O diachronii w pragmalingwistyce

Marek Cybulski 한국슬라브어학회 2009 슬라브어연구 Vol.14 No.1

L’auteur de l’article présente les valeurs d’une approche évolutive dans la recherche en pragmalinguistique. En se référant essentiellement aux exemples de l‘ancien polonais, il démontre l’impact des comportements personnalisés et directes, prédominants à cette époque-là dans les contacts humains, sur l’importance de statut social de l’émetteur et du récepeteur face aux autres facteurs situationnels, ainsi que sur la variabilité et la petrification d’instruments langagiers exprimant différents rôles sociaux, etc. Une approche diachronique adoptée permet d’expliquer et de comprendre entre autres les changements fonctionnelles des comportements langagiers fondamentaux à l’époque en comportements presque insignifiants aujourd’hui et, au contraire, de découvrir des sources presque insignifiantes des comportements les plus essentiels de l’époque moderne. Ce point de vue donne lieu aussi à des divagations sur un nombre de phénomènes anthropologiques.

Special Olympics coaches

Sarah Cybulski,Diane M. Culver,Erin Kraft,Tanya Formeris 한국코칭능력개발원 2016 International Journal of Coaching Science Vol.10 No.2

Research has shown that sports are important for people with intellectual disabilities (ID; Mactavish & Dowds, 2003), assisting this population to develop and feel socially included (McConkey, Dowling, Hassan, & Menke, 2013). Coaches can play a role in helping their athletes to develop life skills and Special Olympics (SO) is an organisation with the goals and means to bring positive change to the lives of people with ID (Weiss et al., 2003). Merriam’s (2002) basic interpretive qualitative approach was used to explore the strategies employed by Special Olympics (SO) coaches to promote life skill development. Non-participant observations and two semi-structured interviews were conducted with six coaches. Results revealed seven deductive themes framed by Camiré, Trudel, and Forneris’s (2012) study with high school coaches: (a) having a philosophy aimed at helping athletes develop, (b) building strong coach-athlete relationships, (c) understanding athletes’ pre-existing makeup, (d) providing athletes with opportunities to show their skills, (e) modelling, (f) taking teachable moments, and (g) volunteerism. While the coaches’ adapted these strategies to their SO athletes, perhaps more interesting is the one inductive theme found: being stern and direct.

Molecular gas content of H I monsters and implications to cold gas content evolution in galaxies

Lee, C.,Chung, A.,Yun, M. S.,Cybulski, R.,Narayanan, G.,Erickson, N. Oxford University Press 2014 MONTHLY NOTICES- ROYAL ASTRONOMICAL SOCIETY Vol.441 No.2

Stressful Events and Serum Concentration of Substance P in Acne Patients

( Anita Rokowska Waluch ),( Mariola Pawlaczyk ),( Marcin Cybulski ),( Jakub Zurawski ),( Mariusz Kaczmarek ),( Michał Michalak ),( Ewa Mojs ) 대한피부과학회 2016 Annals of Dermatology Vol.28 No.4

Background: Psychological stress is an important factor of acne pathogenesis. Stress related production of hormones, cytokines and neuropeptides may result in the chronic course and exacerbations of the disease. Objective: The aim of the study was to evaluate the relationship between acne severity, intensity of emotional stress and serum concentration of substance P (scSP), to compare the intensity of adversities, psychological stress and scSP in acne patients with healthy controls and to compare coping techniques for stress. Methods: The study consisted of 80 patients. Emotional stress was analyzed with the use of social readjustment rating scale, whereas the methods of coping with stress were assessed with the coping inventory for stressful situation questionnaire. The blood concentration of substance P was analyzed by enzyme-linked immunosorbent assay method in a group of 40 patients with acne vulgaris and in control subjects. Results: There was no statistically significant difference between the severity of acne and the intensity of stress. Acne patients presented a higher average scSP than the controls. No statistically significant correlation was observed between the severity of acne and scSP; however, the intensity of stress correlated with scSP in the control group. The evaluation of methods of coping with stress showed significantly higher rate for the avoidance-oriented coping among acne patients. Conclusion: The number of stressful events is not a factor that determines the severity of acne. The course of the disease may depend on tolerance to stress and methods of coping with stress. (Ann Dermatol 28(4) 464∼469, 2016)

The Prevalence of Founder Mutations among Individuals from Families with Familial Pancreatic Cancer Syndrome

Marcin R. Lener,Aniruddh Kashyap,Wojciech Kluzniak,Cezary Cybulski,Agnieszka Soluch,Sandra Pietrzak,Tomasz Huzarski,Jacek Gronwald,Jan Lubinski 대한암학회 2017 Cancer Research and Treatment Vol.49 No.2

