사회체육진흥을 위한 태권도장 경영의 합리화 방안 연구

閔春基,吳盧均 忠南大學校體育科學硏究所 1991 體育科學硏究誌 Vol.9 No.1

This study surveyed the business administration in Tae Kwon Do hall through the Questionaire and pointed out the problems and directions for the development of Sports for All. The following conclusions were obtained : 1. The factors of director for efficient management of Tae Kwon Do hall. : Results showed that optimal level of age for desirable director was ranged from thirty to forty, almost director grade in Tae Kwon Do was over 5th grade Dan of Black belt, a lot of directors' career for management of Tae Kwon Do hall was over 10 years, and over than half of directors' academic career was graduation of High school. 2. The factors of actual condition in Management of Tae Kwon Do hall. : Almost hall could be considered a small-scale business for it's a small number of students and the scale of facilities were not enough although they possessed the basic ones. In the program of Tae Kwon Do hall, additional education performed generally besides Tae Kwon Do and necessity of supportable instrument for the repletion of program is strongly required. A campaign of publicity is very active using modern instruments. And result indicate that the environmental factor of Tae Kwon Do hall is an important factor for efficient management.

師範大學 敎育課程 模型의 開發에 關한 硏究(Ⅰ) : 物理 및 地球科學 敎育課程을 中心으로 With Reference th Physics and Earth Science

李春雨,禹榮均,李華永 공주대학교 사범대학 과학교육연구소 1983 과학교육연구 Vol.15 No.1

One of the major objectives of this study is to arrange the curricula of the rhysics and the earth science course in the teachers college for improving the academic preparation of secondary school science teachers. To accomplish the objectives, the writers have preferentially analyzed the new science curriculum of the middle school and that of the physics and the earth science of the high school, and also the curricula of the physics and the earth science of the teachers college which will be applied in the pilot curriculum of the teachers college. The new science education may be characterized (1) operationally by an anal-ysis of the practician's activities, (2) intellectually by its constructs, (3) method-ologically by the mode of inquiry and procedures for problem solving. Science is the process which makes knowledge and is the interconnected se-ries of concepts and conceptual schemes that have developed as a result of experi-mentation and observations. and are fruitful of further experimentation and obser-vations. The problems set up in the analysis, in detail, are educational objectives, the contents of subject matter, the method of instruction, management of curriculum. The new and tentative curricula of the physics and the earth science in the teachers college is rearranged on the basis of both theoretical foundation and re-sults analyzed. And the new curricula of the physics and the earth science is organized on the basis of 150 credits, and also intensively, systematically, and logically. And the teaching contents of the physics and the earth science education is desirable to consist of higher level and new topics centering around the contents of secondary school science curriculum. And additionally, some of the followings concerned with the implementation of the curricular construction are suggested as the betterment. (1) Now, on-going 140 credits completion essential for the degree of B. A. for the students enrolled at the national teacher's colleges across the nation, should be strongly trengthened up to 150 credits with a view to covering the present bleak in educational achievement for producing more competent secondary school teachers, which can be said fittable for the imminent, prime objective of our teacher's colleges. (2) This study suggests the model of more reasonable curricular construction, and its actual way of implementation, which is based on the supposed 150 cred-its-completion system, which will be a help to the colleges of 140 credits-basis in curricular activities, by adding or rearranging the necessary number of courses for graduation. (3) The system, which the credits for the minor majors can be taken during the period of school vacation in addition to the regular 150 credits is safely said more desirable. Meanwhile, in the actual conducting of the above like-wise curricular activi-ties, it is supposed to be more desirable that both the choice of concerned depart-ments of the physics and the earth science and those regulations of the col-legesconcerned and ministry of education are expected to be justified in accord-ance with each other for more educational fruit-bearing, so, the more active, and long-range study and suggestions for the betterment should be activated hereafter, with no stop, for the development of our scientific education and building up our national strength itself.

