Comparative double blind test에 의한 抗아메바劑 Ro7-0207(Tiberal), Metronidazole 및 Dehydroemetine의 治效成績의 比較

李午政,全鍾暉,朴弼遠,朴壽泳 대한감염학회 1974 감염 Vol.6 No.1

Introduction New and better substances are still being sought for the treatment of amoebiasis. The aim of this trial is to assess the effectiveness and tolerance of Tiberal and oral dehydroemetine in patients with oligosymptomatic (or mild) intestinal amoebiasis comparing with that of metronidazole which are known to be an active amoebicide. Selection of cases. Lately, classical symptomatic amoebiasis accompanying mucus-bloody stool and tenesmus could be seldom experienced at urban areas in this country. At here the majority of intestinal amebiasis is manifested by loose stools containing mucus, pus or blood (rare), and also by a rapid response to antibioties, but with frequent episods of recurrence caused by diet-failure or alcohol drinking. Among 187 cases of mild enterocolitis which were suspected as being mild intestinal amoebiasis clinically, authors selected amoeba-positive 60 cases and additional 7 cases which were included later in this clinical trial study. The 7 drop-outs in the original study were replaced by these additional 7 cases. The clinical trials were carried out at the St. Mary's Hospital, Catholic Medical College, Seoul, Republic of Korea. During 12 month (April 25, 1973-May 17, 1974), we treated 60 cases of so-called oligosymptomatic amoebiasis with above mentioned three amoebicides. 60 ambulatory cases suffering from mild GI troubles were admitted into the trial (liable to recurrent diarrhoeal stools including mucus, or pus with tenesmus, and also to lower abdominal discomfort of mild pain) those were suspected clinically as having intestinal amoebiasis with carriers of E. histolytica (trophozoits and/or cysts in the feces). Oligosymptomatic amoebiasis group, in this clinical trial study, consisted of 34 males and 26 females ranging from 17 to 62 years of age. All were adolescents or adults and their age distribution was shown in Table 1. Methodology on this clinical trials. We have carried out so-called the comparative double blind trials with Tiberal versus Metronidazole versus oral Dehydroemetine in symptomatic amoebiasis of mild grade. The trial drugs were given also without the knowledge of either the one who gave it or the one who got it in this comparative double blind study. Both (drug examiner) doctors and (drug examined) patients have had no knowledge of each drug. Pharmacist responded to doctor's prescription with code numbers. After the completion of the study the exact name of a drug were publically drawn from the code numbers and the purpose of double blind study was attained. In this study an arrangement for a drug administration schedule was set by as pharmacist exclusively. 60 patients were assigned to one of the three drugs by proper randomization so that 20 patients received tiberal and 20 metronidazole and 20 oral dehydroemetine. After the trial, code numbers of the drugs were identified; nos. 1, 6, 10, 14, 19, 23, 25, 27, 28, 29, 33, 34, 35, 36, 44, 45, 47, 51, 53, and 54 were tiberal; 8, 9, 11, 12, 13, 15, 16, 18, 20, 22, 32, 39, 41, 48, 49, 50, 52, 55, 56, and 57 were metronidazole, and nos. 2, 3, 4, 5, 7, 17, 21, 24, 26, 30, 31, 37, 38, 40, 42, 43, 46, 58, 59 and 60 were oral dehydroemetine. Evaluation The therapeutic effects were assessed by the clinical evolution and by stool parasitology (direct examination and concentration method) performed on day 3 and 6 on treatment, and then at the end of treatment (8-10 day) and one month after the initial treatment. This made a total 4 to 5 parasitological examination per patient, including one examination required for diagnosis prior to treatment. At the same time aspect and consistency of the stool were registered. The effect of the drugs on other protozoa found in the stools were also reported. The tolerance were assessed by clinical findings and laboratory studies made in limited cases at least before and after treatment unless otherwise stated. Blood count, BUN, Alkaline phosphatase, SGP, TECG and urinalysis were performed as laboratory controls. Authors have established following evaluation criteria for this clinical study. Radical cure: free of symptoms with no vegetative or cystic forms of E. histolytica in stool on 3 successive tests. Biological cure: no cystic forms of E. histolytica in stool on 3 successive tests, but persistence