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Chiranjeevi Kumar Endukuru,Girwar Singh Gaur,Dhanalakshmi Yerrabelli,Jayaprakash Sahoo,Balasubramaniyan Vairappan 대한비만학회 2020 The Korean journal of obesity Vol.29 No.4
Background: Insulin resistance (IR) is a collective clinical entity that exacerbates metabolic syndrome (MetS). As the gold-standard test to quantify IR involves intravenous insulin loading and repeated blood glucose monitoring, many indices have been developed for IR assessment for convenience. This study tested the ideal cut-off values and clinical utility of IR indices in identifying MetS. Methods: We recruited 150 subjects, 75 MetS patients and 75 healthy controls, then obtained written informed consent to participate in this study. We collected fasting blood samples for glucose and lipid profiles and calculated nineteen indices of IR and insulin secretion using validated formulae. We determined the precision of these IR indices using the area under the curve (AUC) in a receiver operating characteristic analysis. Results: Subjects with MetS have significantly higher IR coupled with lower insulin sensitivity and beta-cell function than controls. Among the surrogate markers of IR tested, the homeostatic model assessment of insulin resistance (HOMA-IR), HOMA-adiponectin (HOMA-AD), triglyceride-glucose (TyG) index, HOMA-1%S (insulin sensitivity), quantitative insulin sensitivity check index (QUICKI), McAuley index, single-point insulin sensitivity estimator (SPISE), and HOMA-2%B (beta-cell function) showed the highest AUC values for detecting MetS. Conclusion: Our study results suggest that the ideal cut-off and AUC values identified for HOMA-IR, HOMA-AD, the TyG index, HOMA-1%S, QUICKI, the McAuley index, SPISE, and HOMA-2%B offer a clinical approach to the early detection and risk stratification for MetS among people in southern India.
Endukuru Chiranjeevi Kumar,Girwar Singh Gaur,Dhanalakshmi Yerrabelli,Jayaprakash Sahoo,Balasubramaniyan Vairappan,Alladi Charanraj Goud 대한약리학회 2023 The Korean Journal of Physiology & Pharmacology Vol.27 No.1
Metabolic syndrome (MetS) involves multi-factorial conditions linked to an elevated risk of type 2 diabetes mellitus and cardiovascular disease. Pre-metabolic syndrome (pre-MetS) possesses two MetS components but does not meet the MetS diagnostic criteria. Although cardiac autonomic derangements are evident in MetS, there is little information on their status in pre-MetS subjects. In this study, we sought to examine cardiac autonomic functions in pre-MetS and to determine which MetS component is more responsible for impaired cardiac autonomic functions. A total of 182 subjects were recruited and divided into healthy controls (n=89) and pre-MetS subjects (n=93) based on inclusion and exclusion criteria. We performed biochemical profiles on fasting blood samples to detect pre-MetS. Using standardized protocols, we evaluated anthropometric data, body composition, baroreflex sensitivity (BRS), heart rate variability (HRV), and autonomic function tests (AFTs). We further examined these parameters in pre-MetS subjects for each MetS component. Compared to healthy controls, we observed a significant cardiac autonomic dysfunction (CAD) through reduced BRS, lower overall HRV, and altered AFT parameters in pre-MetS subjects, accompanied by markedly varied anthropometric, clinical and biochemical parameters. Furthermore, all examined BRS, HRV, and AFT parameters exhibited an abnormal trend and significant correlation toward hyperglycemia. This study demonstrates CAD in pre-MetS subjects with reduced BRS, lower overall HRV, and altered AFT parameters. Hyperglycemia was considered an independent determinant of alterations in all the examined BRS, HRV, and AFT parameters. Thus, hyperglycemia may contribute to CAD in pre-MetS subjects before progressing to MetS.
NaOH-활성 플라이애시/슬래그의 반응생성물에 기여하는 플라이애시의 역할
카마사니치란지비레디 ( Kamasani Chiranjeevi Reddy ),박솔뫼 ( Park Solmoi ) 한국구조물진단유지관리공학회 2021 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.25 No.2
The role of fly ash in fly ash/slag blends activated with 1, 3, and 6M NaOH solution is investigated. The compressive strength decreased with an increase of fly ash content in the binder material. C-(A)-S-H is identified as the prominent reaction product. The dissolved Si from fly ash modified C-(A)-S-H structure by incorporating silica into C-(A)-S-H. The silica incorporation increased with an increase in activator molarity and resulted in enhanced strength.
