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柳道坤,鄭遇悅 圓光大學校 韓醫學硏究所 1991 원광한의학 Vol.1 No.1
It is well known that Oriental medicine has a characteristic system of theory and superior remedial value. The purpose of this study is to elucidate the vague Oriental medical concepts for its objectification and clinical application. Han and Yeal were recognized as a part of climate changes in the first stage of Oriental medicine, Gradually, they have been applied to the medial concepts such as the metabolic principle and nature of diseases. Han, yin is recognized as the decline of physiological function, reduction of defense and induces metabolic abnormal depression. Yeal, yang is recognized as the acceleration of body function, inflammatory disease and induces metabolic abnormal stimulation.
李道烈 又石大學校 1986 論文集 Vol.8 No.-
文章의 構造的特質이 思考展開의 表現에 있다고 볼 때, 展開의 役割을 擔當하는 것이 接續語句이다. 接續語句는 2개 이상의 語, 句, 文, 文章에 의해 表現된 敍述內容 相互間을 關係짓는 職能을 가지며 그 種類나 方法도 多樣하다. 一般的으로 文에 있어서 接續語句를 使用하는 것은 論理的 關係의 明確化를 기함에 있으므로, 적절한 接續語句를 選擇, 表現함이 무엇보다 重要하다. 本 考察에서는 多樣한 接續語句의 機能, 種類, 接續形態, 共通相異點등을 記述함에 目的을 두었으며, 特히 接續詞의 意味關係에 依한 分類에 重點을 두었다. 다만, 接續語句 全體를 考察함으로 因한 各論의 未備點들은 追後 硏究로 돌리고자 한다.
李道烈 又石大學校 1984 論文集 Vol.6 No.-
日本외 平安(Hei-An)時代 以後, 假名(kana)의 發達에 힘입어, 그 때까지 存在하던 神話·傳設·設話 등의 古傳承的인 小話가 散文風의 自由로운 表現形式을 빌어 文學化된 것이 物語(Monogatari)이다. 素材가 多樣함에 따라, 主題도 多彩로왔으며, 臨場感을 나타내기 위한 文章의 表現形式도 作者의 表現意圖에 따라 複雜한 形態로 나타났다. 따라서, 物語의 樣式(style)을 規定하기 위해서 作品의 內容·素材·主題·文章의 敍述形態·文體 등을 綜合的으로 考慮할 必要性이 있다. 많은 物語作品 중에서「竹取物語」를 考察의 對象으로 選擇한 것은 이 作品이 日本 最初의 物語作品일 뿐만 아니라, 從來의 單片的인 樣式規定에서 벗어나 多角的인 檢討를 통해 그 樣式을 再考察함에 目的이 있다. 考察의 順序는, 物語의 定義, 從來의 主張, 內容構成의 分析과 文章의 敍述樣式 및 文末表現特徵을 文體論的 側面에서 小考해보았다. 다만, 綜合的인 觀察에만 置重하여, 考察의 深度가 얕았던 점을 目省하며, 構文論的 硏究는 後稿로 미룬다.
Type 304 스테인리스 강판의 상온 및 저온 피로특성에 미치는 Ni 함량과 가공유기 마르텐사이트 변태의 영향
柳度烈,李守澯,李庸得,姜晶允 대한금속재료학회 2001 대한금속·재료학회지 Vol.39 No.12
Effects of Ni content(8.3∼12 wt.%) and deformation-induced martensitic transformation on the bending and zero to tension fatigue behavior of Type 304 stainless steel used for the membrane of LNG storage tank at room and cryogenic temperature were investigated. By lowering the Ni content, the bending fatigue life at room temperature was decreased at the high level of total strain amplitude. It would be attributed to the crack initiation at γ/α' interface and the low ductility with the increase of α' contents. However, at the low level of total strain amplitude, lowering the Ni content increased the bending fatigue life. It was due to the suppression of crack propagation by the α'-martensite transformation around crack tip and the increase of tensile strength. At cryogenic temperature, lowering the Ni content showed beneficial effect on the bending fatigue life due to the increase of slip deformation resistance. In the zero to tension fatigue test, lowering the Ni content showed better fatigue characteristics regardless of the temperature variation. In this case, the high tensile strength with the α'-martensite transformation mostly affects material's fatigue life.
