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李政遠,趙忠植,金哲中 대전대학교 한방병원 2000 惠和醫學 Vol.9 No.1
According to the comparative study on the IgA nephropathy and hematuria, the results were as follows. 1. IgA nephropathy seems to be caused by deposits of IgA antibodies in the kidney mesangial tissues. 2. The symptoms of IgA nephropathy are repetitive hematuria, secondarily asthenia, slight fever, the urination pain and the flank pain etc. 3. Steroids have a few effect on the incipient stage of IgA nephropathy, but the specific medicine isn't in existence at present. 4. In oriental medicine, hematuria defines the urine including blood or blood clot without pain in urination. 7. The causes of hematuria are cases of heat and asthenia of kidney(腎虛). 8. For the medical prescriptions are used Paljungsan(八正散), Dojo˘ksan(導赤散), Yo˘ngyopaedoksan(連翹敗毒散), Singihwan(腎氣丸), sogyeeumja(小계飮子), Daebuncho˘ngeum(大分淸飮), Dangguieum(當歸飮), Cho˘ngjangtang(淸腸湯), Silyungtang(柴영湯), Kamisagunjatang(加味四君子湯), Jwaguieum(左歸飮)
酸棗仁이 CT105에 의한 신경세포 상해 및 白鼠의 기억에 미치는 영향
정정욱,박창국,박치상,이소연,윤현덕,신오철 대한본초학회 2005 大韓本草學會誌 Vol.20 No.1
Objective: This study was designed to research whether demonstrate neuroprotective and memory enhancing effects of Z1BU, suggesting its beneficial actions for the treatment of AD. Methods: The present study investigated effects of the dichloromethane extract of Semen Zizyphi Spinosae(ZIBU) on neurotoxicity and reactive oxygen species(ROS) and nitric oxide(NO) formation in PC 12 cell line overexpressed with carboxyl-terminal 105 amino acid peptide fragment of amyloid precursor protein(CT105). In addition, the present study evaluated its radical scavenging activity and effects on acetylcholinesterase(AChE) activity. Furthermore, effects on neuronal loss in CAl area and cognitive deficits induced by scopolamine treatment were also evaluated in rats. Result: we found in this study that ZIBU significantly inhibited apoptotic neuronal death induced by CT105 overexpression in PC12 cells, with the IC_(50) value of 23 ㎍/ml. Based on phase-contrast and fluorescence microscopic examinations, ZIBU reversed morphological changes of CT105-expressed PC-12 cells. It was also found that Z1BU significantly induced neurite outgrowth and inhibited formation of ROS and NO.Z1BU scavenged DPPH radicals and inhibited AChE activity. Furthermore, it attenuated memory impairment induced by the injection of scopolamine in rats, based on passive avoidance test. Crystal violet staining of rat brain slices exhibited increase in the viability of pyramidal neurons in hippocampal CAI area. Conclusion: these results demonstrate neuroprotective and memory enhancing effects of ZIBU, suggesting its beneficial actions for the treatment of AD.
Rapid, large-scale generation of Ds transposant lines and analysis of the Ds insertion sites in rice
Kim, Chul-Min,Piao, Hai-Long,Park, Soon-Ju,Chon, Nam-Soo,Je, Byoung-Il,Bingyao Sun,Park, Sung-Han,Park, Jin-Young,Lee, Eun-Jin,Kim, Min-Jung,Chung, Woo-Sik,Lee, Kon-Ho,Lee, Young-Suk,Lee, Jeung-Joo,Wo Plant molecular biology and biotechnology research 2004 Plant molecular biology and biotechnology research Vol.2004 No.-
Rapid, large-scale generation of a Ds transposant population was achieved using a regeneration procedure involving tissue culture of seed-derived calli carrying Ac and inactive Ds elements. In the F_(2) progeny from genetic crosses between the same Ds and Ac starter lines, most of the crosses produced an independent germinal transposition frequency of 10-20%. Also, many Ds elements underwent immobilization even though Ac was expressed. By comparison, in a callus-derived regenerated population, over 70% of plants carried independent Ds insertions, indicating transposition early in callus formation. In the remaining population, the majority of plants carried only Ac. Most of the new Ds insertions were stably transmitted to a subsequent generation. An exceptionally high proportion of independent transposants in the regenerated population means that selection markers for transposed Ds and continual monitoring if Ac/Ds activities may not necessarily be required. By analyzing 1297 Ds-flanking DNA sequences, a genetic map of 1072 Ds insertion sites was developed. The map showed that Ds elements were transposed onto all of the rice chromosomes, with preference not only near donor sites (36%) but also on certain physically unlinked arms. Poulations from both genetic crossing and tissue culture showed the same distribution patterns of Ds insertion sites. The information of these mapped Ds insertion sites was deposited in GenBank. Among them, 55% of Ds elements were on predicted open-reading frame (ORF) regions. Thus, we propose an optimal strategy for the rapid generation of a large population of Ds transposants in rice.
