일부 공업지역 근로자들의 가정의학에 대한 인식도에 관한 소고

윤방부,강성규,김철수 의학교육출판사 1988 Korean Journal of Family Medicine Vol.4 No.12

민속놀이의 활성화 방안 연구

김부환,정삼현,김순금,신동철 東亞大學校附設스포츠科學硏究所 2003 스포츠科學硏究論文集 Vol.21 No.-

As an effort to revive our folk tradition, I am suggesting that our folk plays, especially those with a competitive nature, be turned into a sporting event which youths can enjoy, and which can be taught in every school. This will enable our students to gain a better understanding of our traditions and come to value and love them. Above all, an organization should be created that will play a central role in implementing this agenda. Second, this organization should lead in turning various folk plays into sporting events. Third, those events should be exciting competitions that will gain peoples attention. Fourth, to promote the spread of folk plays, they should be included in school curricula and trained physical educators should help spread these competitions in the schools. In addition, these events should be actively publicized through the press and other mass media. Lastly, this organization ought to take the lead in seeking assistance from the Office of Education to hold a variety of these sporting events. If these projects are carried out successfully, we will have a future in which folk plays are always with us in everyday life.

치과기공사 국가시험 과목 타당성 연구

김웅철,이원철,손영석,오세윤,김부섭,유진호,김지환 한국보건의료인국가시험원 2005 보건의료교육평가 Vol.2 No.1

This study prepared a basic framework for the development and improvement of Korean Dental Technicians' Licensing Examination, based on actual test questions. A peer review was conducted to ensure relevance to current practices in dental technology. For the statistical analysis, 1000 dental laboratory technicians were selected; specialists in dental laboratory technology (laboratory owners, educators, etc.) were involved in creating valid and reliable questions. Results indicated that examination subjects should be divided into three categories: basic dental laboratory theory, dental laboratory specialties, and a practical examination. To ensure relevance to current practice, there should be less emphasis on basic dental laboratory theory, including health-related laws, and more emphasis on dental laboratory specialties. Introduction to dental anatomy should be separated from oral anatomy and tooth morphology; and fixed prosthodontics should be separated from crown and bridge technology and dental ceramics technology. Removable orthodontic appliance technology should be renamed 'orthodontic laboratory technology'. There should be less questions related to health related law, oral anatomy, dental hygiene, dental materials science and inlay, while the distribution ratio of questions related to tooth morphology should be maintained. There should be a decrease in the distribution ratio of questions related to crown and bridge technology, dental ceramics technology, complete dentures and removable partial dentures technology, and orthodontic laboratory technology. In the practical examination, the current multiple choice test should be replaced with tooth carving using wax or plaster. In dental laboratory specialties, subjects related to contemporary dental laboratory technology should be included in the test items.

Benzothiazolyl Biguanides의 항미생물작용

임철부,이인숙,임채욱 중앙대학교 약학연구소 1996 약학 논총 Vol.10 No.-

The twenty benzothiazolyl biguanides synthesized were evaluated for their antimicrobial activities against Staphylococcus aureus. Bacillus subtilis, Mycobacterium phlei, Escherichia coli, Microsporium canis, Candida albicans, Sporothrix schenkii and Trichophyton mentagrophytes. The results obtained were as follow : The most active compound, 1,6-bis{N^5-(6-chlorobenzothiazol-2-yl)-N^1-biguanido} hexane·2HCI (14) showed the growth inhibitory activity against S. aureus at the concentration of 7.81ug/mL, against B.subtilis at 15.63ug/mL and against M. phlei at 31.25ug/mL. 1,6-Bis {N^5-(6-chlorobenzothiazol-2-yl)-N^1-biguanido} hexane·2HCI(14), 1,6-Bis{N^5-(6-bromobenzothiazol-2-yl)-N^1-biguanido) hexane·2HCI (15) and N-(6-chlorobenzothiazol-2-yl)-1-piperidinylamidinoamidine·HCI (24) inhibited the growth of M. phlei at the concentration of 31.25ug/mL respectively. 1,4-Bis{N^5-(6-methylbenzothiazol-2yl)-N^1-biguanido}butane·2HCI(9) and 1,4-bis{N^5-(6-bromobenzothiazol-2-yl)-N^1-biguanido}butane·2HCI(11) exhibited the antimicrobial activity against B.subtilils at the concentration of 31.25ug/mL. Twelve new biguanide compounds showed growth inhibitory activities against C. albicans at the concentration of 400ug/mL.

