대장암으로 오인된 장결핵 3례

문봄내,박찬호,한상훤,김철홍,김경욱,최선희,윤중근,설상영 인제대학교 백병원 2003 仁濟醫學 Vol.24 No.1

A lesion which is visualized on colonoscopic examination is rather confusing in that one will find a ulcerative tumor mass occupying the lumen of the bowel which is most suggestive of carcinoma. Especially, tuberculosis of the distal colon occurring in the absence of pulmonary involvement is often mistaken for neoplasm or Crohn's disease. We experienced three cases of colon tuberculosis mimicking a ulcerative tumor mass occupying the lumen of the colon.

GO-62 : Lower extremity edema in patients with endometrial cancer

( Myong Cheol Lim ),( Jeong Seon Lee ),( Jung Nam Joo ),( Sang Soo Seo ),( Sok Bom Kang ),( Sang Yoon Park ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-

The objective of this study was to investigate clinical manifestations of lower extremity edema (LEE) in endometrial cancer Medical records for LEE and/or responses to the Gynecologic Cancer Lymphedema Questionnaire (GCLQ) were evaluated in 177 patients with endometrial cancer Patients had a median age of 53 years. Sixty-seven patients (37.9%) had past (9 patients, 13.4%) and/or current patient-reported LEE (58 patients, 86.6%). Symptoms reported on the GCLQ in over 20% of respondents were swelling, numbness, aching , and heaviness. GCLQ total symptoms score was significantly higher in patients with current LEE. Most of the LEE (43/67, 64.2%) developed within 12 months after surgery and LEE lasted more than 6 months in most patients (56/59, 94.9%) Prospective clinical trials are needed to know the clinical significance, impact on quality of life, and preventive strategy of LEE in patients with endometrial cancer

분지형 폴리카보네이트의 분자량 조절 및 유변학적 특성 연구

이봄이 ( Bom Yi Lee ),프러산터 ( Prashanta Dahal ),김희승 ( Hee Seung Kim ),유승윤 ( Seung Yoon Yoo ),김연철 ( Youn Cheol Kim ) 한국공업화학회 2012 공업화학 Vol.23 No.4

말단캡핑제(end capping agent) 4종류와 함량별로 분지형 폴리카보네이트를 용융중합법으로 제조하였다. 합성된 분지 형 폴리카보네이트의 화학구조는 FT-IR과 1 H-NMR 스펙트럼을 이용하여 확인하였으며, 말단캡핑제의 반응여부는 FT-IR 스펙트럼의 수산기(3500 cm -1) 존재여부로 확인하였다. 평균 분자량 및 분자량 분포도, 유리전이 온도 및 분해온 도는 GPC, DSC와 TGA를 이용하여 측정하였다. 말단캡핑제의 화학구조에 따라 평균 분자량이 증가 또는 감소를 나타내었으며, 말단캡핑제로 4-tert-butylphenol (TBP)이 사용되었을 때 최적의 분자량 조절 결과를 나타내었다. 말단캡핑제 의 함량이 증가할수록 평균분자량은 감소하였고, 4-tert-butylphenol이 0.05 mol%가 첨가될 때 폴리카보네이트의 대형 사출물 가공에 적합한 20000 정도의 수평균분자량을 나타내었다. 분지형 폴리카보네이트의 용융점도는 분자량이 감 소할수록 감소하였으며, shear thinning effect에는 큰 영향을 주지 않음을 확인하였다. Branched polycarbonates (B-PCs) were synthesized using melt polymerization method with four different end capping agents and vaying concentrations. The chemical structure of the synthesized PC was determined by FT-IR and 1 H-NMR spectroscopy, and the reaction of the end capping agent was confirmed by the existence of hydroxy group in FT-IR spectrum. The average molecular weight and distribution, glass transition and degradation temperatures were determined by GPC, DSC and TGA. The average molecular weight changed with the chemical structure of end capping agent, and 4-tert-butylphenol was estimated as the optimum end capping agent. The average molecular weights of B-PCs decreased with the increase of the concentration of the agent, the number average molecular weight represented 20000 when 0.05 mol% of 4-tert-butylphenol was added to B-PCs. The melt viscosities of the B-PCs decreased with the decrease of the molecular weight of B-PCs, and adding of the agent was not effected to shear thinning tendency.

