정상 한국인에서 연령증가에 따른 혈장 Dehydroepiandrosteronesulfate ( DHEA-S ) 농도 및 DHEA - S / cortisol 비의 변화

박성우,유형준,임성희,최문기,유재명,박민숙,이권엽,박철수,김철홍,김현규,김두만,박규용 대한내분비학회 1997 Endocrinology and metabolism Vol.12 No.2

Backgroud: DHEA-S is the most abundant steroid hormone in circulation, and primarily secreted from the adrenal cortex, but its physiological role is little known. One of the characteristic features of DHEA-S is progressive decrement of plasma DHEA-S level with advancing age, in contrast, plasma levels of other adrenal hormones are not chaging or littie decreasing. To grasp the trends of plasma DHEA-S level and DHEA-S/cortisol ratio by age in healthy Korean, we measured the plasma DHEA-S levels and DHEA-S/cortisol ratios in healthy Korean. Methods: Healthy Korean(men: 99, women: 102, age range: 15-97 year old)were studied. Subjects were not taking drugs(such as glucocorticoid or androgenic medication) or cigarettes known to modify the plasma level of DHEA-S and cortisol, and had no evidence of hepatic, renal disease or hyperlipidemia as determined by serum lipid, bilirubin, SGOT, SGPT, BUN, creatinine. Data were analyzed by 10-year age group for men and women: i.e, 10-19, 20-29, 30-39, 40- 49, 50-59, 60-69, 70-79, 80-89 and 90 year or more. Plasma DHEA-S levels were measured by using a commercially available RIA kit with 125I labeled-DHEA-SO4(Coat-A Count DHEA-SO4), and for the measurement of plasma cortisol levels, commercial Gamma Coat TM[125I] Cortisol Radioimmunassay Kit was used. Results:. 1) In both men and women, plasma DHEA-S level showed high interindividual variation within the same age group. 2) There were individual sex differences in plasma levels of DHEA-S, in all age groups, plasma DHEA-S levels were significantly higher values for men than for women. 3) Maximum plasma DHEA-S levels(men; 237+-3.35 ug/dL, women; 108+-17.5 ug/dL) were at third decade in both men and women. 4) Both men and women showed the continuous decline in plasma DHEA-S level with age. These age-related decline was more prominent in men than in women(men; y= -3.152 * +292.6, r2= 0.8459, P$lt;0.05, women; y= -1.417 * +143.3, r2 = 0.7278, P$lt; 0.05). 5) As an index of aging, there was no stastical difference between DHEA-S and DHEA- S/cortisol ratio. Conclusion: In healthy Korean, there were high interindividual variation of plasrna DHEA-S levels. In both men and women plasma DHEA-S level was peak at third decade, and from when it declined progressively with age. These results suggest that although the reliability of single plasma DHEA-S measurement are limited, the decline of DHEA-S with advancing age might be a specific marker of endocrinologic hormonal milieu(aging index). Also, concerning to individual adrenal secreting capacity, we measured DHEA-S/cortisol ratio. But we did not found that plasma DHEA-S/cortisol ratio is superior to the plasma DHEA-S level as an aging index. (J Kor Soc Endocrinol 12:245-254, 1997)

태권도 수련이 초등학생들의 정서, 사회성 및 생활태도에 미치는 영향

오만원,이철호 濟州大學敎 體育科學硏究所 1996 체육과학연구 Vol.2 No.-

The effect of TKD practice upon the sentiment and social manner of elementary school children was researched and the formation period of it was analyzed. To prove that the effect of TKD pratice has educationally much effective of forming the whole man it was made an object of this study that they are made up of 836 children and their 90 parents of elementary school. 4.5.6th grade among apprentices in drill halls of cheju-do was investigated and analyzed. So the following results were conculded. 1. The children and their parents think that in the change of sentiment through TKD practice. TKD practice of one year or more has more effective of improving the general standard of sentimemts of patience.brighness. self - confidence. reduction of a feeling of uneasiness, spiritual strength , control ability of feelings. concentration, etc. than that of three months below or to twelve months. 2. On the change of sociality by TKD practice all the students and their parents think that TKD practice of one year or more has more effective of improving the general standard of sociality of cooperation. sense of responsibility equality. independeuce. faithfulness, friendship, etc than that of three months below or four to twelve months. 3. On the change of manner of living by TKD practice their parents think that TKD practice of one year or more has more effective of elevating manner of living than that of three months below or four to twelve months. 4. Most of their parents agreed that they made their children practice TKD to have great confidence in themselves. By forming the above we can conclude following. For the high development of the change of sentiment, sociality, manner of living through TKD practice it is needed for children to train for more than one year. As most of the elementary school children have grown in the stream of overprotection, not feeling difficulty. they need the course of study for self - denial. including patience, staying power. Their parents make their children practice TKD to elevate spirit and have great confidence in themselves. So the apprentices from elementary school must realize that they can change their mind and behavior as better persons, developing their mind and body together only after they don't give up practicing TKD halfway but should practice TKD for more than one year with patience. And the readers of TKD should develop scientific and logical TKD practice programs, having the sense of mission that they charge themselves with part of education for the whole man in the course of school education.