Benzothiazolyl Biguanides의 합성

임철부,이인숙,임채욱 중앙대학교 약학연구소 1996 약학 논총 Vol.10 No.-

In order to find new antimicrobial agents, twelve new alkylene bis benzothiazolyl biguanides and eight benzothiazoly biguanides were synthesized. The treatment of alkylenediamines·2HCI with sodium dicyanamide afforded alkylene bis cyanoguanidines. Alkylene bis benzothiazolyl biguanides were synthesized by the reaction of alkylene bis cyanoguanidines with 2-aminobenzothiazole. Benzothiazolyl biguanides were obtained from N-cyanoheterocyclylamidines and 2-aminobenzothiazoles through the similar procedures.

N-치환 Piperazino Ciprofloxacin 誘導體의 合成 및 抗菌作用

任哲夫,韓完植 중앙대학교 약학연구소 1993 약학 논총 Vol.7 No.-

In order to find more potent antimicrobial agents, fourteen new 1-clyclo-propyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-(N-substituted)-1-piperazinyl]-3-quinoline carboxylic acid derivatives(R=methyl, ethyl, n-propyl, isopropyl, n-butyl, t-butyl, phenyl, 2,4-dimethoxy phenyl) and their pivaloyloxymethyl esters were synthesized and evaluated for their antimirobial activities. Treatment of isocynates with 1-cyclopropyl-6-fluoro-1,4-digydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid[Ciprofloxacin]afforded N-substitued carbamoyl piperazino quinoline carboxylic [acids(1)-(8)]. Their pivaloyloxymethyl esters were obtained by the reaction of N-substitued ciprofloxacins with pivaloyloxymethyl chloride in the presence of potassium carbonate and potassium iodide[(9)-(14)]. The synthesized compounds were examined their antimicrobial activities in vitro against Streptococus pyogenes 77 A, Streptococcus faecium MD 8, b, Staphylococcus aureus SG 511, Escherichia coli 1507 E, Pseudomonas aeruginosa 1711 M, Pseudomonas aeruginosa 1592 E, Salmonella typhimurium, Klebsiella oxytoca 1082 E, Klebsiel la aerogenes 1522 E, Enterobacter cloacae 1321 E. 1. The most active compound [12], 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-(N-isopropyl carbamoyl)-1-piperazinyl]-3-quinoline, carboxylic acid pivaloyoxymethyl ester, exhibited the growth inhibitory activity at a concentration of 0.5㎍/ml against St.pyogenes 77 A, 1.0㎍/ml against St.faecium MD 8b, 1.0㎍/ml against Staphylococcus aureus SG 511, 0.06㎍/ml against Escherichia coli 1507 E, 0.25㎍/ml aginst Peudomanas aeruginosa 1711 M, 0.25㎍/ml against Pseudomonas aeruginosa 1592 E, 0.25㎍/ml against Salmonella typhimurium, 0.06㎍/ml against Klebsiella oxytoca 1082 E, 0.06㎍/ml against Klebsiella aerogenes 1522 E, 0.25㎍/ml against Enterobacter cloacae 1321 E. 2. Most synthesized carbamoyl piperazino ciprofloxacins showed more potent antimicrobial activities than those their pivaloyloxymethyl esters.