도시민의 여가 선용을 위한 공간 확충 방안

민춘기,오노균 忠南大學校體育科學硏究所 1993 體育科學硏究誌 Vol.11 No.1

This research was tried to find out the expnasion methods of leisure space for citizen rest. The objects of study was composed of 40 public official servants and 238 citizen whose have selected by random sampling. The following were the conclusion. 1. A concept of leisure space surveyed in order of replied that they wanted comfortable place which break away from pollution(noise, environment air), gave in pleasure and relieve the fension, gave in recreation and activity of life. 2. They call on the his favorite place inside of 1km: Bomun M. T. park, Mini-park of downtown, river side park, fitness park in village but find out a few park of leisure. 3. The rent of leisure space surveyed replied that, They wanted to free pass and make use of 3-4 day on weeks with his family and follows. 4. The expansion of leisure space and physical fitness park surveyed replied that they wanted become of the main group according to self-governing body. 5. The problem of leisure space for expansion finded out financial affairs and purchanse of the ground. They insisted on that these problems must supporting both a self-governing body of localiy and government. 6. A scale of leisure park find out favorite Mini-park and Middle park which adequate to Korea's leisure siture situation.

조직학적 진단된 chronic necrotizing pulmonary aspergillosis 2예

김연숙,정숙인,기현균,김춘관,김신우,한정호,김성민,백경란,송재훈 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.1

CNPA는 기존의 폐질환 및 폐절제술로 인해 국소방어기전에 저하가 있거나 비특이적 전신면역상태저하를 갖고 있는 환자들에게서 주로 발생하는 만성적인 공동성 폐질환이다. 현재까지 우리나라에서는 CNPA의 보고가 없는 상태이고, 저자들은 최근 조직학적으로 진단된 CNPA 2예를 경험하였기에 보고하는 바이다. 저자들이 경험한 CNPA 환자들은 만성알코올 중독 및 기관지확장증과 같은 기저질환과 폐절제술을 받은 병력이 있었다. Aspergillus가 폐실질을 침윤하고 있는 조직소견과 조직배양에서 Aspergillus가 검출되어 조직학적 진단이 가능하였고, amphotericin B의 정주요법 및 경구 itraconazole 투여와 폐절제술 등으로 성공적으로 치료되었다. 아직 많은 임상의들에게는 낯선 질환인 CNPA의 치료성적은 환자의 동반질환 및 CNPA 자체의 중증도, 진단과 치료 시작의 지연 등에 의해 크게 좌우되므로 만성적으로 진행하는 공동성 폐병변을 갖고 있는 환자에게서 CNPA를 감별하는 것이 중요하다. Chronic necrotizing pulmonary aspergillosis (CNPA) is a chronic cavitary form of pulmonary aspergillosis. Dozens of CNPA cases have been reported in patients with systemic immunologic dysfunction or altered local defense mechanism from preexisting pulmonary disease. Review of literatures revealed that no CNPA cases have been reported in Korea yet. We experienced two cases of CNPA proven by lung biopsy. A 53-year-old alcoholic male in poor nutritional state was admitted with generalized weakness and weight loss. Chest CT revealed a cavitary nodule surrounded with ground-glass attenuation. CT-guided fine needle aspiration and biopsy was done. The biopsy specimen demonstrated dichotomously branching septated hyphae consistent with those of Aspergillus sp. Another case was a 39-year-old man with bronchiectasis who was admitted with persistent hemoptysis. He had a past history of pulmonary tuberculosis. A parahilar lesion with intracavitary soft tissue mass was incidentally detected in high-resolution GT. Left lingular segmentectomy was done due to uncontrolled hemoptysis and CNPA was histologically diagnosed. Both patients were successfully treated with intravenous amphotericin B followed by oral itraconazole. Even though CNPA is unfamiliar to most clinicians, it should be included in differential diagnoses of chronic progressive cavitary pulmonary lesion, especially in patients with immunologic dysfunction.

