Oncogenic RUNX3: A Link between p53 Deficiency and MYC Dysregulation

Date, Yuki,Ito, Kosei Korean Society for Molecular and Cellular Biology 2020 Molecules and cells Vol.43 No.2

The RUNX transcription factors serve as master regulators of development and are frequently dysregulated in human cancers. Among the three family members, RUNX3 is the least studied, and has long been considered to be a tumor-suppressor gene in human cancers. This idea is mainly based on the observation that RUNX3 is inactivated by genetic/epigenetic alterations or protein mislocalization during the initiation of tumorigenesis. Recently, this paradigm has been challenged, as several lines of evidence have shown that RUNX3 is upregulated over the course of tumor development. Resolving this paradox and understanding how a single gene can exhibit both oncogenic and tumor-suppressive properties is essential for successful drug targeting of RUNX. We propose a simple explanation for the duality of RUNX3: p53 status. In this model, p53 deficiency causes RUNX3 to become an oncogene, resulting in aberrant upregulation of MYC.

Mesh Simplification and Adaptive LOD for Finite Element Mesh Generation

Date, Hiroaki,Kanai, Satoshi,Kishinami, Takeshi,Nishigaki, Ichiro Society for Computational Design and Engineering 2006 International Journal of CAD/CAM Vol.6 No.1

In this paper, we propose a new triangular finite element mesh generation method based on simplification of high-density mesh and adaptive Level-of-Detail (LOD) methods for efficient CAE. In our method, mesh simplification is used to control the mesh properties required for FE mesh, such as the number of triangular elements, element shape quality and size while keeping the specified approximation tolerance. Adaptive LOD methods based on vertex hierarchy according to curvature and region of interest, and global LOD method preserving density distributions are also proposed in order to construct a mesh more appropriate for CAE purpose. These methods enable efficient generation of FE meshes with properties appropriate for analysis purpose from a high-density mesh. Finally, the effectiveness of our approach is shown through evaluations of the FE meshes for practical use.

Bifunctional role of Pd/MMT-K 10 catalyst in direct transformation of furfural to 1,2-pentanediol

Date, Nandan S.,Chikate, Rajeev C.,Roh, Hyun-Seog,Rode, Chandrashekhar V. Elsevier 2018 CATALYSIS TODAY - Vol.309 No.-

<P><B>Abstract</B></P> <P>The acid functionality of montmorillonite clay K 10 (MMT-K 10) was found to play a key role to give 1,2-pentanediol (1,2-PeDO) in Pd catalysed furfural hydrogenation. Among various Pd loadings on MMT-K 10, 3% Pd/MMT-K 10 catalyst exhibited excellent performance giving almost complete conversion of FFR and the highest selectivity of 66% to 1,2-PeDO. Py-IR of the catalyst evidenced the presence of Brønsted acidity which was responsible in C5-O cleavage of furan ring after the formation of furfuryl alcohol which is the first step intermediate in FFR hydrogenation. At a lower temperature of 140°C, highest selectivity of 56% was achieved for FAL while increase in temperature to 220°C, enhanced the selectivity to 1,2-PeDO. Keeping the temperature constant at 220°C, increase in H<SUB>2</SUB> pressure from 500 to 750psig, resulted in decrease in 1,2-PeDO selectivity from 66 to 34% with proportionate increase in THFAL selectivity. Thus as per the requirement, the product selectivities can be tailored by varying the reaction parameters suitably. Several control experiments were also performed the results of which combined with the characterization data allowed to propose a plausible reaction pathway for the formation of 1,2-PeDO.</P> <P><B>Highlights</B></P> <P> <UL> <LI> 3% Pd/MMT-K10 gave complete FFR conversion with 66% 1,2-PeDO. </LI> <LI> Brønsted acidity of the catalyst is responsible for C5-O cleavage of furan ring. </LI> <LI> Product selectivities by varying H<SUB>2</SUB> pressure. </LI> <LI> Proposed reaction pathway to 1,2-PeDO involved FAL formation as the key step. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Brønsted acidity of Pd/MMT-K10 responsible to give 1,2-PeDO in single step furfural hydrogenation.</P> <P>[DISPLAY OMISSION]</P>

