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      • 난소에 전이된 간세포암 1예

        박용관,박치영,조은택,조기섭,박찬국,송창훈,이미자,기근홍 朝鮮大學校 附設 醫學硏究所 1995 The Medical Journal of Chosun University Vol.20 No.2

        Hepatocellular carcinoma frequently metastasizes through direct extension, lymphatic, and hematogenous routes. The most common sites of metastasis are the lungs and the lymph nodes, glands, bones, spleen, kidneys, colon, and pleura are the sites of metastasis in decreasing order of frequency. But metastasis to the ovary is very rare. It is thought that metastasize to the ovary occurs through infiltration or dissemination. However, we observed ovarian metastasis of primary hepatic tumor in a 34-year old female who suffered from lower abdominal pain. At first, it was diagnosed as a primary ovarian tumor. But histologically, it presented sinusoidal pattern surrounded by the tumor cells and contained rounded by the tumor cells and contained round hyaline globules in minority of the cytoplasm. Then, the histologic features of percutaneous, sono-guided liver biopsy speecimen of the liver mass are similar to those of resected ovarian tissues. Therefore, we concluded that ovarian tumor was originated from hepatocellular carcinoma. In summary, this report examines a case of hepatocellular carcinoma with ovarian metastasis in a female and reviews the literature.

      • 서해산 돌가자미 Kareius bicoloratus의 초기발생시 수온과 염분의 영향

        전제천,김치홍,정의영,이창훈,김병균 한국어류학회 2002 韓國魚類學會誌 Vol.14 No.3

        본 연구는 돌 가자미(Kareius bicoloratus)의 난발생에 미치는 수온과 염분의 영향을 알아보지 위하여 수행되었다. 5단계의 수온 조건 (7, 10, 13, 16 및 19℃) 및 5단계의 염분 조건(25, 30, 35, 40psu 및 현장해수 염분 : 33.6psu)에서 수정란을 발생시켜 발생 속도와 부화율 측정하였다. 수정란의 발생속도는 수온이 높을수록 빨랐으며, 수온(T: ℃)과 각 발생 단계별 소요시간(h:hour) 사이의 관계를 직선 함수에 회귀시켰을 때 각 발생단계별 관계식은 다음과 같다. 8세포기 : 1/h = 0.01441T - 0.02728(r^(2) = 0.998) 낭배기 : 1/h = 0.00269T - 0.00319(r^(2) = 0.997) 안포형성기 : 1/h = 0.00171T - 0.00053(r^(2) = 0.998) 심장형성기 : 1/h = 0.00121T - 0.00018(r^(2) = 0.995) 부화기 : 1/h = 0.00101T - 0.00266)(r^(2) = 0.998) 이상의 관계식으로부터 추정된 돌 가자미의 난 발생이 개시되는 생물학적 영도는 1.3℃이었다. 8세포기, 낭배기, 안포형성기. 심장형성기 및 부화기까지의 적산수온은 각각 72.9, 356.7, 525.8, 735.2 및 1156.7℃로 계산되었다. 수온은 부화율에 큰 영향을 미치는 것으로 나타났다(p<0.001). 부화율이 수온이 증가할수록 감소하였으며, 7℃일 때 부화율이 62.0%로 가장 높았다. 수온이 16℃ 이상일 때 기형어의 출현율이 증가하였다(p<0.05). 염분 또는 부화율에 큰 영향을 미치고 있었다(p<0.001). 염분에 따른 부화율은 자연해수의 염분인 33.6psu에서 54.1%로 가장 높았고, 이보다 낮거나 높은 경우에는 부화율이 감소하였다. 특히, 염분이 30psu 미만으로 감소할 경우 기형어의 출현율 증가하였다(p<0.04). 돌 가자미의 난 발생 및 정상적인 부화를 위한 조건은 산란시기의 수온과 염분에 가까울수로고 좋은 것으로 판단된다. This study was conducted to determine the influences of water temperature and salinity on the embryonic development of the stone flounder, Kareius bicoloratus as a part of research on the artificial seedling production of the fish. Embryos were incubated under five different temperatures (7, 10, 13, 16 and 19℃) and five different salinities (25, 30, 35, 40 psu and the ambient salinity: 33.6 psu) until they hatched. The required times for embryonic development decreased with increase of water temperature. The relationships between the water temperature (T: ℃) and required times (h: hour) for the embryo to attain each develop-mental stage were obtained by linear regressions as follows; 8-cell stage : l/h = 0.01441T-0.02728 (r² = 0.998) 50%-epiboly stage : Uh = 0.00269T-0.00319 (r² = 0.997) Optic vesicle formation stage : l/h = 0.00171T-0.00053 (r² = 0.998) Heart formation stage : l/h = 0.00121T-0.00018 (r² = 0.995) Hatching stage : l/h = 0.00101T-0.00266 (r²= 0.998) From these equations, the biological minimum temperature for embryonic development of K. bicoloratus was estimated to be 1.3℃. Cumulative water temperatures to reach 8-cell stage, 50%-epiboly stage, optic vesicle formation stage, hearth formation stage, and hatching stage were 72.9, 356.7, 525.8, 735.2, and 1,156.7℃, respectively. Water temperature affected significantly the hatching rate (p< 0.001). The hatching rate decreased with increase of water temperature. The highest hatching rate was 62.0% at 7℃. When the water temperature was higher than 16℃, the proportion of abnormal larvae increased (p < 0.05). Salinity also affected significantly the hatching rate (p< 0.001). The highest hatching rate was 54.1% at the salinity (33.6 psu) of ambient seawater. When the salinity was lower than 30 psu, the proportion of abnormal larvae increased ip < 0.05).

