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( Darae Kim ),( Young Eun Chon ),( Sang Hoon Ahn ),( Hana Park ),( Seung Up Kim ),( Do Young Kim ),( Kwang Hyub Han ),( Chae Yoon Chon ),( Jun Yong Park ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: Entecavir (ETV) and adefovir (ADV) combination can be used as a rescue therapy for patients who had failed nucleos(t)ide analogues where tenofovir has not been introduced. We evaluated the efficacy of ETV and ADV combination therapy in patients who had failed to previous nucleos(t)ide analogue (NA). Methods: This study included consecutive 66 compensated chronic hepatitis B (CHB) patients who have failed to previous NAs. All patients received ETV and ADV combination therapy for at least 6 months. While all of the patients had experienced lamivudine (LAM), 48 (72.7%) had experienced ADV and 53 (80.3%) had been treated with ETV. Genetic resistance to LAM, ADV, and ETV at baseline were detected in 65 (98.5%), 12 (18.2%), and 36 (54.5%), respectively. Results: Median HBV DNA level was 5.63 (1.86∼8.23) log IU/mL and fifty nine patients had HBeAg positivity. During a median of 15 (6-38) months of ETV and ADV combination therapy, virological response (VR, < 60 IU/mL by PCR assay) was achieved in 18 of 66 (27.3%) patients. Cumulative VR rates were 21.5%, 28.4%, 36.6% and 36.6% at 6, 12, 24 and 36 months, respectively. When we investigated predictors for VR, baseline ADV resistance along with low baseline ALT level (p=0.027) were significantly associated with decreased VR from multivariate analysis. Conclusions: ETV and ADV combination rescue therapy showed limited efficacy for CHB patients who had failed to previous NAs, however, it can be considered as a rescue therapy in patients who do not have resistance to ADV and high baseline ALT level.
A NUMERICAL METHOD FOR THE PHASE-FIELD MODEL OF THE VESICLE DYNAMICS
Darae Jeong,Yibao Li,Junseok Kim 한국산업응용수학회 2013 한국산업응용수학회 학술대회 논문집 Vol.8 No.1
In this paper, we propose an accurate and robust numerical method for the phase-field model of the Willmore flow with area conservation and interface length constraint in two-dimensional space. Our method is similar to the one used by Du et al. [A phase field approach in the numerical study of the elastic bending energy for vesicle membranes, J. Comput. Phys. 198 (2004) 450?468] with a key difference. Here, we use a space-time dependent Lagrange multiplier to accurately conserve the area of vesicle membranes while Du et al. introduced a penalty term to roughly enforce the area conservation. We also derive the phase-field model for the Willmore functional using a simple argument. The proposed numerical method is based on an unconditionally gradient stable scheme and a direct area correction algorithm. The accuracy and effectiveness of the proposed model and numerical algorithm are demonstrated through numerical examples.
Darae Jeong,In-Suk Wee,Junseok Kim 한국산업응용수학회 2011 한국산업응용수학회 학술대회 논문집 Vol.6 No.1
This paper presents an accurate and efficient numerical method for solving the Black-Scholes equation. The method uses an adaptive grid technique which is based on a far-field boundary position of the equation and also the Peclet condition. For a given error tolerance, we determine a priori a suitable far-field boundary location and then put a uniform fine grid around the non-smooth points and a non-uniform grid in the remaining regions. Numerical tests are presented to demonstrate the accuracy and efficiency of the proposed method. The results show that the computational times using this new adaptive grid method are reduced substantially when compared to those of a uniform grid method with a similar magnitude of error.
AN ADAPTIVE MULTIGRID TECHNIQUE FOR OPTION PRICING UNDER THE BLACK–SCHOLES MODEL
DARAE JEONG,YIBAO LI,YONGHO CHOI,KYOUNG-SOOK MOON,JUNSEOK KIM 한국산업응용수학회 2013 Journal of the Korean Society for Industrial and A Vol.17 No.4
In this paper, we consider the adaptive multigrid method for solving the Black?Scholes equation to improve the efficiency of the option pricing. Adaptive meshing is generally regarded as an indispensable tool because of reduction of the computational costs. The Black?Scholes equation is discretized using a Crank?Nicolson scheme on block-structured adaptively refined rectangular meshes. And the resulting discrete equations are solved by a fast solver such as a multigrid method. Numerical simulations are performed to confirm the efficiency of the adaptive multigrid technique. In particular, through the comparison of computational results on adaptively refined mesh and uniform mesh, we show that adaptively refined mesh solver is superior to a standard method.