Type 304 스테인리스 강판의 Ni 함량 변화에 따른 굽힘 피로수명 예측에 관한 연구
유도열,이수찬,강정윤 대한금속재료학회 2004 대한금속·재료학회지 Vol.42 No.7
The prediction of bending fatigue life was carried out for Type 304 stainless steel sheets containing various nickel contents from 8.3 up to 12 wt.%. After the slopes of the elastic strain (Δε_(e)/2) and the plastic strain (Δε_(p)/2) lines were obtained by the tensile test and bending fatigue test data at room and cryogenic temperatures, the prediction equations for the bending fatigue life were made by using the method of universal slope. At the ranges above 10³ Cycles, the predicted equations showed higher bending fatigue life same as measured one with lowering the nickel contents in the range of 8.3-12 wt. %. But, at the ranges below 10³ Cycles, the predictions of low-cycle bending fatigue life varying the nickel contents were different from the measured ones. A limitation was encountered for the prediction of the bending fatigue life with using the tensile data. In order to increase the reliability of the prediction equations at the ranges below 10³ Cycles, it is necessary to take into account the behavior of the α'-martensite transformation during fatigue affecting the generation and propagation of fatigue cracks. (Received March 8, 2004)
The Effects of Peroxiredoxins on Sperm Function and Male Fertility
Do-Yeal Ryu,Woo-Sung Kwon,Md Saidur Rahman,Amena Khatun,Myung-Geol Pang 한국동물생명공학회(구 한국동물번식학회) 2017 발생공학 국제심포지엄 및 학술대회 Vol.2017 No.10
Peroxiredoxins (PRDXs), which are essential antioxidant enzymes for physiological activity, have reported that influence sperm function and consequently male fertility. Although PRDXs are well known as important factor to affect male fertility, there has been a lack of attempt to discover the accurate role and mechanism of PRDXs in male fertility. Therefore, the principal objective of this study is to elucidate the role of PRDXs in sperm function and fertilization. We treated mouse spermatozoa with different dose of specific inhibitor of PRDXs, conoidin A (1, 10, or 100 μM). Our results revealed that conoidin A significantly decreased oxidized form of PRDXs (PRDXs-SO3) in mouse spermatozoa. Inhibited PRDXs activity are then resulted in a significant decrease in sperm motility/motion kinematics, viability, mitochondrial membrane potential, and intracellular ATP levels. On the other hand, intracellular levels of ROS and DNA fragmentation index were significantly increased following exposure to conodin A. Next, we evaluated capacitation and acrosome reaction status, and subsequently tyrosine phosphorylation and protein kinase-A activity to investigated underlying mechanism of PRDXs on sperm capacitation status. Capacitation and acrosome reaction were significantly decreased perhaps due to reduction of tyrosine phosphorylation and protein kinase- A activity. Finally, we investigated the effect of PRDXs on fertilization and early embryonic development. Our results described that decreased PRDXs activity significantly decreased fertilization and early embryonic development. Consequently, we demonstrated that inhibition of PRDXs activity has a direct impact on male fertility via decreased important physiological sperm function, eventually resulted in poor fertilisation and embryonic development.
Freezability biomarkers in epididymal spermatozoa
Do-Yeal Ryu,Won-HeeSong,Won-KiPang,Sung-JaeYoon,Md Saidur Rahman,Myung-Geol Pang 한국수정란이식학회 2018 한국수정란이식학회 학술대회 Vol.2018 No.11
Sperm cryopreservation is well known as a valuable method to preserve the genetic traits. Although many studies have established semen cryopreservation protocols, lack of studies were conducted to discover the differences of sperm proteome and functions between ejaculated and epididymal spermatozoa following to cryopreservation. Therefore, the objective of this study was to (i) evaluate the effect of cryopreservation on bull epididymal spermatozoa and (ii) discover the potential biomarkers, which have highly tolerance to freezing on bull epididymal spermatozoa. Our preliminary study demonstrated that spermatozoa from each bulls have different resistance on freezing during cryopreservation. We divided spermatozoa into two groups according to sperm motility following to cryopreservation; high freezing-tolerant spermatozoa (HFS) and low freezing-tolerant spermatozoa (LFS). Several sperm functional parameters, i.e. sperm motility/motion kinematics, speed parameters, viability, mitochondrial membrane potential, and capacitation status. Our results showed that all parameters except for motion kinematics and capacitation status had significant differences between HFS and LFS. Subsequently, two dimensional electrophoresis were conducted to compare the expression levels of sperm proteome between both groups. Three proteins {glutathione s-transferase mu 5 (GSTM5), voltage-dependent anion-selective channel protein 2 (VDAC2), and ATP stynthase subunit beta (ATP1B1)} were differentially expressed. Based on these results, we propose that epididymal spermatozoa from individual bull have different freezability upon cryopreservation and three differentially expressed proteins might be selected as a biomarker to predict high freezing-tolerant epididymal spermatozoa.