In-situ 중합방법에 따른 폴리카보네이트(PC)/그래핀 옥사이드(GO) 복합체의 GO 분산성 연구

이봄이 ( Bom Yi Lee ),박주영 ( Ju Young Park ),김연철 ( Youn Cheol Kim ) 한국공업화학회 2015 공업화학 Vol.26 No.3

Three different types of polycarbonate (PC)/graphene oxide (GO) composites using diphenyl carbonate as a monomer were fabricated by melt polymerization. Those were the PC/GO composite (PC/GO) using a twin extruder, in-situ PC/GO composite (PC/GO-cat.) using a catalyst, and in-situ PC/GO composite (PC/GO-COCl) using a GO-COCl treated by -COCl, Chemical structures of the composites were confirmed by C-H and C=O stretching peak at 3000 cm-1 and 1750 cm-1, respectively. The slope for the storage (G′) versus loss (G″) modulus plot decreased with an increase in the heterogeneous property of polymer melts. So we can check the GO dispersion of the PC/GO composites using by the slop for G′-G″ plot. According to the G′- G″ slopes for three different types of PC/GO composites, GO was well dispersed within PC matrix in case of PC/GO and PC/GO-cat.. It was also confirmed by atomic force microscope (AFM) photos. One of the reasons for the poor GO dispersion of PC/GO-COCl is branching and crosslinking processes occurred during polymerization, which was further confirmed by a plot for the complex modulus versus phase difference.

중풍 한방처방전의 효능비교 연구; 황련해독탕, 거풍지보단, 가미사물탕이 국소 전뇌허혈에 의한 학습과 기억에 미치는 효과

이봄비 ( Bom Bi Lee ),정진용 ( Jin Yong Chung ),김선녀 ( Sun Yeou Kim ),김호철 ( Ho Cheol Kim ),권용준 ( Youn Jun Kwon ),함대현 ( Dae Hyun Hahm ),이혜정 ( Hae Jeong Lee ),심인섭 ( In Sup Shim ) 대한경락경혈학회 2002 Korean Journal of Acupuncture Vol.19 No.2

Kupunggibodan(KU), Gamisamul-tang(GA) and Whangryunhaedok-tang(WH) are clinically the most popular prescriptions as an herbal medicine in the treatment of ischemia. In order to compare and evaluate their protective effects on the ischema-induced cognitive deficits by middle cerebral artery occlusion (MCAO), we examined its ability to improve ischemia-induced cell loss and impairements of learning and memory in the Morris water maze and eight-arm radial arm maze. Focal cerebral ischemia produced a marked cell loss, decrease in acetylcholinesterase(AchE) reactivity in the hippocampus, and learning and memory deficits in two behavioral tasks. Pretreatment with WH (100 mg/kg, p.o.) produced a substantial increase in acquisition in the Morris water maze. Pretreatment with KU increased the perfomance of the resention test in the Morris water maze. WH, KU and GA caused a significant improvement in choice accuracy in radial arm maze test. WH was superior to KU and GA in perfomance of the radial arm maze test. Consistent with behavioral data, staining with cresyl violet showed that pretreatments with WH, but not KU and GA significantly recovered the ischemia-induced cell loss in the hippcampal CA1 area. In addition, pretreatments with WH and KU recovered the ischemia-induced reduction of AchE reactivity in the hippocampal CA1 area. These results demonstrated that KU, GA and WH have protective effects against ischimea-induced learning and memory impairments and that the efficacy was the order of WH>KU>GA in tratment of ischemia induced memory deficits. The present studies provide an evidence of KU, GA and WH as putative treatment of vascular dementia. Supported by a fund from the Ministry of Health and Welfare(HMP-00-OO-04-0004), and the Brain Korea 21 Project from Korean Ministry of Education, Korea.

