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Statistical physics of the T Cell Immune Response
Park, Jeong-Man,Deem, Michael W. 가톨릭대학교 자연과학연구소 2003 자연과학논문집 Vol.24 No.-
We present a statistical physics theory of the naive and memory T cell immune responses and show how the sequence-level dynamics of the T cell repertoire is related to the immune response against mutated viral antigens. We measure specific lysis against altered peptide ligands and find the results are consistent with experimental data.
Evolutionary processes in finite populations.
Lorenz, Dirk M,Park, Jeong-Man,Deem, Michael W Published by the American Physical Society through 2013 Physical review. E, Statistical, nonlinear, and so Vol.87 No.2
<P>We consider the evolution of large but finite populations on arbitrary fitness landscapes. We describe the evolutionary process by a Markov-Moran process. We show that to O(1/N), the time-averaged fitness is lower for the finite population than it is for the infinite population. We also show that fluctuations in the number of individuals for a given genotype can be proportional to a power of the inverse of the mutation rate. Finally, we show that the probability for the system to take a given path through the fitness landscape can be nonmonotonic in system size.</P>
Post-natal parental care in a Cretaceous diapsid from northeastern China
Junchang Lü,Yoshitsugu Kobayashi,D. Charles Deeming,Yongqing Liu 한국지질과학협의회 2015 Geosciences Journal Vol.19 No.2
Post-natal parental care seems to have evolved numerous times in vertebrates. Among extant amniotes, it is present in crocodilians, birds, and mammals. However, evidence of this behavior is extremely rare in the fossil record and is only reported for two types of dinosaurs, and a varanopid ‘pelycosaur’. Here we report new evidence for post-natal parental care in Philydrosaurus, a choristodere, from the Yixian Formation of western Liaoning Province, China. We review the fossil record of reproduction in choristoderes, and this represents the oldest record of post-natal parental care in diapsids to our knowledge.