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고대곤 大邱敎育大學校 科學敎育硏究所 1987 과학·수학교육연구 Vol.11 No.-
There are many sayings that it is a TIME of COMPUTER nowadays and I don't think there seems any one who hesitates to say that computer has introduced a new era, what is called information age, in the advancement of mankind. A dominant opinon which golds among scientists and educational experts is that one should be learned how to use computer and skillfully put it into practice as soon as possible in one's early days. Educational curriculums, which will be adapted on and after year of 1990, on the 4th, the 5th and the 6th grade in elementary school in our country, contains some obserbable contents concerning with computer and it's applications. In this study, it is examined what effects of computer education and computer assisted instruction in mathematics on achievement of pupils in grade five in elementary school is. Ti's aim is to activate computer literacy and to raise it's effectiveness. In this study, the population is divided into three groups and each group is composed of three sub-groups, one of which is selected for sample to be experimented, the called E-set, and the rests which are called the U-set are controlled for comparision with the former. The E-set is trained using computer and studied by CAI programs and the U-set are not. the results cannot be given until eight times tests being held. Several significance in statistics are thougtfully examined before carring the experiments. After operation the same tests are also done as before. From the above mentions it can be concluded as the followings; 1. computer teaching helps to understand arithmetics considerablely. 2. CAI in arith. 춤 provide individual learning with their abilities and offering much freedom in learning can helps one easily compensate one's loss in learning at anywhere and at anytime. 3. the inferior in learning may be more influenced than the superior. 4. showing possibilities of it's good usage in broder fields and so on. This study has been executed under the many restricted conditions. Therefore, it does not seem that some arrive conclusions are always correct. In spite of that it is worthwhille to study this project continuously for the time being and a good results will be expected.
고대곤 大邱敎育大學校 科學敎育硏究所 1990 과학·수학교육연구 Vol.14 No.-
Instructional matters in computer-assisted intruction(CAI)are presented mainly on a CRT terminal. But Voice is also a useful and important media in transferring information to learners. In this respect we design and implement a system which controls interactively image data and phonetic data by means of interfacing an audio control media-auto audio cassette deck-with a computer, with the intension of making use of audio-visual learning in CAI. The result of this paper shows that there is some loose time in sysnchronizing both the two informations, and that the success rate in accessing voice information is quite depedent on the driving speed of a cassette deck.
안성훈,김은옥,고대곤 한국컴퓨터교육학회 2004 컴퓨터교육학회 논문지 Vol.7 No.2
본 연구에서는 ICT 교유그의 효과를 높이고자 ICT 활용 학습 과정 시 학습자에게서 나타나는 오류의 사례들을 분석하여 오류 유형을 설정하고 그에 대한 효과적인 처치 방안을 탐색하였다. 관찰, 면담, 설문 조사 등의 방법을 이용하여 오류 사례를 탐색한 결과 기능 혼동 오류, 개념 혼동 오류, 인터페이스 해석 장애 오류, 심리적 불안으로 인한 오류, 학습자 성격 유형에 의한 오류, 습관적인 오류 등 6가지 오류 유형을 설정하였다. 그중 가장 많은 빈도를 차지하는 기능 혼동 오류와 개념 혼동 오류 중심으로 웹 기반 Q&A 학습 시스템을 개발하고 이용한 오류 처치 방안을 제안하였다. 또한 제안한 오류 처치 방안을 현장에 적용하고 그 효과를 검증하였다. In this paper, I analyze error cases a learner made during learning using ICT, set up error types, and search for effective treatment methods in order to enhance the effects of ICT education. I search for error case to use the methodology of the study which is observation, interviews, and survey. I set up the error types which is the error type of confusion with functions, that of confusion with concepts, that of barriers in interface interpretation, that caused by psychological anxiety, that according to learner personality patterns, and habitual error type. The biggest frequency of errors was found in the error type of confusion with function and that of confusion with concepts, whose treatment methods were searched for using the web-based Q&A learning. Also, I apply the error treatment methods on the classroom and prove the effect.