Iodine Uptake Patterns on Post-ablation Whole Body Scans are Related to Elevated Serum Thyroglobulin Levels After Radioactive Iodine Therapy in Patients with Papillary Thyroid Carcinoma

Jeong, Geum-Cheol,Song, Minchul,Park, Hee Jeong,Min, Jung-Joon,Bom, Hee-Seung,Cho, Sang-Geon,Park, Ki Seong,Kang, Sae-Ryung,Kim, Jahae,Song, Ho-Chun,Kwon, Seong Young The Korea Society of Nuclear Medicine 2016 핵의학 분자영상 Vol.50 No.4

Purpose Serum thyroglobulin (Tg) level is frequently elevated shortly after radioactive iodine (RAI) ablation therapy. The authors studied the relationship between the elevation of serum Tg after RAI therapy and iodine uptake pattern on post-ablation whole body scans (RxWBSs) in patients with papillary thyroid carcinoma (PTC). Materials and Methods The study subjects were patients with PTC that had undergone first RAI therapy with thyroid hormone withdrawal after total thyroidectomy. Patients with a high level of serum anti-Tg antibody (TgAb, ${\geq}60U/mL$), possible regional or distant metastasis as determined by pre-ablation or post-ablation studies, and negative iodine uptake of the anterior neck on RxWBS were excluded. Serum Tg was checked twice, that is, 7 days after (post-ablation Tg) and on the day of RAI therapy (pre-ablation Tg). Ratio of pre-ablation Tg to post-ablation Tg (Tg ratio) was used to assess changes in serum Tg levels after RAI therapy. Patients were classified into two groups according to the presence of midline uptake above the thyroidectomy bed on RxWBS (negative (group 1) or positive (group 2) midline uptake). Variables were subjected to analysis to identify differences between the two groups. Results Two hundred and fifty patients were enrolled in this study; 101 in group 1 and 149 in group 2. Based on univariate analysis, post-ablation Tg ($8.12{\pm}11.05$ vs. $34.12{\pm}54.31$; P < 0.001) and Tg ratio ($7.81{\pm}8.98$ vs. $20.01{\pm}19.84$; P < 0.001) were significantly higher in group 2. On the other hand, gender, tumor (T) stage, lymph node (N) stage, size, multiplicity or bilaterality of primary tumor, dose of $^{131}I$, serum TgAb and thyroid-stimulating hormone (TSH) level (before or after RAI therapy) were not significantly different in the two groups. Variables with P values of < 0.25 by univariate analysis were subjected to multivariate analysis, which showed post-ablation Tg (OR 1.060, 95 % CI = 1.028-1.092; P < 0.001) and Tg ratio (OR 1.059, 95 % CI = 1.028-1.092; P = 0.001) were significantly higher in group 2. Conclusion Serum Tg level after RAI therapy was significantly higher in patients with midline uptake on RxWBS, compared with patients without midline uptake on RxWBS. Further investigations are needed to reveal the correlation between serum Tg elevation and clinical outcome according to the presence of midline uptake.

