ITA/EA Innovation Performance and Governance : Actionable Architecture: A Case Study Example

( Colleen Coggins ) 한국ITA학회 2006 학술대회 Vol.2006 No.-

Modernization of the United States Department of the Interior (DOI) : U.S. Department of Interior Mission

Colleen Coggins 한국EA학회 2006 한국EA학회 학술발표논문집 Vol.2006 No.10

Personal Identities and Depressive Symptoms in Urban Youth

Colleen Corte 한국간호과학회 2011 한국간호과학회 학술대회 Vol.2011 No.10

Actionable Architecture : A Case Study Example

Colleen Coggins 한국EA학회 2006 한국EA학회 학술발표논문집 Vol.2006 No.10

The Phonetic and Linguistic Environment of Third Singular Allomorphs in Parent Input

Colleen E. Fitzgerald,Rebecca C. Wettstein,Rebecca L. Ebert,Shannon M. Bridges 한국언어재활사협회 2018 Clinical Archives of Communication Disorders Vol.3 No.2

Purpose: The third person singular present tense morpheme (3s) has a protracted course of development for children with language disorders and for typically developing children compared to other phonetically or linguistically similar morphemes. This study’s objective is to describe the phonetic and linguistic environment of 3s allomorphs in parent input. Methods: Participants were 14 monolingual English-speaking parents of typically developing toddlers. Parents’ allomorphs of 3s were examined for sentence position, allomorph type, coda of the inflected verb, onset of the following word, and the verb’s input frequency both before and after the toddlers first used 3s. Results: At both measurement points, the majority of instances of 3s were sentence medial, took the form of an/s/or/z/allomorph, and both followed and preceded non-sibilant consonants. At the second measurement point, when emergence of 3s had begun for all children, parents inflected a significantly greater number of different verb types with 3s. Parents also inflected a greater number of verbs with low frequency in parent input at Time 2, as demonstrated through the calculation of a Weighted Verb Diversity score. Conclusions: The findings of this study are both compatible with previous investigations of phonetic and linguistic environment and also build on those findings by examining the environment in greater detail. Speech-language pathologists could consider selecting target verbs that are intransitive and end with sibilants to increase the salience of the 3s morpheme for clinical populations at risk for delayed acquisition of the 3s morpheme.

The influence of limited scope formulae on children’s subject-copula combinations

Colleen E. Fitzgerald,Amanda M. Spangenberg 한국언어재활사협회 2019 Clinical Archives of Communication Disorders Vol.4 No.2

Determinants of Postoperative Spinal Height Change among Adult Spinal Deformity Patients with Long Construct Circumferential Fusion

Rentenberger Colleen,Okano Ichiro,Salzmann Stephan N.,Shirahata Toshiyuki,Reisener Marie-Jacqueline,Shue Jennifer,Sama Andrew A.,Cammisa Frank P.,Girardi Federico P.,Hughes Alexander P. 대한척추외과학회 2021 Asian Spine Journal Vol.15 No.2

Study Design: Retrospective clinical study. Purpose: To describe postoperative height changes and identify the predictive factors of spinal height (SH) changes among patients with adult spinal deformity (ASD) who underwent circumferential lumbar fusion with instrumentation. Overview of Literature: Postoperative height changes remain an important issue after spinal fusion surgery that affects the overall satisfaction with surgery. Previous studies of postoperative height change have focused exclusively on young patients with adolescent idiopathic scoliosis (AIS). Methods: We retrospectively reviewed the clinical and imaging data of ASD patients who underwent lumbar corrective circumferential fusion of ≥3 levels (n=106). SH was defined as the vertical distance between C2 and S1 on a standing lateral image. As potential predictors of postoperative height change, the number of lateral lumbar interbody fusion (LLIF) levels, change in spino-pelvic parameters, total number of levels fused, and pedicle subtraction osteotomies (PSO) were documented. Univariate and multivariate linear regression analyses were performed to identify the predictors of postoperative height change. Results: The mean SH change was −2.39±50.8 mm (range, −160 to 172 mm). The univariate analyses showed that the number of LLIF levels (coefficient=10.9, p =0.03), the absolute coronal vertical axis change (coefficient=0.6, p =0.01), and the absolute Cobb angle change (coefficient=−0.9, p =0.03) were significant predictors for height change. Patients with PSOs (n=14) tended to have a shorter height postoperatively (coefficient=−26.1); however, this difference was not significant (p =0.07). Multivariate analyses conducted with variables of p <0.20 showed that pelvic tilt (PT) change is an independent contributor to SH change (coefficient=−0.99, p =0.04, R2 =0.11). Conclusions: Utilizing a modified definition of SH used in previous AIS studies, we demonstrated that patients with ASD lose SH postoperatively and that PT change was an independent contributor of SH change.

