Cisplatin에 의해 유발된 급성신부전에 단삼추출액이 미치는 영향

김충희,박희성,정장용 진주산업대학교 농업기술연구소 2005 農業技術硏究所報 Vol.18 No.-

한의학에서 강장약, 통경약, 진통약, 항염약, 지혈약으로 월경불순, 복통, 폐경, 산후통 등에 효과가 있다고 알려진 단삼(Salvia mulitorrhiza Bunge)이 cisplatin에 의해 유발된 신장의 세포손상에 대하여 항산화작용과 신장의 기능에 미치는 영향에 대하여 조사한 결과 다음과 같은 결과를 얻었다. 1. 단삼 추출액이 cisplatin에 의하여 유발된 신피질 절편의 독성효과에 대한 효과를 알아 보기위한 실험으로 300mM cisplatin에 노출시켰을 때 단삼 추출액 0.05%, 0.1%를 함께 첨가한 군이 LDH 유출 및 지질과산화를 유의성 있게 감소시켰다. 2. 단삼 추출액 0.3g/kg을 7일간 전처리 한 다음 cisplatin 5㎎/kg을 복강투여한 후 24시간 뒤에 혈액을 채취하여 혈청 BUN과 creatinine 농도를 측정한 결과, 단삼 추출액을 전처리 한 군에서 cisplatin 단독처리한 군보다 신장의 BUN 및 creatinine 제거율이 유의성 있게 높게 나타났다. 이상의 결과로 볼 때 단삼 추출액은 cisplatin에 의하여 유발된 신장의 독성효과에 대하여 항산화작용과 세포보호 작용을 나타내며, 신장의 기능에도 영향을 미쳐 BUN과 creatinine 제거율도 높게 나타내었다. 따라서 단삼이 신장의 세포손상이나 질환이 있을 경우 보호효과를 나타낼 것으로 생각되며, 이러한 계기로 단삼을 대량 재배하여 신장보호를 위한 기능성 식품을 개발할 수 있다면 신장기능부전환자나 단삼재배 농가에 큰 도움을 줄 수 있으리라 생각한다. Salvia mulitorrhiza Bunge is known to be effective on healthiness drug, pain-killing drug, anti-inflammation, hemostatic agent, irregular menstruaction, abdominal pain, menopause, after parturition pain activity in oriental medicine. In addition of the effects, I further investigated the effect Salvia mulitorrhiza Bunge extract(SMBE) on the antioxidant effect on a renal cortical slices cell and kidney protecting effects. The results were as follows. 1. When renal cortical slices separated from a rabbit's kidney were treated with oxidant 300μM cisplatin in the presence of 0.05% or 0.1% SMBE at 37℃ for 60min. Cisplatin caused an increase a LDH release and lipid peroxidation. Cisplatin also induced a increase in LDH release and lipid peroxidation. SMBE significant prevented cisplatin-induced increase in LDH release and lipid peroxidation. 2. Pretreatment with 0.3g/kg SMBE for seven day and treatment with 5mg/kg cisplatin by the intraperitoneal injection. After 24hours, BUN and creatinine in serum were measured. The results were that the pretreatment group with SMBE showed a significant clearance rate of BUN and creatinine in the kidney than the administering single agent group of cisplatin. These results indicate that lipid peroxidation plays a critical in cisplatin-induced acute renal failure. SMBE exerts the protective effect against acute renal failure induced by cisplain, and its effect may be attributed to an antioxidant action. Furthermore I suggest the development of functional food with SMBE for the kidney tissue damage or renal incompletion in human.

