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Fall Risk Assessment of Rural Elderly Population in Korea
Dahye Park,Hongsik Jo,Chul Ho Yoon,Eun Shin Lee,오민균,Chang Han Lee 대한재활의학회 2019 Annals of Rehabilitation Medicine Vol.43 No.3
Objective To investigate the risk factors for fall in the elderly population residing in rural areas of Korea and provide useful data for their prevention. Methods As part of farmers’ health promotion project, a retrospective study was conducted with a total of 350 elderly people recruited from March 2016 to December 2016. These subjects were divided into two groups: 254 non-fallers and 96 fallers. A person who fell to the floor at least once in the past year was defined as a faller. Participants were asked to visit the hospital once. The demographic characteristics, social environment, and educational levels were surveyed using a questionnaire. Physical examination was performed in the following order: cognitive function, lower leg strength and torque, body composition, and knee image test. Results Statistically significant factors for falls in univariate analysis were female gender, age, living alone, educational level less than middle school, skeletal muscle mass, Mini-Mental State Exam, knee osteoarthritis, hip torque, hip power mean, knee torque, and knee power mean. Multivariate analysis was performed to identify variables most relevant to falls among statistically significant factors in univariate logistic analysis. It was confirmed that female gender and age of 70–79 years were statistically significant factors related to falls. Conclusion Female gender and elderly status (70–79 years) are important risk factors for falls in rural areas underscoring the need for special attention when considering risk factors for falls among the elderly living in rural areas.
Endoscopic Management of Pancreaticopleural Fistula in a Child with Hereditary Pancreatitis
Dahye Lee,Eun Joo Lee,Ju Whi Kim,Jin Soo Moon,Yong-Tae Kim,Jae Sung Ko 대한소아소화기영양학회 2019 Pediatric gastroenterology, hepatology & nutrition Vol.22 No.6
Pancreaticopleural fistula (PPF) a fistulous connection between the pancreas and pleural space due to prolonged chronic pancreatitis (CP). PPF is a very rare complication which presents in 0.4% of chronic pancreatitis cases, especially among children. We report a case involving a 3-year-old boy who presented with pleural effusion caused by a PPF, a complication of hereditary pancreatitis, which was, for the first time in Korea, successfully managed with endoscopic treatment. Chest radiography and computed tomography showed massive pleural effusion. Percutaneous catheter drainage was performed. High amylase levels were observed in the pleural fluid and serum, suggesting PPF. The patient was managed with bowel rest and octreotide infusion. Endoscopic retrograde cholangiopancreatography revealed CP, and pleural effusion was successfully managed with stent placement. PRSS1 genetic screening revealed R122H mutation.
Dahye Jeong,Muhammad Irfan,Sung-Dae Kim,Suk Kim,Jun-Hwan Oh,Chae-Kyu Park,Hyun-Kyoung Kim,Man Hee Rhee 고려인삼학회 2017 Journal of Ginseng Research Vol.41 No.4
Background: Korean Red Ginseng has been used for several decades to treat many diseases, enhancing both immunity and physical strength. Previous studies have documented the therapeutic effects of ginseng, including its anticancer, antiaging, and anti-inflammatory activities. These activities are mediated by ginsenosides present in the ginseng plant. Ginsenoside Rg3, an effective compound from red ginseng, has been shown to have antiplatelet activity in addition to its anticancer and anti-inflammatory activities. Platelets are important for both primary hemostasis and the repair of the vessels after injury; however, they also play a crucial role in the development of acute coronary diseases. We prepared ginsenoside Rg3-enriched red ginseng extract (Rg3-RGE) to examine its role in platelet physiology. Methods: To examine the effect of Rg3-RGE on platelet activation in vitro, platelet aggregation, granule secretion, intracellular calcium ([Ca<SUP>2+</SUP>]i) mobilization, flow cytometry, and immunoblot analysis were carried out using rat platelets. To examine the effect of Rg3-RGE on platelet activation in vivo, a collagen plus epinephrine-induced acute pulmonary thromboembolism mouse model was used. Results: We found that Rg3-RGE significantly inhibited collagen-induced platelet aggregation and [Ca<SUP>2+</SUP>]<SUP>i</SUP> mobilization in a dose-dependent manner in addition to reducing ATP release from collagen-stimulated platelets. Furthermore, using immunoblot analysis, we found that Rg3-RGE markedly suppressed mitogen-activated protein kinase phosphorylation (i.e., extracellular stimuli-responsive kinase, Jun Nterminal kinase, p38) as well as the PI3K (phosphatidylinositol 3 kinase)/Akt pathway. Moreover, Rg3-RGE effectively reduced collagen plus epinephrine-induced mortality in mice. Conclusion: These data suggest that ginsenoside Rg3-RGE could be potentially be used as an antiplatelet therapeutic agent against platelet-mediated cardiovascular disorders.
