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Microwave Assisted One-pot Synthesis of Novel α-Aminophosphonates and heir Biological Activity
Rao, Alahari Janardhan,Rao, Pasupuleti Visweswara,Rao, Valsani Koteswara,Mohan, Challamchalla,Raju, Chamarthi Naga,Reddy, Cirandur Suresh Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.7
A simple and efficient synthesis of various $\alpha$-aminophosphonates (3a-l) by the reaction of substituted aromatic/heterocyclic aldehydes, 2-amino-6-methoxy-benzothiazole and dibutyl/diphenyl phosphites under microwave irradiation without catalyst was accomplished. The phosphonates were characterized by elemental analysis, IR, $^1H$, $^{13}C$- and $^{31}PNMR$ spectra. They showed promising antimicrobial, anti-oxidant activities depending on the nature of bioactive groups at the $\alpha$-carbon.
Microwave Assisted One-pot Synthesis of Novel α-Aminophosphonates and Their Biological Activity
Alahari Janardhan Rao,Pasupuleti Visweswara Rao,Valsani Koteswara Rao,Challamchalla Mohan,Chamarthi Naga Raju,Cirandur Suresh Reddy 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.7
A simple and efficient synthesis of various α-aminophosphonates (3a-l) by the reaction of substituted aromatic/heterocyclic aldehydes, 2-amino-6-methoxy-benzothiazole and dibutyl/diphenyl phosphites under microwave irradiation without catalyst was accomplished. The phosphonates were characterized by elemental analysis, IR, 1H, 13C- and 31PNMR spectra. They showed promising antimicrobial, anti-oxidant activities depending on the nature of bioactive groups at the α-carbon.