Rainfall induced instability of mechanically stabilized earth embankments
Roy, Debasis,Chiranjeevi, K.,Singh, Raghvendra,Baidya, Dilip K. Techno-Press 2009 Geomechanics & engineering Vol.1 No.3
A 10.4-m high highway embankment retained behind mechanically stabilized earth (MSE) walls is under construction in the northeastern part of the Indian state of Bihar. The structure is constructed with compacted, micaceous, grey, silty sand, reinforced with polyester (PET) geogrids, and faced with reinforced cement concrete fascia panels. The connections between the fascia panels and the geogrids failed on several occasions during the monsoon seasons of 2007 and 2008 following episodes of heavy rainfall, when the embankment was still under construction. However, during these incidents the MSE embankment itself remained by and large stable and the collateral damages were minimal. The observational data during these incidents presented an opportunity to develop and calibrate a simple procedure for estimating rainfall induced pore water pressure development within MSE embankments constructed with backfill materials that do not allow unimpeded seepage. A simple analytical finite element model was developed for the purpose. The modeling results were found to agree with the observational and meteorological records from the site. These results also indicated that the threshold rainwater infiltration flux needed for the development of pore water pressure within an MSE embankment is a monotonically increasing function of the hydraulic conductivity of backfill. Specifically for the MSE embankment upon which this study is based, the analytical results indicated that the instabilities could have been avoided by having in place a chimney drain immediately behind the fascia panels.
Rekha, Dasari,Kumar, Jengiti. Dilip,Jayaraj, Bellum,Lingappa, Y.,Chiranjeevi, Pattium Korean Chemical Society 2007 Bulletin of the Korean Chemical Society Vol.28 No.3
A micro organism Agrobacterium tumifacient as an immobilized cell on a solid support was presented as a new biosorbent in a simple and sensitive spectrophotometry determination of Ni(II) in various samples using 4-hydroxy benzaldehyde-4-bromophenyl hydrazone as a color developing agent (λmax 497 nm) at pH 4.0 ± 0.2. Beer's law was obeyed over the range of 0.01-0.1 μg L-1. The molar absorptivity and Sandell's sensitivity were 1.285 × 105 L mol-1cm-1 and 0.007245 μg cm-2 respectively. Under these conditions, the preconcentration factor obtained was 82, and the detection limit achieved was 0.05 μg L-1. The detailed study of various interfering ions made the method more sensitive and selective. The recovery of Ni(II) from various samples range from 97.75 to 99.35%. The present method was successfully applied for the determination of Ni(II) in spiked, natural water and alloy samples. The proposed method was compared with reported methods in terms of Student's ‘t'-test and Variance ratio ‘f'-test which indicates that there is no significant difference between proposed and literature method at 95% confidence level.
Dasari Rekha,Jengiti. Dilip Kumar,Bellum Jayaraj,Y. Lingappa,Pattium Chiranjeevi* 대한화학회 2007 Bulletin of the Korean Chemical Society Vol.28 No.3
A micro organism Agrobacterium tumifacient as an immobilized cell on a solid support was presented as a new biosorbent in a simple and sensitive spectrophotometry determination of Ni(II) in various samples using 4-hydroxy benzaldehyde-4-bromophenyl hydrazone as a color developing agent (lmax 497 nm) at pH 4.0 0.2. Beers law was obeyed over the range of 0.01-0.1 g L-1. The molar absorptivity and Sandells sensitivity were 1.285 105 L mol-1cm-1 and 0.007245 g cm-2 respectively. Under these conditions, the preconcentration factor obtained was 82, and the detection limit achieved was 0.05 g L-1. The detailed study of various interfering ions made the method more sensitive and selective. The recovery of Ni(II) from various samples range from 97.75 to 99.35%. The present method was successfully applied for the determination of Ni(II) in spiked, natural water and alloy samples. The proposed method was compared with reported methods in terms of Students t-test and Variance ratio f-test which indicates that there is no significant difference between proposed and literature method at 95% confidence level.