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Chien-Tai Hong,Lung Chan,Chaur-Jong Hu,Chien-Min Lin,Chien-Yeh Hsu,Ming-Chin Lin 한국유방암학회 2017 Journal of breast cancer Vol.20 No.4
Purpose: Whether tamoxifen affects the risk of neurodegenerative disease is controversial. This nationwide population-based study investigated the risk of Parkinson’s disease (PD) associated with tamoxifen treatment in female patients with breast cancer using Taiwan’s National Health Insurance Research Database. Methods: A total of 5,185 and 5,592 female patients with breast cancer who did and did not, respectively, receive tamoxifen treatment between 2000 and 2009 were included in the study. Patients who subsequently developed PD were identified. A Cox proportional hazards model was used to compare the risk of PD between the aforementioned groups. Results: Tamoxifen did not significantly increase the crude rate of developing PD in female patients with breast cancer (tamoxifen group, 16/5,169; non-tamoxifen group, 11/5,581; p=0.246). Tamoxifen did not significantly increase the adjusted hazard ratio (aHR) for subsequently developing PD (aHR, 1.310; 95% confidence interval [CI], 0.605–2.837; p= 0.494). However, tamoxifen significantly increased the risk of PD among patients followed up for more than 6 years (aHR, 2.435; 95% CI, 1.008–5.882; p=0.048). Conclusion: Tamoxifen treatment may increase the risk of PD in Taiwanese female patients with breast cancer more than 6 years after the initiation of treatment.
Chien-Yeh Ho,Chien-Ming Wang,Chang-Hua Lin 전력전자학회 2011 ICPE(ISPE)논문집 Vol.2011 No.5
This paper proposes a novel multi-phase PWM dimming control scheme which possesses two-phase, four-phase, six-phase, and eight-phase for backlight inverter. Each phase driving circuit can control the lamp current of two ccfls at least. From the experimental results for four-phase and six-phase PWM dimming control, we got a conclusion which power efficiency η (%) is directly proportional to No. of phases and lamp current error E (%) is inversely proportional to No. of phases. Hence higher phases dimming will achieve uniform output lamp currents which is called current equalization. We develop a design rule which compare system parameters in multi-phase dimming control for backlight inverter. We conclude that the experimental results also can apply for two-phase and eight-phase PWM dimming control.
Modeling strength of high-performance concrete using genetic operation trees with pruning techniques
Chien-Hua Peng,I-Cheng Yeh,Li-Chuan Lien 사단법인 한국계산역학회 2009 Computers and Concrete, An International Journal Vol.6 No.3
Regression analysis (RA) can establish an explicit formula to predict the strength of High-Performance Concrete (HPC); however, the accuracy of the formula is poor. Back-Propagation Networks (BPNs) can establish a highly accurate model to predict the strength of HPC, but cannot generate an explicit formula. Genetic Operation Trees (GOTs) can establish an explicit formula to predict the strength of HPC that achieves a level of accuracy in between the two aforementioned approaches. Although GOT can produce an explicit formula but the formula is often too complicated so that unable to explain the substantial meaning of the formula. This study developed a Backward Pruning Technique (BPT) to simplify the complexity of GOT formula by replacing each variable of the tip node of operation tree with the median of the variable in the training dataset belonging to the node, and then pruning the node with the most accurate test dataset. Such pruning reduces formula complexity while maintaining the accuracy. 404 experimental datasets were used to compare accuracy and complexity of three model building techniques, RA, BPN and GOT. Results show that the pruned GOT can generate simple and accurate formula for predicting the strength of HPC.
The Performance Study of a Virtualized Multicore Web System
( Chien-te Lu ),( C. -s. Eugene Yeh ),( Yung-chung Wang ),( Chu-sing Yang ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.11
Enhancing the performance of computing systems has been an important topic since the invention of computers. The leading-edge technologies of multicore and virtualization dramatically influence the development of current IT systems. We study performance attributes of response time (RT), throughput, efficiency, and scalability of a virtualized Web system running on a multicore server. We build virtual machines (VMs) for a Web application, and use distributed stress tests to measure RTs and throughputs under varied combinations of virtual cores (VCs) and VM instances. Their gains, efficiencies and scalabilities are also computed and compared. Our experimental and analytic results indicate: 1) A system can perform and scale much better by adopting multiple single-VC VMs than by single multiple-VC VM. 2) The system capacity gain is proportional to the number of VM instances run, but not proportional to the number of VCs allocated in a VM. 3) A system with more VMs or VCs has higher physical CPU utilization, but lower vCPU utilization. 4) The maximum throughput gain is less than VM or VC gain. 5) Per-core computing efficiency does not correlate to the quality of VCs or VMs employed. The outcomes can provide valuable guidelines for selecting instance types provided by public Cloud providers and load balancing planning for Web systems.
Conjugation of mono-sulfobetaine to alkyne-PPX films via click reaction to reduce cell adhesion
Chien, Hsiu-Wen,Keng, Ming-Chun,Chen, Hsien-Yeh,Huang, Sheng-Tung,Tsai, Wei-Bor Techno-Press 2016 Biomaterials and biomedical engineering Vol.3 No.1
A surface resisting protein adsorption and cell adhesion is highly desirable for many biomedical applications such as diagnostic devices, biosensors and blood-contacting devices. In this study, a surface conjugated with sulfobetaine molecules was fabricated via the click reaction for the anti-fouling purpose. An alkyne-containing substrate (Alkyne-PPX) was generated by chemical vapor deposition of 4-ethynyl-[2,2]paracyclophane. Azide-ended mono-sulfobetaine molecules were synthesized and then conjugated on Alkyne-PPX via the click reaction. The protein adsorption from 10% serum was reduced by 57%, while the attachment of L929 cells was reduced by 83% onto the sulfobetaine-PPX surface compared to the protein adsorption and cell adhesion on Alkyne-PPX. In conclusion, we demonstrate that conjugation of mono-sulfobetaine molecules via the click chemistry is an effective way for reduction of non-specific protein adsorption and cell attachment.
