A modified trans-anconeus approach to facilitate fixation of a posterior radial head fracture: a cadaveric feasibility study

Ahmed Mohamed Desouky(Ahmed Mohamed Desouky ),Ahmed Naeem Atiyya(Ahmed Naeem Atiyya ),Mohamed Elbishbishi(Mohamed Elbishbishi ),Marwa Mohamed El Sawy(Marwa Mohamed El Sawy ) 대한해부학회 2023 Anatomy & Cell Biology Vol.56 No.1

Fixation of radial head fracture with minimally invasive posterior approach remains a significant challenge. The aim of this study was to determine the feasibility of trans-anconeus posterior elbow approach and to observe lateral ulnar collateral ligament (LUCL) in extended elbows. This cadaveric study was performed in twenty upper limbs of fresh fixed adult male cadavers. An oblique incision was made in the middle segment of anconeus until the lateral ligament complex and the joint capsule had been revealed. A deep dissection was explored to observe the anatomical relationship of the LUCL to the anconeus. Measurements of the LUCL were recorded while the elbow was fully extended. The mean distance between the edge of the radial head and the proximal insertion of the LUCL was 13.3 mm (11.5–16.2 mm); the mean distance between the edge of the radial head and the distal insertion of the LUCL was 20.9 mm (19.2–23.4 mm); the distance between the edge of the radial head and the distal edge of the annular ligament was 11.2 mm (8.22–11.7 mm). By estimate correlation of the previous measurements, the direct and accessible way to expose the posterolateral articular capsule of the elbow joint was through a window in medial 2/3 of the middle segment of anconeus muscle. These trans-anconeus approach is useful. It provides good visualization, facilitates applying the implants, and lessens the risk of radial nerve injury. Awareness of the anatomy is mandatory to avoid injury of LUCL.

The Relation between Exposure to Environmental Tobacco Smoke and the Quantity of Cotinine in the Urine of School Children in Taif City, Saudi Arabia

Desouky, Dalia El Sayed,Elnemr, Gamal,Alnawawy, Ali,Taha, Azza Ali Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.1

Environmental tobacco smoke (ETS) is a major public health problem for all ages. Despite the high prevalence of smoking among the Saudi population, there is limited information about levels of urinary cotinine in Saudi children exposed to SHS. The aim of the study was to assess the exposure of schoolchildren to ETS, and measure their urinary cotinine levels. Multistage cluster sampling was carried out, where schoolchildren from 4 schools were randomly chosen from primary schools in Taif city. A questionnaire including questions on SHS exposure and smoking rules in the residence were sent to students parents/guardians. Urine samples were taken and analyzed for total cotinine using chemiluminescent immunoassay. Of the studied children, 38.4% had a smoking father, 61.8%, 41.2% and 49.3% of them were exposed to ETS indoors, outdoors and both indoors and outdoors respectively. The mean urinary cotinine was significantly higher among children exposed to ETS compared to unexposed children. Urinary cotinine levels in children with both indoor and outdoor exposure was significantly higher compared with its level in children with single exposure. A significant positive correlation was found between urinary cotinine concentrations and the number of cigarette packs smoked by parents, and the number of smokers in the residence. The mean urinary cotinine level was significantly higher in children who reported no smoking rules at the residence.. The study revealed a high exposure of Saudi children to ETS. An antismoking media awareness campaign on the harmful effects of ETS should be carried out, in addition to family counseling programs targeted to parents to protect their children from ETS.

Physiological and biochemical responses of two faba bean (Vicia faba L.) varieties grown in vitro to salt stress

Desouky Abeer F.,Ahmed Ahmed H. Hanafy,Reda Abdel salam A.,Stȕtzel Hartmut,Hanafy Moemen S. 한국작물학회 2023 Journal of crop science and biotechnology Vol.26 No.2

Faba bean (Vicia faba L.) is one of the most important legume crops worldwide. High salinity is a major constraint for faba bean productivity in many countries, including Egypt. Here, we examined the efects of salinity-induced toxicity on the growth of two local faba bean genotypes by analyzing physiological and biochemical responses to identify the salt-tolerant attributes between the genotypes. In vitro experiments were carried out to characterize the response of two faba bean genotypes (Sakha 3 and Nubaria 2) to salinity imposed by diferent sea-salt concentrations (1000, 3000, 5000 and 7000 ppm). For both genotypes, salinity induced a marked reduction in dry matter gain along with a reduction in shoots height, roots length, leaves number and branches number. In addition, the photosynthetic pigments (chlorophyll a, b) were signifcantly decreased with the increase in salinity. Changes in tissue ion levels, peroxidase (POD) and polyphenol oxidase (PPO) activities depended on genotype, tissue and salinity level. The deteriorating efect of salt stress on the growth performance of genotype Nubaria 2 was lower than that of Sakha 3. This is maybe ascribed to its better antioxidant enzymes activities. Moreover, Nubaria 2 accumulated low quantities of Na+ in the shoots with a higher accumulation of ions in the roots compared to Sakha 3. The obtained results suggested Nubaria 2 seedlings have a strong ability to sustain sea-salt stress by the regulation of transport and distribution of ions and this genotype may be characterized as a salt excluder.

