혼합형 자가면역성용혈성빈혈과 동반된 Evans 증후군 1례

선길홍,윤찬영,박상곤,박경희,우정주,한경택,김진화,김영훈,정춘해,박치영 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Evans syndrome is defined as a simultaneous or sequential occurrence of autoimmune hemolytic anemia and autoimmune thrombocytopenia. Autoimmune hemolytic anemia (AIHA) is usually induced by IgG warm autoantibody or cold-active IgM antibodies reacting specifically with antigens associated with a patient's RBC. AIHA is a fairly uncommon disorder, with estimates of the incidence at 1 to 3 cases per 100,000 per year. Mixed-type AIHA is a relatively uncommon form of AIHA, with studies noting the incidence of 7-8% among cases of AIHA. We experienced a patient, 46-year-old woman who was diagnosed having a very rare clinical presentation of mixed warm and cold antibody mediated Evans syndrome. She was treated with corticosteroid therapy only and has been maintaining a complete response for 15 weeks. 저자들은 혼합형의 자가면역성 용혈성 빈혈과 자가면역성 혈소판 감소증이 동시에 발생한 혼합형 Evans 증후군으로 진단하고 스테로이드 요법 후 혈액학적으로 회복된 상태로 15주가 지난 현재 steroid 5 mg/일 까지 감량한 상태에서 추적 관찰 치료중인 46세 여자 환자를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

영구형 항서맥 심박조율기 환자의 장기추적관찰

최현석,이무용,최영진,최성준,김효수,손대원,오병희,이명묵,박영배,최윤식,이영우,이명용 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.5

노화가 인체 중간엽 줄기세포로부터 조골세포로의 증식 및 분화에 미치는 영향

백기현,태현정,오기원,이원영,조정기,권순용,강무일,차봉연,이광우,손호영,강성구,김춘추 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.3