Thyroid fine-needle aspiration cytology in Taiwan: a nationwide survey and literature update
Chien-Chin Chen,Jen-Fan Hang,Chih-Yi Liu,Yeh-Han Wang,Chiung-Ru Lai 대한병리학회 2020 Journal of Pathology and Translational Medicine Vol.54 No.5
In Taiwan, thyroid fine-needle aspiration cytology is easily accessible and reliable for evaluating thyroid nodules. The sonographic pattern plays a major role and is the deciding factor for aspiration. We conducted a nationwide survey in 2017 and it revealed that 31% of laboratories had adopted The Bethesda System for Reporting Thyroid Cytopathology. There was a relatively high unsatisfactory rate (24.04%) and low rates of indeterminate diagnoses, including atypia of undetermined significance/follicular lesions of undetermined significance: 4.87%, and follicular neoplasm/suspicious for a follicular neoplasm: 0.35%. Moreover, the risks of malignancy in benign, atypia of undetermined significance, and suspicious for a follicular neoplasm were relatively high. These may reflect strict diagnostic criteria for indeterminate categories and better patient selection for surgery. Improvements in specimen sampling and continuing education programs are crucial. Newly-developed thyroid cytology technologies, such as immunocytochemistry, molecular testing, and computerized cytomorphometry, may further facilitate cytology diagnoses.
Conjugation of mono-sulfobetaine to alkyne-PPX films via click reaction to reduce cell adhesion
Chien, Hsiu-Wen,Keng, Ming-Chun,Chen, Hsien-Yeh,Huang, Sheng-Tung,Tsai, Wei-Bor Techno-Press 2016 Biomaterials and Biomechanics in Bioengineering Vol.3 No.1
A surface resisting protein adsorption and cell adhesion is highly desirable for many biomedical applications such as diagnostic devices, biosensors and blood-contacting devices. In this study, a surface conjugated with sulfobetaine molecules was fabricated via the click reaction for the anti-fouling purpose. An alkyne-containing substrate (Alkyne-PPX) was generated by chemical vapor deposition of 4-ethynyl-[2,2]paracyclophane. Azide-ended mono-sulfobetaine molecules were synthesized and then conjugated on Alkyne-PPX via the click reaction. The protein adsorption from 10% serum was reduced by 57%, while the attachment of L929 cells was reduced by 83% onto the sulfobetaine-PPX surface compared to the protein adsorption and cell adhesion on Alkyne-PPX. In conclusion, we demonstrate that conjugation of mono-sulfobetaine molecules via the click chemistry is an effective way for reduction of non-specific protein adsorption and cell attachment.
Chu-Yeh Tien,Ping-Yu Kuei,Liann-Be Chang,Chien-Pin Hsu 대한전기학회 2015 Journal of Electrical Engineering & Technology Vol.10 No.4
The performance of the AlGaN/GaN MSM-2DEG varactor with different dielectric films deposited by the E-beam deposition is investigated in detail. The capacitance swing and the capacitance ratio of the varactor without dielectric film as well as with, SiO2, Gd2O3, and Si3N4 films, respectively, are determined by electrodes of varying areas. The maximum capacitance, the minimum capacitance and the capacitance ratios are proportional to the increasing of the electrode areas. The capacitance ratio determined by the maximum and the minimum capacitance is found to be 18.35 (with Si3N4 dielectric film) and 149.51 (without dielectric film), respectively. The transition voltages of the fabricated varactors are almost the same for a bias voltage of about ±5 V and leakage current can be lower three orders of magnitude while the varactors with dielectric films. The tunability of the capacitance ratio makes the AlGaN/GaN MSM-2DEG varactor with a dielectric film highly useful in multirange applications of a surge free preamplier.
Tien, Chu-Yeh,Kuei, Ping-Yu,Chang, Liann-Be,Hsu, Chien-Pin The Korean Institute of Electrical Engineers 2015 Journal of Electrical Engineering & Technology Vol.10 No.4
The performance of the AlGaN/GaN MSM-2DEG varactor with different dielectric films deposited by the E-beam deposition is investigated in detail. The capacitance swing and the capacitance ratio of the varactor without dielectric film as well as with, SiO<sub>2</sub>, Gd<sub>2</sub>O<sub>3</sub>, and Si<sub>3</sub>N<sub>4</sub> films, respectively, are determined by electrodes of varying areas. The maximum capacitance, the minimum capacitance and the capacitance ratios are proportional to the increasing of the electrode areas. The capacitance ratio determined by the maximum and the minimum capacitance is found to be 18.35 (with Si<sub>3</sub>N<sub>4</sub> dielectric film) and 149.51 (without dielectric film), respectively. The transition voltages of the fabricated varactors are almost the same for a bias voltage of about ±5 V and leakage current can be lower three orders of magnitude while the varactors with dielectric films. The tunability of the capacitance ratio makes the AlGaN/GaN MSM-2DEG varactor with a dielectric film highly useful in multirange applications of a surge free preamplier.