( Do Yeal Ryu ),( Ye Ji Kim ),( June Sub Lee ),( Md Saidur Rahman ),( Woo Sung Kwon ),( Sung Jae Yoon ),( Myung Geol Pang ) 한국동물자원과학회(구 한국축산학회) 2014 한국축산학회지 Vol.56 No.26
Background: Endocrine disruptors are exogenous substance, interfere with the endocrine system, and disrupt hormonal functions. However, the effect of endocrine disruptors in different species has not yet been elucidated. Therefore, we investigated the possible effects of 17ß-estradiol (E2), progesterone (P4), genistein (GEN) and 4-tert-octylphenol (OP), on capacitation and the acrosome reaction in bovine, mouse, and porcine spermatozoa. In this in vitro trial, spermatozoa were incubated with 0.001-100 μM of each chemical either 15 or 30 min and then assessed capacitation status using chlortetracycline staining. Results: E2 significantly increased capacitation and the acrosome reaction after 30 min, while the acrosome reaction after 15 min incubation in mouse spermatozoa. Simultaneously, capacitation and the acrosome reaction were induced after 15 and 30 min incubation in porcine spermatozoa, respectively. Capacitation was increased in porcine spermatozoa after 15 min incubation at the lowest concentration, while the acrosome reaction was increased in mouse spermatozoa after 30 min (P <0.05). E2 significantly increased the acrosome reaction in porcine spermatozoa, but only at the highest concentration examined (P <0.05). P4 significantly increased the acrosome reaction in bovine and mouse spermatozoa treated for 15 min (P <0.05). The same treatment significantly increased capacitation in porcine spermatozoa (P <0.05). P4 significantly increased capacitation in mouse spermatozoa treated for 30 min (P <0.05). GEN significantly increased the acrosome reaction in porcine spermatozoa treated for 15 and 30 min and in mouse spermatozoa treated for 30 min (P <0.05). OP significantly increased the acrosome reaction in mouse spermatozoa after 15 min (P <0.05). Besides, when spermatozoa were incubated for 30 min, capacitation and the acrosome reaction were higher than 15 min incubation in E2 or GEN. Furthermore, the responsiveness of bovine, mouse and porcine spermatozoa to each chemical differed. Conclusions: In conclusion, all chemicals studied effectively increased capacitation and the acrosome reaction in bovine, mouse, and porcine spermatozoa. Also we found that both E2 and P4 were more potent than environmental estrogens in altering sperm function. Porcine and mouse spermatozoa were more responsive than bovine spermatozoa.
Ryu, Do-Yeal,Kim, Ye-Ji,Lee, June-Sub,Rahman, Md. Saidur,Kwon, Woo-Sung,Yoon, Sung-Jae,Pang, Myung-Geol Korean Society of Animal Sciences and Technology 2014 한국축산학회지 Vol.56 No.7
Background: Endocrine disruptors are exogenous substance, interfere with the endocrine system, and disrupt hormonal functions. However, the effect of endocrine disruptors in different species has not yet been elucidated. Therefore, we investigated the possible effects of $17{\beta}$-estradiol (E2), progesterone (P4), genistein (GEN) and 4-tert-octylphenol (OP), on capacitation and the acrosome reaction in bovine, mouse, and porcine spermatozoa. In this in vitro trial, spermatozoa were incubated with $0.001-100{\mu}M$ of each chemical either 15 or 30 min and then assessed capacitation status using chlortetracycline staining. Results: E2 significantly increased capacitation and the acrosome reaction after 30 min, while the acrosome reaction after 15 min incubation in mouse spermatozoa. Simultaneously, capacitation and the acrosome reaction were induced after 15 and 30 min incubation in porcine spermatozoa, respectively. Capacitation was increased in porcine spermatozoa after 15 min incubation at the lowest concentration, while the acrosome reaction was increased in mouse spermatozoa after 30 min (P < 0.05). E2 significantly increased the acrosome reaction in porcine spermatozoa, but only at the highest concentration examined (P < 0.05). P4 significantly increased the acrosome reaction in bovine and mouse spermatozoa treated for 15 min (P < 0.05). The same treatment significantly increased capacitation in porcine spermatozoa (P < 0.05). P4 significantly increased capacitation in mouse spermatozoa treated for 30 min (P < 0.05). GEN significantly increased the acrosome reaction in porcine spermatozoa treated for 15 and 30 min and in mouse spermatozoa treated for 30 min (P < 0.05). OP significantly increased the acrosome reaction in mouse spermatozoa after 15 min (P < 0.05). Besides, when spermatozoa were incubated for 30 min, capacitation and the acrosome reaction were higher than 15 min incubation in E2 or GEN. Furthermore, the responsiveness of bovine, mouse and porcine spermatozoa to each chemical differed. Conclusions: In conclusion, all chemicals studied effectively increased capacitation and the acrosome reaction in bovine, mouse, and porcine spermatozoa. Also we found that both E2 and P4 were more potent than environmental estrogens in altering sperm function. Porcine and mouse spermatozoa were more responsive than bovine spermatozoa.