A New Pyrrole Alkaloid Isolated from Arum palaestinum Boiss. and its Biological Activities

El-Desouky, S.K.,Kim, Ki-Hun,Ryu, Shi-Young,Eweas, Ahmad Farouk,Gamal-Eldeen, Amira M.,Kim, Young-Kyoon 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.8

The phytochemical analysis of the ethyl acetate fraction of Arum palaestinum Boiss. (Araceae) led to the isolation and identification of a new polyhydroxy alkaloid compound; (S)-3,4,5-trihydroxy-1H-pyrrol-2(5H)-one (1), and other five known compounds; caffeic acid (2), isoorientin (3), luteolin (4) and vicenin II (5), as well as the rare compound 3,6,8-trimethoxy, 5,7,3',4'-tetrahydroxy flavone (6). The structural elucidations of all the compounds were based on spectroscopic data ($^1H-$ and $^{13}C-NMR$, DEPT, HSQC, HMBC and NOE difference techniques) and comparison with literature data. Investigation of the antioxidant activity of the ethyl acetate fraction indicated its strong scavenging capacity for 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals ($SC_{50}$ $3.1{\pm}0.82$ ${\mu}g/mL$). Moreover, the treatment of different human cancer cell lines with the ethyl acetate fraction led to dose-dependant suppression in the proliferation of both breast carcinoma cells (MCF-7; $IC_{50}$ $59.09{\pm}4.1$ ${\mu}g/mL$) and lymphoblastic leukemia cells (1301; $IC_{50}$ $53.1{\pm}2.9$ ${\mu}g/mL$); however, it was found to have no effect on the growth of hepatocellular carcinoma cells (Hep G2).

Two New Diketopiperazines from ARUM Palaestinum

El-Desouky, S. K.,Hawas, U. W.,Kim, Y. K. Springer Science + Business Media 2014 Chemistry of natural compounds Vol.50 No.6

A Cytotoxic Lupeol Fatty Acid Ester and Other Pentacyclic Triterpenes from Salvadora persica Seeds

Samy K. El-Desouky 한국생약학회 2023 Natural Product Sciences Vol.29 No.3

The phytochemical investigation of the ethyl acetate fraction of the methanol seed extract of Salvadora persica resulted in the isolation and identification of five pentacyclic triterpenes (1-5), oleanolic acid (1), ursolic acid (2), β-amyrin (3), β-amyrin acetate (4) and lupeol tricosanoate (5). The structures of these compounds were established by the analysis of their NMR spectroscopic and mass spectrometric data. In the bioactivity assay, compound 5 showed moderate cytotoxic activities against breast cancer cell lines (MCF-7), colon cancer cell lines (HT-29) and hepatocellular carcinoma cell lines (HepG2) with IC50 values of 9.4, 6.85 and 12.74 μg/mL. respectively. In all previous studies, lupeol tricosanoate (5) has been isolated as a mixture of triterpenoid long-chain fatty acid esters and this is the first report of its isolation and characterization as a pure molecule. Moreover, the occurrence of fatty acid ester of triterpene in this plant is of taxonomic importance.

Expanding Eyes: Language, literature, History, and Identity - Perceptions of Korea in the Middle East and Comparative literary Perspectives

( Ayman A. Ei-desouky ) 한국어문학국제학술포럼 2010 Journal of Korean Culture Vol.14 No.-

이 발표문은 중동, 특히 아랍 문화권에서의 한국에 대한 인식과 한국학 교육 현황을 소개하고 이와 관련해서 문화와 역사적 맥락, 그리고 ‘한국학’ 내의 다양한 학문분야들, 특히 비교문학 관점에서 본 한국문학의 전망에 대해서 논하고자 한다. 여기서 중동은 아랍국가들 및 터키, 이란, 그리고 이스라엘을 포함한 지역을 얘기하며 본문에서 명시하는 아랍 문화권은 중동지역과 더불어 북아프리카의 아랍국가들을 포함한다. This presentation will first offer a brief overview of the state of Korean studies in the Middle East, particularly focussing on the Arab Middle East, with reference to some of the embedding cultured and historical contexts. It will be hoped then to offer some insights regarding the vision and possibilities of a range of comparative disciplines within Korean studies. As a geopolitical term, the Middle East comprises most countries of the Arab World, Turkey, Iran and Israel. The countries of North Africa, generally designated as a separate geopolitical entity, will be subsumed here under the Arab World

A New Pyrrole Alkaloid Isolated from Arum palaestinum Boiss. and its Biological Activities