관상동맥질환자에서 경흉부 도플러 심초음파를 이용한 좌심실 확장기 기능의 평가 : 좌심실 확장기 장애 형태에 따른 분류

전희경,윤호중,유기동,박지원,전두수,정욱성,채장성,김재형,최규보,홍순조 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.1

적응적 방법에 의한 하이퍼큐브 네트워크 결함 진단 알고리즘

최혜연,김선신,강성수,최길호,이충세 충북대학교 컴퓨터정보통신 연구소 2003 컴퓨터정보통신연구 Vol.11 No.2

시스템 레벨의 대부분의 진단 알고리즘은 PMC 모델을 바탕으로 결함의 개수가 t개를 초과하지 않는다는 t-진단가능 시스템의 특성을 이용하여 결함을 진단한다. 그러나, 다중처리 시스템 상에서 큰 규모의 결함 집합을 고려할 때에 여러 가지 제약이 따른다. 또한 병렬처리 시스템의 규모가 커짐에 따라 시스템 내에서 발생되는 결함의 빈도가 높아지게 된다. 진단 알고리즘에서 가정하는 결함의 개수 t는 병렬처리 시스템 안에 있는 노드의 수에 비해 상당히 작은 개수이며, 결함의 개수가 t개를 초과할 경우의 연구는 거의 이루어지지 않았다. Somani와 Peleg은 k개의 부정확한 진단을 용인함으로써 결함의 개수가 t개를 초과할 경우에도 시스템을 진단하는 t/k-dignosable 시스템을 제안하였다. 이 논문에서는 Somani 등이 제안한 것처럼 k=1개의 부정확한 진단을 용인하는 경우에 하이퍼큐브를 진단하는 알고리즘을 제안한다. 이 논문에서 제안한 알고리즘은 더 많은 결함을 진단하면서도 기존의 알고리즘보다 효율이 거의 떨어지지 않는다는 사실을 분석을 통하여 확인할 수 있었다. System level diagnosis algorithms are based on the PMC model and use the properties of t-diagnosable system where the maximum number of the faults does not exceed t. Diagnostic algorithms have limit when dealing with large fault sets in multiprocessor systems. Somani and Peleg proposed t/k-diagnosable system to system diagnose by allowing upper bounded few number of units to be diagnosed incorrectly, which can diagnosis more faults than t-diagnosable system. In this paper, we propose hypercube diagnosis algorithm using t/k-diagnosable system. When the number of faults exceeds t, we allow a fault(k=1) to be diagnosed incorrectly, Based on this idea, we find that the performance of the proposed algorithm is nearly as efficient as any previously known strategies and detect more faults.

C-Scan 장치를 이용한 초음파 탐상에 관한 연구(Ⅰ)

玄淸男,韓熙悳 홍익대학교 산업기술연구소 2003 産業技術 Vol.13 No.-

In this study, the flaws in the several test specimens are detected by using a C-Scan system. The following results are obtained through this research; 1. How to detect the flows in the specimens 2. How to determine the depth of the flaws in the specimens 3. How to determine the size of the flaws in the specimens 4. How to determine if the specimen is in one piece or not and how to detect defects at the joining part 5. Analysis by using Linear Profile and 3D View In order to determine the depth and size of the flaws in the specimens precisely, it is very important to operate the C-Scan system properly.

우리나라 청정지역에서 측정한 PM_(2.5) 입자의 특성

이종훈,김용표,문길주,김희강,정용승,이종범 江原大學校 附設 環境硏究所 1998 環境硏究 Vol.15 No.-

Atmospheric fine particles (PM_(2.5)) were collected at the background sites, Kangwha, Taean, and Kosan and characterized to understand their behaviors at the sites. Daily samples of PM_(2.5) mass were measured and ionic species, carbonaceous species, and gaseous species were analyzed. Four-daγ backward trajectory analysis was also carried out. The mean concentrations of anthropogenic species were highest at Kangwha among three sites, while contributions from sea salts were highest at Taean during the measurement period due to higher wind speed at Taean. Major chemical components in fine particles were sulfates organic carbon, nitrate, and ammonium. Most of the non-sea-salt (nss) sulfates in PM_(2.5) might be present as ammonium sulfates at these sites. Most air parcels arriving at Kangwha and Taean were from northern China. Therefore, both sites were thought to be affected by the same air parcel. At Kosan, during the measurement period, air parcels were from either northern China or southern China. The nss sulfate concentration in the air parcels from southern China was higher, while the nss calcium nitrate, and ammonium concentrations were higher when the air parcels were from northern China.

