알코올 의존과 후보 유전자들간의 연관성 연구

정인원,김헌,홍주봉,지경환,이규영 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.6

연구목적 : 알코올 대사와 중추신경계내의 알코올 작용부위와 관련한 일부 후보유전자들이 알코올 의존과 관련이 있는지를 확인하고자 하였다. 방 법 : DSM-IV로 진단된 알코올 의존 환자 128명과 정상 대조군 128명을 대상으로 후보 유전자들의 다형성을 중합효소 연쇄반응과 제한효소처리법을 이용하여 동정하였다. 여기서 분리된 대립유전자와 유전자형에 따른 빈도의 차이를 유전자별로 각각 비교하였으며, 알코올 의존에 작용하는 서로 다른 유전자들에 의한 영향력을 배제하기 위하여 logistic regression 분석을 적용하였다. 결 과 : 알코올 의존군에서는 ALDH_2 유전자의 NN(wild type)형이 정상대조군에 비하여 유의하게 많았다(chi-square test, p<0.001). logistic regression analysis를 통하여 다른 유전자들에 의한 영향을 보정한 상태에서 ALDH_2가 NN(wild type)인 경우 다른 아형에 비하여 알코올 의존에 대한 odds ratio는 130.312이며 그 신뢰구간은 (17.22, 986.43)이었다. 한편, ASA는 N-glycosylation 부위에 변이형 대립유전자를 갖고 있는 경우(AG or GG)는 wild type에 비하여 알코올 의존에 대한 위험도는 2.344배이며 그 95% 신뢰구간은 (1.128, 4.871)이었다. 결 론 : 알코올 의존과 ALDH_2 유전자간에는 밀접한 연관성이 확인되었다. 또한 다른 유전자들은 개별 연관분석에서 의미있는 연관성이 관찰되지는 않았지만 logistic regression analysis를 통하여 N-glycosylation 부위에 다형성이 있는 ASA 유전자가 알코올 의존과 관련이 있음을 시사하였다. Objectives : This study was to explore the association between alcohol dependence and five candidate genes related to the metabolism of alcohol and the enzymes of the suspected sites in CNS. Methods : The genotype and allele frequencies of five candidate genes in 128 male hospitalized patients who met DSM-IV criteria for alcohol dependence were compared with 128 age-matched healthy male control subjects using polymerase chain reaction and restriction fragment length polymorphism. A logistic regression analysis was applied in order to exclude the reciprocal interactions among five candidate genes. Results : The NN genotype frequency of the ALDH_2 gene was significantly higher in alcoholic patients than in control subjects(chi-square test, p<0.001). No difference in frequency was found in the other four genes. In a logistic regression analysis, the odds ratio for alcohol dependence in the NN genotype of the ALDH_2 gene and AG or GG genotypes of the N glycosylation site on the ASA gene were 130.312(95% confidence interval, 17.22-986.43) and 2.344(95% confidence interval. 1.128-4.871), respectively. Conclusion : The result reiterates the association of the ALDH_2 gene polyporphism and the alcohol dependence. Logistic regression analysis additionally suggested that the N-glycosylation site on the ASA gene was associated with alcohol dependence.

眞理的堅持

汪中文(Chung- wen Wang),沈美綺(Mei-chi Shen) 대구대학교 인문과학연구소 2012 人文科學硏究 Vol.38 No.-

Yin-ke Chen, from Yi-ning, Jiang-shi in China, was not only a history specialist but also a knowledgeable master in Chinese Classics. His statements on the memorial of Guan-tang Wang from Ching-hua University says, ”The study principle for a learned person is to glorify truth by freeing the mind from the control of the secularity. I’d rather die without the freedom of thought.” It is clear to see from his life that he was a typical figure, with the thoughts of freedom, who faced spiritual and physical frustration when there was a political reformation in China. However, the political constraint could never change his strong mind toward the insistence on free will and independent spirit. A huge number of his poems express his persistent spirit on culture. To explore this spirit, his poems are provided in this study

Prevalence of Musculoskeletal Symptoms in Taiwan's Traditional Industries

Yu, Chi-Yuang,Hsu, Yau-Wen,Chung, Yi-Chan,Tsai, Chih-Hung The Korean Society for Quality Management 2004 The Asian Journal on Quality Vol.5 No.2