Calpains and Apoptosis

Tagliarino, Colleen,Pink, John J.,Boothman, David A. The Korean Society for Integrative Biology 2001 Korean journal of biological sciences Vol.5 No.4

Calpains are a family of cysteine proteases existing primarily in two forms designated by the $Ca^{2+}$ concentration needed for activation in vitro, $\mu$-calpain (calpain-I) and m-calpain (calpain-II). The physiologica1 roles of calpains remain unclear. Many groups have proposed a role for calpains In apoptosis, but their patterns of activation are not well characterized. Calpains have been implicated in neutrophil apoptosis, glucocorticoid-induced thymocyte apoptosis, as well as many other apoptotic pathways. Calpain activation in apoptosis is usually linked upstream or downstream to caspase activation, or in a parallel pathway alongside caspase activation. Calpains have been suggested to be involved in DNA fragmentation (via endonuclease activation), but also as effector proteases that cleave cellular proteins involved in DNA repair, membrane associated proteins and other homeostatic regulatory proteins. Recently, our laboratory demonstrated $\mu$-calpain activation in NAD(P)H: quinone oxidoreducatse 1 (NQO1)-expressing cells after exposure to $\beta$-lapachone, a novel quinone and potential chemo- and radio-therapeutic agent. Increased cytosolic $Ca^{2+}$ in NQO1-expressing cells after $\beta$-lapachone exposures were shown to lead to $\mu$-calpain activation. In turn, $\mu$-calpain activation was important for substrate proteolysis and DNA fragmentation associated with apoptosis. Upon activation, $\mu$-calpain translocated to the nucleus where it could proteolytically cleave PARP and p53. We provided evidence that $\beta$-lapachone-induced, $\mu$-calpain stimulated, apoptosis did not involve any of the known caspases; known apoptotic caspases were not activated after $\beta$-lapachone treatment of NQO1-expressing cells, nor did caspase inhibitors have any effect on $\beta$-1apachone-induced cell death. Elucidation of processes by which $\beta$-1apachone-stimulated $\mu$-calpain activation and calpains ability to activate endonucleases and induce apoptosis independent of caspase activity will be needed to further develop/modulate $\beta$-lapachone for treatment of human cancers that over-express NQO1.

Characterization of activated cyclic olefin copolymer: effects of ethylene/norbornene content on the physiochemical properties

O'Neil, Colleen E.,Taylor, Scott,Ratnayake, Kumuditha,Pullagurla, Swathi,Singh, Varshni,Soper, Steven A. The Royal Society of Chemistry 2016 The Analyst Vol.141 No.24

<P>The ethylene/norbornene content within cyclic olefin copolymer (COC) is well known to affect the chemical and physical properties of the copolymer, such as the glass transition temperature (<I>T</I>g) and transparency. However, no work has been reported evaluating the effects of the ethylene/norbornene content on the surface properties of COC following UV/O3 or O2 plasma activation. Activation with either O2 plasma or UV/O3 is often used to assist in thermal assembly of fluidic devices, increasing the wettability of the surfaces, or generating functional scaffolds for the attachment of biological elements. Thus, we investigated differences in the physiochemical surface properties of various ethylene/norbornene compositions of COC following activation using analytical techniques such as water contact angle (WCA), ATR-FTIR, XPS, TOF-SIMS, UV-VIS, AFM and a colorimetric assay utilizing Toluidine Blue O (TBO). Results showed that increased norbornene content led to the generation of more oxygen containing functionalities such as alcohols, ketones, aldehydes and carboxyl groups when activated with either UV/O3 or O2 plasma. Specifically, COC with ∼60% norbornene content showed a significantly higher -COOH functional group density when compared to COC with a 50% norbornene content and COC with a 35% norbornene content following UV/O3 or O2 plasma activation. Furthermore, COC with large norbornene contents showed a smaller average RMS roughness (0.65 nm) when compared to COC containing low norbornene contents (0.95 nm) following activation making this substrate especially suited for nanofluidic applications, which require smooth surfaces to minimize effects arising from dielectrophoretic trapping or non-specific adsorption. Although all COC substrates showed >90% transparency at wavelengths >475 nm, COC possessing high norbornene contents showed significantly less transparency at wavelengths below 475 nm following activation, making optical detection in this region difficult. Our data showed distinct physiochemical differences in activated COC that was dependent upon the ethylene/norbornene content of the thermoplastic and thus, careful selection of the particular COC grade must be considered for micro- and nanofluidics.</P>

Conscientious internationalisation in higher education: contextual complexities and comparative tensions

Susan Ledger,Colleen Kawalilak 서울대학교 교육연구소 2020 Asia Pacific Education Review Vol.21 No.4

In this paper, authors focus on how internationalisation is defined, interpreted, and responded to by Universities in Australia and Canada, two decades after de Wit’s (Strategies for the internationalisation of higher education. A comparative study of Australia, Canada, Europe and the USA. European Association for International Education, Amsterdam, 1995) comparison of internationalisation in four higher education contexts. Guided by humanitarian factors that impact internationalisation in higher education contexts, authors find convergence and divergence with de Wits earlier study. A critical policy lens is employed to further analyse, probe and pose critical questions related to people, philosophy, place, processes, and power (5Ps). Authors argue that the intent (philosophy) of institutions (place) to internationalise (process) are impacted by the interests (power) of individuals and institutions (people) and these often conflict with descriptions and ideals of internationalisation. The authors offer conscientious internationalisation (CI) to recalibrate discourse and practices embedded in the internationalisation of higher education. CI prioritises ethics over markets. It is characterized as practices and processes informed by constitutive principles and ethical practices that amplify equity, reciprocity, and integrity.