of some intestinal disturbances. Relapse: apparent cure or improvement (with negative of 3 successive tests) followed by recurrence with vegetative amoeba on direct smear within 30 days. (re-infection may be included) Failure: the trophozoites or cystic form of E. histolytica has persisted for treatment periods, with some intestinal troubles. Methods of treatment and parasitologic examination In each group one third of the patients received 2 capsnles of 250mg. Tiberal thrice daily for 7 days, one third received 2 tablets of 250 mgmetronidazole thrice daily for 7 days, and one third received 2 tablets of 10 mgdehydroemetine thrice daily for 7 days as the only specific drug. No associated drugs were given together for symptomatic relief in all cases. The reason why fixed 7 days dose were delivered to every cases was based on convenience of stool examination and equalizing the number of days for therapy. The therapeutic drugs were delivered usually for 2 days dose (1st prescription), 3 days dose and 2 days dose (3rd prescription) successively, therefore stool examination had been done on 3rd, 6th and 8-10th day of therapy. Clinical results In oligosymptomatic amoebiasis, 20 cases each were treated with doses of 1,500mg/day of Tiberal and metronidozole for 7 days respectively, and 20 cases were treated with doses of 60mg/day of dehydroemetine for 7 days. The total doses administered were 10,5g, 10,5g, and 420mg respectively in a period of 7 days. Among tiberal group 19 cases were found to be negative after therapy whereas there was 1 with parasitological failure. The clinical effect was fast in 95% of the cases. Effective cure was achieved in 17 whereas symptoms persist in 3 patients among 20 cases. There were 1 failure and 2 late relapse. Comparing data of therapeutic results with that of metronidazole and dehydroemetine were shown in Table 2 & 3. Table 3 shows the negativity rate of trophozoits or cystic form of E. histolytica in stools according to therapeutic periods of trial drugs received. The data would indicated that 5 days dose could not be enough to eradicate the parasites even in the susceptible cases. The result data of clinical improvement and clearance of E. histolytica in patient stool among drug trial groups were shown in Table 4. The cases treated with Tiberal showed no clinical signs on average 4,9 days and negative amoeba in stool on average 4,1 days of therapeutic periods, comparing with on average 5,8 days and 4,1 days in metronidazole-treated group, and on average 6,3 days and average 4,5 days in dehydroemetine-treated group respectively. Authors put in order the therapeutic procedures and their result of failed or relapsed cases with unplanned measures in table 5. These data could be obtained after the completion of the comparative double blind study by the code numbers which were publically drawn afterwards. These therapeutic procedures had been made just incidentally, not by prior plan. 2 cases, 4 cases and 3 cases could get finally effective cure by doubling doses of 7 days course of Tiberal, metronidazole and dehydroemetine respectively. 1 failed case treated with dehydroemetine and 1 another failed case with tiberal could get effective cure by additionally receiving metronidazole and dehydroemetine respectively. 2 failed cases treated with metronidazole could be cleared of parasites by adding tiberal effectively. Adverse reactions were noticed in 20% each of the patients treated with Tiberal and also with metronidazole, and 25% of those treated with dehydroemetine. They were all transient and never severe. There was not a single case who was discontinued on therapy owing to its side-effects. No significant change of laboratory data was noticed by the administration of trial drugs. Brief summary Tiberal, metronidazole and dehydroemetine (oral) were all recognized as highly efficacious anti-amoebic drugs in this clinical studies. On account of following standpoints 1) clearance of parasites in stool 2) clinical symptomatic relieving 3) drug tolerance 4) rate of relapse and failure 5) side-effects, Tiberal could be received much more recognition than metronidazole and dehydroemetine did. P. S. Authors has experienced other 10 cases of amoebiasis among in patients (5 moderate severe intestinal amoebiasis, 4 liver abscesses and 1 lung abscess) treated with Tiberal and metronidazole with excellent therapeutic results, without any sequelae or relapse.