The purpose of this study was to analyze the prevalence of self-reported musculoskeletal symptoms among the three Taiwan's traditional industries as lathe, electronics and food by the Nordic Musculoskeletal Questionnaire (NMQ). Moreover, the study was also to make a comparison among the aforesaid industries for revealing their differences. The result of the questionnaire indicated that the symptoms appeared on the three industries were all originated from four parts as neck, shoulders, elbows, and wrists/hands. More than 68% of the interviewers thought that their symptoms might be related to their work. However, the rate of harmful influence resulted from life or job was over 50%. As to the respect of the interviewers' attitude in treating their symptoms, more than 80% of them neglected or just treated the symptoms by massaging or cold/hot compressing and resting. From the questionnaire, the proportion of symptoms discussed in each item indicated that the distribution, in perceiving symptom, of interviewers were not quite identical; however the Chi-square test discovered majority did not reach 0.05 levels, hence the difference among industries were not significant.

악하선 암의 치료성적과 예후인자

임치영(Chi Young Lim),남기현(Kee Hyun Nam),이잔디(Jan Dee Lee),장항석(Hang Seok Chang),정웅윤(Woong Youn Chung),차인호(In Ho Cha),이창걸(Chang Geol Lee),최은창(Eun Chan Choi),박정수(Cheong Soo Park) 대한두경부종양학회 2005 대한두경부 종양학회지 Vol.21 No.2

Purpose: Submandibular gland tumor is rare, less than 6% of head and neck tumor. The purpose of this article is to analysis the clinical experience and treatment outcomes of malignant submandibular gland tumor, suggesting a guideline of management. Methods: We retrospectively evaluated 26 patients who underwent operation for malignant submandibular gland tumor at Severence hospital between 1986 and 2004. Statistical analysis was performed by Kaplan-Meier method, log rank test, Chi-square test, Fisher's exact test using SPSS v12.0 for Windows. Results: They consisted of 18 males and 8 females whose median age was 47 years(range: 20-71). 10 cases of adenocystic carcinoma, 8 cases of carcinoma ex pleomorphic adenoma, 4 cases of mucoepidermoid carcinoma, 1 case each for acinic cell carcinoma, undifferentiated carcinoma, adeno carcinoma, epithelioid hemangioendothelioma. Sialoadenectomy only was performed in 10 cases(36.5%) and sialoadenectomy with neck node dissection was performed in 16 cases(63.5%). Adjuvant radiotherapy was done in 22 cases(84.6%). 10 year disease free survival rate for malignant submandibular gland tumor was 63.1 % and 10 year overall survival rate for malignant submandibular gland tumor was 70.1%. In univariate analysis, prognostic factors affecting recurrence of malignant submandibular gland tumor was initially papable lateral neck node in physical examination and metastasis of lateral neck node in pathologic confirmation. The prognostic factors affecting survival of malignant submandibular gland tumor was tumor size, TNM stage, recurrence and type of recurrence. Conclusion: In this study, prognostic factors affecting recurrence of malignant submandibular gland tumor was initially papable lateral neck node in physical examination and metastasis of lateral neck node in pathologic confirmation. The prognostic factors affecting survival of malignant submandibular gland tumor was tumor size, TNM stage, recurrence and type of recurrence. To prevent recurrence and to improve survival, early diagnosis and aggressive surgery must be considered.

일 도시 여고생의 음주관련 요인에 관한 연구

김주형,김은경,김효정,문현숙,오선민,박나경,신혜정,이경원,이지선,최연옥,최진희,한유정,현수인 대한간호학회정신간호학회 2002 정신간호학회지 Vol.11 No.1

This study was designed to examine the factors associated with alcohol consumption among the Korean high schools girls. 283 female students were sampled from two high school in Seoul, Korea. They were given questionnaires and were asked to fill in and return them during a class hours. The factors included in the questionnaire were analyzed to see their contributions to alcohol consumption using chi-square. Alcohol consumption was associated with lower school performance(p=.001). High alcohol expectancies increased alcohol consumption(p=.000); however, depression did not show a statistically significant relationship to alcohol consumption. Mothers' alcohol consumption, having many alcohol consuming friends and watching TV commercials picturing alcohol were found to be associated with alcohol consumption, p=.049, .000, .000. respectively. Results may imply that alcohol consumption may not be a coping behavior of the depressed high school girls. Parents in Korea should be more concerned about alcohol consumption and its impacts on their daughters. Media effects on alcohol consumption need to be stressed and deserve attention from the public.