FAST AND AUTOMATIC INPAINTING OF BINARY IMAGES USING A PHASE-FIELD MODEL
DARAE JEONG,YIBAO LI,HYUN GEUN LEE,JUNSEOK KIM 한국산업응용수학회 2009 Journal of the Korean Society for Industrial and A Vol.13 No.3
Image inpainting is the process of reconstructing lost or deteriorated parts of images using information from surrounding areas. We propose a computationally efficient and fast phase-field method which uses automatic switching parameter, adaptive time step, and automatic stopping of calculation. The algorithm is based on an energy functional. We demonstrate the performance of our new method and compare it with a previous method.
Darae Jeong,하태영,Myoungnyoun Kim,신재민,In-Han Yoon,김준석 대한수학회 2014 대한수학회보 Vol.51 No.4
We present an accurate and efficient numerical method for solving the Black-Scholes equation. The method uses an adaptive grid technique which is based on a far-field boundary position and the Peclet condition. We present the algorithm for the automatic adaptive grid generation: First, we determine a priori suitable far-field boundary location using the mathematical model parameters. Second, generate the uniform fine grid around the non-smooth point of the payoff and a non-uniform grid in the remaining regions. Numerical tests are presented to demonstrate the accuracy and efficiency of the proposed method. The results show that the computational time is reduced substantially with the accuracy being maintained.
INPAINTING OF BINARY IMAGES USING A PHASE-FIELDMODEL
Darae Jeong,Li YiBAO,Hyun Geun Lee,Junseok Kim 한국산업응용수학회 2009 한국산업응용수학회 학술대회 논문집 Vol.2009 No.5
Image inpainting is the filling in missing or damaged regions of images using information from surrounding areas. We compared our new modified CH equation with the modified CH eq. in previous paper [1] and developed on automatic varying ? and adaptive time step.
The Korean Organ Transplant Registry (KOTRY): Second Official Adult Heart Transplant Report
Darae Kim,Jin-Oh Choi,Jaewon Oh,Hyun Jai Cho,Sung-Ho Jung,Hae-Young Lee,Seok-Min Kang,Jae-Joong Kim,Eun-Seok Jeon 대한심장학회 2019 Korean Circulation Journal Vol.49 No.8
Background and Objectives: This second adult heart transplantation (HTx) report is based on Korean Organ Transplant Registry data submitted on 400 HTxs in recipients of all ages. Methods: From March 2014 to December 2017, a total of 400 HTxs were performed at 4 major centers in Korea. We analyzed demographics and characteristics according to transplant years. Patterns of immunosuppression, allograft rejection, and survival after HTx were analyzed. Donor and recipient age were highlighted. Results: Some distinct differences in HTx statistics were noted. Mean donor age increased significantly in the most recent years compared to 2014–2015, while mean recipient age did not change. The proportion of patients on pre-transplant extracorporeal membrane oxygenation (ECMO) increased over time. One-year and intermediate-term survival was significantly worse in patients on pre-transplant ECMO compared to those without mechanical support. Over the years, tacrolimus has increased to become the most frequently used calcineurin inhibitor over cyclosporine, while the number of patients using steroids both at discharge and 1-year follow-up has declined. Age did not affect 1-year survival, but significantly affected intermediate-term survival. Conclusions: From 2014 to 2017, centers were willing to accept older donors to address increasing organ shortages and more patients received transplant under ECMO care. Increasing age was a strong independent factor for intermediate-term survival, however, post-transplant comorbidities did not differ among age groups. Further studies with longer follow-up duration are needed to better understand age-related post-transplant prognosis.