험자들이 향상되었고, 계속적으로 의문사 이해능력이 유지되었다. 둘째, 모든 피험자들의 구어 표현력의 향상되었다. 구어 표현력 또한 지속적으로 유지되었다. 결론적으로 자기 교시 언어치료 전략을 사용한 문장 지도 프로그램이 정신지체 아동의 언어 능력을 향상시키는데 효과적이었다. First, the ability to understand interrogative was improved after treatment in all subjects. The subjects maintained the ability to understand an interrogative continuously. Second, this research showed the improvement of children's ability to express the spoken language in all subjects. The subjects maintained the ability to express the spoken language continuously. In conclusion, the sentence instruction program by using self-instruction language treatment strategy was effective on improving the language ability of mentally retarded children.

자매에서 발생한 중증 마이코플라즈마 폐렴에서 스테로이드 치료

김도희,이경일,김명숙,윤유숙,황자영,임정우,강진한,이준성 대한감염학회 2009 감염과 화학요법 Vol.41 No.3

Numerous evidences support the pathogenesis that M. pneumonias pneumonia is associated with cell-mediat-ed immune reaction. We report 2 cases of severe M. pneumoniae pneumonia in previously healthy sisters, who were both admitted during an epidemic of M. pneumoniae pneumonia. The elder sister, who was 16 years old, was admitted with M. pneumoniae pneumonia. She showed no response to treatment with clarithroycin and levo-floxacin, and eventually progressed to severe ARDS, requiring mechanical ventilation. After treatment with hydrocortisone (200 mg/day), there were rapid improvements in clinical manifestations and chest radiographic findings. The younger sister, who was 14 years old, was admitted 10 days later, Presenting with fever but no pneumonic lesions on chest radiograph. Just like her sister, the infection showed no response to clarithromycin. Fever persisted and pneumonic consolidation with mild pleural effusion was noticed in the left lower lobe on the 5th hospital-day. After treatment with oral prednisolone (1 mg/kg), she showed rapid defervescence and on the 8th hospital day, no pneumonic lesions were detectable on chest radiograph. Given the fact that the pathogenesis of pneumonia and extrapulmonary manifestations in M. pneumoniae infection is immune-mediated, an immuno-suppressive therapy would be validated for selected patients with M. pneumoniae infections.

Freud의 'Rat Man' 증례를 통해 본 강박신경증의 정신분석적 이해

조도연 한국정신분석학회 1994 精神分析 (Psychoanalysis) Vol.5 No.1

오래 잠그어 둔 수도에서 유출되는 철분의 함량

송도미,이승희,신연욱,장혜경,오경숙,전현 효성여자대학교 가정대학 학도호국단 1984 家政大論集 Vol.3 No.-

This study given here presents the results of an experimental investigation of the iron contents contained in the city water which not used for a long time in the winter. The measurements were performed after turning on and for flowing water in a moment. And the quantitative analysis was studied by chemical form and the results were as follows. 1. The content of the ferrous ion was 113.8-14.4 ppm, water soluble iron was 22.5-14.4 ppm and acid soluble iron was 150-10 ppm. 2. Iron contents of the each chemical from gradually reduced but it appeared high value than standard value of city water until five minutes.

복합섬유 보강 고인성 시멘트 복합체의 특성

윤현도,양일승,한병찬,福山洋,전에스더,문연준 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

In this paper, workability, fiber dispersion. compressive strength and splitting strength of hybrid fiber reinforced cement composites(HFHCC) have been investigated by means of Korean Standard (KS). Two type of HFRCC were constructed using fiber combinations of Polyethylene(PE) and steel fibers. Polyvinyl alcohol(PVA) and steel fibers. Test results showed that the fibers, when used in a hybrid form. could result in superior composite performance compared to their individual fiber reinforced cement Composites. Synthetic micro fibers. such as PE and PVA. are effective at imparting fiber dispersion and ductility to the steel fiber (five twisted steel fiber) reinforced cement Composite.

불응성 자가면역질환에서의 자가조혈모세포이식

민도준,양동원,민창기,김완욱,이상헌,박성환,김동욱,이종욱,조철수,민우성,김범생,김호연,김춘추 대한조혈모세포이식학회 2001 대한조혈모세포이식학회지 Vol.6 No.1