      • 폐정맥 부분이상환류 개심술 : A Case Report of Open Heart Surgery

        노준량,최지원,이영균 최신의학사 1969 最新醫學 Vol.12 No.10

        A case of partial anomalous pulmonary venous drainage in a :ten years old Korean girl was treated surgically. The preoperative diagnosis by right heart catheterization was atrial septal defect. The operation was carried out under utilizing Rygg-Kyvsgaard bag oxygenator, when right superior and inferior pulmonary veins entering directly into right atrium near the atrial septal defect were found. The anomalously drained pulmonary veins were successfully diverted into left atrium with an Ivalon patch graft in addition to septal defect closure. She enjoyed her normal life without any symptom for these thirteen months postoperatively.

      • KCI등재

        유기용제에 장기간 폭로된 근로자의 정신의학적 기능과 삶의 질

        김석재,강순아,유지숙,국승희,윤진상,문재동,이형영 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.5

        연구목적: 본 연구는 Y공단의 제조공정에서 저농도의 유기용제(solvent)에 장기간 노출된 근로자의 정신의학적 기능과 삶의 질을 평가하고자 하였다. 방법: 총 142명의 남성근로자 중 유기용제에 폭로된 군(이하 폭로군) 82명과 폭로되지 않는 군(이하 비폭로군) 60명에게 간이정신진단검사(Symptom Checklist-90-R, SCL-90-R), 인지 및 정신운동성검사 (Critical Flicker Fusion Threshold. CFFT; Choice Reaction Time, CRT;Compensatory Tracking Task, CTT;Digit-Symbol Substitution, DDS) 및 한국판 스미스클라인 비챰 삶의 질 척도(Korean version of the SmithKline Beecham 'Quality of Life' Scale, KvSBQOL) 등을 적용하였다. 두 군간의 비교는 평가치의 평균에 대해 t-검증을 하였고 또한 연령과 학력을 공변인으로한 공변량분석(ANCOVA)을 하였다. 결과: SCL-90-R의 9개 증상 차원과 3개 전체 지표 점수는 두 군이 각각 정상범위였다. 그러나 신체화 (Somatization, SOM), 우울(Depression, DEP), 적대감(Hostility, HOS), 공포불안(Phobic anx-iety, PHOB)의 증상차원과 전체심도지수(Global Severity Index, GSI), 표출증상합계(Positive Symptom Total, PST)의 전체 지표는 폭로군이 비폭로군보다 유의하게 높았다. 인지 및 정신운동성 검사와 삶의 질은 두 군간에 유의한 차이는 없었다. 결론: 이상의 결과는 유기용제가 허용치 이하일지라도 장기간 폭로되는 경우에는 정신의학적 문제를 다소 일으킬 수 있음을 시사하였다. 중심단어:유기용제·근로자·정신건강·정신운동성 기능·삶의 질. Objectives: The aim of this study was to evaluate the psychiatric function and quality of life of the chemical workers who had been exposed to long-term, low-level organic solvents in the Y industrial complex. Method: A total of 144 male workers, of whom 82 were in the exposed group and 60 in the unexposed-control group, were evaluated by using Symptom Checklist-90-R(SCL-90-R), series of neuropsychological tests(critical flicker fusion threshold, CFFT) ; choice reaction time, CRT ; compensatory tracking task, CTT) ; digit symbol substitution test, DSS), and the Korean version of the SmithKline Beecham Quality Of Life scale(KvSBQOL). For the statistical analyses, comparisons of the means of the two groups were performed for each variable with two-tailed t-test as well as ANCOVA including age and education as covariates. Results: For the SCL-90-R, the nine symptom scales and the three global indices were clinically within normal range in both groups. However, the scores on the symptom scales of 'somatization','depression','hostility' and 'phobic anxiety', and those on the global indices of 'global severity index' and 'positive symptom total', were significantly higher in the exposed group than in the unexposed group. In terms of the neuropsychological function and the quality of life, there wes no significant difference between the two groups. Conclusion: These findings suggested that the long-term eposure to mixed organic solvents, even at the low level below the permissible exposure limit, might induce some psychiatric problems. KEY WORDS: Organic solvent·Worker·Mental health·Psychomotor function·Quality of life.

