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이성근,정득룡,장연주,전윤식,정상혁 대한치과교정학회 발행 2005 대한치과교정학회지 Vol.35 No.6
측모두부방사선사진의 중첩만으로는 교합평면상의 치아이동을 알 수 없으며, occlusogram 역시 촬영 및 중첩의 오류를 피할 수 없다. 본 연구는 석고모형의 3차원 영상을 촬영한 후 3차원 영상 소프트웨어를 이용하여 중첩된 영상을 통해 상악 소구치 발치공간 폐쇄 후 상악 구치부 회전양상을 알아보고자 하였다. 성인여성 19명을 연구대상으로 하여 치료 전 석고모형 및 치료 완료후 석고모형의 3차원 영상을 촬영한 후, 상악 경구개면을 기준으로 두 영상을 중첩한 다음, 치료 전후의 상악 구치부의 회전양상을 비교 분석하였다. 연구결과, 구치부의 회전 양상은 매우 다양하였다. 그 주요 원인은 치료 전 상악 구치의 다양한 회전 상태와 치열궁 및 치아의 형태학적인 특성 때문인 것으로 추측되었다. 따라서 발치공간 폐쇄 시 일어나는 구치의 회전 양상을 3차원 영상을 이용하여 정확히 평가하기 위해서는 치료 전후에 일어나는 구치의 회전을 초기 배열 전후의 구치 회전, 발치공간 폐쇄 전후의 구치 회전, 그리고 마무리 단계 전후의 구치 회전으로 세분하여 평가해야 함을 알 수 있었다. Cephalometric superimposition is unable to evaluate tooth movement along the occlusal plane and the errors of photographing and superimposition of the occlusogram is also inevitable. The purpose of the present study was to evaluate the rotational movements of the maxillary posterior teeth following space closure after extraction of maxillary first premolars, using 3D dental images. In 19 adult females, analysis of rotational movements of the maxillary posterior teeth was performed between the initial and final 3D dental images superimposed on the maxillary hard palate. The results showed a diversity of rotational movements of posterior teeth. The causes of various rotational movements may be different rotation of molars in each case at the beginning of treatment. individual characters of the dental arch and tooth morphology. The results of the study indicate that accurate evaluation of retational movements of posterior teeth following space closure after extraction of premolars using 3D dental images can be obtained through the subdivision of tooth movement during the initial aligning, space closure and finishing stages.
Yen-Chun Peng,Soo-Ray Wang,Yi-Fang Lai,Nu-Man Tsai,Keh-Liang Lin,Shyh-Jye Lin,Tzi-Peng Yang 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.2
Isoamylamine (IA) is an aliphatic monoamine molecule present in cheese, eggs, and wine. It belongs to the family of polyamines and also can be synthesized endogenously. It has been known that regulation of polyamines in cells is related to cell cycle and tumor formation. Malignant melanoma is difficult to treat and easily resistant to chemotherapy/radiotherapy through autophagy. In this study, we aim to clarify whether IA has a growth control effect on melanoma tumor cells and the regulatory mechanism. We treated B16-F1 melanoma cells with IA at concentrations of 0, 200, 400, and 600 ppm for 24 h. The 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay was checked for cell viability and results showed that IA has an inhibitory effect on B16-F1 melanoma cells. The signaling molecules, which included Raf/MEK/ERK, were activated, while MSK1 and protein kinase B (AKT) were suppressed. Autophagy was also confirmed to be induced by IA. The acridine orange stain-positive cells were increased and BECN-1/LC3 upregulated. The data also showed that the autophagy regulatory molecule, 5′-adenosine monophosphate-activated protein kinase (AMPK), was induced after IA treatment, so we used dorsomorphin to inhibit AMPK and found that it could suppress autophagy. In conclusion, IA has an effect of inducing autophagy in B16-F1 cells and it is regulated through AMPK.
Non-holistic Meaning Anatomism and the No-Principled-Basis Consideration
Chun-Ping Yen 서울대학교 철학사상연구소 2017 철학사상 Vol.S No.-
Jerry Fodor and Ernest Lepore (1999/2002) frame the debate over meaning holism in terms of a distinction between meaning atomism and meaning anatomism. The former holds that the meaning of an expression E is determined by some relation between E and some extra-linguistic entity. The latter holds that the meaning of E is at least partly determined by some of E’s “inward” relations (IRs) with other expressions in the very language. They (1992) argue that meaning anatomism inevitably collapses into meaning holism, which is the view that the meaning of E is determined by E’s IRs with every other expression in the very language because there is no principled distinction for the anatomist to divide the meaning-determining IRs from the non-meaning-determining ones. In response, the non-holistic anatomist urges that Fodor and Lepore’s no-principled-basis consideration is groundless because the lack of a generally accepted criterion for such a distinction does not undermine the viability of the distinction itself. While this point is well taken, I think that Fodor and Lepore are onto an important question here. That is, what does it make non-holistic anatomism distinctive from its holistic counterpart if without a principled basis for the distinction among IRs? I look into this question and give an alternative argument from Fodor and Lepore’s to suggest that non-holistic anatomism cannot bypass the no-principled-basis consideration. The non-holistic anatomist will need a principled distinction in kind between IRs to back her point.
Yen-Chun Chen,Yan-Rou Cai,Ming-Yang Cheng,Ke-Han Su 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.24 No.3
The main idea behind the conventional extended state observer is that the total disturbance including nonlinearity, modeling error, and external disturbance, etc., is regarded as an augmented state variable which can be estimated using system input/output, system parameters and a nonlinear function. In order to further improve estimation accuracy, this paper proposes an adaptive PI-type sliding mode nonlinear extended state observer (APISMESO). In particular, a nonlinear function that contains an integral term is used in the proposed observer structure to reduce estimation error, especially when dealing with static friction and high-frequency noise often existing in servomechanisms. Moreover, an adaptive law is designed to provide on-line estimation of system parameters. In addition, the stability of the complementary sliding mode control scheme with the proposed APISMESO is investigated using the Lyapunov stability theory. Several contour following experiments are performed to compare the performance of the proposed APISMESO with that of several existing variants of extended state observers. Experimental results reveal that the proposed APISMESO outperforms the other variants of extended state observers also tested in the experiment.