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Ismail Demiryilmaz,Ebru Sener,Nihal Cetin,Durdu Altuner,Fatih Akcay,Halis Suleyman 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.9
In this study, the biochemical and histopathologicaleffects of thiamine and thiamine pyrophosphate onischemia–reperfusion induced oxidative damage in ratovarian tissue were investigated. Animals were divided intofour groups of six rat each, ovarian ischemia–reperfusion(IR), 25 mg/kg thiamine ? ovarian ischemia–reperfusion(TIR), 25 mg/kg thiamine pyrophosphate ? ovarian ischemia–reperfusion (TPIR) and Sham group (SG). The resultsof the biochemical experiments have shown that the ratovarian tissue with thiamine treatment, the level of MDA,GSH and the 8-hydroxyguanine are almost the same as theIR group; while in the group with thiamine pyrophosphatetreatment, the level of MDA, GSH and the 8-hydroxyguanineare almost the same as the SG. Ovarian tissue of rats inthe IR group were congested and dilated vessels, edema,hemorrhage, necrotic and apoptotic cells. In this group, themigration and the adhesion of the polymorphonuclear leucocytesto the endothelium were observed. Both ovaries inTPIR group, there was no difference according to the SG. Histopathology of ovarian tissues in the TIR group wasalmost the same with the IR group. Our results indicate thatthiamine pyrophosphate significantly prevents the ischemia–reperfusion induced oxidative damage in ovarian tissue,whereas thiamine has no effect. In conclusion, we havefound that thiamine pyrophosphate prevents oxidativedamage due to ischemia–reperfusion injury, whereasthiamine does not have this effect. Furthermore, we haveconfirmed that the results of our biochemical analyses are inconcordance with the histopathological findings.
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