도시하천 생태 체험 프로그램 적용이 초등학생의 환경 감수성에 미치는 영향

배효선(Hyo-Seon Bae),최도성(Do Sung Choi),김영록(Young Rock Kim) 한국환경교육학회 2011 環境 敎育 Vol.24 No.1

The goal of this study is to investigate the effect of ecological experience program at the urban stream on the environmental sensitivity of elementary school students. In order to perform this study, two classes of 6th graders of M elementary school in Gwangju were selected and divided into two groups; one groups was the experimental group that undergoes ecological experience program at the Gwangju River, and another group was the control group that studied about environment in the classroom. The results of this study were as following. First of all, the experimental group has more influence on the environmental sensitivity than the control group. Secondly, the ecological experience program at the urban stream can be the effective method to build the environmental sensitivity of elementary school students. In conclusion, the results are showing that the ecological experience program at the urban stream helps elementary school students to change their environmental sensitivity in positive ways, also it gives idea that how to protect the environment and what they actually can do.

비·부비동 종양의 신생혈관 형성에서 COX-2 및 VEGF의 역할

도남용,박성용,조성일,윤혁수,박선홍,박영균,권대승,임성철 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1

Background and Objectives : COX-2, the inducible form of cyclooxygenase(COX), is upregulated in transformed cells and in malignant cells, which have important roles in promotion of colorectal carcinogenesis, invasiveness and angiogenesis. Vascular endothelial growth factor(VEGF) may act as endothelial cell mitogen in various cancer tissues. It will increase tumor growth and angiogenesis. Aims of this study were to asses COX-2/VEGF expression and it's clinical correlation in sinonasal tumors and to investigate the effects on angiogenesis also. Materials and Method : The study samples were obtained from surgical removal of 27 cases of inverted papilloma(IPs), 5 cases of IP with malignant transformation(IP-MT), 16 cases of Squamous cell carcinoma(SCC) in sinonasal cavity COX-2 and VEGF expressions were assessed by immunohistochemical staining. Synchronism of COX-2/VEGF expression in one tumor cell was demonstrated with double immunofluorescence technique. Results : The expression rates of COX-2 were 37% in IP, 80% in IP-MT and 100% in SCC. The positive rates of VEGF were 29 6% in IP, 100% in IP-MT and SCC. COX-2 and VEGF expressions were increased as tumor progressed, and there is a positive correlation between COX-2 &EGF expressions. All clinical features which were compared are not associated with COX-2 &EGF expressions except malignant change in IP(p=0 028). Synchronism of COX-2/VEGF expressions was noted in all positive immunostaining samples. Conclusion : These findings suggest the role of COX-2 pathway could be involved in sinonasal tumor angiogenesis, which is modulated by VEGF COX-2 may act as autocrine factor in VEGF expression. There is a potential role for selective COX-2 inhibitors in the treatment of these lesions.

볶음보리 추출물의 아질산염 소거인자

도정룡,김선봉,이용우,구연숙,박영호 한국노화학회 1991 한국노화학회지 Vol.1 No.1

신경인성 방광의 치료에서 요도부목 설치의성공례와 실패례 -증례 보고-

임선희,나은우,이일영,문혜원,임신영,정도영 大韓再活醫學會 2000 Annals of Rehabilitation Medicine Vol.24 No.1

비강 및 부비동 종양에서의 종양혈관형성에 관한 면역조직화학적 연구

도남용,노용훈,박선홍 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1

Background and Objectives : Angiogenesis is essential for the growth of solid tumors. Microvessel density(MVD), which represent a measure of tumor angiogenesis, have been found to have prognostic significance in many tumor types for predicting an increased risk of metastasis. However, the significance of angiogenesis in sinonasal malignant tumor remains controversial. The purpose of this study was to asses the tumor vascularity using the highly specific endothelial cell marker CD34, and the expression of its related protein p53, in sinonasal malignant tumors. Materials and Methods : The study samples were obtained after surgical removal of 27 cases of inverted papilloma(IPs), 5 cases of IPs with malignant transformation(IP-MT), 16 cases of squamous cell carcinoma(SCC) in sinonasal cavity. Microvessels were stained with anti-CD34 and p53 expressions were assessed by immunohistochemical staining. Results : The degree of tumor angiogenesis in squamous cell carcinoma group was higher than in inverted papilloma group, and which reached at highest level in IP-MT(p<05). The p53 expressions were increased as tumor progressed, which was statistically significant also(p<05). Significant correlation between MVD and p53 expressions was observed in IP(p<05) but there were no correlation in IP-MT and SCC. Conclusions : These results suggest that overexpression of p53 and MVD in the sinonasal tumors seemed to be associated with tumorigenesis but further studies on tumor angiogenesis of sinonasal tumors are needed before it can be adopted as a prognostic marker.