나일론66/유리섬유 복합체의 압출횟수에 따른 특성 연구

이봄이(Lee, Bom Yi),김연철(Kim, Youn-Cheol) 한국산학기술학회 2014 한국산학기술학회논문지 Vol.15 No.6

나일론66/유리섬유 복합체의 경우 300 ℃ 이상의 고온에서 사출가공 될 때 물성 저하가 일어날 수 있어, 재이용시 열이력에 대한 체계적인 연구가 필요하다. 305/290/273/268/265/260 ℃ 온도조건의 이축압출기(twin screw extruder)를 이용 하여 나일론66/유리섬유 복합체의 압출시료를 압출횟수에 따라 제조하였다. 압출횟수에 따른 화학구조, 열적특성, 용융지수, 결정구조, 아이조드 충격강도 및 유변학적 특성을 FT-IR, 용융지수 측정기, DSC, TGA, XRD, Izod 시험기, 그리고 유변물성 측정기를 이용하여 분석하였다. 적외선분광 스펙트럼을 이용하여 확인한 결과 압출횟수에 따른 압출시편에서의 화학구조 변화는 확인되지 않았다. 압출횟수에 따라 분자량이 감소하는 것을 용융지수와 복소점도를 이용하여 확인하였다. 나일론66/ 유리섬유 복합체의 용융온도는 큰 변화가 없으나, 압출횟수 증가에 따라 분해온도가 20 ℃ 정도까지 감소하는 것을 DSC와 TGA를 이용하여 확인하였다. 압출시편의 아이조드 충격강도는 압출횟수가 증가함에 따라 감소하였다. 또한 나일론66/유리 섬유 복합체 압출시편의 G'-G" 곡선의 기울기나 형태가 변하지 않는 것으로부터 압출시편에 가교와 같은 구조변화가 크게 나타나지 않음을 알 수 있었다. Because the physical properties can be decreased when a Nylon 66/glass fiber composite is injected into a mold over 300 ℃, a systematic study of the thermal history in the case of re-use is needed. Nylon 66/glass fiber extrudates as a function of the extrusion number were prepared using a twin screw extruder at 305/290/273/268/265/260 ℃. The chemical structure, thermal properties, melt index, crystal structure, Izod impact strength, and rheological properties were measured by Fourier transform infra-red (FT-IR), melt indexer, DSC, TGA, XRD, Izod impact tester, and dynamic rheometer. The FT-IR spectra indicated that the number of extrusions did not affect the chemical structure. The decrease in molecular weight with increasing extrusion number was confirmed by the melt index and the complex viscosity of extrudates. Based on the DSC and TGA results, the thermal history had no effect on the melting temperature, regardless of the number of extrusions, but the degradation temperature decreased up to 20 ℃ with increasing extrusion number. The Izod impact strengths of the extrudates were found to decrease with increasing extrusion number. No structural change after extrusion was also confirmed because there was no change in the slope and shape of the G'-G" plot.

고관절 통증에 대한 한의학적 치료: 증례연구의 문헌적 분석

박상철 ( Sang-cheol Park ),성수현 ( Soo-hyun Sung ),안뜰에봄 ( Tteul-e-bom An ),신병철 ( Byung-cheul Shin ),최광호 ( Gwang-ho Choi ),박종현 ( Jong-hyun Park ) 대한한의학회 한방재활의학과학회 2017 한방재활의학과학회지 Vol.27 No.1

Objectives This study aimed to review case studies on interventions of Korean medicine for hip pain. Methods We searched seven electronic databases for relevant studies up to Oct 2016. Case studies of Korean medicine interventions for hip pain were included and analysed. Results 15 case studies were included (Korean databases; n=15) and Total number of patients was 17 cases. A total of 13 types of interventions were reported, of which acupuncture (93.3%), herbal medicine (80.0%) and pharmacopuncture (40.0%) were the most frequently used. GB30 (66.7%), LR3 (41.7%), BL36 (33.3%) and ST31 (33.3%) were used in at least 4 papers. Cheongpa-jeon (25.0%) and symptom change (46.7%) were most frequently used in herbal medicine and outcome measure respectively. Conclusions Clinical studies, especially double-blinded randomized controlled trials, of Korean medicine interventions for hip pain must be conducted to obtain definite conclusions. (J Korean Med Rehabil 2017;27(1):27-35)