일개 대학병원에서 경험한 방선균증의 임상상

정숙인,김연숙,기현균,김춘관,김신우,이혁,김성민,백경란,송재훈 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.3

배경 : 방선균증은 혐기성의 그람양성 간균에 의한 만성 화농성 감염으로, 경안면부, 흉부, 복부, 골반부 등을 주로 침범한다. 최근 구강 위생의 향상과 항생제의 사용으로 인해 방선균증의 빈도의 감소와 함께 그 임상양상 또한 크게 변화하였다. 저자들은 국내에서의 방선균증의 임상상을 분석하기 위해 본 연구를 시행하였다. 방법 : 1995년 5월부터 1998년 9월까지 삼성서울병원에서 방선균증으로 진단받은 환자를 대상으로 임상기록지를 토대로 감염병소와 임상경과 등을 후향적으로 조사하였다. 결과 : 방선균증 환자는 모두 12명으로 경안면부 1례, 흉부 3례, 복부 3례, 골반부 5례였다. 임상양상은 주로 종괴의 형태로 나타나 진단을 내리기까지 종양과의 감별에 어려웠으며 진단은 모두 조직검사나 흡인액에서 유황과립을 확인함으로써 이루어졌다. 방선균증으로 진단된 환자는 모두 호전소견을 보였다. 결론 : 국내에서도 방선균증이 드물지 않게 발생하고 있으며 임상양상이 다양하여 가장 많이 오진되는 질환 중의 하나이다. 방선균증은 조직검사나 균배양검사를 통해 진단하고 항생제를 통해 완치될 수 있는 질환이므로 환자 진단에 관심을 가지면 불필요한 수술을 피할 수 있을 것으로 생각된다. Background: Actinomycosis is an indolent, slowly progressive bacterial infection, caused by Actinomyces. a gram-positive, non-spore-forming anaerobic or microaerophilic rod. Actinomycosis affects nearly every organ and body site. The disease is classically divided into four types, depending on the anatomic sites involved: cervicofacial, thoracic, abdominal, and pelvic. It has been considered as a rare disease, and only several cases have been reported in Korea. We performed this study to analyse the clinical manifestations of actinomycosis in Korea. Method: We retrospectively reviewed the medical records of patients with actinomycosis at the Samsung Medical Center from May 1995 to December 1998. Results: During the study period, actinomycosis was diagnosed in 12 patients: 1 patient had cervicofacial lesion, 3 thoracic, 3 abdominal, and 5 pelvic. The male and female ratio was 1 : 2 and the mean age was 47.2 years. Sulfur granule was observed in the pathologic specimens from all cases, but organism did not grow at all. It was very difficult to differentiate actinomycosis from tumorous conditions without pathologic diagnosis. All patients were clinically improved with antibiotics or surgical procedures. Conclusion: Actinomycosis is not a rare disease nowadays and has various clinical manifestations. It can be diagnosed by pathologic examination or culture and cured by antibiotics without surgical management.

허혈양상화, Adenosine 및 Pinacidil이 허혈 및 재관류후 흰쥐넙다리곧은근에서 Superoxide dismutase발현에 미치는 영향

