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A full-quantum three-dimensional analysis on the dynamics of a single atom in an all-optical trap
Young-Tak Chough,Young-Tak Chough 한국물리학회 2004 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.44 No.2
We analyze two recent \state-of-the-art" experiments on the dynamics of a single atom in an all-optical trap by using computer simulations based on the theory of quantum trajectories. We compare the so-called \quasi-classical" simulations of the experiments with our full-quantum calculations and discuss how far the two models agree. We point out that the atomic wave packet spreading in quantum calculations is mimicked by an interesting behavior of atom skipping around from a potential minimum to another in the quasi-classical model.
Flow Cytometric DNA Content Study on Uterine Leiomyomatous Tumors
Chough, Soo Yong,Lee, Kap N. 中央醫學社 1993 中央醫學 Vol.58 No.2
Flow cytometric DNA content analysis of 21 cases of benign leiomyomas, 2 cases of symplastic leiomyomas, 1 case of atypical leiomyoma, 1 case of borderline malignancy of leiomyoma and 3 cases of leiomyosarcomas with paraffin blocks from uterine hysterectomy specimen were performed. Only two cases out of 21 cases of benign leiomyomas (9 %) showed aneuploid patterns, one out of three leiomyosarcomas was aneuploidy and all others were diploidy. In histograms, the only G2 + M/G1 ratio fraction showed significant differences between benign leiomyomas and other symplastic, atypical leiomyomas, borderline malignancy of leiomyoma and leiomyosarcomas (P < 0.05). In histogramic fractions between benign and non-benign tumors, there were very significant differences in Go + M/Gi ratio (P < 0.001). There were no differences in ploidy pattern, Go/G1 fraction; S phase fraction, G2 + M fraction, prolifereation index and DNA index. Between benign leiomyomas and leiomyosarcomas, in cases of diploid tumors, only G2 + M/G1 ratio showed significant difference (P < 0.05) and in cases of aneuploid tumors, there was only suggestion of difference in only Go/G1 fraction.
Syntheses and antimicrobial and antitumor activities of isatin derivatives
Chough, Yun-Sung,Kang, Kun-Il The Pharmaceutical Society of Korea 1973 약학회지 Vol.17 No.3
Eight isatin N-Mannich bases were synthesized and tested their antimicrobial and antitumor activities. N-Piperidinomethylisatin-(N-cyclohexyl)-thiosemicarbazone is active against St. aureus at 10${\mu}$g/disk and isatin thiosemicarbazone against P. chrysogenum at 10${\mu}$g disk.
Chough, Chieyeon,Lee, Sunmin,Joung, Misuk,Lee, Jaemin,Kim, Jong Hoon,Kim, B. Moon The Royal Society of Chemistry 2018 MedChemComm Vol.9 No.3
<P>Based on (<I>R</I>)-<I>N</I>-methyl-<I>N</I>-(5-azaspiro[2.4]heptan-7-yl)-7<I>H</I>-pyrrolo[2,3-<I>d</I>]pyrimidin-4-amine as a core scaffold, we identified (<I>R</I>)-3-(7-(methyl(7<I>H</I>-pyrrolo[2,3-<I>d</I>]pyrimidin-4-yl)amino)-5-azaspiro[2.4]heptan-5-yl)-3-oxopropanenitrile [(R)-6c] as a JAK1 selective inhibitor. The structural design was based on the combination of tofacitinib's 7-deazapurine and 5-azaspiro[2.4]heptan-7-amine. Compound (R)-6c exhibited an IC50 value of 8.5 nM against JAK1 with a selectivity index of 48 over JAK2. To optimize (R)-6c as a lead compound, we performed <I>in vitro</I> ADME, hERG, kinase profiling, and pharmacokinetic tests. Mouse and rat <I>in vivo</I> studies verified that (R)-6c exhibited desired efficacies in CIA and AIA models.</P>
Chough, Chieyeon,Joung, Misuk,Lee, Sunmin,Lee, Jaemin,Kim, Jong Hoon,Kim, B. Moon Elsevier 2018 Bioorganic & medicinal chemistry Vol.26 No.8
<P><B>Abstract</B></P> <P>A series of 3(<I>R</I>)-aminopyrrolidine derivatives were designed and synthesized for JAK1-selective inhibitors through the modification of tofacitinib’s core structure, (3<I>R</I>,4<I>R</I>)-3-amino-4-methylpiperidine. From the new core structures, we selected (<I>R</I>)-<I>N</I>-methyl-<I>N</I>-(pyrrolidin-3-yl)-7<I>H</I>-pyrrolo[2,3-<I>d</I>]pyrimidin-4-amine as a scaffold for further SAR studies. From biochemical enzyme assays and liver microsomal stability tests, (<I>R</I>)-3-(3-(methyl(7<I>H</I>-pyrrolo[2,3-<I>d</I>]pyrimidin-4-yl)amino)pyrrolidin-1-yl)-3-oxopropanenitrile (<B>6</B>) was chosen for further <I>in vivo</I> test through oral administration. Compound <B>6</B> showed improved selectivity for JAK1 compared to that of tofacitinib (IC<SUB>50</SUB> 11, 2.4 × 10<SUP>2</SUP>, 2.8 × 10<SUP>3</SUP>, and 1.1 × 10<SUP>2</SUP> nM for JAK1, JAK2, JAK3, and TYK2, respectively). In CIA and AIA model tests, compound <B>6</B> exhibited similar efficacy to tofacitinib citrate.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
State-of-the-Art OMCVD-Grown HEMT's With 200 GHz CapabiIity
Chough,K. B.,Hong,W. P.,Caneau,C.,Lin,P. S. D.,Song,J. I. 대한전자공학회 1993 ICVC : International Conference on VLSI and CAD Vol.3 No.1
The performance of 0.15 ㎛ gate InAlAs/InGaAs HEMT's grown by OMCVD is reported The HFMT layer structure exhibited excellent transport properties, indicating the high quality of heterointerface. Hall mobilities of the device .structure were 17,900 and 52,800 ㎠/V-s with carrier concentrations of 3.1x10^(12) and 3.3x10^(12) cm^(-3) at 300 and 77 K, respectively. The devices fabricated using α 0.15㎛-long T=gate process showed a performance of f_T of as high as 200 GHz and f_(max) of 230 GHz extrapolated from 26 GHz at - 6 dB/octave. These are the best speed characteristics of any OMCVD-grown FETs. The results clearly demonstrate that OMCVD is a powerful growth technique for materials for high-speed applications.
Chough, Yun-Sung,Kim, Mie-Young The Pharmaceutical Society of Korea 1973 약학회지 Vol.17 No.3
Fifteen thiosemicarbazone derivatives were synthesized and evaluated for their antimicrobial activity against Staphylococus aureus, Escherchia coli and Pichia sp. Anticancer activity in vitro was also tested against human carcinoma HeLa cells.