接木한 배나무의 樹齡에 따르는 燐酸의 消長에 대한 硏究

金晙敎,元世鎬,安鶴洙,鄭熙敦 건국대학교 1968 學術誌 Vol.9 No.1

It is very essential problem that the study on the translocation of nutritious substances between the scion and the stock when the seedlings were grafted. So the present experiments was carried out to investigate the behavior of phosphorous in the leaves, stems, new shoots and roots of scion and stock for the different age of tree after the pear-tree was grafted. For the study the seedlings were raised in the green-house of Agr. and Indus. college of Kon-kuk University. The results obtained from this work may be summarized as follows. ① The Phosphosrous contents in leaves, 2 to 3 year grafted-pear was slightly increased as compare with the same year-old stock. ② The phosphorous contents in the new shoots, one year grafted-pear was markedly decreased as compare with the same year-old stock. However 2 year-old galled-pear was gently increased. ③ The phosphorous contents in the stem and roots, there is no different between the grafted-pear (scion) and stock without relation to the age of tree.

심인성 색전 요인이 없는 뇌경색 환자에서 경식도 심초음파와 Acoustic Quantification을 이용한 대동맥 탄성의 평가

이종민,윤호중,임효영,박지원,김휘열,전희경,문건웅,정욱성,채장성,김재형,최규보,홍순조 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

심첨부 비후 심근증에서 심근 내 미세 관상동맥의 혈류 예비력 평가 : 경흉부 도플러 심초음파를 이용한 연구 Study Using Transthoracic Doppler Echocardiography

윤호중,박철수,신재원,임상현,조은주,정해억,전희경,오용석,정욱성,김재형,최규보,홍순조 대한순환기학회 2004 Korean Circulation Journal Vol.34 No.3

A GOLDEN DECADE OF GAMMA-RAY PULSAR ASTRONOMY

Chung-Yue Hui 한국천문학회 2018 Journal of The Korean Astronomical Society Vol.51 No.6

To celebrate the tenth anniversary since the launch of {\it Fermi} Gamma-ray Space Telescope, we take a retrospect to a series of breakthroughs {\it Fermi} has contributed to pulsar astronomy in the last decade. Apart from significantly enlarging the population of $\gamma-$ray pulsars, observations with the Large Area Telescope onboard {\it Fermi} also show the population is not homogeneous. Instead, many classes and sub-classes have been revealed. In this paper, we will review the properties of different types of $\gamma-$ray pulsars, including radio-quiet $\gamma-$ray pulsars, millisecond pulsars, $\gamma-$ray binaries. Also, we will discuss the prospects of pulsar astronomy in the high energy regime.

Fission yeast-based screening to identify putative HDAC inhibitors using a telomeric reporter strain.

Chung, Kyung-Sook,Ahn, Jiwon,Choi, Chung-Hae,Yim, Nam Hui,Kang, Chang-Mo,Kim, Chun-Ho,Lee, Kyeong,Park, Hee-Moon,Song, Kyung-Bin,Won, Misun Korean Society for Molecular Biology 2008 Molecules and cells Vol.26 No.1

<P>Transcriptional silencing is regulated by promoter methylation and histone modifications such as methylation and acetylation. We constructed a Schizosaccaromyces pombe reporter strain, KCT120a, to identify modifiers of transcriptional silencing, by inserting the ura4(+) gene into a heterochromatic telomere region. Two compounds inhibited the activity of histone deacetylases, induced acetylation of histone H3 and caused apoptotic cell death in HeLa cells. Expression of gelsolin and p21(waf1/cip1) also increased, as it does in response to HDAC inhibitors such as TSA. Therefore, these compounds appear to be potent inhibitors of HDACs, and hence potential anti-cancer drugs. Our observations suggest that a yeast cell-based assay system for transcriptional silencing may be useful for identifying histone deacetylase inhibitors and other agents affecting chromatin remodeling.</P>