백두진,유영미,황규성,안동춘,정호삼,강봉균 대한체질인류학회 2000 해부·생물인류학 (Anat Biol Anthropol) Vol.13 No.1

본 실험은 흰쥐에서 나타나는 허혈양상화의 효과와 그 발생기전을 규명하고자 하였다. 실험동물로는 300-350g 내외의 숫흰쥐를 사용하였으며 온엉덩동맥을 2시간 결찰한 후, 3시간, 6시간, 12시간, 24시간 및 72시간 재관류시켰으며, 온엉덩동맥을 5분간 결찰하고 5분간 재관류시키는 과정을 3회 반복하여 허혈양상화시키거나 시술적전 adenosine 혹은 pinacidil을 투여하고 같은 방법으로 허혈 및 재관류시켰다. 8-cyclopentyl-1,3-dipropylxanthine 혹은 glibenclmide 투여하고 허혈양상화시킨 다음 허혈 및 재관류시키고 넙다리곧은근을 적출하여 파라핀절편을 제작하고 in situ hybridization 조직화학법으로 Cu, Zn 및 Mn-SOD mRNA의 발현을 비교관찰하여 다음과 같은 결과를 얻었다. 1. 모든 실험군 넙다리곧은근에서 Cu, Zn 및 Mn-SOD mRNA는 단면적이 작은 근육섬유에서만 발현되었다. 2. 정상대조군 넙다리곧은근에서 Cu, Zn- 및 Mn -SOD mRNA는 약하게 발현되였다. 3. 허혈 및 재관류군에서는 재관류 시간경과에 따라 넙다리곧은근에서 CU, Zn-SOD mRNA는 중등도로 발현되었고, Mn-SOD mRNA는 재관류 3시간 및 6시간 경과시 약하게 혹은 중등도로 발현되었으며 재관류 12시간 경과시 약하게 혹은 미약하게 발현되었고, 24시간 경과시에는 중등도로 발현되었으며 72시간 경과시에는 약하게 혹은 중등도로 발현되었다. 4. 허혈양상화 처치로 넙다리곧은근에서는 Cu, Zn-SOD mRNA의 발현이 증가하여 12시간 경과시 중등도로 발현되었고 24시간 경과시 약하게 혹은 중등도로 발현되었으며 72시간 경과시에는 약하게 발현되었다. Mn-SOD mRNA 는 처치후 12시간 경과시 중등도로 발현되였고 24시간 경과시 중등도 혹은 강하게 발현되었으며 72시간 경과시 약하게 발현되었다. 5. 허혈양상화 허혈 및 재관류군에서 Cu, Zn-SOD mRNA는 재관류 6시간까지 중등도로 발현되었으며 재관류 12시간 및 24시간 경과시에는 약하게 혹은 중등도로 발현되였고 72시간 경과시에는 약하게 발현되였다. Mn-SOD mRNA는 재관류 12시간까지 중등도로 발현되었고 24시간 경과시 중등도 혹은 강하게 발현되었으며 72시간 경과시에는 약하게 발현되었다. 6. Adenosine 투여후 허혈 및 재관류시에는 넙다리곧은근에서 Cu, Zn-SOD mRNA는 재관류 12시간 경과시까지 중등도로 발현되었고 재관류 24시간 경과시에는 약하게 혹은 중등도로 발현되였으며 재관류 72시간 경과시에는 약하게 발현되었다. 7. Pinacidil 투여후 허혈 및 재관류시에는 넙다리곧은근에서 Cu, Zn-SOD mRNA는 재관류 6시간까지 중등도로 발현되었고 재관류 12시간 경과시에는 약하게 혹은 중등도로 발현되었으며 재관류 24시간 및 72시간 경과시에는 약하게 발현되었다. 8. 8-cyclopentyl-1,3-dipropylxanthine 투여후 허혈양상화 허혈 및 재관류시 넙다리곧은곤에서 Cu, Zn-SOD mRNA는 재관류 3시간까지 중등도로 발현되였고 재관류 6시간 및 12시간에는 약하게 흑은 중등도로 발현되었으며 재관류 24시간 및 72시간 경과시에는 약하게 발현되였다. Mn-SOD mRNA를 재관류 3시간까지 약하게 발현되었고 재관류 12시간까지 중등도 혹은 약하게 발현되였으며, 재관류 24시간 경과시에는 약하게 발현되었고 재관류 72시간 경과시에는 중등도로 발현되었다. 9. Glibenclamide 투여후 허혈양상화 허혈 및 재관류시에는 넙다리곧은근에서 Cu, Zn-SOD mRNA는 재관류 24시간까지 중등도로 발현되었고, 재관류 72시간 경과시까지는 약하게 혹은 중등도로 발현되었다. Mn-SOD mRNA는 재관류 기간을 통하여 중등도로 발현되었다. 이상의 소견을 종합하면 허혈 및 재관류시 Cu, Zn- 및 SOD mRNA의 발현은 증가하였고 허혈양상화로 특히 Mn-SOD mRNA의 발현이 증가하였으며, 허혈양상화의 효과는 adenosine A_(1) 수용체와 K_(ATP) 통로의 자극과 밀접한 연관이 있는 것으로 결론 지을 수 있다. A brief episode of ischemia and reperfusion termed 'ischemic preconditioning' has been established as rendering muscle tolerance to damage during a subsequent prolonged ischemia. The effects of ischemic preconditioning in the cardiac muscle are related to the stimulation of adenosine A, receptor and the opening of KATP channel. The effect and mechanisms of ischemic preconditioning in the skeletal muscle are not known clearly. The superoxide radical injures the skeletal muscle during the ischemia and reperfusion. There are two types of SOD, which metabolizes the superoxide radicals to H_(2)O_(2) and O_(2), in the cell. One of them is Cu, Zn-SOD in the cytoplasm and the other is Mn-SOD in the mitochondria. The activities of SOD are increased against the formation of superoxide radical during the reperfusion. The author performed the present study to investigate the effect and the mechanisms of ischemic preconditioning by measuring the expression of SOD mRNA on timely reperfused ischemic muscles. The healthy Sprague-Dawley rats weighing from 300g to 350g were used as experimental animals. Under pentobarbital(50 mg/kg) anesthesia, lower abdominal incision was done and left common iliac artery was occluded by vascular clamp for 2 hours. Rectus femoris muscles were obtained respectively at 3, 6, 12, 24 and 72 hours after reperfusion. The ischemic preconditioning group underwent three episodes of 5minute occlusion and 5minute reperfusion of common iliac artery followed by 2hours of ischemia and timely reperfusion. Adenosine (50 ㎍/kg) or pinacidil(1 mg/kg) was administered intravenously before ischemia. 