상안와열 증후군의 치험례 : A CASE REPORT 1 례 보고

황오열,이종현,이원구,강호만 大韓成形外科學會 1985 Archives of Plastic Surgery Vol.12 No.4

The superior orbital fissure syndrome may arise from inflammatory of neoplatic cause but, when the etiology is due to trauma, this may result either direct compression of the structures passing through the fissure (Ⅲ,Ⅳ,Ⅴ,Ⅵ Cranial nerve) or to presence of a hematoma. In most case a combination of these factor will be present. The following case is that of a man who was treated maxillofacial fracture and was found to have signs of the superior orbital fissure syndrome. The clininal and therapeutic aspect of this syndrome are described and we emphasize the need for conservative treatment because spontaneous recovery is usual.

DOA 추정을 위한 고유치 분해법의 FPGA 구현

윤종오,변건식,정봉식 東亞大學校附設 情報技術硏究所 2005 情報技術硏究所論文誌 Vol.13 No.1

This paper is concerned with how to implement the MUSIC algorithm in high-speed way. The key point to transplant an algorithm into a practical application is to find a way to simplify the algorithm's computational complexity so that it can be implemented by hardware system. In this paper the hardware architecture of the EigenValue Decomposition(EVD) processor of symmetric correlation matrix for the application of an adaptive antenna technology such as DOA (Directions of Arrival) estimation is proposed and the basic idea is also presented.

Mapping of sentinel lymph nodes by firefly fluorescence imaging with da Vinci xi system for endometrial and cervical cancers

( Ji Y Tak ),( Gun O Chong ),( Yoon H Lee ),( Dae G Hong ),( Yoon S Lee ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-

Objectives: We evaluate the detection rate and metastasis of primary sentinel nodes (SLN) and downstream secondary fluorescence nodes for endometrial and cervical cancer by firefly fluorescence imaging with da Vinci xi system. Materials and Methods; A total of 27 patients were included in the study (13 endometrial and 14 cervical cancers). Mean age was 55 years (range, 32-73 years). Mean BMI was 25.5 kg/m² (range, 21-39 kg/m²). All patients had inframesenteric paraaortic lymphadenectomy but 11 patients had infrarenal paraaortic lymphadenectomy. All procedures were performed by firefly fluorescence imaging with da Vinci xi system. Four intracervical injection of indocyanine green (ICG) at 3 and 9 o'clock was performed in all cases before insertion of telescope. Results: Total obtained nodes count were 43.4 (range 18-61). Five patients had node metastasis with sentinel node. The mean primary SLN counts were 9.9 (range, 2-15). And downstream 2ndary fluorescent staining nodes count were 14.9 (range, 0-25). And primary SLN was identified in 27 cases (100%), with bilateral pelvic mapping in 25 (93%). An aortic 2ndary SLN was identified in 20 (74%) of the 27 mapped cases as not primary but 2ndary fluorescent nodes. The most frequent site of primary SLN was obturator nodes, external iliac medial node, presacral nodes, internal iliac node, parametrial nodes, and external iliac lateral nodes in the order. And frequent site of downstream 2ndary fluorescent staining node was external iliac lateral nodes, inframesenteric nodes, right paraaortic nodes, external iliac medial nodes, common iliac nodes, presacral nodes, aortocaval node, internal iliac nodes, gluteal node and infrarenal nodes in the order. Positive SLNs were identified in 19% of patients (5/27). Four had secondary paraaortic node metastasis both in patients with positive pelvic SLN. Three patients (11%) had metastatic node outside to metastatic primary SLN and downstream fluorescence nodes (3/27). There were no allergic reactions to the ICG. Conclusions: Firefly fluorescence imaging with ICG in da Vinci system is an excellent and safe method for SLN mapping with a very high overall (100%) and bilateral (93%) detection rate. Our results revealed there are important information about conception of primary sentinel node and downstream fluorescence nodes. Which is rather different results to previous others studies.