배경: 기존의 치료에 불응하고 예후가 불량한 자가면역질환 환자들에게 최근 고용량 면역억제 및 조혈모 세포이식이 새로운 치료방법으로 대두되고 있다. 저자들은 다발성 경화증(multiple sclerosis, MS) 및 류마티스 관절염(rheumatoid arthritis, RA) 등 2명의 자가면역질환 환자들에서 자가조혈모세포 이식을 시행하였다. 방법: 말초혈액 조혈모세포 가동화를 위하여 cyclophosphamide (4 g/㎡) 및 granulocyte colony stimulating factor (10 g/kg/day)를 투여하였고, CD34+ 세포를 분리·채집 하였다, 이식 전처치로 MS 환자에서 BEAM 및 antihymocyte globulin (ATG) (3.75 mg/kg), RA 환자에서 fludarabine (180 mg/㎡), ATG (10 mg/kg)와 busulfan (8 mg/kg)을 투여하였다. 결과: 호중구 수가 500/㎕ 이상으로 회복되는 기간은 MS 환자에서 9일, RA 환자에서 15일이었다. 혈소판이 20.000/㎕ 이상으로 회복되는 가간은 RA 환자에서 9일 이었고, MS 환자에서는 혈소판 감소증이 발생하지 않았다. 비혈액학적 독성으로 MS 환자에서 WHO 1도의 오심 및 점막염이 관찰되었다. MS 환자는 이식 6개월 후까지 시력감소가 남아있었으나, 이식전에 관찰되던 감각이상 및 운동장애 등의 신경학적 이상 소견은 더 이상 관찰되지 않았다. RA 환자는 이식 1개월 후 관절 증상 및 검사소견의 호전을 보였다. 결론: 불응성 자가면역질환 환자에서 고용량 면역억제 및 조혈모세포이식은 적은 독성으로 높은 치료효과를 기대할수 있으며, 향후 이 시술의 임상적 의의를 규명하기 위하여 전향적이고 장기적인 연구가 필요할 것으로 사료된다. Background: High-dose immunosuppressive therapy followed by autologous hemathpoietic stem cell transplantation (HSCT) has been proposed as a new approach to treat severe, refractory autoimmune diseases. We describe two patients with refractory autoimmune diseases (one multiple sclerosis 〔MS〕and one rheumatoid arthritis〔RA〕) who underwent T-cell-depleted autologous peripheral bleed stem cell transplantation for the first time in Korea. Methods: We mobilized autologous stem cells with cyclophisphamide (4 g/㎡) and granulocyte colony-stimulating factor (10 ㎍/kg/day). Stem cells were enriched ex vivo using CD34-positive immunoselection and reinfused after high-dose chemotherapy with BEAM and antithymocyte globulin (ATG) (3.75 mg/kg) in MS, or fludarabine (180 mg/㎡), ATG (10 mg/kg) and busulfan (8 mg/kg) in RA. Results: The engraftment with an absolute nerutrophil count greater than 500㎕ occurred on day 9 in MS and 15 in RA, respectively. The time to nontransfused platelet count greater than 2.000/㎕ was 9 day in RA. MS patient did not show ant episode of thrombocytopenia. Regimen-related non-hematopoietic toxicity was minimal. For 6 months since HSCT, them patient with MS had been free from previously existed sensory and motor abnormalities except decreased visual acuity. Then patient with RA and only one tender joint and two mildly swollen joints with improvement in laboratory parameters at one month after HSCT. Conclusion: These results underscore the feasibility and potential efficacy of intensive immunosuppression followed by autologous HSCT for treatment of intractable autoimmune diseases. The durability of remission, however, remains to be clarified.

甲狀腺炎과 Lithium 治療에 의한 甲狀腺機能低下症

鄭道彦,禹鍾仁,李定均,趙普衍,高昌舜,金勇一 大韓神經精神醫學會 1982 신경정신의학 Vol.21 No.2

A case of a female Manic Depressive Illness patient with goitrous hypothyroidism is presented. After ten and half months of lithium maintenance therapy starting during her first psychiatric admission, she was admitted again due to acute recurrent manic episode. On admission, she complained of easy fatigability and cold intolerance, and thyroid gland was palpable and enlarged in moderate degree. Thyroid function test revealed markedly increased TSH and moderately decreased thyroxine levels. TRH stimulation test showed an exaggerated response. Needle biopsy specimen revealed chronic lymphocytic and immune complex thyroiditis. However, antithyroglobulin and antimicrosomal antibodies were negative. In pretreatment thyroid evaluation on her first admission, neither goiter nor thyroid function abnormality was detectable and no signs of underlying thyroid disease or hereditary predisposition to hypothyroidism were present. Within three weeks of discontinuation of lithium, goiter was no more palpable and within five weeks, thyroid function test returned to normal range. The possibility that patients with underlying thyroiditis may be particularly susceptible to a rapid onset of lithium-induced hypothyroidism is discussed.

다양한 운동형태의 일회성 운동에 따른 혈액성분 및 혈장량 변화에 대한 연구

김도윤,김원현,김광회 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.1

Acute Blood Compositions change were determined in 18 Healthy college aged-men completing three counterbalanced running trial at different exercise intensities: trial 1 at 50%LT, trial 2 at 100% LT intensity and 150%LT intensity. For each trial, blood samples were collected at pre-exercise(baseline), immediately post-exercise(PE), 24 hours(24h) and 48 hours post-exercise. Serum samples were analyzed for Hematocrit(Hct), Red Blood Cell(RBC), White Blood cell(WBC), Hemoglobin(Hb), and plasma Volume Change(PVC). In addition, capillary blood samples were collected for analysis of blood lactate concentrations during incremental test to determine LT. All samples were compared to pre-exercise(baseline). In assessing the blood compositions change variables, significant difference was determined in chages of Hct, RBC, Hb at various intensities over time. However, there was no significant difference in WBC, PVC at any intensity. Consequently, there was significant difference between the 150%LT and the 50%LT for the blood compositions change. I thought that the 50%LT and the 100%LT which was used the exercise protocol with 400 calories consumption didn't support the stimulation enough to response during the exercise even though 150%LT stimulated subjects to get less response than previous studies.

위점막조직에서 Ghrelin 양성세포의 발현

박도윤,전태용 부산대학교 병원 암연구소 2009 부산대병원학술지 Vol.- No.25