단무지 공장에서 발생한 질식 사고의 원인과 방사선학적 소견: 중례보고 및 가스분석 결과

박충기,김만구,김흥철,안범규,박만수,황우철,최철순,강익원 江原大學校 附設 環境硏究所 1994 環境硏究 Vol.11 No.-

목 적:단무지 공장에서 질식사고를 일으켰던 가스의 종류를 알아내고, 이러한 가스중독의 방서선학적 소견을 소개하기 위하여 본 연구를 하였다. 대상 및 방법:단무지 공장에서 발생한 질식 사고자 3예중 생존자 1예를 대상으로 단순흥부X-선검사와 CT 소견을 분석하였으며, 가스의 종류를 알아내기 위하여 단무지를 유리병에 넣어 발생된 가스를 가스크로마토그래픽을 이용하여 분석하였다. 결 과:단무지 공장에서 발생한 질식사고자중 생존한 1명의 방사선학적 검사에서 신속히 호전되는 폐경결(consolidation)을 볼 수 있었으며 이는 폐부종의 소견임을 알 수 있었다. 협기성 상태에서 단무지를 담은 유리병의 상층부 가스를 실험 분석한 결과 이산화탄소, 에칠알코올이 다량으로 검출되었으나 독성가스는 주로 황화수소이였다. 결 론:단무지 공장의 질식 사고자에서 폐방사선학적 소견은 폐경결을 보이는 폐부증으로서 이는 실험을 통해 단무지에서 발생되는 유독가스인 황화수소 때문임을 입증하였다. Purpose: To identify the main toxic gas released from salted radish in rice bran(Dan-M-Ji) and to introduce the radiological findings of the patient who was exposed to the gas. Materials and Methods: Chest radiographs and CT scans of one survivor among three men who were exposed to the gas from Dan-Mu-Ji were reviewed. Gas obtained from the closed bottle containing Dan-Mu-Ji was analized by using the gas chromatography. Results: The radiographlc examinations of the survivor were suggestive of pulmonary edema with it's rapidly improving consolidations in both lung. The headapace gas within the bottle containing Dan-Mu-Ji was mainly composed with carbon dioxide, ethyl alcohol and hydrogen sulfide, of which hydrogen sulfide was considered the main toxic gas released. Conclusion: Under the anaerobic condition, Dan-Mu-Ji released toxic hydrogen sulfide. Inhalation of hydrogen sulfide might produce non-cardiogenic pulmonary edema.

부신피질 호산성 과립세포종 1예

이성진,이호권,박철영,정인경,홍은경,오기원,김현규,김두만,유재명,임성희,최문기,유형준,박성우 대한내분비학회 2004 Endocrinology and metabolism Vol.19 No.1

저자들은 건강검진에서 시행한 복부 초음파검사상 우연히 좌측 부신 종괴가 발견되어 복부 전산화 단층 촬영검사와 호르몬검사를 시행한 후 부신피질 악성종양과의 감별 진단을 위해 부신절제술과 전자현미경검사를 포함한 병리조직학적 검사를 시행하여 부신피질호산성 과립세포종으로 진단한 증례를 경험하였기에 문헌고찰과 함께 이를 보고하는 바이다. Oncocytomas are neoplasms, histologically are composed of epithelial cells, with abundant, acidophilic and granular cytoplasm. Electron microscopic studies of oncocytomas have shown that the cytoplasm of oncocytes is packed with mitochondria. The adrenal gland is a very rare anatomical site for oncocytomas, and to the best of our knowledge, only thirty-six cases of adrenal oncocytomas have been described. Herein, a case of a large adrenal mass in a forty-year-old man, which was incidentally detected by abdominal ultrasonography, is presented. This patient demonstrated no clinical manifestation associated with adrenal hyperfunction. Hormonal studies showed no abnormal findings, except for a mild elevation of the 24-hour urinary VMA level. Abdominal computed tomography with enhancement revealed a large, well-defined left adrenal mass, measuring 5.0×4.2 ×3.0 cm. The patient underwent a left adrenalectomy, and a light microscopic examination confirmed an adrenocortical oncocytoma, with characteristic oncocytes and polygonal, abundant, eosinophilic and granular cytoplasm. The tumor cells were positive for cytokeratin and vimentin as well as S-100, but negative for chromogranin on immunohistochemical staining. An electron microscopic examination demonstrated closely packed mitochondria, containing intramitochondrial inclusions. After surgery, there was no evidence of a recurrent or distant metastatic disease at the 5 month follow-up. In summary, an extremely rare case of a man with an adrenocortical oncocytoma is reported, which was confirmed by histological examinations, including electron microscopy (J Kor Soc Endocrinol 19:82∼89, 2004).