Irbesartan과 Lercanidipine의 병용요법이 고혈압 및 혈관재형성에 미치는 효과

이도형, 임태완, 조은지, 박현수, 정상혁, 한주희, 병창선 충남대학교 약학대학 의약품개발연구소 2017 藥學論文集 Vol.32 No.-

Hypertension is one of the major risk factor for cardiovascular disease and can lead to or make worse many complications, heart disease, atherosclerosis and diabetes. Thus, managing blood pressure effec tively using therapeutic drugs such as angiotensin II receptor blocker (ARB) and Ca2+ channel blocker (CCB) can be prevent other complications. Therefore, we investigated the synergistic effect of these two drugs, ir besartan and lercanidipine, for antihypertension, cardioprotection and antidiabetes. Irbesartan (28.74 mg/kg, 14.37 mg/kg) or lercanidipine (1.92 mg/kg, 0.96 mg/kg) alone or combination was administered to sponta-neously hypertensive rats (SHRs) and C57BL/6 mice. A two-week treatment of combination with irbesartan and lercanidipine significantly attenuated systolic blood pressure (SBP) and mean arterial pressure (MAP) compared with monotherapy. Futhermore. the combination therapy protected myocardial ischemia reperfusion injury more effectively than monotherapy. In vascular remodeling, combination therapy significantly diminished cuff -induced neointima formation and reduced serum -indllced vascular smooth muscle cells (VSMCs) pro-liferation compared with monotherapy. However, combination therapy had no significant synergistic effect of blood glucose regulation. Taken together, present study suggest that the combination therapy of irbesartan and lercanidipine may be more effective therapeutic strategy for the treatment of hypertension and related complications, myocardial infarction and arterial restenosis than monotherapy

군산 구(舊)조계지의 필지변화와 주거건축에 관한 연구

윤도선,홍승재 대한건축학회 2004 대한건축학회논문집 Vol.20 No.1

The characteristic and change of dwelling architecture of Japanese and plot transition were analyzed with the old international settlement in Gunsan. By learning about one side of modern history that was broken off in the historical form of dwelling and observing the dwelling environment that have been changing historically, it can be significant as the basic material of observing our dwelling today. Along with prior investigations and studies related to the late 19th century (opening of port period) urban dwellings, the urban tissue was analyzed through documents about the history of Gunsan city and other cities that were occupied by Japan. In addition, along with survey investigation based on the cadastral map, construction management register and aerial map, I also worked on drawing up dwellings and urban tissue. As for the time range, the urban tissue of Gunsan, before opening of port, and after opening of port from 1899 to 1945 during the Japanese Occupation, was studied. And, the urban tissue was studied up to the current 2002, where the plot transition is changing or continuously maintained. As for the district subjected for study, the established international settlement district of Gunsan during the early stage of opening of port, was established as spacial range, focusing on Yeonghwa-dong which was the center of international settlement district, which was abolished in 1913. This was the first district in Gunsan to be planned with grid streets structure, and this could be said to be the main dwelling that keeps the characteristic of Japanese dwellings. The old international settlement of Gunsan has become the center of urban tissue development of the current Gunsan, and the initially established street pattern influenced the form and plot of dwellings. The dwellings have been changing with correlation to the current plot. As the plot line is fixed according to the line divided within a long building(長屋), the form is changed through a small scale of subdivided plots combining, in the process of new construction by removing the existing structures again. The plot is changing of possessing one-way improvement only by facing the street, as the bare grounds (alleyway) disappeared. The dwellings in this district, long buildings or machiyas(町屋), have developed with precedent pattern according to the street, and the dwellings have developed in the direction of inner household. In addition, as for the dwelling space, there was change in the use and extension, due to the factors such as difference in style, change in life style and modernization of accommodation system.