Thiocarbamyl Norfloxacin 유도체의 합성 및 항균작용

이강수,임철부 중앙대학교 약학연구소 1989 약학 논총 Vol.3 No.-

Eleven new l-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-N-(substituted)-thiocarbamyl-piperazin- yl]-3-quinolinecarboxylic acid derivatives (R- methyl, n-propyl, isopropyl, n-butyl, isobutyl, phenyl, 4-chorophenyl, 4-methylphenyl,4-methylphenyl, 4-ethoxyphenyl, m-naphthyl) and their pivaloyloxyme-thyl esters were synthesized and evaluated for their antimicrobial activities. 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-N-(substiuted)-thiocarbamyl-1-piperazinyl]-3-quino-linecarboxylic acid derivatives were prepared by the reaction of alkyl-and arylisothiocyanates with 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperainyl)-3-quinolinecarboxylic acid (Norfloxa-cin). Treatment of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-N-(substituted)-thiocarbamyl-1-piper-azinyl]-3-quinolinecarboxylic acids with pivaloyloxymethy]chloride afforded eleven 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-N-(substiuted)-thiocarbamyl-1-piperazinyl]-3-quinolinecarboxylic acid pivaloyoxymethyl esters. The synthesized compounds were examined their antimicrobial activities against Escheri-chia coli 6-PE-4, Staphylococcus aureus CHA 79110, Bacillus subtilis 74-51, Klebsiella pneumo-niae. Proteus vulgaris 78615, and Pseudomonas aeruginosa /8765-1P_2, in vitro. The results obtained were as follows; 1. The most active ester compound[23], 1-ethyl-6-fluoro-1-4-dihydro-4-oxo-7-[4-N-(methyl)-thiocarbamyl-1-piperazinyl]-3-quinolinecarboxylic acid pivaloyoxymethyl ester, inhibited the growth of Escherichia coli at the concentration of 3.90㎍/mℓ, Staphylococcus aureus at 7.81㎍/mℓ, Bacillus subtilis at 0.06㎍/mℓ, Klebsiella pneumoniac at 1.95㎍/mℓ, Proteus vul-garis at 15.63㎍/mℓ, and Pseudomonas aeruginosa at 15.63㎍/mℓ, respectively. 2.In general, aliphatic substituted thiocarbamyl norfloxacin pivaloyloxymethyl esters showed more potent antimicrobial activities than those of aromatic substituted thiocarbamyl norflox-acin esters.