연구배경: 일반적으로 골다공증과 연관된 위험인자로는 연령, 폐경, 약물, 불충분한 칼슘섭취, 만성질환 및 운동부족 등이 있는데, 특히 노화가 진행할수록 골밀도가 감소하는 것은 잘 알려져 있다. 노화와 관련하여 진행되는 골소실은 조골세포 및 전구조골세포의 기능적 결핍에 의한 골형성의 감소가 주요한 요인으로 여겨지고 있다. 그 동안 연령이 조골모 세포의 양과 조골모 세포로부터 성숙조골세포로의 분화 및 증식에 미치는 영향에 대한 일부 보고들이 있었으나 아직 일치된 견해는 없는 형편이다. 방법: 다양한 연령의 사람으로부터 골수를 채취, 중간엽 줄기세포가 포함된 단핵세포를 분리한 후 조골세포로 분화하기 좋은 조건하에서 배양하였다. 대상군은다시 젊은군과 노령군으로 구분하여 다양한 변수를 비교 분석하였다. 일차배양에서는 CFU-F를 계수하여 골수내 중간엽 줄기세포의 수를 추산하였고, 칼슘측정을 통하여 기질의 무기화 정도를 비교하였다. 계대배양후 이차배양에서는 시기별로 알카리성 포스파타제 활성도를 측정하고 오스테오칼신 mRNA의 발현을 관찰하여 젊은군과 노령군 사이의 증식능 차이를 비교하였다. 또한 이차배양 시기별로 MTT 측정을 하여 양군간에 증식능 차이가 있는지 알아보았다. 결과: 1. 일차배양 15일째에 평균 CFU-F의 수는 젊은군에서 유의하게 많았다(젊은군 148.3±28.9, 노령군 54.3±9.1, p=0.02). CFU-F의 평균면적은 젊은군에서 넓은 경향을 보였으나 통계적으로 유의하지는 않았다. 2. 일차배양 17일 경과 후 양군간에 기질 칼슘 침착정도는 유의한 차이를 보이지 않았다(젊은군 103.6±50.6, 노령군: 114.0±56.5, p=NS). 3. 이차배양 10일째에 젊은군에서 알카리성 포스파타제 활성도가 고령군에 비해 유의하게 높았다(젊은군: 935.5±115.0 U/mg, 노령군: 578.4±115.7U/mg,p.0.05). 고령군에서는 시간 경과에 따른 변화가 미약했으며 전반적으로 알카리성 포스파타제의 활성도가 젊은군에 비해 낮았다. 4. 이차배양도중 오스테오칼신 mRNA의 발현은 배양시기별로 젊은군에 비해 고령군에서 더 낮은 경향을 관찰할 수 있었다. 5. 이차배양 10일과 15일에 젊은군에서 노령군보다세포증식이 유의하게 증가된 양상을 보였다(10앓 젊은군 0.73±0.05, 노령군 0.58±0.04, p=0.05, 15일; 젊은군 0.80±0.05, 노령군 0.70±0.03, p=0.05).결론: 이상의 연구에서 저자들은 노령군에서 젊은군보다 골수 내 중간엽줄기세포의 수가 적고, 노령군에서 유래한 전구조골세포의 성숙조골세포로의 증식 및 분화가 젊은군 보다 감소해 있는 것을 관찰할 수 있었다. Background: Osteoblasts originate from osteoprogenitor cells in bone marrow stroma, termed mesenchymal stem cells (MSCs) or bone marrow stromal cells. Each MSC forms colonies (colony forming units-fibroblasts [CFL-Fs]) when cultured ex vivo. There are some reports about the age-related changes of the number and osteogenic potential of osteoprogenitor cells, but any relationship has not been clearly established in humans. In this study, we counted MSCs using CFU-Fs count and examined the proliferative capacity and differentiation potential of osteoprogenitor cells. Finally, we analyzed how these parameters varied with donor age. Methods: Bone marrow was obtained from the iliac crest of young (n=6, 27.2±8.6 years old) and old (n= 10, 57.4k6.7 years old) healthy donors. Mononuclear cells, including MSCs, were isolated and cultured in osteogenic medium. In primary culture, we compared the colony-forming efficiency of MSCs between the two groups and determined the matrix calcification. When primary culture showed near confluence, the cells were subcultured. Alkaline phosphatase activity, osteocalcin expression by RT-PCR and proliferative potential by MTT assay were examined by the time course of secondary culture. Results: At the 15th day of primary culture, the mean number of CFU-Fs was significantly higher in the younger donors (young: 148.3±28.9, old: 54.3±9.1, p=0.02) and the mean size of CFL-Fs was also larger in the younger donors than the older donors. However, matrix calcification was not different between the two groups (young: 103.6±50.6, old: 114.0±56.5, p=NS). In secondary culture, alkaline phosphatase activities were significantly lower in the older donors. The younger donors showed peak alkaline phosphatase activity at day 10, while the older donors didn't showed a remarkable peak (young: 935.5±115.OU/mg, old: 578.4±115.7U/mg, p<0.05). Total cell number as a proliferative index increased progressively during the secondary culture and a significantly greater cell number was noted in the younger donors. Osteocalcin expression was generally upregulated in the younger donors, but this was not statistically significant. Conclusion: Our study shows that the number of osteoprogenitor cells is decreased during aging and that the proliferative capacity and differentiation potential of osteoprogenitor cells seem to be reduced during aging (J Kor SOC Endocrinol 18:296-305, 2003).