8-cyclopentyl-1,3-dipropylxanthine(15 mg/kg) or glibenclamide(0.5 mg/g) was administered intravenously before ischemic preconditioning. Paraffin sections with 4 ㎛ thickness in all groups were obtained. The expression of Cu, Zn- and Mn-SOD mRNA was observed by use of in situ hybridization. The results obtained were as follows. I. The expression of SOD mRNA was seen only in small muscle fibers of the rectus femoris muscle of the rat. 2. Weak expressions of Cu, Zn- and Mn-SOD mRNA were observed in the normal control rat. 3. After 2 hours of ischemia, moderate expression of Cu, Zn-SOD mRNA was observed until 72 hours of reperfusion. Weak or moderate expression of Mn-SOD mRNA at 3 hours and 6 hours of reperfusion, weak or trace expression at 12 hours of reperfusion, moderate expression at 24hours of reperfusion and weak or moderate expression at 72hours of reperfusion were observed. 4. After ischemic preconditioning, moderate expressions of Cu, Zn-SOD mRNA were seen in the groups of 3, 6, 12 and 24 hours of reperfusion. Moderate expressions of Mn -SOD mRNA were seen in the group of 0, 3, 6 and 12hours of reperfusion and strong expression was seen in the group of 24hours of reperfusion after ischemic preconditioning. 5. After 2 hours of ischemia with ischemic preconditoining, moderate expressions of Cu, Zn-SOD mRNA were seen in the groups of 0, 3, 6, 12, 24 hours of reperfusion. Moderate expressions of Mn-SOD mRNA were observed in the groups of 0, 3, 6, and 12 hours of reperfusion and moderate or strong expression was seen in the group of 24 hours of reperfusion. 6. After 2 hours of ischemia with the pretreatment of adenosine, moderate expressions of Cu, Zn-SOD mRN A were seen in the group of 0, 3, 6, 12 and 24hours of reperfusion. Moderate expression of Mn-SOD mRNA in the groups and 3 hours of reperfusion, strong expression in the group of 6 and 12 hours of reperfusion and moderate expression in the group of 24hours of reperfusion were seen. 7. After 2 hours of ischemia with the pretreatment of pinacidil, moderate expressions of Cu, Zn-SOD mRNA were seen in the groups of 0, 3, 6 and 12 hours of reperfusion and those of Mn-SOD mRNA were seen in the groups of 3, 6, 12 and 24 hours ofreperfusion. 8. After 2hours of ischemia with ischemic preconditioning and the pretreatment of 8 -cyclopentyl- l,3dipropylxanthine, moderate expression of Cu, Zn-SOD mRNA were observed in the groups of 0, 3, 6. and 12hours of reperfusion and those of Mn-SOD were seen in the groups of 6, 12 and 72hours of reperfusion. 9. After 2hours of ischemia with ischemic preconditioning and the pretreatment of glibenclamide, moderate expressions of CU, Zn-and Mn-SOD mRNA were seen in all groups of reperfusion. Consequently, these results suggest that the expression of Cu, Zn and Mn-SOD mRNA increases during 2hours ischemia and reperfusion with or without ischemic preconditioning. The effects of ischemic preconditioning are closely related to the stimulation of adenosine A₁receptor and K.ATP channel.

