Low levels of tissue inhibitor of metalloproteinase-2 at birth may be associated with subsequent development of bronchopulmonary dysplasia in preterm infants

Lee, Choae,An, Jaewoo,Kim, Ji Hee,Kim, Eun Sun,Kim, Soo Hyun,Cho, Yeon Kyung,Cha, Dong Hyun,Han, Man Yong,Lee, Kyu Hyung,Sheen, Youn Ho The Korean Pediatric Society 2015 Clinical and Experimental Pediatrics (CEP) Vol.58 No.11

Purpose: Bronchopulmonary dysplasia (BPD) is characterized by inflammation with proteolytic damage to the lung extracellular matrix. The results from previous studies are inconsistent regarding the role of proteinases and antiproteinases in the development of BPD. The aim of the present study was to investigate whether matrix metalloproteinase (MMP)-8, MMP-9, tissue inhibitor of metalloproteinase (TIMP)-2, and TIMP-1 levels in the serum of preterm infants at birth are related to the development of BPD. Methods: Serum was collected from 62 preterm infants at birth and analyzed for MMP-8, MMP-9, TIMP-2, and TIMP-1 by using enzyme-linked immunosorbent assay. MMPs and TIMPs were compared in BPD (n=24) and no BPD groups (n=38). Clinical predictors of BPD (sex, birth weight, gestational age, etc.) were assessed for both groups. The association between predictors and outcome, BPD, was assessed by using multivariate logistic regression. Results: Sex, birth weight, and mean gestational age were similar between the groups. BPD preterm infants had significantly lower TIMP-2 levels at birth compared with no BPD preterm infants ($138.1{\pm}23.0ng/mL$ vs. $171.8{\pm}44.1ng/mL$, P=0.027). No significant difference was observed in MMP-8, MMP-9, and TIMP-1 levels between the two groups. Multivariate logistic regression analysis indicated that the TIMP-2 levels were predictive of BPD after adjusting for sex, birth weight, gestational age, proteinuric preeclampsia, and intraventricular hemorrhage (${\beta}=-0.063$, P=0.041). Conclusion: Low TIMP-2 serum levels at birth may be associated with the subsequent development of BPD in preterm infants.

연속적 분석법을 통한 어머니와 유아의 상호작용 연구

최진경(Jin Kyong Choae) 한국아동학회 1985 兒童學會誌 Vol.6 No.1

The purpose of this study was the application of sequential analysis to mother-infant interaction data, with particular reference to goodness of fit. The subjects of this study were 22 7- to 16-month-old infants(12 girls and 10 boys) and their mothers. Each mother-infant dyad was videotaped in a 5-min free-play session in the playroom. The videotaped data was transcribed on the behavioral checklist every 3 seconds. The recorded raw data were lagged by one time interval (3 sec.). Transitional probabilities from behavior at time t-1 to behavior at time t were gathered. The statistical analysis of frequency data and transitional probabilities consisted of Z test, t test, and sign test. It was found that regarding 1) direction of effect: the transitional probability of infant vocalization following maternal vocalization was significantly higher than the reverse; the transitional probability of a `Coacting State` following a `Mother Active State` was significantly higher than the reverse; the probability of a `Mother Active State` following `Quiescent State` was significantly higher than that of a `Coacting State` following an `Infant Active State`; 2) sex differences: male infants` transitional probability from an `Infant Active State` to a `Quiescent State` was significantly higher than that of female infants; 3) age differences: more than younger infants older infants had higher transitional probabilities from a `Mother Active State` to a `Coacting State`, from a `Parallel State` to a `Coacting State`, and from a `Quiescent State` to a `Parallel State`. These showed goodness of fit for sex and age differences, particularily for direction of effect.

豆科根瘤菌의 分類에 關한 硏究

崔泰辰 안성산업대학교 1992 論文集 Vol.24 No.-

현재까지 근립형성조사에서 급된 관찰대상식물의 수는 14,000여종의 총두과식물 중에서 불과 1,000 여종(7~8%)에 불과하며 그 공생관계에 관한 연구대상이 된 식물 수는 120여종에 지나지 않는다. 한편 재배식물이 아닌 야생의 열대성두과식물의 방대한 실소고정자원식물에 관한 연구는 거의 방치하고 있는 상태이다. 그러므로 앞으로 이들의 모든 두과식물에서 발견될 많은 종류의 새로운 근립균이 연구될 때에는 표2의 분류법도 재정리되어야 할 것이다.

畓의 透水性과 肥種 및 施肥量과의 關係에 關한 考察

崔泰辰 안성산업대학교 1984 論文集 Vol.16 No.-

1. While growing of rice plant at paddy field, the rice and soil come under the influence of sinking property into the ground of moisture, that is, in case that sinking property is great the consumption of irrigation water as well as the amount of losing nutritive element will be great, the other way, in case that sinking property of moisture is smoll, the soil come to reductive condition, many inhibitory substance such as organic acid or sulfur dihydrate is accumulate and then the inhibitory materials does injure to the rice plant, so that reason, the sinking property of paddy field water need to do such a equvalent situation, do not lean to one side. 2. Therefore, kind of none losing fertilizer such a organic fertilizer or a calcium phosphate fertilizer throw into the fire will be more profitable in the soil of great sinking property of moisture, and in the soil of smoll property of moisture it need to be careful about using of fertilizer such as a inhibitor producing soures like a sulfate fertilizer or a orbanic acid producing sources. 3. In the soil like a feeble sinking property of moisture and producing inhibitor, it will be to use time materials.