防波堤의 任意 配置에 對한 波浪 廻折

李한배,李庸揆,吳世汎,片宗根 명지대학교 공학기술연구소 1988 공학기술연구소 논문집 Vol.3 No.-

In harbor design, it is a necessary condition to retain calmness inside a harbor. For this purpose, breakwaters are disposed as exterior structures against incident waves. There are cases that necessitate main and auxiliary breakwaters according to frequent directions of incident waves. In these cases, harbor entrances have various geometric shapes in horizontal plane. In the program developed here, harbor entrances are classified into six different cases by the disposition of breakwaters and the attack angle of incident waves. For each case, the diffraction phenomena inside and around harbor entrance are analysed by superposing the solutions of Sommerfeld's. The method gives fairly good results compared with those reported before, and also is proved to be computationally very efficient. Therefore, the method may be applicable to the preliminary design of breakwater dispositions, and also the program can be used as the basic subroutine in the calculation of wave height distributions inside a harbor with reflected waves.

소음성 청력장애에 관한 조사연구

김준언,이채언,문덕환,김진옥,하회영,윤병용,배기택,김용완,전종휘 인제대학교 1982 仁濟醫學 Vol.3 No.2

부산지역 일부 섬유, 고무 및 제강 산업장의 소음 작업부서 종사 근로자들중 6분법에 의한 청력장애(21dB이상)자는 조사대상의 6.30%이었다. Authors surveyed on the status of prevalence and several characters related with the occurrence of noise induced hearing impairment on 2,963 numbers of workers engaged in noisy department of twelve industries which were Textile, Rubber and Steel-Wire in Busan from July 1st, 1980 to September 30th, 1981. The obtained results were as follows: 1.About 90 percent of workers in noisy department engaged in the place of noise level less than 100dB(A). 2.The prevalence of occupational healing loss of workers engaged in noisy department by each level of hearing loss was respectively 5.43 percent at 21dB and above. 2.53 percent at 31dB and above, 0.80 percent at 41dB and above. 3.Workers of noise induced hearing impairment showed typical Cs-dip in Audiogram. 4.About 80 percent and above of workers of noise induced hearing impairment determined hearing loss of 40dB and below. 5.Hearing loss of workers of noise induced hearing impairment increased with aging. 6.Hearing loss of workers of noise induced hearing impairment was in accordance with the duration of employment in 7 years and below. 7.The occurred rate of noise induced hearing impairment using ELI(Early Loss Index) was about 92 percent(D-E scale).

말초전정병증에서 빙수자극에 의한 안진의 두위의존성

최병윤,구자원,오승하,장선오,김종선 대한평형의학회 2003 Research in Vestibular Science Vol.2 No.2

Long-term MAX-DOAS network observations of NO2 in Russia and Asia (MADRAS) during the period 2007–2012: instrumentation, elucidation of climatology, and comparisons with OMI satellite observations and global model simulations

Kanaya, Y.,Irie, H.,Takashima, H.,Iwabuchi, H.,Akimoto, H.,Sudo, K.,Gu, M.,Chong, J.,Kim, Y. J.,Lee, H.,Li, A.,Si, F.,Xu, J.,Xie, P.-H.,Liu, W.-Q.,Dzhola, A.,Postylyakov, O.,Ivanov, V.,Grechko, E.,Ter Copernicus GmbH 2014 Atmospheric Chemistry and Physics Vol.14 No.15

