Antiangiogenic-Like Properties of Fermented Extracts of Ayurvedic Medicinal Plants

Che´rif Rabhi,Guillaume Arcile,Le´on Cariel,Christine Lenoir,Je´rome Bignon,Joanna Wdzieczak-Bakala,Jamal Ouazzani 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.9

The three ayurvedic medicinal plants, Withania somnifera, Emblica officinalis, and Bacopa monnieri, were extracted by high-pressure static extraction using the Zippertex® technology. The extracts were mixed to reach quantifiable amounts of active compounds identified by high-pressure liquid chromatography-mass spectrometry (HPLC-MS) analysis. The mixture of extracts was incubated with resting cells of the fungus Beauveria bassiana ATCC 7159. The fermentation promoted the fluidization of the starting dense mixture, while HPLC monitoring evidenced the disappearance of glucogallin from E. officinalis extract and the concomitant increase in gallic acid content. Topical exposure of the chick embryo chorioallantoic membrane (CAM) to the nonfermented extract led to the extensive necrosis and destruction of the treated membrane. However, the fermented extract was shown to be free of any toxicity. Furthermore, compared with the untreated CAM, the fermented sample reduced CAM vascularization, suggesting its antiangiogenic potency. The innocuity of the fermented extract was demonstrated using the in vivo LD50 test, the morphological examination of internal organs of treated rats, as well as the evaluation of blood biomarkers of liver damage (aspartate aminotransferase and alanine aminotransferase). The fermented extract was developed as a nutraceutical antiangiogenic treatment of age-related macular degeneration and commercialized in an oral form named Ethnodyne-Visio™.

제주 우수 육상경기 선수들의 년중 훈련효과 분석 및 처방

김철원,임상용,김승곤,오만원,김성찬,이창준,남사웅,이세형,류재청 濟州大學敎 體育科學硏究所 1996 체육과학연구 Vol.2 No.-

The study was undertaken to analysis, evaluate, and prescribe t h e annual effect of training of periodically anaerobic and aerobic motor ability for Che-Ju representive team of elementary, middle and high school athletes. first. the performance can be obtained when it was prescribed proper training after analysis of physical fitness by each events. second, individually fitness. scientific analysis. prescription. proper management of athlete will be necessary to apply. In addition to physiology aspect, it is essential to consider sport biomechanics. sport psychology when we prescribe specific events and necessary approach in demension coach-athlete-researcher for individual.

제주 우수 수영 선수들의 년중 훈련효과 분석 및 처방

김철원,임상용,김승곤,오만원,김성찬,이창준,남사웅,이세형,류재청 濟州大學敎 體育科學硏究所 1996 체육과학연구 Vol.2 No.-

The study was undertaken to analysis, evaluate, and prescribe the annual effect of training of periodically anaerobic and erobic motor ability for Che-Ju representive team of elementary, middle and high school athletes, first the performance can be obtained when it was prescribed proper training after analysis of physical fitness by each events, second individually fitness scientific analysis. prescription. proper management of athlete will be necessary to apply.

의료소비자의 관계혜태 지각이 관계의 질 및 행동의도에 미치는 영향

허철선(Che이-Seon Heo),유광우(Kwang-Woo Yoo) 한국무역연구원 2014 무역연구 Vol.10 No.1

Medical institutions are important to develop and maintain enduring relationship with medical service conswners. So, this research aims to find out the effect of medical service conswners perception of relational benefits on relationship quality and behavioral intention. On the basis of the literature review, the research model is established. This research has been done through the survey utilizing medical service consumers in Gangwondo, and the effective 368 questionnaires are tested for the research model. The main findings are as follows. First, among 5 key dimensions of relational benefits, psychological, customization, economic, and information benefits except social benefits have significant effects on relationship satisfaction. Also, medical institutions type and medical service consumers type as moderating variables are included concurrently, and the significant differences are found in other 4 benefits except relationship between social benefits and relationship satisfaction. Second, relationship satisfaction relates positively to relationship commitment and behavioral intention. But the normative commitment, one of 3 key dimensions of relationship commitment, has no significant effects on recommendation to others. Third, the revisit intention has significant effect on recommendation to others. Finally, the findings reveal that the overall goodness fit index of the model is comparatively good and model set in this research is significant. At the end of the research, managerial implications, limitations and future research directions are suggested.

