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Chintan N Gandhi,R Balaraman 경희대학교 융합한의과학연구소 2009 Oriental Pharmacy and Experimental Medicine Vol.9 No.3
Curcumin (CMN) is known to have beneficial role in anorexia, coryza, cough, diabetic wounds, and hepatic disorders apart from its inherent antioxidant effects. Therefore, the present study was aimed to evaluate antioxidant effect of CMN in prevention of nephrolithiasis in rats-induced by ethylene glycol (EG) and Vitamin D3 (Vit. D3). Male Wistar rats (175 - 200 g) were randomized in groups like control, EG + Vit. D3 induced nephrolithiatiatic rats, CMN treated rats, CMN + EG + Vit. D3 treated rats, Vit. E + EG + Vit. D3 treated rats. Urine was collected weekly throughout the experimental protocol and estimated for calcium oxalate (CaO) count. After completion of experimental protocol serum was estimated for blood urea nitrogen and creatinine. Both the kidneys were excised and used to evaluate levels of biomarkers of oxidative stress and calcium oxalate crystal deposition by histopathological studies. Administration of EG and Vit. D3 to rats resulted in increased oxidative stress, hyperoxaluria and renal deposition of CaO crystals. Supplementation with CMN improves kidney function, reduces elevated oxidative stress, urinary oxalate level and renal deposition of CaO which shows its protective action in nephrolithiasis. The increased deposition of stone in the kidney and stone forming constituents of nephrolithiatic rats were effectively lowered by treatment of CMN. Curcumin (CMN) is known to have beneficial role in anorexia, coryza, cough, diabetic wounds, and hepatic disorders apart from its inherent antioxidant effects. Therefore, the present study was aimed to evaluate antioxidant effect of CMN in prevention of nephrolithiasis in rats-induced by ethylene glycol (EG) and Vitamin D3 (Vit. D3). Male Wistar rats (175 - 200 g) were randomized in groups like control, EG + Vit. D3 induced nephrolithiatiatic rats, CMN treated rats, CMN + EG + Vit. D3 treated rats, Vit. E + EG + Vit. D3 treated rats. Urine was collected weekly throughout the experimental protocol and estimated for calcium oxalate (CaO) count. After completion of experimental protocol serum was estimated for blood urea nitrogen and creatinine. Both the kidneys were excised and used to evaluate levels of biomarkers of oxidative stress and calcium oxalate crystal deposition by histopathological studies. Administration of EG and Vit. D3 to rats resulted in increased oxidative stress, hyperoxaluria and renal deposition of CaO crystals. Supplementation with CMN improves kidney function, reduces elevated oxidative stress, urinary oxalate level and renal deposition of CaO which shows its protective action in nephrolithiasis. The increased deposition of stone in the kidney and stone forming constituents of nephrolithiatic rats were effectively lowered by treatment of CMN.
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Risk based approach for design and optimization of site specific delivery of isoniazid
Chintan Vora,Riddhish Patadia,Karan Mittal,Rajashree Mashru 한국약제학회 2015 Journal of Pharmaceutical Investigation Vol.45 No.2
The research envisaged focuses on risk managementapproach for development and optimization ofenteric coated tablet of isoniazid giving extended release inpH 6.8 phosphate buffer. Risk assessment using failure modeand effects analysis was done to depict the effects ofunambiguous failure modes related to particular formulation/process variable. A 2³ full factorial design wasemployed for optimization of core tablet to investigate effectof amount of Polyox WSR303 (A), hardness (B) and amountof ethyl cellulose (C) on percent drug release in pH 6.8phosphate buffer. Main effects and interaction plots weregenerated to study effects of variables. The selection ofoptimized formulation was done on overlay contour plotsand desirability function. The optimized formulationexhibited percent drug release at first hour of 26.97 %, secondhour of 44.20 %, fourth hour of 66.15 %and eighth hourof 97.9 % in phosphate buffer pH 6.8. Akaike informationcriteria and Model selection criteria revealed that the modelwas best described by Korsmeyer–Peppas power law. TheKopcha and Peppas–Sahlin model revealed diffusion aspredominant mechanism of release which may be due to highsolubility of drug and drug loading. Enteric coating optimizationrevealed weight gain of 10 %w/w as optimum; givingnil release of isoniazid in 0.1 N hydrochloric acid. Thecomposite desirability for optimized formulation computedusing equations and software were 0.91 and 0.90 respectively. Capability analysis on reproducibility batchesrevealed all indices above 1.33 signifying process was withincontrol of producing batches as per desired specifications.