Park, Chul-Kee,Kim, Jeong Hoon,Nam, Do-Hyun,Kim, Chae-Yong,Chung, Sang-Bong,Kim, Young-Hoon,Seol, Ho Jun,Kim, Tae Min,Choi, Seung Hong,Lee, Se-Hoon,Heo, Dae Seog,Kim, Il Han,Kim, Dong Gyu,Jung, Hee-Wo Oxford University Press 2013 Neuro-oncology Vol.15 No.8
<P><B>Background</B></P><P>To determine the benefit of surgical management in recurrent glioblastoma, we analyzed a series of patients with recurrent glioblastoma who had undergone surgery, and we devised a new scale to predict their survival.</P><P><B>Methods</B></P><P>Clinical data from 55 consecutive patients with recurrent glioblastoma were evaluated after surgical management. Kaplan–Meier survival analysis and Cox proportional hazards regression modeling were used to identify prognostic variables for the development of a predictive scale. After the multivariate analysis, performance status (<I>P</I> = .078) and ependymal involvement (<I>P</I> = .025) were selected for inclusion in the new prognostic scale. The devised scale was validated with a separate set of 96 patients from 3 different institutes.</P><P><B>Results</B></P><P>A 3-tier scale (scoring range, 0–2 points) composed of additive scores for the Karnofsky performance status (KPS) (0 for KPS ≥ 70 and 1 for KPS < 70) and ependymal involvement (0 for no enhancement and 1 for enhancement of the ventricle wall in the magnetic resonance imaging) significantly distinguished groups with good (0 points; median survival, 18.0 months), intermediate (1 point; median survival, 10.0 months), and poor prognoses (2 points; median survival, 4.0 months). The new scale was successfully applied to the validation cohort of patients showing distinct prognosis among the groups (median survivals of 11.0, 9.0, and 4.0 months for the 0-, 1-, and 2-point groups, respectively).</P><P><B>Conclusions</B></P><P>We developed a practical scale to facilitate deciding whether to proceed with surgical management in patients with recurrent glioblastoma. This scale was useful for the diagnosis of prognostic groups and can be used to develop guidelines for patient treatment.</P>
박원우 ( Won Wo Park ),서승철 ( Seung Chul Seo ),이현경 ( Hyun Kyung Lee ),이성순 ( Sung Soon Lee ),이영민 ( Young Min Lee ),이혁표 ( Hyuk Pyo Lee ),김주인 ( Joo In Kim ),최수전 ( Soo Jeon Choi ),염호기 ( Ho Kee Yum ) 대한천식알레르기학회 2006 천식 및 알레르기 Vol.26 No.3
Reactive airway dysfunction syndrome (RADS) is a clinical entity characterized by sudden onset of obstructive airway disorder and nonspecific airway hyperresponsiveness after exposure to a toxic or irritant chemical with negative history of obstructive airway symptoms prior to exposure. After exposure to high concentrations of irritating substances, obstructive symptoms are usually persistent. Causative substances are nonspecific and various. The exact mechanism of this dysfunction remains to be elucidated. We report a case of RADS which presented with dyspnea elicited by smoking insecticide of cockroach containing dichlorvos as a main ingredient. (Korean J Asthma Allergy Clin Immunol 2006;26:246-248)
LEE, JAE-CHUL,TAE, HYUN-JIN,CHO, GEUM-SIL,KIM, IN HYE,AHN, JI HYEON,PARK, JOON HA,CHEN, BAI HUI,CHO, JEONG-HWI,SHIN, BICH NA,CHO, JUN HWI,BAE, EUN JOO,PARK, JINSEU,KIM, YOUNG-MYEONG,CHOI, SOO YOUNG,WO D.A. Spandidos 2015 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.35 No.6
<P>Pyramidal neurons in region I of hippocampus proper (CA1) are particularly vulnerable to excitotoxic processes following transient forebrain ischemia. Kynurenic acid (KYNA) is a small molecule derived from tryptophan when this amino acid is metabolized through the kynurenine pathway. In the present study, we examined the effects of ischemic preconditioning (IPC) on the immunoreactivity and protein levels of KYNA following 5 min of transient forebrain ischemia in gerbils. The animals were randomly assigned to 4 groups (sham-operated group, ischemia-operated group, IPC + sham-operated group and IPC + ischemia-operated group). IPC was induced by subjecting the gerbils to 2 min of ischemia followed by 1 day of recovery. In the ischemia-operated group, we observed a significant loss of pyramidal neurons in the CA1 stratum pyramidale (SP) at 5 days post-ischemia; however, in the IPC + ischemia-operated group, the pyramidal neurons were well protected. KYNA immunoreactivity in the SP of the ischemia-operated group was significantly altered following ischemia-reperfusion and was very low 5 days following ischemia-reperfusion. In the IPC + ischemia-operated group, however, KYNA immunoreactivity was constitutively detected in the SP of the CA1 region after the ischemic insult. We also found that the alteration pattern of the KYNA protein level in the CA1 region following ischemia was generally similar to the immunohistochemical changes observed. In brief, our findings demonstrated that IPC maintained and even increased KYNA immunoreactivity in the SP of the CA1 region following ischemia-reperfusion. The data from the present study thus indicate that the enhancement of KYNA expression by IPC may be necessary for neuronal survival following transient ischemic injury.</P>