부산·울산·경남지역 직업병 감시체계

김정일,김병권,김정원,채창호,이철호,강동묵,김지홍,김진하,김영욱,이영하,이지호,김정호,윤형렬,유철인,정백근,장태원,김운규,윤동영,강진욱,김종은,안진홍,이동준,장준호,이광영,송혜란,최영희,이용환,조병만,최홍렬,고상백,김은아,이유진,홍영습,정갑열,김정만,김준연 大韓産業醫學會 2004 대한직업환경의학회지 Vol.16 No.1

Objective: Occupational medicine specialists in the Busan, Ulsan and Kyung-Nam areas established an area-based occupational disease surveillance system and used this system to collected case information for the purpose of preventing occupational diseases Methods: l l hospital participated in this system. The authors selected five main diseases, which were hand-arm vibration syndrome (HAVS), work-related musculoskeletal disorder (WRMSD), occupational asthma, occupational skin disease and occupational and occupational lung cancer and established their case definitions. All cases were reported on the web, and real time analysis was conducted. Results: Between April 2001 and April 2003, 192 cases of HAVS, 118 cases of WRMSD, 33 cases of occupational asthma, 17 cases of occupational skin disease and 17 cases of occupational lung cancer (for a total of 377 cases of these five main diseases) were reported. most of the HAVS cases came from shipbuilding, and 172 of them (92.7%) were associated with grinding. Of the four main types of WRMSD, carpal tunnel syndrome (CTS) was the most prevalent with 46 cases and shipbuilding was also the main industry involved (83.9%). The ergonomic risk factors involved mainly associated with the hand. In 19 (57.6%) and 4 (12.1%) cases of occupational asthma, the agents involved. The causative agents of occupational lung cancer included Cr, welding fume, PAH, Ni, etc. 10(58.8%) of the cases were diagnosed as squamous cell carcinoma and 5(29.4%) as adenoma. Conclusion: This result showed that an area-based occupational disease surveillance system might provide an effective method of evaluating the prevalence of such diseases, however the Busan, Ulsan and Kyung-Nam provinces are too large to be treated as individual areas. Therefore, the authors suggest that each province should establish its own surveillance system.

자두 추출물을 이용한 미용비누 제조 및 여드름 환자에 대한 효과

한만덕 ; 윤옥현 ; 박동철 ; 박지원 김천대학교 2003 김천대학교 논문집 Vol.24 No.-

In this study, authors investigated the bathroom soap development using plum(Prunus salicina Lindl. cv. Soldam) extracts and studied the effects and safety of a plum soap on acne patients. For obtaining antibacterial material from dried plum, the serial extraction using organic solvent was carried out and gained of 0.2% hexane, 0.2% chloroform, 0.23% ethyl acetate, 9.8% butanol and 2.1% water extracts. The main bioactive contents of the soap were consisted of 0.006% plum extract, 0.1% glycyrrhiza extract, and 0.15% tocopheryl acetate. A clinical study of soap containg 0.006% plum extracts was carried out on three groups of people: a treatment and 2 control groups on acne patients. Efficacy and safety were assessed at baseline and at one month later. The group applving the soạp with plum extract felt better than the one applying the 2 control group. Some patients developed mild and transient local side effects. The plum soap didn't change at 40℃ and was 130 hardness. In conclusion, cleansing three times a day with a facial soap consisting 0.006% ethyl acetate extract of plum was found to be effective and safe for patients suffering from acne vulgaris

