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An Jen Chiang,Min-Yu Chen,Chia-Sui Weng,Hao Lin,Chien-Hsing Lu,Peng-Hui Wang,Yu-Fang Huang,Ying-Cheng Chiang,Mu-Hsien Yu,Chih-Long Chang 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.5
Objective: The malignant transformation (MT) of ovarian mature cystic teratoma (MCT)to squamous cell carcinoma (SCC) is very rare. This study analyzed cases from multiplemedical centers in Taiwan to investigate the clinicopathologic characteristics, treatment, andprognostic factors of this disease and reviewed related literature. Methods: Pathological reports of 16,001 patients with primary ovarian cancer who weretreated at Taiwan medical centers from 1990 to 2011 were reviewed. In total, 52 patients withMT of MCT to SCC were identified. Results: Among all ovarian MCTs, the incidence of MT to SCC is 0.2%. The median age ofpatients was 52 years (range, 29–89 years), and the mean tumor size was 10.5 cm (range, 1–40cm). We analyzed the patients in our study and those in the literature and determined thatearly identification and complete surgical resection of the tumor are essential for long-termsurvival. In addition, adjuvant chemotherapy or concurrent chemoradiotherapy can be usedto treat this malignancy. Old age, large tumor size (≥15.0 cm), and solid components in MCTsare suitable indicators predicting the risk of MT of MCT to SCC. Conclusion: Similar to general epithelial ovarian cancers, the early detection of MT of MCTto SCC is critical to long-term survival. Therefore, older patients with a large tumor or those with a tumor containing a solid component in a clinically diagnosed MCT should beevaluated to exclude potential MT to SCC.
Che-Chao Chiang,Min-chi Chang,Po-Tsang Chen,Fu-Ming Chiang 세계문화관광학회 2010 Conference Proceedings Vol.11 No.0
This study examines the information searching of business travelers and their behavior based on the cultural differences. Despite growing academic interest in business travel i n recent years, there has been little investigation of the information search behaviors of business travelers in a cross-culture context. The above themes are rational assumed that information search behaviour are necessary to understand. To address the identified gap s in the literature, the proposed relationships are examined and presented through using chi-square method with a survey sample. The research sample included Japanese, English and Chinese business travellers. A self-administrated questionnaire was distributed to 211 business travelers attending international conventions in Taipei. The research findings reveal that information preferences of business travelers are significantly differed from the three recognized groups in the case of Taiwan. Some significant differences in information search behaviors were recognized amongst the three recognized respondent groups. Marketing implications were also proposed and presented.
Ying-Cheng Chiang,Chi-An Chen,Chun-Ju Chiang,Tsui-Hsia Hsu,Ming-Chieh Lin,San-Lin You,Wen-Fang Cheng,Mei-Shu Lai 대한부인종양학회 2013 Journal of Gynecologic Oncology Vol.24 No.4
Objective: To investigate the changes of incidence and prognosis of epithelial ovarian cancer in thirty years in Taiwan. Methods: The databases of women with epithelial ovarian cancer during the period from 1979 to 2008 were retrieved from the National Cancer Registration System of Taiwan. The incidence and prognosis of these patients were analyzed. Results: Totally 9,491 patients were included in the study. The age-adjusted incidences of epithelial ovarian cancer were 1.01, 1.37, 2.37, 3.24, 4.18, and 6.33 per 100,000 person-years, respectively, in every 5-year period from 1979 to 2008. The age-specific incidence rates increased especially in serous, endometrioid and clear cell carcinoma, and the age of diagnosis decreased from sixty to fifty years old in the three decades. Patients with mucinous, endometrioid, or clear cell carcinoma had better long-term survival than patients with serous carcinoma (log rank test, p<0.001). Patients with undifferentiated carcinoma or carcinosarcoma had poorer survival than those with serous carcinoma (log rank test, p<0.001). The mortality risk of age at diagnosis of 30-39 was significantly higher than that of age of 70 years or more (test for trend, p<0.001). The mortality risk decreased from the period of 1996-1999 (hazard ratio [HR], 0.90; p=0.054) to the period after 2000 (HR, 0.74; p<0.001) as compared with that from the period of 1991-1995. Conclusion: An increasing incidence and decreasing age of diagnosis in epithelial ovarian cancer patients were noted. Histological type, age of diagnosis, and treatment period were important prognostic factors for epithelial ovarian carcinoma.