배와 포도 栽培에서의 土壤水分量과 植物生育과의 關係

崔泰辰 안성산업대학교 1982 論文集 Vol.14 No.-

이 試驗은 土壤水分量과 배 또는 포도의 生育과의 關係를 調査하기 爲한 것이었으며 그 結果는 다음과 같다. 1. 배의 初期萎凋係數는 有機物 2.3%의 壤土質 土壤에서 7.4%이고 포도는 2.8%이었으며 그 差異는 4.6%로서 배가 乾燥에 弱한데 反하여 포도는 耐乾性이 大端히 强하다. 2. 土壤水分量이 10%일때 배는 完全히 生育이 停止되며 포도는 그보다 낮은 9%에서 生育이 停止된다. 3. 90%以上의 正常生育이 可能한 適正土壤水分量은 배가 28%∼40%로서 그 範圍가 좁고 포도는 22%∼40%로서 그 範圍가 넓다. 4. 正常生育의 限界水分量 以下가 될 때에는 急激한 生育沮害가 일어난다. This experiment was carried out to investigate the correlation between the amount of soil moisture and the plant growth on the culture of pear or grape and then the results was obtained as following summary. 1. The amount of soil moisture at beginning wilting point on loamy soil containing 2.3% of organic matter was 7.4% in pear culture on it was 2.8% in the grape culture and so the gap between the two was 4.6% therefore pear have more good fiting property for soil dryness than grape. 2. Pear grow nothing at all in the soil moisture under 10% and grape was suspended the growth completely at 9% soil moisture. 3. The amount of optimum soil moisture be able to expect the growth above 90% was 28%~40% of close range in the pear culture and it was 22~40% of wide range in the grape culture. 4 In the case of soil dryness below the limit moisture that be able to grow in the normal condition, both the plant (pear and grape) receive critical obstruction of growing.

水稻作에서의 왕겨施肥效果

崔泰辰 안성산업대학교 1985 論文集 Vol.17 No.-

1. 왕겨의 施肥時期는 收穫以後 翌年의 春耕期까지 어느時期에 實施해도 그效果는 같다. 2. 왕겨의 施肥가 分蘗에 미치는 影響과 玄米收量에 미치는 影響으로 보아 그 施肥量은 100kg/10a가 適量인 同時에 施肥限界量이다. 3. 왕겨를 施用할 때는 질소기아현상에 對한 對策으로서 N成分을 2kg/10a程度 이앙후 15 目頃에까지 거름용 追肥로서 浦充하여 玄米收量을 높이도록 하여야 한다. 또한 Eh의 低下현상에 對한 對策으로서 適切한 土壤中 酸素供給方策을 강구하여야 한다. 1. Effect of the rice bran used for the welted rice cultivation nearly equal all the time, whenever it is applied to the paddy field from the harvesting time to the next year's spring plowing season. 2. When 900 Kg/10a of rice bran is manured for the rice welted cultivation, we will produce a good result. Nothing bur on the other hand, it is both vest appropriate amount and critical limiting amount of rice bran fertilization. 3. Therefore the fertilization of rice bran to the welted rice paddy field will bring about the starvation of nitrogen in the soil, it is important thing for the purpose of increased rice yield that the manuring for rice welted cultivarion 2 Kg/10a of nitrogen at fitting time, 15 days after rice seedling transplanting date, and on the other hand it need to take adequate countermeasures for the reduction state of soil.

연령관련황반변성에서 유리체강내 혈관내피성장인자억제제 주입술 후 망막색소상피파열의 위험인자

최우석,박재홍,이우석,김상원,윤희성,Woo Seok Choae,Jae Hong Park,Woo Seok Lee,Sang Won Kim,Hee Seong Yoon 대한안과학회 2013 대한안과학회지 Vol.54 No.10