Mo¨nckeberg 중막 석회화로 인해 초기자궁내막암이 진행성 자궁내막암으로 판독되었던 1례

김승만,배철성,김동훈,김정란,이현경,윤혜원 동국대학교 경주대학 1997 東國論集 Vol.16 No.1

Mo¨nckeberg 중막 석회화는 크거나 중간크기의 근육성 동맥(large and medium-sized muscular arteries)의 중막(media)에 노화와 관련되어 퇴행성 과정인 윤상석회화가 특징적으로 나타나는 동맥경화증의 일종으로, 근본적으로 폐쇄성 죽상경화증(occlusive atherosclerosis)과는 다른 과정으로 동맥의 관강(lumen)을 막는 경우는 드물어 상대적으로 임상적 의의는 적거나 거의 없다. 저자들은 Mo¨nckeberg 중막 석회화때문에 초음파 및 컴퓨터 단층촬영에 의한 병기결정에 혼란을 초래하였던 초기 자궁내막암 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. The Mo¨nckeberg medial calcification is aging change rather than disease entity. The Mo¨nckeberg medial calcification involve muscular arteries of limb, head, and genital track and cause fibrosis change associated with hyalinization and fine basophilic staining, suggesting early calcification with little or no clinical significance but is demonstrable on roentgenograms as regular and diffuse radiopaque shadow under intima. We experienced one case of mis-staging of early endometrial cancer due to the Mo¨nckeberg medial calcification therefore, we report this case with a brief review of the literature of the Mo¨nckeberg medial calcification.

AGV 용 서스펜션의 진동 모드에 관한연구 : 중력 가속도가 5G인 경우 A Case of Gravity Acceleration is 5G

주만식,김민주,이승수,최영철,추정근,김중완,전언찬 한국공작기계학회 2000 한국공작기계학회 추계학술대회논문집 Vol.2000 No.-

This study is to choose the most proper model for AGV throughout simulation of behavior of suspension to reduce trial and error because there is no AGV treating heavy weight at harbor loading and unloading at home. Therefore, we estimate the vibration modes of the various suspension applied to AGV, which is over 75 ton included the weight of two containers on 5G using the Matlab, one of the simulation programs

탄성파자료 속도분석에 관한 연구

서만철,이원국 공주대학교 기초과학연구소 1992 論文集 Vol.30 No.1

A study on seismic velocities was carried out through theoretical calculation and interpretation of real seismic shot records acquired in the Yellow Sea region. Seismic data were recoreded for 5 seconds using a tuned airgun array of about 1830 in3 and a 3250 m long marine streamer. Theoretical studies shows that stacking velocity becomes larger than both root mean square velocity and average velocity for a given subsurface model. This implies that velocity data driven from the velocity analysis program of seismic data processing package should be diminished for the use of those velocities in migration process and depth conversion of seismic sections. Velocity data computed using seismic refraction method represent the existence of a major velocity discontinuity at a depth of about 566 m below sea level. Velocities of the upper and lower units are 1639m/sec and 2273m/sec, respectively. The upper layer is interpreted as an unconsolidated sedimentary layer and the lower unit as a consolidated clastic sedimentary layer. The prominent velocity discontinuity is interpreted as the mid-Miocene regional unconformity of the Yellow Sea region.

지도방법 유형이 배구기능 학습에 미치는 효과

오만원,김철호 濟州大學敎 體育科學硏究所 1997 체육과학연구 Vol.3 No.-

The purpose of this study was to examine the effects of the command teaching mehtod and problem solving teaching method by Mosston in achieving the serve, pass and volley skills of volleyball. The subjects of this study were 100 middle school boys and girls students divided into 4 classes. Two classes were taught volleyball skills by using the command teaching method and the others were taught by using the problem solving teaching method. All groups took experimental treatment 3 hours a week for 6 weeks. The subjects were pre-tested before they got experimental treatment. After 6 weeks of teaching the test of serve pass and volley skills applied AAHPERD(1969) were taken to the subjects. The experimentation of this study was based on based on 2(teaching method) X 2(sex) X 2(enforcement). The data analysis was practised by index of trinity dispersion. On the basis of the results compared and analyzed by the pre and post-test, the conclusions were drawn as follows. 1. In achieving the serve skills. there were significant differences between boy-groups and girl-groups but less differences between problem solving teaching method and command teaching method 2. In achieving the pass skills. problem solving teaching method was more effective, especially in boy-groups than command teaching method. 3. But. in achieving the volley skills. it showed no siginificant differences between boys and girls groups, problem solving and command teaching method