입원 남성 및 여성 알코올리즘 환자의 인구학적, 임상적 및 인격적 특성비교

정원후,김성부,장기용,손진욱,박철수 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.4

저자들은 1996년 5월 1일부터 1996년 7월 15일까지 부산·경남·대구 소재의 대형정신병원과 종합병원에 입원해 있는 여성 알코올리즘을 대상으로 하고, 또한 같은 기간에 국립부곡정신병원에 입원한 남성 알코올리즘을 비교군으로 해서 사회인구학적 특성, 음주양상, 음주와 관련된 문제점, 성격 및 정신병리등을 비교하여 남녀 알코올리즘에서의 원인과 임상적 특성에서의 차이점을 알고자해서 본 연구를 하게 되었다. 저자들이 작성한 반구조화된 설문지, MAST(Michigan alcoholism screening test). Zung의 SAS(Self-rating anxiety scale)과 SDS(Self-rating depression scale). MMPI(Minnesota Multiphasic Personality Inventory), SCL-90-R(Symptom checklist-90-revision) 및 EPQ(Eysenck personality questionnaire)등의 검사도구를 이용하였고, 그 결과를 독립표본 t-test(independent-samples t-test)와 χ²-test로 검정하여 다음과 같은 결론을 얻었다. 1) 여성 알코올리즘에서 남성 알코올리즘보다 더 낮은 교육 수준을 보였으며 초등학교수준 이하가 52.4%를 차지하였다. 반면에 남성 알코올리즘에서는 중학교·고등학교 수준이 76.7%였다.(p〈0.01). 2) 여성 알코올리즘에서 형제들 중에서 더 낮은 서열을 보였으며 세째딸이 1/3로 가장 많았고 다음이 외동딸로써 23.8%를 차지하였다. 반면 남성 알코올리즘에서는 장남이 46.7%였다.(p〈0.01). 3) 여성 알코올리즘이 사회경제적 수준에서 더 낮았다(p〈0,01). 4) 여성 알코올리즘의 음주시작동기는 대인관계를 위한 사교목적, 심리적 갈등이나 다른 정신적인 문제, 가족들과의 갈등 등이 비슷하게 많았다. 그러나 남성 알코올리즘에서는 대인관계를 위한 사교목적으로 음주하는 경우가 절대적으로 많았다.(p〈0.05). 5) 처음으로 음주를 시작한 연령은 여성 알코올리즘보다는 남성 알코올리즘에서 유의하게 더 어린 연령에서 시작하였다.(p〈0.001). 6) 1일 평균 음주량은 여성 알코올리즘에서 유의하게 더 적었다.(p〈0.01). 7) 금단증상경험, 알코올성 신체장애 및 음주로 인한 법적 처벌경험도 남성 알코올리즘보다는 여성 알코올리즘에서 유의하게 더 낮았다.(p〈0.05). 8) SCL-90-R에서 PSY척도에서 유의하게 여성 알코올리즘군에서 더 높았고, EPQ에서는 L척도에서 유의하게 여성 알코올리즘이 더 높았다(p〈0.05). 결론적으로 본 연구는 심리적 요인과 사회적 요인이 남녀 알코올리즘간에서 많은 차이가 있는 것을 알 수 있었으며, 여성 알코올리즘의 원인에는 심리적 또는 사회인구학적 요인이 더 밀접하게 연관이 되어 있음을 알 수 있었다. Objective : This study was designed to compare the characteristics of demographic data, clinical features, and personality in male and female alcoholics and to identify the clinically meaningful differences in the etiologies and the clinical features between the two groups. Methods : The study group was composed of 30 males and 21 females who were recruited into the impatient treatment. The researchers used self-reporting questionnaire composed of demographic data and drinking patterns, Michigan alcoholism screening test(MAST), self-rating anxiety scale(SAS) and self-rating depression scale(SDS) of Zung, Minnesota Multiphasic Personality Inventory(MMPI), symptom Checklist-90-revision(SCL-90-R), and Eysenck personality questionnaire(EPQ). The differences between the two groups were tested by chi-square test and independent-sample t-test. Result : 1) Education level of the female alcoholics was significantly less than that of male alcoholics(p〈0.05) and the birth order the female alcoholics was significantly higher than that of male alcoholics(p〈0.05). 2) The level of socioeconomic status of female alcoholics was significantly lower than that of male alcoholics(p〈0.01). 3) The initial motivations of female alcoholics were mainly due to social, psychological, and intrafamilial problems while those of male alcoholics were due to social problems. There were significant difference between the two groups(p〈0.05). 4) The onset of initial drinking in female alcoholics was significantly earlier than that of male alcoholics(p〈0.001). 5) The average amount of daily drinking in female alcoholics was significantly less than that of male alcoholics(p〈0.01). 6) Withdrawal symptoms, physical disorder, and social or legal problems induced by alcohol drinking in female alcoholics were significantly less than those of male alcoholics(p〈0.05). 7) The mean scores of PSY scale of SCL90R and of L scale of EPQ in female alcoholics were significantly higher than those of male alcoholics(p〈0.05). Conclusion : Demographic and psychosocial factors differed to a significant degree between male and female alcoholism. We suggest that these factors are more important in female alcoholism than in male one in the etiologies and the clinical features. These differences are due to more complex factors rather than simple ones, thus the further evaluations are needed to elucidate the differences in the etiologies between male and female alcoholism.

6-Exomethylene penamsulfone 유도체의 β-lactamase 저해작용

김해종,여성현,임채욱,임철부,김미영 중앙대학교 약학연구소 1996 약학 논총 Vol.10 No.-

6-Exomethylene penam derivatives were tested as possible β-lactamase inhibitors. The in vitro β-lactamase inhibitory activities were determined by a spectrophotometric assay using Type Ⅰ, Ⅱ, Ⅲ, Ⅳ and TEM β-lactamase. Their activities were compared with sulbactam, tazobactam and clavulanic acid. The 6-exomethylene sulfone derivatives were more potent than clavulanic acid and sulbactam against Type Ⅳ β-lactamase. The Z-isomers showed stronger activities than the E-isomers against TEM and Type Ⅳ β-lactamase.

(4-Nicotinate-2-yl)thiobutyl 6-Exomethylene Penam의 합성

임채욱,박희석,임철부 중앙대학교 약학연구소 1996 약학 논총 Vol.10 No.-

The synthesis of new 6-exomethylene penam containing triazole ring was described. 1, 3-Dipolar cycloaddition of 4-azidobutanol with propargyl aldehyde gave 1-(4-hydroxybutyl)-1,2,3-triazole-4-carboxaldehyde, which reacted with 6,6-dibromopenicillanate to yield the stereoisomeric mixture of 6-bromo -6-〔hydroxy-1-(triazol-4-yl)methyl〕 penicillanate compound. This hydroxy compound was treated with acetic anhydride and zinc to afford the 6-exomethylene penam compound.