Purpose Familial pancreatic cancer describes families with at least two first-degree relatives with pancreatic cancer that do not fulfil the criteria of other inherited tumor syndromes with increased risks of pancreatic cancer. Although much has been learned regarding the aggregation of pancreatic cancer in some families, the genetic basis for this familial aggregation is poorly understood. This study evaluated the prevalence of 10 Polish founder mutations in four genes among individuals from families with diagnosed familial pancreatic cancer syndrome and assessed their possible association with the familial pancreatic cancer (FPC) risk in Poland. Materials and Methods In this study, 400 FPC individuals and 4,000 control subjects were genotyped for founder mutations in BRCA1 (5382insC, 4153delA, C61G), CHEK2 (1100delC, IVS2+1G>A, del5395, I157T), NBS1 (657del5), and PALB2 (509_510delGA, 172_175delTTGT) genes. Results A statistically significant association was observed between the 172_175delTTGT mutation of the PALB2 gene and an increased risk of FPC syndrome (odds ratio [OR], 10.05; p=0.048). In addition, an increased risk of cancer was observed in the FPC family members with a BRCA1 mutation (OR, 6.72; p=0.006). Novel associations were found between the FPC family members with cancer and CHEK2mutations (OR, 2.26; p=0.008) with a noticeable contribution of the missense variant, I157T of CHEK2 (OR, 2.17; p=0.026). Conclusion The founder mutations in the genes, BRCA1, PALB2, and CHEK2, cause a small percentage of familial pancreatic cancer syndrome in the Polish population. Following confirmation in larger studies, these mutations can be added to the panel of genes to be tested in families with a diagnosis of FPC syndrome.

An AzTEC 1.1-mm survey for ULIRGs in the field of the Galaxy Cluster MS 0451.6−0305

Wardlow, J. L.,Smail, Ian,Wilson, G. W.,Yun, M. S.,Coppin, K. E. K.,Cybulski, R.,Geach, J. E.,Ivison, R. J.,Aretxaga, I.,Austermann, J. E.,Edge, A. C.,Fazio, G. G.,Huang, J.,Hughes, D. H.,Kodama, T.,K Blackwell Publishing Ltd 2010 MONTHLY NOTICES- ROYAL ASTRONOMICAL SOCIETY Vol.401 No.4

<P>ABSTRACT</P><P>We have undertaken a deep (σ∼ 1.1 mJy) 1.1-mm survey of the <I>z</I>= 0.54 cluster MS 0451.6−0305 using the AzTEC camera on the James Clerk Maxwell Telescope. We detect 36 sources with signal-to-noise ratio (S/N) ≥ 3.5 in the central 0.10 deg<SUP>2</SUP> and present the AzTEC map, catalogue and number counts. We identify counterparts to 18 sources (50 per cent) using radio, mid-infrared, <I>Spitzer</I> InfraRed Array Camera (IRAC) and Submillimetre Array data. Optical, near- and mid-infrared spectral energy distributions are compiled for the 14 of these galaxies with detectable counterparts, which are expected to contain all likely cluster members. We then use photometric redshifts and colour selection to separate background galaxies from potential cluster members and test the reliability of this technique using archival observations of submillimetre galaxies. We find two potential MS 0451−03 members, which, if they are both cluster galaxies, have a total star formation rate (SFR) of ∼100 M<SUB>⊙</SUB> yr<SUP>−1</SUP>– a significant fraction of the combined SFR of all the other galaxies in MS 0451−03. We also examine the stacked rest-frame mid-infrared, millimetre and radio emission of cluster members below our AzTEC detection limit, and find that the SFRs of mid-IR-selected galaxies in the cluster and redshift-matched field populations are comparable. In contrast, the average SFR of the morphologically classified late-type cluster population is nearly three times less than the corresponding redshift-matched field galaxies. This suggests that these galaxies may be in the process of being transformed on the red sequence by the cluster environment. Our survey demonstrates that although the environment of MS 0451−03 appears to suppress star formation in late-type galaxies, it can support active, dust-obscured mid-IR galaxies and potentially millimetre-detected LIRGs.</P>

Founder Mutations for Early Onset Melanoma as Revealed by Whole Exome Sequencing Suggests That This is Not Associated with the Increasing Incidence of Melanoma in Poland

Tadeusz Debniak,Rodney J Scott,Rodney A Lea,Bohdan Górski,Bartlomiej Masojc,Cezary Cybulski,Andrzej Kram,Romuald Maleszka,Tomasz Gromowski,Katarzyna Paszkowska-Szczur,Aniruddh Kashyap,Marcin R. Lener 대한암학회 2019 Cancer Research and Treatment Vol.51 No.1

Purpose Germline mutations within melanoma susceptibility genes are present only in minority of melanoma patients and it is expected that additional genes will be discovered with next generation sequence technology and whole-exome sequencing (WES). Materials and Methods Herein we performed WES on a cohort of 96 unrelated Polish patients with melanoma diagnosed under the age of 40 years who all screened negative for the presence of CDKN2Avariants. A replication study using a set of 1,200 melanoma patient DNA samples and similarly large series of healthy controls was undertaken. Results We selected 21 potentially deleterious variants in 20 genes (VRK1, MYCT1, DNAH14, CASC3, MS4A12, PRC1, WWOX, CARD6, EXO5, CASC3, CASP8AP2, STK33, SAMD11, CNDP2, CPNE1, EFCAB6, CABLES1, LEKR1, NUDT17, and RRP15), which were identified by WES and confirmed by Sanger sequencing for an association study. Evaluation of the allele distribution among carriers and their relatives in available family trios revealed that these variants were unlikely to account for many familial cases of melanoma. Replication study revealed no statistically significant differences between cases and controls. Conclusion Although most of the changes seemed to be neutral we could not exclude an association between variants in VRK1, CREB3L3, EXO5, and STK33 with melanoma risk.