의료 화상을 위한 전처리 필터들의 특성에 관한 연구

강명아,최종주,정종필,정채영,정남채 조선대학교 기초과학연구소 1997 自然科學硏究 Vol.20 No.1

There has been no fixed rule of pre-processing course required to do image processing that it was barely possible to find the proper pre-processing course, only to process with experience till now. In this paper, lots of application method of pre-processing algorithm, only available by the non-typified and experiential method, shall quantify and the algorithm method of algorithm according to the rule shall calculate the frequency of the value of each pixel gray level and the histogrm of the image. And then average it to all pixel number and finally set a high-ranking or optional % standardized by the average value in teh standard value. The result of a experiment showed the Median filter is superior to the Mean filter in all image of the smoothing filter. The sobel filter extracted feature. The laplacian filter presented sectional feature which not showed in original image.

Heinrich Heine의 “Buch der Lieder”에 關한 試論 : 그의 初期作品 "Die Heimkehr”를 中心으로

韓在弘 부산대학교 과학교육연구소 1976 교사교육연구 Vol.3 No.1

Den Sinn der Schreibart in Heines Friihen Werken will ich innere Physiognomie seiner Gedichte beobachten. Anfangs wich Heine instinktiv seiner Phantasie aus, schlug einen großen Bogen um sie und merkte nicht, da/3 sie es war, die einen Garten fur ihn aufgebaut hatte, den Garten der Lieddichtung. Bei dem Glaube, den er allmahlich gewann, kam ihm das von Schlegel geweckte Interesse an metrischen und formalen Fragen zustatten. Im Winter 1819, der dem Schreiben der Tragodien vorausging, hatte er in Bonn August Wilhelm Schlegel (1767-1845) kennengelernt. Auf schlegels Rat verbesserte er auch viel an alten Gedichten und schrieb neue Gedichten hinzu. Schlegels Ratschlage wiesen ihm die rechte Bahn. Vielleicht ahnte Heine, da/3 es besser sei, allein mit seinen Problemen fertig zu werden als mit Schlegels Hilfe. Heine hat erst im Schmerz neue Welten entdeckt. Jedenfalls verließ er im Sommer 1820 Schlegel und Eaon und studierte nach den Ferien zuerst in Gottingen, dann in Berlin weiter. In Berlin vollendete er einen Zyklus von 66 kleinen Liedchen, denen er den Titel "Lyri-sches Intermezzo". Nicht viel spater folgte ein zweiter Liederzyklus, "Die Heimkehr". In der "Heimkehr" griff Heine die freie Schreibweise wieder auf. So hing die Produktivitat jener Zeit gerade mit seinen Schwierichkeitea in der Lyrik zusammen. Die romantische Ironie in Heines "Die Heimkehr" lenkte sich allmahlich auf die wirklichen Welt. Erst in "Gestandnisse” (1854) wies er ihm den Platz zu, der ihm in seinem Werk gebuhrt. "Ich weiß”,schrieb er in einem Riickblick auf seine Dichtung, "es war das, letzte ireie Waldlied der Romantik', und ich bin ihr letzter Dichtung;mit mir ist die alte Schule der Deutschen geschlossen, wahrend zugleich die neue Schule, die moderne deutsche Lyrik ·von mir eroffnet ward". Zugleich damit nahm die neue Lyrik Gestalt an. In den Traum dringt die ode Alltagserfa- lirung die Leidenschaft ein, und seine Idee verzerrt sich im Spiegel der Realitat zur Grimas-se, Gefiihl und Stimmung. Schon die romantische Ironie verwies auf. die Diskrepanz von Poesie und wirklichem Leben