불소투여에 따른 태내백서 치아의 생화학적 및 주사전자현미경적 연구

임도선 韓國電子顯微鏡學會 2000 Applied microscopy Vol.30 No.3

임신중에 투여된 불소가 흰쥐태아의 법량질형성에 미치는 영향을 알아보고자 어미흰쥐에게 불소를 음용 시킨 후, 생후 11일이 경과된 어린 흰쥐를 희생하였다. 이후, 하악절치를 발치한 후, 법랑단백질의 종류 및 양적 변화와 법랑질 표면의 형태학적 변화를 관찰하였다. 분비법랑질과 성숙법량질에서 추출한 법랑단백질을 전기 영동한 결과, 분비법랑질에서는 분자량 22-24kDa의 amelogenin이 확인되었는데, 대조군에서보다 불소투여 농도가 높아질수록 양이 감소하였다. 성숙법량질에서는 분자량이 68kDa의 enamelin이 확인되었으며, 대조군에 비해 불소투여 농도가 높을수록 양적인 증가가 확인되었다. 그리고 주사전자현미경을 사용하여 법량질 표면을 관찰한 결과, 대조군에서는 평탄하고 매끄러운 표면인 반면에 불소투여군은 거친 표면과 균열이 심하게 나타났고, 불규칙한 소공이 관찰되었다. 그리고 일부에서는 균열과 함께 주머니 같은 결절과 법랑질 형성부전을 확인하였다. 따라서 본 연구결과, 태아발생과정 중 투여된 불소가 법랑질형성에 관여하는 법랑모세포에 영향을 줌으로써 단백질의 형성과 분비가 지연 또는 억제되며, 수분과 단백질 제거에 관여하는 법랑모세포의 기능을 저하시키는 것으로 사료된다. 이러한 단백질의 비정상적인 형성과 분비는 법랑질 형성부전 등의 법량질형성에 전반적으로 영향을 마치는 것으로 확인되었다. The present study has been carried out to investigate the effect of fluoride toxicity on the morphology as well as inorganic chemical constituents of rat teeth. Rats were administered sodium fluoride at dose of 0ppm, 100ppm, 200ppm and 300ppm at the beginning of pregnancy. Animals were perfused intravascularly with glutaraldehyde and the incisors were removed. Changes in the protein composition of the secretory and maturation enamel were investigated using polyacrylamide gel electrophoresis (SDS PAGE). And the enamel surface of incisors was examined under scanning electron microscope (SEM). Changes of protein quantities were found significantly in high levels fluoride administration for experimental groups compared with control. The SDS PAGE analysis demonstrated as follows. In control group, secretory phase enamel protein, amelogenins, was detected more quantities than experimental group. The enamelin, presence in maturation phase enamel, showed more quantities than control enamel with an increasing fluoride concentration in the drinking water. Also, the scanning electron micrographic data showed hypoplastic, tough, uneven, pitted and cracked enamel surfaces covered with granular deposits as a result of excessive intake of fluoride. From these results we conclude that high dose of fluoride administration leads to severe structural alterations on the enamel surface and these structural changes could be through defective mineralization.

만성중이염의 골도청력변화

박선홍,노용훈,이도용,나한조,김용기,최봉남,도남용 朝鮮大學校 附設 醫學硏究所 1996 The Medical Journal of Chosun University Vol.21 No.1

We have usually experienced bone conduction impairment in chronic otitis media, but it is unclear that raised bone conduction threshold is due to the reflection of cochlear dam- age and / or Carhart effect ( an artificial elevation of bone conduction threshold due to conductive defect ) or both. The purpose of this study is to verify the influence of the artificial elevation of the bone conduction threshold in chronic otitis media and to estimate Carhart effect. A total of 336 cases of tympanoplasty with unilateral chronic otitis media without any other causes of sensorineural hearing loss was studied. The average threshold levels of the bone conduction in diseased ears ranged from 18.5dB at 4kHz to 12.1dB at 250Hz The longer duration of the disease, the larger perforation size, the more severe damage of the middle ear structure and the presence of the cholesteatoma made bone conduction threshold increased. The postoperative thresholds of bone conduction were Improved in 36 cases (40.4%) of the 89 cases that underwent operation with type I tympanoplasty technique without electrie drilling. The degree of the maximal improvement was 14.3dB at 2000Hz and the minimum was 8.8dB at 250Hz. but these result did differ from a statistically significant degree. The result suggest that the bone conduction threshold in chronic otitis media is elevated artificially by conductive defect and improved by successful reconstructive surgery.