S-137 Comparison of tenofovir therapy between nucleos(t)ide-naive and -resistant chronic hepatitis B
( Dahye Kim ),( Joong Gi Bae ),( Hyun Seong Lee ),( Young Min Shin ),( Kyung Hye Park ),( Byung Uk Lee ),( Jae Ho Park ),( Byung Gyu Kim ),( Seok Won Jung ),( In Du Jeong ),( Sung-jo Bang ),( Jung Woo 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Background:?Tenofovir (TDF) is a nucleotide analog used in the treatment of chronic hepatitis B (CHB) infection regardless of whether nucleos(t)ide (NA) resistance. Little data are available on the comparison of TDF therapy between NA-naive and NA-resistant chronic hepatitis B (CHB) patients.?Methods:?Of the 735 eligible patients, 466 were NA-naive and 269 were resistance to NA therapy prior to TDF rescue therapy. A matched study population was constructed to compare the antiviral efficacy of TDF therapy by a propensity score analysis. The primary endpoint was a virological response (VR), defined as an HBV DNA level of <12 IU/mL.?Results: Two hundreds fifty-four CHB patients were selected after matching propensity score with 1:1 ratio. VR occurred in 204 patients (111 patients belonged to the NA-naive group and 93 patients belonged to the NA-resistant group) during the treatment period. There was statistically significant difference in VR between the NA-naive group and the NA-resistant group (87.4% vs. 73.2%; p=0.005). Partial virologic response rates were also differ between both groups (37.8% and 55.1% in the NA-naive group and the NA-resistant group, respectively; p=0.006). ALT normalization rates did not differ between both groups (91.0% and 93.0% in the NA-naive group and the NA-resistant group, respectively; p=0.770). During TDF therapy, 17.5% (14 of 80) of patients in the NA-naive group, and 13.0% (10 of 77) of patients in the NA-resistant group achieved HBeAg seroconversion, respectively (p=0.432). Multivariate logistic regression analysis using selected baseline factors identified absolute HBV-DNA levels at baseline (p<0.001; OR, 0.755; 95% CI, 0.683-0.834), NA-resistant group (p<0.001; OR, 1.655; 95% CI, 1.249-2.194), and HBeAg positivity (p<0.001; OR, 0.531; 95% CI, 0.383-0.737) as factors showing significant association with VR.?Conclusions:?TDF therapy would be more superior in NA-naive patients than NA-resistant chronic hepatitis B patients. The lower HBV DNA levels at baseline and HBeAg-negative CHB patients also were significantly associated with virologic response.
Dahye Kim,In Wook Yeo 대한지질학회 2021 대한지질학회 학술대회 Vol.2021 No.10
We attempted to visualize transition processes from linear to nonlinear flow regimes in a rough-walled fracture, which used to remain in the territory of numerical and theoretical approaches. The state-of-the-art technique using the micro-particle image velocimetry was used to identify flow structure and to measure fluid velocity in a rough-walled analog fracture. This flow imaging study demonstrated that the onset of nonlinear flow was closely related to flow structure changes in rough-walled segments, such as the narrowing of the main flow channel and the growth of eddies. These changes in flow structure resulted in the greater fluid velocity gradient. The greater the fluid velocity gradient, the more accelerated the fluid particles, leading to the inertial forces dominating the viscous forces in the narrowed main flow channel of rough-walled segments. The order-of-magnitude analysis using the Navier-Stokes equations and the measured fluid velocity vectors also showed that inertial forces began to exceed viscous forces in some parts of the main flow channels of rough-walled segments from Re = 5, overwhelming viscous forces in most of the narrowed main flow channels from Re = 15 - 20. This study will serve for a better understanding of the evolution of flow regime and the causal mechanism of onset of nonlinear flow in rock fractures.