Chiang Chenwei,Anak Agung Gede Dharma,Kiyoshi Tomimatsu 한국멀티미디어학회 2011 한국멀티미디어학회 국제학술대회 Vol.2011 No.-
In this paper, we propose a new interaction method system which utilizes mobile application and social media. At present, a new digital service, which is called Social Networking Service (SNS), is emerging and gradually become worldwide phenomenon. SNS has been proven to affects habitual pattern of internet users, as well as influenced their daily lives. Based on those facts, we propose a framework to utilize SNS possibilities in the form of a mobile application. In order to describe the framework, we describe two case studies that explain possible alternatives for utilizing social networking service. The first case consists of a mobile application that integrates SNS messages to promote positive habits. The other one is a new communication tool that combines augmented reality (AR) technology, SNS, and mobile device. Furthermore, through those cases we discovered a new way to communicate and interact through SNS. Our findings suggest that SNS has profound possibilities to be used as an innovative communication tool. In particular, by combining latest technologies and analyzing inherent mental models we can conclude that our study has explored an alternative way to unleash one of the SNS’ potentials.
A simple model for explaining muon-related anomalies and dark matter
Chiang, Cheng-Wei,Okada, Hiroshi World Scientific Publishing 2019 International Journal of Modern Physics A Vol.34 No.20
<P>We propose a model to explain several muon-related experimental anomalies and the abundance of dark matter. We introduce a vector-like exotic lepton that form an iso-doublet and three right-handed Majorana fermions as an iso-singlet. A real/complex scalar field is added as a dark matter candidate. We impose a global <TEX>$ U(1)_{\mu }$</TEX> symmetry under which fields associated with the SM muon are charged. To stabilize the dark matter, we impose a <TEX>$ Z_{2}$</TEX> (or <TEX>$ Z_{3}$</TEX>) symmetry under which the exotic lepton doublet and the real (or complex) scalar field are charged. We find that the model can simultaneously explain the muon anomalous magnetic dipole moment and the dark matter relic density in no conflict with any lepton flavor-violating/conserving observables, with some details depending upon whether the scalar field is real or complex. Besides, we extend the framework to the quark sector in a way similar to the lepton sector, and find that the recent anomalies associated with the <TEX>$ b \rightarrow s\mu ^{+}\mu ^{-}$</TEX> transition can also be accommodated while satisfying constraints such as the <TEX>$ B_{s(d)} \rightarrow \mu ^{+}\mu ^{-}$</TEX> decays and neutral meson mixings.</P>
Chiang, Chien-Sung,Huang, Ching-Hui,Chieng, Hockling,Chang, Ya-Ting,Chang, Dory,Chen, Ji-Jr,Chen, Yong-Cyuan,Chen, Yen-Hui,Shin, Hee-Sup,Campbell, Kevin P.,Chen, Chien-Chang Ovid Technologies Wolters Kluwer -American Heart A 2009 Circulation research Vol.104 No.4
<P>Voltage-gated T-type Ca(2+) channels (T-channels) are normally expressed during embryonic development in ventricular myocytes but are undetectable in adult ventricular myocytes. Interestingly, T-channels are reexpressed in hypertrophied or failing hearts. It is unclear whether T-channels play a role in the pathogenesis of cardiomyopathy and what the mechanism might be. Here we show that the alpha(1H) voltage-gated T-type Ca(2+) channel (Ca(v)3.2) is involved in the pathogenesis of cardiac hypertrophy via the activation of calcineurin/nuclear factor of activated T cells (NFAT) pathway. Specifically, pressure overload-induced hypertrophy was severely suppressed in mice deficient for Ca(v)3.2 (Ca(v)3.2(-/-)) but not in mice deficient for Ca(v)3.1 (Ca(v)3.1(-/-)). Angiotensin II-induced cardiac hypertrophy was also suppressed in Ca(v)3.2(-/-) mice. Consistent with these findings, cultured neonatal myocytes isolated from Ca(v)3.2(-/-) mice