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Hesperidin improves warm ischemia/reperfusion-induced oxidative renal injury in rats
Chintan Gandhi,Rishit Zalawadia,R Balaraman 경희대학교 융합한의과학연구소 2009 Oriental Pharmacy and Experimental Medicine Vol.9 No.4
Ischemia/reperfusion injury, which is commonly seen in the field of renal surgery or transplantation, is a major cause of acute renal failure. Previous studies showed that antioxidant treatments attenuated renal ischemia/reperfusion injury. The objective of this study was to examine the role of hesperidin in modulating reactive oxygen species induced inflammation and apoptosis after renal ischemia/reperfusion injury. Rats were subjected to right nephrectomy, 15 days later 45 min of renal ischemia and 24 h reperfusion with or without treatment with hesperidin. Renal function, inflammation and apoptosis were compared at 24 h after reperfusion injury. Hesperidin improved the renal dysfunction and reduced inflammation and apoptosis after ischemia/reperfusion injury. In conclusion, hesperidin shows potent anti-apoptotic and antiinflammatory properties due to antioxidant property. These findings may have major implications in the treatment of human ischemic acute renal failure. Ischemia/reperfusion injury, which is commonly seen in the field of renal surgery or transplantation, is a major cause of acute renal failure. Previous studies showed that antioxidant treatments attenuated renal ischemia/reperfusion injury. The objective of this study was to examine the role of hesperidin in modulating reactive oxygen species induced inflammation and apoptosis after renal ischemia/reperfusion injury. Rats were subjected to right nephrectomy, 15 days later 45 min of renal ischemia and 24 h reperfusion with or without treatment with hesperidin. Renal function, inflammation and apoptosis were compared at 24 h after reperfusion injury. Hesperidin improved the renal dysfunction and reduced inflammation and apoptosis after ischemia/reperfusion injury. In conclusion, hesperidin shows potent anti-apoptotic and antiinflammatory properties due to antioxidant property. These findings may have major implications in the treatment of human ischemic acute renal failure.
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Hesperidin improves warm ischemia/reperfusion-induced oxidative renal injury in rats
Gandhi, Chintan,Zalawadia, Rishit,Balaraman, R. Kyung Hee Oriental Medicine Research Center 2009 Oriental pharmacy and experimental medicine Vol.9 No.4
Ischemia/reperfusion injury, which is commonly seen in the field of renal surgery or transplantation, is a major cause of acute renal failure. Previous studies showed that antioxidant treatments attenuated renal ischemia/reperfusion injury. The objective of this study was to examine the role of hesperidin in modulating reactive oxygen species induced inflammation and apoptosis after renal ischemia/reperfusion injury. Rats were subjected to right nephrectomy, 15 days later 45 min of renal ischemia and 24 h reperfusion with or without treatment with hesperidin. Renal function, inflammation and apoptosis were compared at 24 h after reperfusion injury. Hesperidin improved the renal dysfunction and reduced inflammation and apoptosis after ischemia/reperfusion injury. In conclusion, hesperidin shows potent anti-apoptotic and antiinflammatory properties due to antioxidant property. These findings may have major implications in the treatment of human ischemic acute renal failure.
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Gandhi, Chintan N,Balaraman, R Kyung Hee Oriental Medicine Research Center 2009 Oriental pharmacy and experimental medicine Vol.9 No.3
Curcumin (CMN) is known to have beneficial role in anorexia, coryza, cough, diabetic wounds, and hepatic disorders apart from its inherent antioxidant effects. Therefore, the present study was aimed to evaluate antioxidant effect of CMN in prevention of nephrolithiasis in rats-induced by ethylene glycol (EG) and Vitamin D3 (Vit. D3). Male Wistar rats (175 - 200 g) were randomized in groups like control, EG + Vit. D3 induced nephrolithiatiatic rats, CMN treated rats, CMN + EG + Vit. D3 treated rats, Vit. E + EG + Vit. D3 treated rats. Urine was collected weekly throughout the experimental protocol and estimated for calcium oxalate (CaO) count. After completion of experimental protocol serum was estimated for blood urea nitrogen and creatinine. Both the kidneys were excised and used to evaluate levels of biomarkers of oxidative stress and calcium oxalate crystal deposition by histopathological studies. Administration of EG and Vit. D3 to rats resulted in increased oxidative stress, hyperoxaluria and renal deposition of CaO crystals. Supplementation with CMN improves kidney function, reduces elevated oxidative stress, urinary oxalate level and renal deposition of CaO which shows its protective action in nephrolithiasis. The increased deposition of stone in the kidney and stone forming constituents of nephrolithiatic rats were effectively lowered by treatment of CMN.