Purpose: Intravitreal anti-vascular endothelial growth factor (VEGF) treatment has become an important part in the treatment of neovascular age-related macular degeneration (AMD). In the present study we describe the clinical feature of retinal pigment epithelium (RPE) tears after intravitreal injection of anti-VEGF agent and compared the tear group to the control group. Methods: In this retrospective case series, data of 11 patients with eyes that developed RPE tears after intravitreal anti- VEGF injection (8 ranibizumab and 3 bevacizumab) were collected and analyzed. The tear group included 11 patients with eyes that developed RPE tears and the control group included 22 patients with no RPE tears after treatment. We investigated age, gender, bilaterality, duration from injection to tear, pigment epithelial detachment (PED) height and diameter, along with central retinal thickness (CMT) using optical coherence tomography (OCT), fluorescein angiography (FAG), and visual acuities before and after treatment. Results: The mean age of the tear group was 81.36 ± 5.55 years which was significantly different from the control group’s mean age of 74.82 ± 5.28 years (p = 0.003). OCT findings showed PED greatest linear dimension (GLD) was 2978.45 ± 947.69 μm in the tear group and 2250.23 ± 988.49 μm in the control group (p = 0.027). PED height was 507.09 ± 153.97 μm in the tear group and 353.23 ± 199.42 μm in the control group (p = 0.010). CMT was 431.64 ± 200.33 μm in the tear group and 289.95 ± 61.27 μm in the control group (p = 0.005). There was no significant difference between groups according to gender, bilaterality, visual acuities, and subretinal fluid based on OCT and FAG findings. In the tear group, visual acuities before and after the tear were not significantly different. Conclusions: Old age and eyes with high and wide PED appear to be more vulnerable to RPE tear. Further investigation with a larger number of patients is needed to further confirm these results.

논문편 : 사회극적 놀이 경험이 취학전 아동의 언어 발달에 미치는 효과

지혜련,김온기,최진경 ( Helen R . Tieszen,On Gi Kim,Jin Kyong Choae ) 대한가정학회 1984 Human Ecology Research(HER) Vol.22 No.1

연령관련황반변성의 혈관내피성장인자억제제 주사치료 후 발생한 망막색소상피파열의 장기 경과관찰

박재홍,최우석,윤희성,Jae Hong Park,Woo Seok Choae,Hee Seong Yoon 대한안과학회 2014 대한안과학회지 Vol.55 No.9

Purpose: To evaluate the long-term clinical outcomes of retinal pigment epithelium (RPE) tears after intravitreal injection of anti- vascular endothelial growth factor (VEGF) agent for the treatment of neovascular age-related macular degeneration (AMD). Methods: The authors performed a retrospective chart review of 13 eyes of 13 patients who developed RPE tears after intravitreal anti-VEGF injection between February 2009 and June 2013. We investigated continuation of the treatment after tear, visual acuity, presence of cystoid macular edema, and central macular thickness (CMT) using optical coherence tomography (OCT) before and after treatment and visual outcomes depending on foveal sparing. Results: After RPE tear, 12 of 13 patients continued injection of an anti-VEGF agent. The average number of injections was 6.08 ± 5.18. Mean visual acuity immediately after tear was 1.65 ± 0.8 log MAR, and that at the last visit was 1.82 ± 0.88 log MAR. Nine eyes with macular edema in OCT continued receiving injection, and improvement of macular edema was observed in four eyes at the final visit. The final visual acuity of patients with foveal involvement was 2.17 ± 0.49 log MAR, which was worse than the 1.51 ± 1.06 log MAR in patients without foveal involvement, although the difference was not significant (<em>p</em> = 0.295). Conclusions: When anti-VEGF injections were continued after RPE tear, no improvement in visual acuity was observed, although better anatomical outcomes did result. Patients with foveal involvement had worse visual acuity than patients without foveal involvement, but the difference was not significant. J Korean Ophthalmol Soc 2014;55(9):1340-1346

원추각막에서 각막내 링(KeraRing#174;) 삽입술의 임상성적

최성욱,최우석,허준,Sung Wook Choi,MD,Woo Seok Choae,MD,Jun Her,MD 대한안과학회 2011 대한안과학회지 Vol.52 No.3

Purpose: To report the outcomes after the implantation of intrastromal corneal ring segments (KeraRing<sup>®) by manual tunnel creation for the correction of keratoconus. Methods: The present retrospective case series was comprised of 12 eyes of 11 consecutive keratoconic patients. Intrastromal corneal ring segments (KeraRing<sup>®) were implanted for keratoconus correction after manual tunnel creation. Uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), refractive outcome, and complete ophthalmologic examinations were performed before and after surgery at 1 day, 1 week, 3 months, and 6 months. Corneal topography was measured before surgery, 6 months after surgery and during any necessary follow-up visits. Results: Intrastromal corneal ring segments (KeraRing<sup>®) implantation significantly increased BCVA from logMAR 0.47 ± 0.19 to logMAR 0.28 ± 0.17 (p < 0.05) and decreased the spherical equivalent from -6.03 ± 3.24 D to -2.24 ± 1.96 D. The simulated keratometric value in the Orbscan IIz significantly decreased in K maximum from 50.7 ± 2.93D to 47.65 ± 3.15 D and in K minimum from 47.65 ± 3.15 D to 44.92 ± 2.80 D. Conclusions: Intrastromal corneal ring segments implantation (KeraRing<sup>®) by manual tunnel creation appears to be effective in improving BCVA and reducing corneal astigmatism and keratometric value in keratoconic patients. KeraRing<sup>® may delay or prevent the need for a corneal graft, and reduce the contact lens intolerance. J Korean Ophthalmol Soc 2011;52(3):277-284