Saccharomyces cerevisiae에서 Trichoderma Endoglucanase의 발현과 분비

남수완,김병우,신동하,김재범,신지원,정대균,정춘수 동의대학교 기초과학연구소 1999 基礎科學硏究論文集 Vol.9 No.1

The endoglucanase gene, egl6, of Trichoderma sp. was connected with the yeast ADH1 promoter, and the resultant plasmid, pVT-C4, was introduced into three S. cerevisiae host strains (YNN27, 2805, and SEY2102). Among each 80 transformants, the cell growth and expression level of endoglucanase were compared in test-tube cultivation, and three respective transformants for each host cells showing the highest expression level and cell growth were selected. When three recombinant yeast cells were batchwise cultivated for 48 hr in flask, the total activities of endoglucanase expressed were about 1140 unit/1 with 2805/pVT-C4, 1020 unit/l with SEY2102/pVT-C4, and 590 unit/l with (YNN27/pVT-C4. Irrespective of host strain, about 80% of the expressed endoglucanase was detected in the extracellular medium. In addition, it was also found that the recombinant enzyme was secreted into the culture medium as two major forms of lightly and heavily glycosylated proteins.

토끼 수막염 모델을 이용한 다제내성 폐렴구균에 대한 Meropenem의 치료 효과

김신우,진정화,강수정,정숙인,김연숙,기현균,김춘관,이혁,김성민,백경란,송재훈 대한화학요법학회 2001 대한화학요법학회지 Vol.19 No.1

목적 : 다제내성 폐렴구균에 의한 수막염은 기존과 단일 항생제로는 근치가 어려워 ceftriaxone과 vancomycin 혹은 rifampin의 병용요법이 권유되고 있다. 다제내성 폐렴구균에 사용할 수 있는 다른 약제 중 meropenem은 시험관내 폐렴구균에 대한 항균력이 좋고 경련 등의 중추신경계 부작용이 거의 없어 다제내성 폐렴구균에 의한 수막염의 치료에 이용할 수 있을 것으로 기대되나 이에 대한 자료가 매우 부족한 상태이다. 이에 연자 등은 meropenem과 meropenem+vancomycin의 병용요법이 다제내성 폐렴구균 수막염의 치료에 효과가 있는지를 토끼 수막염 동물 모델을 이용하여 검증하고자 하였다. 방법 : 인체에서 수막염을 일으킨 다제내성 폐렴구균 균주(penicillin MIC 2, ceftriaxone MIC 4, meropenem MIC 0.5㎍/㎖)를 토끼 척수강 내에 직접 주입하여 수막염을 유발한 후 ceftriaxone, vancomycin, rifampin, meropenem의 단일 항균요법, ceftriaxone+vancomycin, ceftriaxone+rifampin, meropenem+vancomycin의 병용요법 간에 치료 효과의 차이를 비교 하였다. 각 치료군은 6 마리의 토끼를 대상으로 하였다. 각각의 항생제는 5 시간 간격으로 2번 정주하였으며, ceftriaxone은 1회 투여하였다. 균주 주입 후 각 치료군이 토끼에서 치료 후 0, 5, 10, 24 시간에 척수액을 채취하여 균주의 수를 측정하여 24시간째의 살균 여부를 최종 치료 효과로 판정하였다. 결과 : meropenem 단독 요법은 10시간째에 모든 균주를 살균하였으나 24시간 째에 다시 균의 성장이 관찰되었으며, meropenem+vancomycin의 병용요법은 단독 약제보다 우수한 살균효과를 보였으나 상승작용은 없었다. 