Permanent waVe와 Decoloration에 의한 모발손상에 관한 연구

배선향,윤수홍,이도영 한국위생과학회 2002 한국위생과학회지 Vol.8 No.2

펌 및 탈색 시 모발 손상을 줄이기 위한 기초자료를 제공하기 위해 20대 여대생의 건강한 모발을 펌 및 탈색을 하면서 전자 현미경으로 그 형태적 변화를 조사한 결과는 다음과 같았다. 자연 모발은 굵기가 60~80 ㎛인 비교적 가는 건강한 직모로 나타났다. 모표피(hair cuticle)의 비늘은 벌어지거나 벗겨짐이 서로 밀착되어 있었으며, 비늘의 겹쳐진 폭이 규칙적이었다. 또한 비늘 사이의 경계가 뚜렷하였고, 비늘의 표면은 매끈하였다. 25 ℃에서 1회 펌을 한 모발의 경우 한 부위에서만 비늘의 가장자리가 벌어졌을 뿐 다른 부위에서는 비늘의 벌어짐이 없이 밀착된 상태로 나타났다. 25 ℃에서 3회 펌을 한 모발의 경우에는 네 부위에서 비늘의 가장자리가 약간 더 벌어졌으나 25 ℃에서 1회 펌을 한 모방의 손상 정도와 큰 차이가 없었다. 50 ℃에서 1회 펌을 한 모발은 전체부위에서 비늘이 약간씩 벌어졌다. 25 ℃에서 3회 펌을 한 모발에 비해 비늘의 형태가 더 손상된 형태로 나타났다. 50 ℃에서 3회 펌을 시술한 모발은 심하게 손상되었다. 약 40 %의 비늘 가장자리가 벌어졌고, 약 10 %의 비늘은 미세한 주름이 생겼으며, 모발의 한 부위에는 구멍이 생겼다. 25 ℃에서 1회 탈색한 모발의 경우 전체에서 비늘이 벌어졌으며, 두 부위에서는 비늘이 탈락되어 비늘의 간격이 불규칙하였고, 전체 모발 중에서 약 15 %의 비늘에 세로 주름이 나타났다. 25 ℃에서 3회 탈색한 경우에는 모발 전체에서 비늘이 용해되어 두꺼워졌고, 모표피의 문리가 일정하지 않았으며, 모발의 몇몇 부위에 구멍이 생겼다. 50 ℃에서 1회 탈색한 경우 90 % 이상의 비늘이 벌어졌고, 약 25 %의 비늘에 뚜렷한 세로 주름이 생겼으며, 한 장의 비늘에 작은 구멍이 나타났다. 50 ℃에서 3회 탈색한 경우에는 모발 전체에서 모표피의 문리가 없어졌고, 용해된 비늘이 뭉쳐 있었으며, 또한 작은 구멍들이 여러 부위에 생겼다. 펌을 한 경우보다 탈색한 경우 모방의 손상 정도가 큰 것으로 나타났으며, 가장 손상의 정도가 큰 것은 50 ℃에서 3회 탈색한 경우로 나타났다. The morphological changes were investigated for the purpose of suggest the basic information to lesson hair damages by perm and decoloration. Women hairs were permed and decolored one time and three times at different temperature(25 ℃, 50 ℃), respectively. Then, the hairs were photographed with scanning electron microscope. The virgin hairs, which were not permed and not decolored, were morphologically healthy. Hair cuticle scales were not splayed and overlapped regularly. Perm hairs, which were treated one time at 25 ℃, were relatively healthy though one scale of hair cuticle was splayed. and, on the occasion of perm hairs treated three times at 25 ℃, four scales of hair cuticle were splayed. Hairs, which were permed at 50 ℃, were more damaged than those which permed at 25 ℃. Hair scales, which were permed at 50 ℃, were almost splayed. On the occasion of perm hairs treated three times at 50 ℃, 10 percentages of hair scales were wrinkled, and one scale was holed. Hair scales, which were decolored one time at 25 ℃ were almost splayed, and 15 percentages of hair scales were wrinkled. Hair scales, which were decolored three times at 25 ℃, were almost melted and thickened. 90 percentages of hair scales, which were decolored one time at 50 ℃, were splayed, and 25 percentages of hair scales were wrinkled. On the occasion of decoloration hairs treated three times at 50 ℃, the boundaries between scales were almost disappeared, and hair scales were melted and were agglomerated. Hairs, which were decolored, were more morphologically damaged than those which premed.