      • 양서류 표피의 미세구조

        金翰華,盧鏞泰,鄭英和,池永得 최신의학사 1977 最新醫學 Vol.20 No.11

        The authors observed the ultrastructures of the keratinocytes in the epidermis of dorsal skin of the four species in the Korean amphibia: Bombina orientalis; Kaloula borealis, Rana nigromaculata and Rana rugosa. The results were as follows: 1. Amphibian epidermis consisted of 5 or 6 layers of keratinocytes and were divided into four strata: stratum germinativum (1 cell layer), stratum spinosum (1 or 2 cell layers), stratum granulosum (1 or 2 cell layers) and stratum corneum (1 or 2 cell layers) 2. Many microfilaments and secretory mucous granules developed" during cornification of the keratinocytes in the amphibian epidermis without keratohyalin granules developing in the mammalian epidermis. 3. The keratinocytes of the amphibian epidermis were mostly connected with desmosomes. Hemidesmosomes were found between the basal lamina and the basal face of the stratum germinativum and composite desmosomes between the upper face of the stratum granulosum and the basal face of the stratum corneum. The, surface keratinized cells were connected with zonula occludens in the upper portion and with modified desmosomal elements in the lower portion, 4. The keratinocytes of the amphibian epidermis were different in ultrastructure at each stratum. a. In the stratum germinativum, the keratinocytes were columnar or cuboidal in form. Many mitochondria, microfilaments and ribosomes were found in the cytoplasm. b. In the stratum spinosum, the keratinocytes were cuboidal or polygonal in form, Many microfilaments and ribosomes were found and a few granular and agranular endoplasmic reticulum and Golgi complex developed in the cytoplasm. c. In the stratum granulosum, the keratinocytes were squamous in form and the intercellular spaces well developed. Many microfilaments, ribosomes, secretory mucous granules and pigment granules were found in the cytoplasm. d. In the stratum corneum, the keratinocytes were squamous in form and were filled with microfilaments. A few vacuoles and remnants of cell organelles were seen in the cytoplasm.

      • KCI등재

        일 도시 여고생의 음주관련 요인에 관한 연구

        김주형,김은경,김효정,문현숙,오선민,박나경,신혜정,이경원,이지선,최연옥,최진희,한유정,현수인 대한간호학회정신간호학회 2002 정신간호학회지 Vol.11 No.1

        This study was designed to examine the factors associated with alcohol consumption among the Korean high schools girls. 283 female students were sampled from two high school in Seoul, Korea. They were given questionnaires and were asked to fill in and return them during a class hours. The factors included in the questionnaire were analyzed to see their contributions to alcohol consumption using chi-square. Alcohol consumption was associated with lower school performance(p=.001). High alcohol expectancies increased alcohol consumption(p=.000); however, depression did not show a statistically significant relationship to alcohol consumption. Mothers' alcohol consumption, having many alcohol consuming friends and watching TV commercials picturing alcohol were found to be associated with alcohol consumption, p=.049, .000, .000. respectively. Results may imply that alcohol consumption may not be a coping behavior of the depressed high school girls. Parents in Korea should be more concerned about alcohol consumption and its impacts on their daughters. Media effects on alcohol consumption need to be stressed and deserve attention from the public.

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