결론 : meropenem+vancomycin의 병용요법은 기존의 ceftriaxone+vancomycin보다 24시간째에 더 큰 균의 감소 경향을 보여(P=0.054) 임상에서 사용이 가능할 것으로 기대되며 향후 실제 수막염 환자에서의 임상효과를 증명하는 연구가 필요할 것으로 생각된다. Background : Because antimicrobial monotherapy for pneumococcal meningitis caused by penicillin-resistant strains is not satisfactory, ceftriaxone+vancomycin [C+V] or ceftriaxone+rifampin [C+R] regimens are recommended. Meropenern [M] is one of the monotherapy options for penicillin-resistant pneumococcal meningitis due to good in-vitro activity against pneumococci and rare adverse reactions in CNS. But there have been few reports in the efficacy of meropenern against pneumococcal meningitis. We evaluated therapeutic efficacy of the meropenern and meropenem+vancomycin in a rabbit model of meningitis caused by penicillin-resistant S. pneumoniae (PRSP). Methods : Meningitis was induced by intracistemal inoculation of a pneumococcal strain isolated from a patient with meningitis (MIC; penicillin 2, ceftriaxone 4, meropenem 0.5 g/㎖). Bacterial concentrations in the CSF were measured at 0, 5, 10, and 24 h after therapy was started. Therapeutic efficacy was evaluated by the final bacterial concentration in the CSF at 24 h. Results : C+V cleared the CSF at 10 h, but regrowth of bacteria was noted at 24 h. Meropenem monotherapy resulted in sterilization at 10 h but regrowth at 24 h. M+V was superior to M or V monotherapy but did not show synergism. Therapeutic efficacy of M+V was at least equal or superior to that of C+V (P = 0.054). Conclusion : Meropenem+vancomycin regimen could be one of the useful options in the treatment of PRSP meningitis. Clinical trials to evaluate the M or M +V are warranted in the future.

추적관찰 중 종괴의 크기가 커진 경화성 혈관종 1례

안형수,장안수,이준혁,박성우,고은석,백상현,박재성,허균,신화균,박춘식 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

We report a case of a sclerosing hemangioma of the lung with increased size during follow up, a rare benign neoplasm of the lung. A 32-year-old woman had round increased opacity in right upper lobe on posteroanterior chest radiograph. That lesion has grown slowly over four years. Computed tomographic scan showed a well circumscribed lung mass in medial aspect of right upper lobe. Radiological differential diagnosis for the lesion included inflammatory pseudotumor, atypical carcinoid, lung cancer and localized fibrous tumor of pleura. Nonspecific findings were shown by the bronchoscopy and percutaneous transthoracic needle aspiration. Anterior and apical segmentectomy was carried out and the lesion was pathologically diagnosed as sclerosing hemangioma of lung.

Biochemistry,Molecular Biology : Constitutive Expression of Defense Genes in Transgenic Arabidopsis Overproducing Methyl Jasmonate

Choon Kyun Jung,Seoung Hyun Lyou,Yeon Jong Koo,Jong Tae Song,Yang Do Choi,Jong Joo Cheong 한국응용생명화학회 2003 Journal of Applied Biological Chemistry (J. Appl. Vol.46 No.2