해조류 에탄올 농도별 추출물의 항돌연변이원성 및 항균성

박제석,오명철,오창경,현재석,김봉오,김수현 濟州大學校工科大學産業技術硏究所 1996 尖端技術硏究所論文集 Vol.7 No.2

톳. 미역 및 다시마의 에탄올 농도별 추출물이 MMS. ICR191 및 sodium azide에 의해 유도되는 돌연변이원성의 억제효과 및 E. coli, B. subtilis 및 S. serevisiae에 대한 항균효과를 검정하였다. 톳의 90% 에탄올 추출물은 MMS와 ICR191에 대한 항돌연변이 원성이 각각 70 및 95% 이상으로 매우 높았으나, sodium azide에 대한 항돌연변이원성은 없었다. 미역의 에탄올 농도별 추출물은 30∼90% 에탄올 추출물에서 50% 이상의 항돌연변이 효과를 보았으나 MMS와 sodium azide에 대한 항돌연변이 효과는 없었다. 다시마의 30∼90% 에탄올 추출물의 ICR191에 대한 항돌연변이 효과는 70% 이상이었으나, MMS와 sodium azide에 대한 효과는 없었다. 에탄올 농도별 톳의 추출물들에 대한 항균성 검색 결과 70과 90% 추출물들이 E. coli와 B. subtilis에 대하여 뚜렷한 항균효과는 미역 추출물 보다 다시마의 추출물이 더욱 요과적이었다. 미역 추출물은 50% 추출물만이 S. cerevisiae에 대한 성장저지효과를 나타낸 반면, 다시마 추출물은 90% 에탄올 추출물에서는 시험된 모든 공시균주에 대하여, 그리고 70% 에탄올 추출물에서는 E. coli와 B. sutilis에 대하여 높은 성장저지효과를 나타내었다. Desmutagenic against MMS-, ICR191- and sodium azide-induced mutations, and antimicrobial effects against Escherichia coli, Bacillus subtilis and Saccharomyces cerevisiae by the extracts from Hizikia fusiforme. Laminaria japonica and Undaria pinnatifida with ethanol of a different concentrations were investigated. Desmutagenic effects against MMS and ICR191 of 90% ethanol extracts from Hizikia fusiforme were up 70 and 95%. respectively. no against sodium azide. Desmutagenic effects against ICR191 of 30∼90% ethanol extracts from Undaria pinnatifida and Laminaria japonica were up to 50 and 70%. respectively. but no against sodium azide and MMS. Antimicrobial effect of 70 and 90% ethanol extracts from Hizikia fusiforme had potent antimicrobial activities against E. coli and B. subtilis. Ethanol extracts from Laminaria japonica showed more effective antimicrobial effects than those from Undaria pinnatifida. Only 50% ethanol extract from Undaria pinnatifida showed growth inhibition effect against S. cerevisiae. Seventy percent ethanol extract from Laminaria japonica showed growth inhibition effect against all strains tested. while 90% ethanol extract showed against E. coli and B. subtilis.

박물관 건설경영에 관한 연구

林采震,文鍾承 홍익대학교환경개발연구원 2001 환경개발연구논문집 Vol.6 No.-

An instance of domestic exhibition facility building case, the shortage of managing personal constructive resulted serious issue on expenses, times, quality, and safty with no satisfaction on its process and result. According to subject's speciality the CM's application methods are varied and because of its speciality, overall process of building an exhibition facility operating by its owner. This study intends to exam a application possibility of CM on exhibition facility construction to make smooth communication among varied area that following to exhibition facility construction.

