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Should You Initiate Treatment with One or Two Bronchodilators?
( Claus F. Vogelmeier ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Guideline documents give conflicting recommendations how to initiate treatment in a newly diagnosed symtomatic COPD patient with no major exacerbation history: some recommend to start with a single long-acting bronchodilator (LAMA), some to start with a LAMA/LABA combination. There is evidence that many patients on mono-bronchodilator treatment are (still) highly symptomatic. Most studies that evaluated the efficacy of dual bronchodilators have been compromised by the concurrent use of ICS in a considerable part of the included patient population. The EMAX study is the first major prospective study testing the efficacy of LAMA/LABA versus monotherapies in patients without ICS. EMAX showed a consistent and sustained benefit of LAMA/ LABA (umeclidinium/vilanterol) over monotherapies including clinically important improvements in lung function versus monotherapies in both maintenance treated and maintenance naive subgroups. If patients do not improve with dual bronchodilator treatment, non-pharmacologic treatments and comorbidities have to be considered.
Room-Temperature Stimulated Emission in ZnO: Doubts on Excitonic Lasing
Claus Klingshirn,Johannes Fallert,Robert Hauschild,Mario Hauser,Heinz Kalt,Huijuan Zhou 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.5
Concerning stimulated emission, we discuss for ZnO the roles of excitonic processes and of re- combination in an inverted electron-hole plasma. While excitonic processes are well justied at lower temperatures and densities, doubts arise concerning the concept of excitonic lasing in ZnO at or even above room temperature. The densities at laser threshold and at room temperature are frequently at or above the Mott density, but below the density at which population inversion is reached. We suggest alternative processes in a non-inverted plasma.
Goals of COPD Treatment: Focus on Symptoms and Exacerbations
( Claus F. Vogelmeier ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
The two clinical parameters that guide treatment in COPD patients are “symptoms” and “exacerbations”. In patients with symptoms only ㆍ many patients on mono-bronchodilator treatment are still symptomatic ㆍEMAX was the first major prospective study testing the efficacy of LAMA/LABA versus monotherapies in patients without ICS. EMAX showed consistent and sustained benefit of LAMA/LABA over monotherapies In patients with symptoms + exacerbations ㆍ + blood eosinophils >100/μl escalation to LAMA/LABA/ICS may improve symptoms, reduce exacerbations and mortality
The Effect of Displaying Products in Their Usage Context - A Field Experimental Investigation -
Claus, Ebster,Wagner, Udo,Auzinger, Cora Korean Academy of Marketing Science 2007 마케팅과학연구 Vol.17 No.2
The widespread use of self-service concepts in retailing has resulted in increased attention to the design of retail environments and to stimuli operating at the point of sale. One such merchandising technique, the "bundled presentation", i.e., related products are presented in close proximity to each other, is widely used by retailers but has rarely been investigated by academic consumer researchers. This study presents the results of a field experiment into the effects of presenting products in their usage context. Customers' attitudes towards the same product displayed in different ways are compared with each other. The results show that related products, i.e., products that are used together, should be presented in a coordinated display. Furthermore, the bundled presentation enhanced consumers' attitudes of the product when they saw it first in a bundled presentation and then evaluated it in front of a traditional presentation.