fail to respond hypertrophic stimulation by treatment with angiotensin II. Together, these results demonstrate the importance of Ca(v)3.2 in the development of cardiac hypertrophy both in vitro and in vivo. To test whether Ca(v)3.2 mediates the hypertrophic response through the calcineurin/NFAT pathway, we generated Ca(v)3.2(-/-), NFAT-luciferase reporter mice and showed that NFAT-luciferase reporter activity failed to increase after pressure overload in the Ca(v)3.2(-/-)/NFAT-Luc mice. Our results provide strong genetic evidence that Ca(v)3.2 indeed plays a pivotal role in the induction of calcineurin/NFAT hypertrophic signaling and is crucial for the activation of pathological cardiac hypertrophy.</P>
Chiang-Soon Song,Jae-Heon Lim,Byeong-Hyeon Jeon,Hye-Sun Lee 대한고유수용성신경근촉진법학회 2019 PNF and Movement Vol.17 No.2
Purpose: The purpose of this study was to evaluate the effects of a virtual upper extremity training program using the RAPAEL Smart Glove on upper extremity function in stroke survivors with chronic hemiparesis and to focus the training program development using the Smart Glove as a feasibility study. Methods: This study was conducted using a single group and pre-post test research design in the outpatient departments of local rehabilitation units. Ten chronic hemiparetic stroke survivors with a diagnosis of first stroke received therapeutic rehabilitation at the rehabilitation units. All the participants used a virtual reality program with the RAPAEL Smart Glove for 30 minutes per session 3 days a week over 8 weeks. They also received conventional occupational therapy with functional electrical stimulation for 40 minutes per session 3 days a week for 8 weeks as an additional therapy. To analyze the effects of this therapeutic intervention, four clinical measures, including the box-block test (BBT), the Wolf motor function test (WMFT), the trail-making score, the Jebsen Taylor hand function test (JTHFT), and grip strength, were used. Results: Upon completion of the intervention in week 8, all the participants demonstrated significant WMFT, JTT, BBT, grip strength, and trail-making score gains compared to the respective baselines at week 0. Conclusion: This study suggests that virtual upper extremity training using the RAPAEL Smart Glove has a reasonable and beneficial effects on upper extremity function in chronic hemiparetic stroke survivors.
Chiang, Michael H. 성균관대학교 동아시아학술원 2013 Sungkyun Journal of East Asian Studies Vol.13 No.1
the Yongzheng Emperor's attempts to inculcate proper political behavior and bureaucratic accountability. The essay begins with a brief discussion of the state of affairs in Fujian and Taiwan under officials appointed by the Kangxi Emperor. It then turns to the Yongzheng Emperor's efforts to revitalize what he perceived to be a moribund bureaucracy in the region through the pursuit of a case of corruption. The trial that resulted from a censor's accusation revealed a complex web of patronage, manipulation, malfeasance, and mutual recrimination among officials and provides us a glimpse into the workings of Qing field administration under pressure from a reformist emperor. The corruption case in Taiwan was important to the emperor not on its own merits, but as an object lesson in proper political behavior and bureaucratic accountability.
Chiang, Cheng-Wei,Senaha, Eibun North-Holland Pub. Co 2017 Physics letters. Section B Vol.774 No.-
<P><B>Abstract</B></P> <P>We study gauge dependence of gravitational waves produced from a first-order phase transition in classical scale-invariant U <SUP> ( 1 ) ′ </SUP> models. Accidental gauge independence of the one-loop effective potential in this class of models is spoiled by including thermal resummation. The gauge artifact in the resummed effective potential propagates to the gravitational wave spectrum and results in one order of magnitude uncertainties in the prediction under a specific gauge choice.</P>