<P>Abstract. We conducted long-term network observations using standardized Multi-Axis Differential optical absorption spectroscopy (MAX-DOAS) instruments in Russia and ASia (MADRAS) from 2007 onwards and made the first synthetic data analysis. At seven locations (Cape Hedo, Fukue and Yokosuka in Japan, Hefei in China, Gwangju in Korea, and Tomsk and Zvenigorod in Russia) with different levels of pollution, we obtained 80 927 retrievals of tropospheric NO2 vertical column density (TropoNO2VCD) and aerosol optical depth (AOD). In the technique, the optimal estimation of the TropoNO2VCD and its profile was performed using aerosol information derived from O4 absorbances simultaneously observed at 460-490 nm. This large data set was used to analyze NO2 climatology systematically, including temporal variations from the seasonal to the diurnal scale. The results were compared with Ozone Monitoring Instrument (OMI) satellite observations and global model simulations. Two NO2 retrievals of OMI satellite data (NASA ver. 2.1 and Dutch OMI NO2 (DOMINO) ver. 2.0) generally showed close correlations with those derived from MAX-DOAS observations, but had low biases of up to ~50%. The bias was distinct when NO2 was abundantly present near the surface and when the AOD was high, suggesting a possibility of incomplete accounting of NO2 near the surface under relatively high aerosol conditions for the satellite observations. Except for constant biases, the satellite observations showed nearly perfect seasonal agreement with MAX-DOAS observations, suggesting that the analysis of seasonal features of the satellite data were robust. Weekend reduction in the TropoNO2VCD found at Yokosuka and Gwangju was absent at Hefei, implying that the major sources had different weekly variation patterns. While the TropoNO2VCD generally decreased during the midday hours, it increased exceptionally at urban/suburban locations (Yokosuka, Gwangju, and Hefei) during winter. A global chemical transport model, MIROC-ESM-CHEM (Model for Interdisciplinary Research on Climate-Earth System Model-Chemistry), was validated for the first time with respect to background NO2 column densities during summer at Cape Hedo and Fukue in the clean marine atmosphere. </P>

${Co_3}{O_4}$와 ${La_2}{O_3}$ 첨가가 Sr 페라이트의 자기적 특성에 미치는 영향

장세동,김종오,김종희,Jang, Se-Dong,Kim, Chong-O,Kim, Jong-Hui 한국재료학회 2001 한국재료학회지 Vol.11 No.8

Sr 페라이트 자석의 자기적 특성을 향상시키기 위하여 화학량론적 조건인 $SrFe_{ 12}$$O_{19}$ [SrM]에서 $_{11.7}$Co$SrFe_{0.3}$ $O_{19}$[$Co_{0.3}$ -SrM]/ 및 $Sr_{0.7}$ $La_{0.3}$F $e_{11.7}$ $Co_{0.3}$ $O_{19}$ /[(La-Co)$_{0.3}$-SrM] 조성으로 혼합후 공기중 하소를 실시하여 하소분의 특성을 조사하였고, 소결조제와 함께 미분쇄한 후 공기 중에서 소결하여 페라이트 자석을 제조한 후 자기특성 변화를 조사하였다. 화학량론적인 조성에서 (La-Co)$_{0.3}$-SrM 조성으로 원소치환을 실시한 하소분말을 사용하여 제조한 페라이트 자석의 소결특성은 포화자화 ($M_{s}$ ) 71.08 emu/g, 보자력 ($iH_{c}$ ) 4.38 kOe 및 잔류자속밀도 ($B_{r}$ ) 4.18 kG, 보자력 ($iH_{c}$ ) 4.35 kOe, 최대에너지적($BH_{max}$ ) 4.3 MGOe으로 화학량론적인 조건에 비해 B $H_{max}$가 10% 이상 더 큰 자기특성값을 나타내었다.나타내었다.다. We carried out these experiments to examine the effects of element substitution of Co and La-Co for Sr-ferrite. The calcined properties of Co and La-Co element substitution were examined, and also the sintered magnetic properties were measured with the stoichiometric condition. The magnetic properties of $(La-Co)_{0.3}-SrM$ composition are as follows; $(M_s)$: 71.08 emu/g, $iH_c$: 4.38 kOe and $B_r$ : 4.18 kG, $iH_ c$ :4.35 kOe, $BH_{max}$: 4.3 MGOe. The $BH_{max}$ value was increased up to 10 % compared with conventional values. Our results imply that the magnetic properties of Sr-ferrite can be improved by the substitution of those elements.

Differential MicroRNA Expression Profiles in Primary and Recurrent Epithelial Ovarian Cancer

Chong, G. O.,Jeon, H.-S.,Han, H. S.,Son, J. W.,Lee, Y. H.,Hong, D. G.,Lee, Y. S.,Cho, Y. L. Potamitis Press 2015 Anticancer research Vol.35 No.5