S. K. El-Desouky,Ki Hun Kim,Shi Young Ryu,Ahmad Farouk Eweas,Amira M. Gamal-Eldeen,Young-Kyoon Kim 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.8

The phytochemical analysis of the ethyl acetate fraction of Arum palaestinum Boiss. (Araceae) led to the isolation and identification of a new polyhydroxy alkaloid compound; (S)-3,4,5-trihydroxy- 1H-pyrrol-2(5H)-one (1), and other five known compounds; caffeic acid (2), isoorientin (3), luteolin (4) and vicenin II (5), as well as the rare compound 3,6,8-trimethoxy, 5,7,3',4'-tetrahydroxy flavone (6). The structural elucidations of all the compounds were based on spectroscopic data (1H- and 13C-NMR, DEPT, HSQC, HMBC and NOE difference techniques) and comparison with literature data. Investigation of the antioxidant activity of the ethyl acetate fraction indicated its strong scavenging capacity for 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals (SC50 3.1±0.82 μg/mL). Moreover, the treatment of different human cancer cell lines with the ethyl acetate fraction led to dose-dependant suppression in the proliferation of both breast carcinoma cells (MCF-7; IC50 59.09±4.1 μg/mL) and lymphoblastic leukemia cells (1301; IC50 53.1±2.9 μg/mL); however, it was found to have no effect on the growth of hepatocellular carcinoma cells (Hep G2).

Disease Progression from Chronic Hepatitis C to Cirrhosis and Hepatocellular Carcinoma is Associated with Increasing DNA Promoter Methylation

Zekri, Abd El-Rahman Nabawy,Nassar, Auhood Abdel-Monem,El-Rouby, Mahmoud Nour El-Din,Shousha, Hend Ibrahim,Barakat, Ahmed Barakat,El-Desouky, Eman Desouky,Zayed, Naglaa Ali,Ahmed, Ola Sayed,Youssef, A Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

Background: Changes in DNA methylation patterns are believed to be early events in hepatocarcinogenesis. A better understanding of methylation states and how they correlate with disease progression will aid in finding potential strategies for early detection of HCC. The aim of our study was to analyze the methylation frequency of tumor suppressor genes, P14, P15, and P73, and a mismatch repair gene (O6MGMT) in HCV related chronic liver disease and HCC to identify candidate epigenetic biomarkers for HCC prediction. Materials and Methods: 516 Egyptian patients with HCV-related liver disease were recruited from Kasr Alaini multidisciplinary HCC clinic from April 2010 to January 2012. Subjects were divided into 4 different clinically defined groups - HCC group (n=208), liver cirrhosis group (n=108), chronic hepatitis C group (n=100), and control group (n=100) - to analyze the methylation status of the target genes in patient plasma using EpiTect Methyl qPCR Array technology. Methylation was considered to be hypermethylated if >10% and/or intermediately methylated if >60%. Results: In our series, a significant difference in the hypermethylation status of all studied genes was noted within the different stages of chronic liver disease and ultimately HCC. Hypermethylation of the P14 gene was detected in 100/208 (48.1%), 52/108 (48.1%), 16/100 (16%) and 8/100 (8%) among HCC, liver cirrhosis, chronic hepatitis and control groups, respectively, with a statistically significant difference between the studied groups (p-value 0.008). We also detected P15 hypermethylation in 92/208 (44.2%), 36/108 (33.3%), 20/100 (20%) and 4/100 (4%), respectively (p-value 0.006). In addition, hypermethylation of P73 was detected in 136/208 (65.4%), 72/108 (66.7%), 32/100 (32%) and 4/100 (4%) (p-value <0.001). Also, we detected O6MGMT hypermethylation in 84/208 (40.4%), 60/108 (55.3%), 20/100 (20%) and 4/100 (4%), respectively (p value <0.001. Conclusions: The epigenetic changes observed in this study indicate that HCC tumors exhibit specific DNA methylation signatures with potential clinical applications in diagnosis and prognosis. In addition, methylation frequency could be used to monitor whether a patient with chronic hepatitis C is likely to progress to liver cirrhosis or even HCC. We can conclude that methylation processes are not just early events in hepatocarcinogenesis but accumulate with progression to cancer.

Evaluating and improving system reliability of bridge structure using gamma distribution

Mustaf, Abdelfattah,El-Desouky, Beih S.,Taha, Ahmed The Korean Reliability Society 2016 International Journal of Reliability and Applicati Vol.17 No.2

In this paper, we study a system of five components. One of them is a bridge network component. Each of these components is identical and has a failure rate as a function of time. The system components have non-constant failure rates. The given system is improved by using the reduction, hot duplication, and cold duplication methods. We derive the equivalence factors of the bridge structure system to be as another system improved according to these different methods. The ${\beta}-fractiles$ are obtained to compare the original system with these improved systems. Finally, we present numerical results to show the difference between these methods.