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- 저자 : Clero, (검색결과 3 건)
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Differentiated Thyroid Carcinoma Risk Factors in French Polynesia
Xhaard, Constance,Ren, Yan,Clero, Enora,Maillard, Stephane,Brindel, Pauline,Rachedi, Frederique,Boissin, Jean-Louis,Sebbag, Joseph,Shan, Larrys,Bost-Bezeaud, Frederique,Petitdidier, Patrick,Drozdovitc Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6
Background: To investigate differentiated thyroid cancer risk factors in natives of French Polynesia is of interest because of the very high incidence of this cancer in the archipelago. Materials and Methods: To assess the role of various potential risk factors of thyroid cancer in the natives of French Polynesia we performed a case-control study. The study included almost all the French Polynesians diagnosed with differentiated thyroid carcinoma between 1981 and 2003 (n=229) and 373 French Polynesian control individuals from the general population without cancer. Results: Thyroid radiation dose received from nuclear fallout before the age of 15, a personal history of neck or/and head medical irradiation, obesity, tallness, large number of children, an artificial menopause, a familial history of thyroid cancer, a low dietary iodine intake, and having a spring as the main source of drinking water were found to be significant risk factors. No roles of smoking habits, alcohol consumption, iodine containing drugs, and exposure to pesticides were evidenced. Conclusions: Except for smoking, differentiated thyroid carcinoma risk factors in natives of French Polynesia are similar to those in other populations. Our finding on the role of having a spring as a drinking water origin is coherent with some other studies and could be due to geological factors.
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Numerical study on the deflections of steel-concrete composite beams with partial interaction
Enrique Mirambell,Jorge Bonilla,Luciano M. Bezerra,Beatriz Clero 국제구조공학회 2021 Steel and Composite Structures, An International J Vol.38 No.1
The use of composite beams with partial interaction, with less shear connectors than those required for full interaction, may be advantageous in many situations. However, these beams tend to show higher deflections compared to beams with full interaction, and codified expressions for the calculation of such deflections are not fully developed and validated. Thus, this paper presents a comprehensive numerical study on the deflections of steel-concrete composite beams with partial interaction. Efficient numerical models of full-scale composite beams considering material nonlinearities and contact between their parts have been developed by means of the advanced software ABAQUS, including a damage model to simulate the concrete slab. The FE models were validated against experimental results, and subsequently parametric studies were developed to investigate the influence of the shear connection degree and the coefficient of friction in the deflection of composite beams. The comparison of predicted deflections using reference codes (AISC, Eurocode-4 and AS-2327.1) against numerical results showed that there are still inaccuracies in the estimation of deflections for the verification of the serviceability limit state, according to some of the analyzed codes.
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Ren, Yan,Kitahara, Cari Meinhold,de Gonzalez, Amy Berrington,Clero, Enora,Brindel, Pauline,Maillard, Stephane,Cote, Suzanne,Dewailly, Eric,Rachedi, Frederique,Boissin, Jean-Louis,Sebbag, Joseph,Shan, Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13
Background: Numerous studies have suggested that selenium deficiency may be associated with an increased risk for several types of cancer, but few have focused on thyroid cancer. Materials and Methods: We examined the association between post-diagnostic fingernail selenium levels and differentiated thyroid cancer risk in a French Polynesian matched case-control study. Conditional logistic regression models were used to estimate odds ratios and 95% confidence intervals. Results: The median selenium concentration among controls was $0.76{\mu}g/g$. Significantly, we found no association between fingernail selenium levels and thyroid cancer risk after conditioning on year of birth and sex and additionally adjusting for date of birth (highest versus lowest quartile: odds-ratio=1.12, 95% confidence interval: 0.66-1.90; p-trend=0.30). After additional adjustment for other covariates, this association remained non-significant (p-trend=0.60). When restricting the analysis to thyroid cancer of 10 mm or more, selenium in nails was non-significantly positively linked to thyroid cancer risk (p-trend=0.09). Although no significant interaction was evidenced between iodine in nails and selenium in nails effect (p=0.70), a non-significant (p-trend =0.10) positive association between selenium and thyroid cancer risk was seen in patients with less than 3 ppm of iodine in nails. The highest fingernail selenium concentration in French Polynesia was in the Marquises Islands ($M=0.87{\mu}g/g$) and in the Tuamotu-Gambier Archipelago ($M=0.86{\mu}g/g$). Conclusions: Our results do not support, among individuals with sufficient levels of selenium, that greater long-term exposure to selenium may reduce thyroid cancer risk. Because these findings are based on post-diagnostic measures, studies with prediagnostic selenium are needed for corroboration.
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