대한간학회지 제8차 춘계학술대회 초록집 : 구연 ; 담관세포암 육종성변화 관련 발현유전자 cDNA Microarray 분석
( Dae Ghon Kim ),( Young Tae Kim ),( Kyung Ran You ),( Win Jing ),( Deuk Soo Ahn ),( Jung Min Lee ),( Jeong Min Lee ),( Hee Chul You ),( Baik Whan Cho ),( Jung Kyoon Choi ),( Sang Soo Kim ) 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.2(S)
구연 : 간세포암에서 암세포 증식에 관련된 RPL36A 유전자 과발현
( Dae Ghon Kim ),( Kyung Ran You ),( Seung Ok Lee ),( Soo Taek Lee ),( Deuk Soo Ahn ),( Baik Whan Cho ),( Myung Ja Jung ) 대한간학회 2003 Clinical and Molecular Hepatology(대한간학회지) Vol.9 No.3(S)
Background/Aims: Hepatocellular carcinoma (HCC) is a worldwide major malignancy with an increasing incidence. Altered gene expression caused either by mutations or by changes in the regulatory characteristics of HCC compared with corresponding nontumor tissues have been reported. However, these genetic changes reported do not precisely reflect the biological nature or clinical characteristics of all HCCs. Methods: Previously, we identified and reported genes that were differentially expressed in HCC cells using the differential-display PCR method. Among them, we focused preferentially on an up-regulated gene in human HCC in comparison with the nontumor surrounding tissues. We identified a single fragment cDNA (HG23T1) that was over-expressed in a hepatocellular carcinoma (HCC) specimen. We cloned the full-length HG23T1 gene by the rapid amplification of cDNA end (RACE) PCR method. Results: It perfectly matched the gene encoding human ribosomal protein L36A (RPL36A or referred to RPL44). RPL36A mRNA was preferentially over-expressed in 34 of 40 HCC cases (85%, P <0.001) and in all 8 HCC cell lines. Ectotopically over-expressed L36A ribosomal protein localized in the nucleoli of cells and this localization seemed to be controlled by the N-terminal or the internal tetrapeptide consensus with its adjacent N-terminal domain. Over-expression of L36A led to enhanced colony formation and cell proliferation, which may have resulted from rapid cell cycling, and an antisense cDNA effectively reversed these alterations. Conclusions: These results suggest that RPL36A plays a role in tumor cell proliferation and may be a potential target for anticancer therapy of HCC.
( Dae Seon Ahn ),( In Hee Kim ),( Seong Hun Kim ),( Sang Wook Kim ),( Seung Ok Lee ),( Soo Teik Lee ),( Dae Ghon Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: This study was aimed to investigate the initial treatment outcomes and prognosis and to analyze factors associated with initial treatment failure and short-term (30-day)mortality of spontaneous bacterial peritonitis (SBP) in cirrhotic patients. Methods: A total 151 cases of SBP diagnosed in patients with liver cirrhosis between January 2003 and December 2011 were included. SBP was diagnosed based on a polymorphonuclear cell count in ascitic fluid of >250 cells/㎟ in the absence of data compatible with secondary peritonitis. Results: The mean age was 57.6 years, 79.5% of the SBP occurred in men. The rate of initial treatment failure was 58/151 (38.4%). In multivariate analysis, hepatocellular carcinoma (Odd ratio 2.770, p=0.021), gastrointestinal hemorrhage (Odd ratio 4.966, p=0.015), and renal impairment (Odd ratio 4.564, p=0.006) were most important factors associated with initial treatment failure. 7-day and 30-day mortality were 15.2% and 27.8%, respectively. Hepatocellular carcinoma (Odd ratio 2.96, p=0.007) and renal impairement (Odd ratio 4.13, p<0.001) were independent prognostic factors of 30-day mortality. Conclusions: Hepatocellular carcinoma and renal impairment is the main factors associated with initial treatment failure and short-term mortality in patients with SBP.