후두부 발작성 간질파와 동반된 양성 소아기 간질의 임상적 연구

유영수,이상도,김지언,임정근,박영춘 대한신경과학회 1996 대한신경과학회지 Vol.14 No.4

중국의 WTO 가입과 한국경제

김영춘 제주대학교 관광과경영경제연구소 2003 産經論集 Vol.18 No.-

MQL 선삭가공시 가공조건의 표면거칠기 영향 분석

이춘만,황영국,정종윤 한국공작기계학회 2004 한국공작기계학회 추계학술대회논문집 Vol.2004 No.-

At present, industry and researchers are looking for ways to reduce the use of lubricants because of ecological and economical reasons. Therefore, metal cutting is to move toward dry cutting or semi-dry cutting. This paper presents an investigation into MQL(Minimum Quantity Lubrication) machining with the objective of deriving the optimum cutting conditions for the turning process of SM45C. To reach these goals several finish turning experiments were carried out, varying cutting speed, feed rate and oil quantity, with MQL. The surface roughness results of tests were measured and the effects of cutting conditions were analyzed by the method of Analysis of Variance(ANOVA). From the experimental results and ANOVA, it is found that a better surface roughness can be obtained by decreasing oil quantity and feed rate.

피부미용을 위한 아로마테라피(Aromatherapy)의 작용원리 및 활용방법

송선영,김춘일 제주한라대학 1999 論文集 Vol.23 No.-

Aromatherapy is a treatment which recovers the balance of mind and body. This is an application to human body, using aroma oil, that is, volatile oil contained in roots, fowers, leaves, stems, shells and seeds of special herbs and cells of fruits, etc. Aroma oil promotes immunocompetence, has an effect on all internal organs, glands and functions of hormones and heightens resistance to mold. And also it stimulates the nerves and rests our mind by intensifying or relaxing muscles, so it helps remove slight symptoms of everylife rather than severe diseases. This treatise shows you the usage and principles of aromatherapy good for beautiful skin. It counteracts poisonous characters of a body through bathing, foot-bathing, spreading, drinking, inhaling, massage and wet-compressing, promotes to renew cells and then cures and improves the quality of the skin. And also the fragrance of aroma oil stimulates the central nerve linked with the sense of the smell and stabilizes the balanced state of the mind. That has a good effect on mental improvement and stress management. This aromatherapy has been known good for beautiful skin and used in massage salons for 2 to 3 years. New aromatherapy is reported on its effects and approved in medical science as enough as doctors and herb doctors make the institute authorized. Aromatherapy is accessible to causes of diseases not to be seen which are coming from irregular living habits throughout long times and normalizes and improves functions of skin. So I hope the aromatherapy becomes stable and practical skin management and popularized so as to be vital tonics and living science as well as alternative medical science.

국가예산과 경제정책이 국민경제에 미친 효과 : 한국국가통합예산을 중심으로 Based on the Korean Unified State Budgets