A Multiresolution Mesh Processing System for Efficient CAE

Hiroaki Date,Satoshi Kanai,Takeshi Kishinami,Ichiro Nishigaki 제어로봇시스템학회 2006 제어로봇시스템학회 국제학술대회 논문집 Vol.2006 No.10

日本の環境権論の到達点と気候変動問題

大久保規子(Norico Okubo Date) 강원대학교 비교법학연구소 2009 환경법과 정책 Vol.3 No.-

기후변동의 피해는 계속심화되고 있고, 인권보장이라는 관점으로부터, 법적책임원칙이나 피해의 법적구제 메커니즘을 확립하는 것이 중 요하다. 이 문제가 글로벌 대책을 필요로 하고, 불특정다수의 사람에게 피해를 미치는 것을 생각한다면 하나의 단서가 되는 것이 국가를 초월 한 인권에서의 환경권의 발전이다. 이점에 관해 일본에서는 불특정다 수의 사람과 관련된 경관이익이 법률상 보호할 가치가 있는 것으로서 인정되는 등 판례의 새로운 전개가 보여진다. 그렇지만 기후변동에 관 해서는 종래의 공해ㆍ환경피해이상으로 원인행위의 특정, 인과관계나 위법성의 입증이 곤란하기 때문에 기후변동피해에 관련된 인권의 보호 는 첫째로 입법적ㆍ행정적 조치를 통해서 실시하는 것이 현실적이다. 그러나 일본의 온난화관련법제는 자주적 대처의 추진을 기조로 하고 있으며 규제적 방법을 중심으로 구성되어온 경우와는 다르고 명확한 책임원칙에 기초한 사업자의 공법상의 의무가 명확하게 되어있다고는 말하기 어렵다. 따라서 일본에서는 먼저, 다량의 온실가스의 배출행위 가 대기오염이나 수질오독과 같게 인권침해행위로 될 수 있다는 인식 을 확립하는 것이 중요하다. 둘째로, 이 같은 인식에 서서, 가령 사업 자들의 구체적인 법적 의무(배출량의 삭감등) 가 명확화된 경우에는 소송을 통한 책임메카니즘이 기능할 가능성이 있다. 이와 같은 계기는 이미 EU의 환경손해지령에서 보여지고 있지만 이 전제로서는 공익소 송의 도입등을 통한 사법적 접근의 보장이 필요하다.

일본의 환경권론의 도달점과 기후변동문제

오쿠보 노리코(Norico Okubo Date),고영아(번역자),유진식(토론자) 강원대학교 비교법학연구소 2009 환경법과 정책 Vol.3 No.-

Protection against cholera from killed whole-cell oral cholera vaccines: a systematic review and meta-analysis

Bi, Qifang,Ferreras, Eva,Pezzoli, Lorenzo,Legros, Dominique,Ivers, Louise C,Date, Kashmira,Qadri, Firdausi,Digilio, Laura,Sack, David A,Ali, Mohammad,Lessler, Justin,Luquero, Francisco J,Azman, Andrew Elsevier Science ;, The Lancet Pub. Group 2017 LANCET INFECTIOUS DISEASES Vol.17 No.10

<P><B>Summary</B></P><P><B>Background</B></P><P>Killed whole-cell oral cholera vaccines (kOCVs) are becoming a standard cholera control and prevention tool. However, vaccine efficacy and direct effectiveness estimates have varied, with differences in study design, location, follow-up duration, and vaccine composition posing challenges for public health decision making. We did a systematic review and meta-analysis to generate average estimates of kOCV efficacy and direct effectiveness from the available literature.</P><P><B>Methods</B></P><P>For this systematic review and meta-analysis, we searched PubMed, Embase, Scopus, and the Cochrane Review Library on July 9, 2016, and ISI Web of Science on July 11, 2016, for randomised controlled trials and observational studies that reported estimates of direct protection against medically attended confirmed cholera conferred by kOCVs. We included studies published on any date in English, Spanish, French, or Chinese. We extracted from the published reports the primary efficacy and effectiveness estimates from each study and also estimates according to number of vaccine doses, duration, and age group. The main study outcome was average efficacy and direct effectiveness of two kOCV doses, which we estimated with random-effect models. This study is registered with PROSPERO, number CRD42016048232.</P><P><B>Findings</B></P><P>Seven trials (with 695 patients with cholera) and six observational studies (217 patients with cholera) met the inclusion criteria, with an average two-dose efficacy of 58% (95% CI 42–69, <I>I</I><SUP>2</SUP>=58%) and effectiveness of 76% (62–85, <I>I</I><SUP>2</SUP>=0). Average two-dose efficacy in children younger than 5 years (30% [95% CI 15–42], <I>I</I><SUP>2</SUP>=0%) was lower than in those 5 years or older (64% [58–70], <I>I</I><SUP>2</SUP>=0%; p<0·0001). Two-dose efficacy estimates of kOCV were similar during the first 2 years after vaccination, with estimates of 56% (95% CI 42–66, <I>I</I><SUP>2</SUP>=45%) in the first year and 59% (49–67, <I>I</I><SUP>2</SUP>=0) in the second year. The efficacy reduced to 39% (13 to 57, <I>I</I><SUP>2</SUP>=48%) in the third year, and 26% (−46 to 63, <I>I</I><SUP>2</SUP>=74%) in the fourth year.</P><P><B>Interpretation</B></P><P>Two kOCV doses provide protection against cholera for at least 3 years. One kOCV dose provides at least short-term protection, which has important implications for outbreak management. kOCVs are effective tools for cholera control.</P><P><B>Funding</B></P><P>The Bill & Melinda Gates Foundation.</P>