야관문(Lespedezea cuneata G. Don) 추출물이 토끼 음경해면체 평활근에 미치는 생리활성

정영호,임치환 충남대학교 농업과학연구소 2005 농업과학연구 Vol.32 No.1

The extracts in n-hexane layer from Lespedezea cuneata G. Don exelled at sexual activity according to in vitro experiment using biopsy of rabbit corpus cavernosum to investigate effects on sexual function. The extracts were injected into 9 samples at 10㎕. The lowest relaxation was showed at sample C, 4.8±1.4% and the highest relaxation was showed at sample A, 20.2±6.0%. The relaxation by every sample, except sample C and G-1, were higher than by 10^(-7)M ACh, 7.8±5.1%, and their effects were above 10%. Also, the extracts were injected into 9 samples at 15㎕. The lowest relaxation was showed at sample C, 15.4±1.3% and the highest relaxation was showed at sample J, 54.8±9.7%. The relaxationby sample A and D was as much as by 10^(-6)M ACh, 28.0±20.1%. The relaxation by sample H was 41.9±7.3%. The relaxation by sample J was 54.8±9.7% and it was higher than by 10^(-5)M ACh, 53.9±25.9%. Also, the extracts were injected into 9 samples at 20㎕. The lowest relaxation was showed at sample E, 28.9±0.6% and it was a little higher than by 10^(-6)M ACh. The relaxation by sample G was as much as by 10^(-5)M ACh. The two higher relaxation were showed at sample H, 99.4±16.0% and J, 95.7±7.2%, and their relaxation against contraction reaction by PhE were near 100%. Experiment by sample I was not performed for lack of sample amount.

總記와 主題에 關한 小考

鄭致薰 中央大學校 人文科學硏究所 1984 人文學硏究 Vol.11 No.-

피틴산(Phytic acid)이 비브리오(Vibrio vulnificus) 패혈증에 미치는 영향

정영호,조천휘,이선우,임치환 충남대학교 농업과학연구소 2005 농업과학연구 Vol.32 No.1

Phytic acid chelates excellently the metallic ions and the positive ions, especially has high affinity with Fe^(2+) and Ca^(2+). Merits of phytic acid can be taked in easily, edibile and harmless to body, so it was investigated that phytic acid can be substituted for EDTA in this study. 1. The Intensificative effect of chelating agent and disinfective osmotic shock of Vibrio vulnificus The number of initial existent fungi measured 1.7x10^(6). The percentages of the survival fungi against the osmotic shock by distillated water were calculated at 1 minute, 3 minute and 5 minute after inoculation. The percentages of the survival fungi in Mg^(2+) were 92.5%, 91.8% and 79.8% at each time, the average percentage was 88%. Also the sudden extinction was observed around 1 minute after inoculation and the survival fungi were not observed from 3 through 5 minute in spite of repeated experimentation. 2. Influence of Vibrio vulnificus on the survival of the mice. The first mouse started to die in 180 minute after inoculation in case that the inoculating number was 2.3x10^(7) cfu/ml. All died within 4.5 hour. The average of survival time was 226 minute. The first mouse started to die in 228 minute after inoculation in case that the inoculating number was 0.8x10^(6) cfu/ml. All died within 5 hour. The average of survival time was 300 minute and the survival time was 1.3 times high. The tendencies of death in two cases were similar, but the fatal rate were largely dependent on inoculating number.

형식 논리계의 0-1 법칙과 콜모고로프 복잡도

정치봉 순천향대학교 기초과학연구소 1997 순천향자연과학연구 논문집 Vol.3 No.2

본 논문에서는 재귀논리의 유한 구조에 대한 0-1 확률 법칙을 콜모고로프의 복잡도와 관련하여 보였다. 콜모고로프 복잡도 이론은 논리의 유한 구조에 대한 여러 성질을 밝히는데 유용하게 쓰일 수 있는 가능성을 제시하였다. 뿐만아니라 MAXSNP 문제, 재귀 술어의 정의가능 기준과 0-1 법칙의 수렴속도를 논하였다.

방향그래프에서 평균 이득 게임

정치봉 순천향대학교 기초과학연구소 1997 순천향자연과학연구 논문집 Vol.3 No.1

본 논문은 방향그래프에서 평균 이득 게임을 소개하였다. 게임의 최적해로서 결정론적인 최적 위치 전략이 두 경기자에게 존재함을 제시하였고 게임의 값을 구하는 알고리즘을 제시하였다. 또한 평균 이득 게임과 밀접하게 관련된 할인 매개 상수를 가진 할인 이득 게임을 소개하였다. 이들 부류의 게임의 일반화된 모형인 단순 확률 과정 게임을 소개하고, 이 게임의 해의 값은 계산적으로 NP와 coNP 문제임을 소개하였다.