우영춘 한국정책학회 2002 韓國政策學會報 Vol.11 No.1

국가재정은 경제성장 및 안정화 기능, 자원배분기능, 소득재분배 기능의 3가지 기능을 통하여 국민경제에 큰 영향을 준다. 이러한 기초적인 경제학적 사실을 우리나라의 1948년∼2000년까지의 국가재정을 경제성장 및 안정화 기능에 중점을 두고 각 공화국별로 실증적인 분석을 통해 확인해 보는 것을 이 연구의 목적으로 한다. 이를 위하여 우선 중앙과 지방의 정부예산을 통합한 한국국가통합예산을 기반으로 하여 재정변수를 선정하였으며, 정부의 경제정책과 법안 발표 회수를 기반으로 경제정책운용 변수를 선정하여 경제성장 변수와의 관계를 분석하였다. 또한 보전재원 중에서 한국은행 차입금과 국공채와 물가상승률의 상관관계를 분석하여 경제안정화 기능을 살펴보았다. 이 연구 결과에 의하면, 제3공화국∼김영삼정부까지 국가재정은 역대 공화국에 있어서 경제성장에 주도적인 역할을 해왔고 경제성장 정책도 시기적절하게 운영되었다. 그러나 IMF 이후의 국가재정과 경제성장정책은 경제성장에 도움이 되지 못한 것으로 보인다. 경제성장 기능에 비하여 국가재정이 경기를 조절하는 기능과 물가안정정책은 큰 효과가 없는 것으로 나타났다. 또한 한국은행 차입금이나 국공채를 활용한 적자 보전정책은 장기적으로나 단기적으로 구축효과보다는 국민소득증대효과가 더 크게 나타났다. 특히 지금 같은 경기침체기에는 국민경제에 큰 영향을 미치는 정부의 재정정책이나 경제정책에 대해 효과성과 신중성을 다시 생각해 볼 필요가 있다. National finance has a great effect on the national economy through the three functions of economic growth and stabilization, resource allocation and income distribution. The purpose of this article is to examine these well-known facts by analyzing the Korean budgets from 1948 to 2000, which is focused on the function of economic growth and stabilization. For this, variables in finance are chosen on the Korean National Public Budgets, which congregated the budgets of central government and local governments. And variables in policy operation are chosen on the number of publishing economic policies and laws related to them. Then, I will analyze the relation between these and the economic growth variables. Also, I will examine the function of economic stabilization by analyzing the correlation between borrowings from Korean National Bank & public bond and the rate of inflation. Then I came to a conclusion as following. From 3rd republic to Kim Yong-sam government Nation finance played a leading role in Korea's economic growth, and carried out policies for economic growth timely and properly. But since IMF, National finance and economic policies are likely to be helpless for growth. And the function of stabilization is likely to have less effect that of economic growth. In addition, the effect of GDP growth is greater than crowding out in the policy for deficit preservation using the borrowings from Korea Nation Bank and public bonds.

자가면역 용혈빈혈의 임상적 분석

박치영,강지은,박상곤,김상현,김형선,정춘해 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.2

Background: Autoimmune hemolytic anemia (AIHA) is a very uncommon disorder with the incidence between one and three cases per a hundred thousans a year. There have been very few studies about AIHA in Korea because of its low incidence. Most AIHA studies in Korea were about case history. The aim of this study was to review the clinical features, therapy and outcome of AIHA patients in single institution clinic. Methods: We reviewed retrospectively the medical records of AIHA patients from December 2002 to December 2006. Results: Twelve patient with AIHA were identified, and their median age was 49 years (range 27-75). Male to female ratio is 9:3. The median hemoglobin level was 5.0 g/㎗ (range 2.5-8.2). Warm type AIHA was most common (8/12), cold type was three, and mixed type was one. There was histories of associated disease in six patients. Two patients were complicated by systemic lupus erythematosus and mycoplasma infection and one patient by idiopathic myelofibrosis and solid tumor. Oral steroid was used as the first-line treatment in nine patients. An initial response was observed in eight patients with complete response. One patient had not responded to the initial steroid treatment, and then showed complete response with rituximab. Two relapsed patients were treated with rituximab and partial splenic embolization. Conclusion: The majority of patients can be treated with steroid. Rituximab can improve the response rate in relapsed and refractory AIHA.

장기간 항경련제 투여 환자에게서의 신경전도 속도

박영춘,이동국,임정근,이상도,이형 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.3

This study was performed to verify whether or not chronic anticonvulsants therapy(≥12 months ) is associated with peripheral nerve dysfunction in epileptics. Nerve conduction studies were done to 51 epileptics who had been taking long term anticonvulsants therapy over 12 months. The mean age of epileptics was 23 years, and was composed of 29 men and 22 women. The mean nerve conduction velocity(NCV) was not significantly different between epileptics and controls. Compared phenytoin or carbamazepine monotherapy group with controls, the NCV was not significantly different in two groups respectively. In epileptics, the mean NCV was not significantly different between phenytoin and carbamazepine monotherapy group. There was no significant relationship between NCV and duration of therapy with either phenytoin or carbamazepine. In epileptics with phenytoin combined therapy, the mean median sensory NCV was significantly delayed than in those with phenytoin monotherapy.