A Multi-Application Controller for SAGE-enabled Tiled Display Wall in Wide-area Distributed Computing Environments

Fujiwara, Yuki,Date, Susumu,Ichikawa, Kohei,Takemura, Haruo Korea Information Processing Society 2011 Journal of information processing systems Vol.7 No.4

Due to the recent advancement of networking and high-performance computing technologies, scientists can easily access large-scale data captured by scientific measurement devices through a network, and use huge computational power harnessed on the Internet for their analyses of scientific data. However, visualization technology, which plays a role of great importance for scientists to intuitively understand the analysis results of such scientific data, is not fully utilized so that it can seamlessly benefit from recent high-performance and networking technologies. One of such visualization technologies is SAGE (Scalable Adaptive Graphics Environment), which allows people to build an arbitrarily sized tiled display wall and is expected to be applied to scientific research. In this paper, we present a multi-application controller for SAGE, which we have developed, in the hope that it will help scientists efficiently perform scientific research requiring high-performance computing and visualization. The evaluation in this paper indicates that the efficiency of completing a comparison task among multiple data is increased by our system.

Work-related Stress, Caregiver Role, and Depressive Symptoms among Japanese Workers

Honda, Ayumi,Date, Yutaka,Abe, Yasuyo,Aoyagi, Kiyoshi,Honda, Sumihisa Occupational Safety and Health Research Institute 2014 Safety and health at work Vol.5 No.1

Background: In Japan, more than 60% of employees are reported to suffer from anxiety and stress. Consequently, Japanese society has begun to address such important issues as psychogenic disability and job-related suicide. Furthermore, given the aging of society and the surge in the number of elderly people requiring care, it is necessary to adequately and proactively support employees who care for their elderly relatives. The purpose of the present study was to investigate caregiver burden in caring for elderly relatives and work-related stress factors associated with mental health among employees. Methods: We studied 722 men and women aged 18-83 years in a cross-sectional study. The K10 questionnaire was used to examine mental health status. Results: The proportion of participants with a high K10 score was 15% (n = 106). Having little conversation with their supervisor and/or coworkers significantly increased the risk of depression [odds ratio (OR) 1.8], as did high job overload (OR 2.7) and job dissatisfaction (OR 3.8), compared with employees who frequently conversed with their supervisor and/or coworkers. Caring for elderly relatives as a prominent characteristic of an employee was a significant risk factor for depression (OR 2.1). Conclusion: The present study demonstrated that employees who were caring for elderly relatives were significantly associated with an increased risk of depression. To prevent depressive disorders, it may be important to focus on reducing the work-caregiving role conflict, as well as enhancing employees' job control and better rewarding their efforts in the workplace.

Robotic Harvest of a Right Gastroepiploic Lymph Node Flap

Ciudad, Pedro,Date, Shivprasad,Lee, Ming-Hsien,Torto, Federico Lo,Nicoli, Fabio,Araki, Jun,Chen, Hung-Chi Korean Society of Plastic and Reconstructive Surge 2016 Archives of Plastic Surgery Vol.43 No.2