나일론66/실리케이트 복합체의 충격특성 개선 연구

이봄이(Lee, Bom Yi),김연철(Kim, Youn-Cheol) 한국산학기술학회 2014 한국산학기술학회논문지 Vol.15 No.7

나일론66/실리케이트 복합체를 자동차 부품 소재로 적용하기 위해서 충격특성 개선에 대한 연구가 요구된다. 이축압 출기(twin screw extruder)를 이용하여 나일론66/실리케이트 복합체를 실란계열의 γ-APS로 처리한 실리케이트 사용과 MAH가 그라프트된 옥텐계 α 올레핀을 첨가한 경우로 하여 제조하였다. 실란처리된 실리케이트의 화학구조는 적외선 분광 기(FT-IR)을 이용하여 측정하였고, 나일론66/실리케이트 복합체의 열적특성, 실리케이트 삽입여부 및 아이조드 충격강도를 DSC, TGA, XRD, 그리고 Izod 시험기를 이용하여 분석하였다. 실란계열로 처리된 실리케이트의 화학반응여부는 표면 수산 기 피이크의 감소로부터 확인하였다. 복합체의 분해온도에는 큰 차이를 보이지 않았지만 결정화온도와 결정화도는 약간 증 가하였다. 이는 사용한 첨가제들이 나일론 66에 불균일 핵제로의 역할을 했기 때문으로 추측된다. 나일론66/실리케이트 복합 체의 아이조드 충격특성 측정결과 실란으로 처리된 실리케이트를 사용한 경우 약 24% 정도의 충격강도 개선효과를 보여주었다. A study of the improvement in the impact strength is required to apply Nylon 66/silicate composites as an automobile material. Nylon 66/silicate composites were prepared using a twin screw extruder in case of a silicate treatment by γ-APS (S-silicate) and the addition of an octene α olefin grafted by maleic anhydride (PE-g-MAH). The chemical structure of the silane treated silicate was measured by Fourier transform infra-red (FT-IR) spectroscopy. The chemical reaction was confirmed by the decrease in the FT-IR intensity of the OH stretching vibration. The thermal properties, intercalation structure, and Izod impact strength were measured by DSC, TGA, XRD, and Izod impact tester. There was no significant effect on the degradation temperature of the Nylon66/silicate composite, but the crystallization temperature and crystallinity increased slightly in the case of the Nylon66/silicate composites. This suggests that the additives act as heterogeneous nuclei on the Nylon 66 matrix. The Izod impact test indicated that S-silicate enhanced the impact performance by up to 24%.

지지면에 따른 발목관절의 족저굴곡 운동이 비복근 두께에 미치는 영향

이건철 ( Geon Cheol Lee ),김봄 ( Bom Kim ),김지수 ( Ji Su Kim ),남인성 ( In Seong Nam ),박유진 ( Yoo Jin Park ),신우진 ( Woo Jin Shin ),우수민 ( Su Min Woo ),차성기 ( Seong Ki Cha ) 대한통합의학회 2014 대한통합의학회지 Vol.2 No.1

Purpose : The purpose of this study was to perform the calf-raise exercise on the stable support surface and unstable support surface for comparing deference of the gastrocnemius thickness changes that measured by ultrasonography. Method : Subjects stand on unstable support surface and a stable support surface with both feet. Keeping calf-raise position in the 3 seconds, and then had to return back to the starting position. Total of 3 sets of 15 repetitions performed and give a 30-second rest between each set. In this way, exercise performed 3 times a week, performed a total of 6 weeks. Result : 1. gastrocnemius muscle thickness before and after exercise in experimental group A was significantly different(p<.05). 2. gastrocnemius muscle thickness before and after exercise in experimental group B was significantly different(p<.05). 3. gastrocnemius muscle thickness in experimental group A and experimental group B was significantly difference(p<.05). Conclusion : In conclusion, calf-raise exercise on unstable support surface was more efficient than stable support surface for increasing thickness of gastrocnemius.