홍삼 추출물이 감마선에 조사된 생쥐의 혈액상에 미치는 변화

장재철,전철,김동윤,김동조 群山大學校自然科學硏究所 1990 自然科學硏究 Vol.5 No.-

홍삼 추출물이 감마선에 조사된 생쥐의 혈액상에 미치는 변화를 알아보기 위하여 생리적 식염수군을 대조구로 하여, 홍삼추출물 투여구와 홍삼추출물 투여후 5Gy 감마선 전신조사구 및 5Gy 감마선만을 전신조사한 구 등 4구로 분류하였다. 홍삼 추출물 투여에 의한 감마선에 조사된 생쥐의 적혈구 수, 백혈구 수 및 혈소판 수는 회복되어졌으면 반면, 생쥐의 무게나 혈색소량은 거의 유의성이 없었다. 홍삼 추출물 투여구와 생리적 식염수 투여구에 5Gy 방사선 조사구의 백혈구수는 현저히 회복되었다. 이러한 결과는 홍삼 추출물이 방사선에 조사된 생쥐의 혈액상에 방호적인 효과와 회복 효과가 있다고 생각되었다. This study was carried out obtain changes of red ginseng extract on the blood in the gamma ray post-irradiated mice. The experimental groups were control(saline), ginseng, ginseng and wholebody irradiated(??), and wholebody irradiated(??). Gamma ray post-irradiation recoverd by the red ginseng extract were observed in erythrocyte, leucocyte and thrombocyte, while the ginseng extract did not affect weight and hemoglobin. Leucocyte of ginseng and wholebody irradiated groups were significantry recoverd. This results thought that red ginseng extract group before radiation injury have the protective effect and the recovry effects on the mice blood.

정신지체인의 적응행동 요인이 직업유지기간과 이직경험횟수에 미치는 영향

이채식,이성규 한국사회복지정책학회 2005 사회복지정책 Vol.21 No.-

본 연구는 정신지체인의 적응행동(개념적·사회적·직업적 기술 및 사회적 지지) 요인이 직업유지기간과 이직경험횟수에 어떠한 영향을 미치는지 실증적으로 밝히는데 있다. 분석결과를 요약하면 첫째, 직업유지기간에 유의한 영양을 주는 변인들은 일반적 특성 중에서 직종, 종업원수, 장애인수, 작업지도원 배치, 사회적 기술요인 중에서 안전능력, 금전관리능력, 직업적 기술 요인 중에서 직업생활태도, 작업도구수행능력, 직업적 행동특성, 그리고 사회적 지지요인 중에서 전문가 지지 등으로 나타났으며, 요인간의 상대적 크기는 직업적 기술요인이 가장 높게 나타났다. 둘째, 이직경험횟수에 유의한 영향을 주는 변인들은 일반적 특성 중에서 월평균 임금, 복리후생시설수, 직종, 개념적 기술요인 중에서 수개념, 직업적 기술요인 중에서 직업생활태도, 직업적 행동특성 등으로 나타났으며, 요인간의 상대적 크기는 직업적 기술 요인이 가장 높게 나타났다. 이러한 연구결과는 정신지체인의 직업유지기간을 높이는데 있어서 개념적, 사회적 기술보다는 사업체 현장에서 작업자에게 실질적으로 요구되는 작업기술과 관련된 직업적 기술이 중요함을 알 수 있다. 따라서 정신지체인에 대안 직업재활은 작업현장에서 실제적으로 적용할 수 있는 직업기술과 관련된 제도와 서비스 체계가 중요하다는 것이 실증적으로 입증되었다. This study examined practically the effects of adaptation behavior factors (conceptual skills, social skills, occupational skills and social support) of people with mental retardation on the duration of job tenure and the number of separation. To summary the result of analysis, firstly, the variables which influence the duration of job tenure significantly are the number of employees, the number of people with disabilities and the existence of work guide from general characteristics factors; safety managing abilities and money managing abilities from social skills factors; job attitude, tool handling skills and job-related behavioral characteristics from occupational skills factors; and professional support from social support factors. The occupational skills factors have relatively highest influence among other factors. Secondly, the variables which influence the number of separation significantly are average monthly wage, the number of welfare facilities and the type of occupation from general characteristics factors; number concept from conceptual skills factors; and job attitude, and job-related behavioral characteristics from occupational skills factors. The occupational skill factors have relatively highest influence among other factors. These results show that in extending the duration of job tenure of people with mental retardation, the occupational skills, which is related to the work skill required practically to the worker in the work field, are more important than the conceptual skills and social skills. Consequently, it is proved that in vocational rehabilitation for the people with mental retardation, the organization and the service system is important, which is related to the work skill applicable practically to the work field.