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Pankaj Desai,Chintan Patel,Mayank Kabrawala,Subhash Nandwani,Rajiv Mehta,Ritesh Prajapati,Nisharg Patel,Krishna Parekh 소화기인터벤션의학회 2020 Gastrointestinal Intervention Vol.9 No.3
The coexistence of an esophageal leiomyoma with an achalasia cardia is extremely rare and poses a diagnostic dilemma as the clinical presentation of an esophageal leiomyoma strongly resembles to an achalasia cardia. Moreover, at most of the time, an esophageal leiomyoma exist with absence of leiomyoma specific symptoms or findings. It could be the reason why the diagnosis of esophageal leiomyoma is missed while the patient has the coexistence of the both. Here, we present a case series of an unusual coexistence of an esophageal leiomyoma with achalasia in three patients who were presented with dysphagia and had an initial diagnosis of achalasia. Even endoscopic evaluation couldn’t reveal esophageal leiomyoma; it became apparent during the peroral endoscopic myotomy.
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Rishit, Zalawadia,Chintan, Gandhi,Vaibhav, Patel,Balaraman, R Kyung Hee Oriental Medicine Research Center 2009 Oriental pharmacy and experimental medicine Vol.9 No.1
Allergic conjunctivitis is the most common allergic disease. These diseases are severe & frequent which requires search of new treatments. The aim of the study was to investigate the effects of Tinospora cordifolia (TC), Rubia cordifolia Linn. (RC) on experimentally induced allergic conjunctivitis in rats. In this study, dried water soluble extracts of TC and RC. (250 and 500 mg/kg, p.o. for 7 days) were evaluated for their antiallergic activity in Wistar rats. They were tested for inhibition of egg albumin-induced vascular permeability, inhibition of histamine release from the rat conjunctiva as well as in histamine content in tears. TC and RC showed significant (P < 0.05) inhibition in vascular permeability, inhibition in histamine release from the rat conjunctiva which is reflected by reduced level of histamine content in tears. The activities were found to be comparable to azelastine hydrochloride. These results suggest that the inhibitory effect on egg albumin-induced experimental allergic conjunctivitis in rat may be due to the antihistaminic activity of TC and RC. Our studies provide evidence that TC and RC may be beneficial in the treatment of allergic conjunctivitis.
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Pankaj Desai,Chintan Patel,Mayank Kabrawala,Subhash Nandwani,Rajiv Mehta,Ritesh Prajapati,Nisharg Patel,Krishna Parekh 소화기인터벤션의학회 2020 International journal of gastrointestinal interven Vol.9 No.3
The coexistence of an esophageal leiomyoma with an achalasia cardia is extremely rare and poses a diagnostic dilemma as the clinical presentation of an esophageal leiomyoma strongly resembles to an achalasia cardia. Moreover, at most of the time, an esophageal leiomyoma exist with absence of leiomyoma specific symptoms or findings. It could be the reason why the diagnosis of esophageal leiomyoma is missed while the patient has the coexistence of the both. Here, we present a case series of an unusual coexistence of an esophageal leiomyoma with achalasia in three patients who were presented with dysphagia and had an initial diagnosis of achalasia. Even endoscopic evaluation couldn’t reveal esophageal leiomyoma; it became apparent during the peroral endoscopic myotomy.
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Singh Dharmendra,Nanda Chintan,Dahiya Meenakshi 대한공간정보학회 2022 Spatial Information Research Vol.30 No.2
COVID-19 driven lockdown has affected air quality worldwide. Changes in air pollutants concentration, Air Quality Index (AQI), and associated Excess Health Risk (ER%) were assessed using satellite data of before (2019), and during (2020) COVID-19 periods in the industrially, agriculturally developed and highly populated area of Haryana in the northern region of Indo-Gangetic Plains. Parameters such as Aerosol Optical Depth (AOD), Particulate matters (PM), Sulphur Di-Oxide (SO2), Nitrogen Di-Oxide (NO2), Carbon Mono-oxide (CO), and Methane (CH4) were derived using satellite data and validated using ground-based observations (n = 23). The coefficient of correlation (r) 0.91, 0.90, 0.95, 0.73, 0.81 and 0.80 were established with AOD, PM2.5, PM10, SO2, NO2 and CO, respectively. Significant reduction (p\0.005) in the concentration of air pollutants, viz. 38% in AOD, 55% in PM2.5, 61% in PM10, 31% in SO2, 10% in NO2, 5% in CO and 1% in CH4 were observed during lockdown. Significant (p\0.00) improvement in air quality was observed due to a 44% reduction in pollution level, which led to the reduction in ER% by 71%, which is quite significant. AQI and ER% from satellite and ground showed a high r2 i.e. 0.88 and 0.99 respectively, suggesting the potential application of satellite data for periodic AQI and ER% assessment.
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