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Zhou, Guo-Wei,Guo, Guo-Cong,Liu, Bin,Wang, Ming-Sheng,Cai, Li-Zhen,Huang, Jin-Shun Korean Chemical Society 2004 Bulletin of the Korean Chemical Society Vol.25 No.5
Complexes M($C_7H_2NO_5)3H_2O{\cdot}H_2O{\cdot}0.25MeCN$ (M=Ni, Co) were crystallized from the reactions of $Ni(CH_3COO)_2{\cdot}4H_2O\;or\;Co(CH_3COO)_2{\cdot}2H_2O$ with KSCN and 2,6-dicarboxy-4-hydroxypyridine (chelidamic acid). The structures were characterized by X-ray crystallography. The crystal structures of 1 and 2 show a distorted octahedral coordination geometry around the M(II) ions, which are chelated by one nitrogen atom and two oxygen atoms of the chelidamic acid and three water molecules. Complexes 1 and 2 display the hydrogen-bonded 3D framework. The magnetic behavior of 2 exhibits antiferromagnetic interaction.
Moderating Effects and Maintenance of Lung Cancer Cellular Immune Functions by CIK Cell Therapy
Jin, Cong-Guo,Chen, Xiao-Qun,Li, Jia,Wu, Zhi-Pin,Liu, Xin,Wang, Xi-Cai Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6
Aims: To study the CIK cell treatment effects on regulation of cellular immune function disorders in patients with lung cancer, and to analyze the time characteristics. Methods: Cellular immune function was assessed by FCM, and patients with functional disorders were randomly divided into two groups, one given CIK cell therapy within 18 months (5 courses) and the other the controls, which were followed up for 1 year with cellular immune functions tested once a month. Results: There were 5 types of cellular immunity, 4 of which are disorders; after CIK treatment, the improvement rate of the 4 groups were 79.1%, 70.8%, 76.0% and 70.0%, intergroup differences not being statistically significant (P=0.675), all significantly higher than in the control group (P=0.000). The median maintenance times for the 4 groups were 10.4 months (9.76-11.04), 8.4 months (7.86-8.94), 9.8 months (9.20-10.4) and 7.9 months (6.25-9.55), respectively. Conclusions: CIK cells were able to improve the immune functions of patients with lung cancer, the rate of improvement and maintenance time being related to the immune function before the treatment and CIK-cell-therapy courses.
Cong Feng,Zhaojun Yang,Chuanhai Chen,Jinyan Guo,Hailong Tian,Fanning Meng 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.6
Accuracy retention is an important performance index of CNC machine tools. At present, research on the evaluation of machining accuracy retention of CNC machine tools mainly focuses on accuracy value of a fixed time point or different time periods, but studies on the fluctuation degree of degradation trajectory related to time change are limited. Extracting simple and effective degradation characteristics of machining accuracy and then evaluating machining accuracy retention considering fluctuation of degradation trajectory are necessary. The volume error model of CNC machine tools is established on the basis of multibody system theory in this study. Three-dimensional volume error vector is transformed into one-dimensional machining accuracy degradation by calculating offset distance between spatial error and origin points. Degradation data obtained via regular measurement and calculation are used to establish the complete degradation trajectory model of the CNC machine tools machining accuracy using radial basis function interpolation method according to the fluctuation degree of degradation trajectory, and concepts of average degradation rate and average degradation amount are defined. Lastly, examples showed that these two indicators can intuitively reflect fluctuation degree of machining accuracy degradation of CNC machine tools and effectively and quantitatively evaluate accuracy retention of CNC machine tools. The quantitative evaluation method of accuracy retention of CNC machine tools defined in this study considers the fluctuation degree of accuracy degradation trajectory. The quantitative evaluation index of accuracy retention demonstrates satisfactory engineering application because it can reflect not only the accuracy change of a single machine tool but also accurately compare the accuracy retention between different machine tools.
Association Between Nasal Colonization of Staphylococcus aureus and Eczema of Multiple Body Sites
Guo Yang,Dou Xia,Chen Xiao-Fan,Huang Cong,Zheng Ying-Jie,Yu Bo 대한천식알레르기학회 2023 Allergy, Asthma & Immunology Research Vol.15 No.5
Purpose: Staphylococcus aureus is the critical pathogenic bacterium of eczema. The relationship between nasal colonization by S. aureus and eczema has not been well studied. We aimed to evaluate the associations between nasal colonization by S. aureus and eczema of multiple body sites, including persistent and ever-reported eczema. We further examined the associations between eczema and different subtypes of S. aureus, that is, methicillin-resistant S. aureus (MRSA) and methicillin-sensitive S. aureus (MSSA). Methods: The real-world data from the US National Health and Nutrition Examination Survey were used. The associations were calculated using survey-weighted multinomial logistic regression models and further calculated in subgroups stratified by demographic factors. Results: In total, 2,941 adults were included. The prevalence rate of S. aureus nasal carriage was significantly higher in adults with persistent hand eczema (51.0%) than in those with ever-reported hand eczema (23.3%) and never eczema (26.9%). S. aureus nasal colonization was associated with an approximately two-fold increased risk of persistent hand eczema (odds ratios ranges in different models: 2.86–3.06) without significant heterogeneity in the association by demographic factors. No significant associations between S. aureus nasal colonization and persistent eczema of other body sites or ever-reported eczema of multiple body sites (including hands) were observed. Furthermore, similar significant association between nasal colonization of MSSA and persistent hand eczema was seen; the association was much stronger (odds ratios ranges in different models: 4.64–6.54) for MRSA, although with borderline significant. Conclusions: Nasal colonization of S. aureus was associated with increased risk of persistent hand eczema. Our findings imply that preventive measures targeting S. aureus for the anterior nares should be considered in preventing and treating eczema.
Sulfakinin inhibits activity of digestive enzymes in the brown planthopper, Nilaparvata lugens
Guo Di,Zhang Su,Zhang Yi-Jie,Ma Jun-Yu,Gao Cong-Fen,Wu Shun-Fan 한국응용곤충학회 2020 Journal of Asia-Pacific Entomology Vol.23 No.4
In animals, feeding can regulate release of digestive enzymes. Digestive enzymes are produced and released in response to specific ratios of nutrients, so the quality and quantity of food ingested are important factors in the secretion and activity of digestive enzymes. In general, the enzyme activity and secretion in the fed insects are relatively higher than that in the unfed insects. Neuropeptides and peptide hormones are important regulators of enzyme activity. In several insects, the neuropeptide sulfakinin (SK) is known to be a regulator of feeding and digestion similar to cholecystokinin in mammals. However, the roles of diet and SK in regulation of activity of digestive enzymes in the important pest insect, the brown planthopper (Nilaparvata lugens), are unknown. In this study, we identified six genes encoding different digestive enzymes and cloned three of these. We found that enzymatic activity and transcriptional levels of digestive enzymatic activity genes were upregulated by refeeding animals for 5 h after 24 h starvation. Furthermore, injection of N. lugens SK reduces digestive enzyme activity and leads to a downregulation of digestive enzyme gene transcripts. This study provides new views into the action of diet and SK in regulation of digestive enzymes in (hemimetabolous) insects. Taken together with the roles of SK in inducing satiety, our data strongly suggest that SK signaling is important in regulation of food ingestion and processing.