Monte Carlo Method and Quantile Regression for Uncertainty Analysis of Wind Power Forecasting Based on Chaos-LS-SVM

Xin Zhao,Chao Ge,Fangfang Ji,Yajuan Liu 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.11

In the paper, the chaos least squares support vector machine algorithm (Chaos-LS-SVM) is applied. To conduct uncertainty analysis of wind power forecasting, two forecasting algorithms of the probabilistic uncertainty analysis based on the Monte Carlo method and the quantile regression analysis based on Chaos-LS-SVM are discussed. The effectiveness and superiority of the two uncertainty analysis methods in the confidence level of 95%, 90%, and 85% are discussed by simulation analysis, and the confidence interval is given in the corresponding confidence level. The prediction interval coverage probability (PICP) and the prediction interval normalized average width (PINAW) of the two uncertainty methods are compared. In the time scale of 1h-ahead, 4h-ahead, and 6h-ahead, the probabilistic uncertainty analysis based on the Monte Carlo method is suitable. In the time scale of 24h-ahead, the quantile regression analysis based on Chaos-LS-SVM is superior.

Insights into the Structural Features Essential for JAK2 Inhibition and Selectivity

Zhao, Chao,Bikram Khadka, Daulat,Cho, Won-Jea Bentham Science 2016 Current medicinal chemistry Vol.23 No.13

A modified RBSM for simulating the failure process of RC structures

Chao Zhao,Xingu Zhong,Bo Liu,Xiaojuan Shu,Mingyan Shen 사단법인 한국계산역학회 2018 Computers and Concrete, An International Journal Vol.21 No.2

In this paper, a modified rigid body spring model (RBSM) is proposed and used to analyze the damage and failure process of reinforced concrete (RC) structures. In the proposed model, the concrete is represented by an assembly of rigid blocks connected with a uniform distribution of normal and tangential springs to simulate the macroscopic mechanical behavior of concrete. Steel bars are evenly dispersed into rigid blocks as a kind of homogeneous axial material, and an additional uniform distribution of axial and dowel springs is defined to consider the axial stiffness and dowel action of steel bars. Perfect bond between the concrete and steel bars is assumed, and tension stiffening effect of steel bars is modeled by adjusting the constitutive relationship for the tensile reinforcement. Adjacent blocks are allowed to separate at the contact interface, which makes it convenient and easy to simulate the cracking process of concrete. The failure of the springs is determined by the Mohr-Coulomb type criterion with the tension and compression caps. The effectiveness of the proposed method is confirmed by elastic analyses of a cantilever beam under different loading conditions and failure analyses of a RC beam under two-point loading.

Identification and Characterization of an Anaerobic Ethanol-Producing Cellulolytic Bacterial Consortium from Great Basin Hot Springs with Agricultural Residues and Energy Crops

( Chao Zhao ),( Yun Jin Deng ),( Xing Aa Wang ),( Qiu Zhe Li ),( Yi Fan Huang ),( Bin Liu ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.9

In order to obtain the cellulolytic bacterial consortia, sediments from Great Basin hot springs (Nevada, USA) were sampled and enriched with cellulosic biomass as the sole carbon source. The bacterial composition of the resulting anaerobic ethanol-producing celluloytic bacterial consortium, named SV79, was analyzed. With methods of the full-length 16S rRNA librarybased analysis and denaturing gradient gel electrophoresis, 21 bacteria belonging to eight genera were detected from this consortium. Clones with closest relation to the genera Acetivibrio, Clostridium, Cellulosilyticum, Ruminococcus, and Sporomusa were predominant. The cellulase activities and ethanol productions of consortium SV79 using different agricultural residues (sugarcane bagasse and spent mushroom substrate) and energy crops (Spartina anglica, Miscanthus floridulus, and Pennisetum sinese Roxb) were studied. During cultivation, consortium SV79 produced the maximum filter paper activity (FPase, 9.41 U/ml), carboxymethylcellulase activity (CMCase, 6.35 U/ml), and xylanase activity (4.28 U/ml) with sugarcane bagasse, spent mushroom substrate, and S. anglica, respectively. The ethanol production using M. floridulus as substrate was up to 2.63 mM ethanol/g using gas chromatography analysis. It has high potential to be a new candidate for producing ethanol with cellulosic biomass under anoxic conditions in natural environments.

Design and synthesis of novel androgen receptor antagonists via molecular modeling

( Chao Zhao ),( You Hee Choi ),( Daulat Bikram Khadka ),( Yifeng Jin ),( Kwang-youl Lee ),( Won-jea Cho ) 전남대학교 약품개발연구소 2016 약품개발연구지 Vol.25 No.-

Several androgen receptor (AR) antagonists are clinically prescribed to treat prostate cancer. Unfortunately, many patients become resistant to the existing AR antagonists. To overcome this, a novel AR antagonist candidate called DIMN was discovered by our research group in 2013. In order to develop compounds with improved potency, we designed novel DIMN derivatives based on a docking study and substituted carbons with heteroatom moieties. Encouraging in vitro results for compounds 1b, 1c, 1e, 3c, and 4c proved that the new design was successful. Among the newly synthesized compounds. 1e exhib-ited the strongest inhibitory effect on LNCaP cell growth (IC-₅₀=0.35 μm) and also acted as a competitive AR antagonist with selectivity over the estrogen receptor (ER) and the glucocorticoid receptor (GR). A docking study of compound 1e fully supported these biological results. Compound 1e is considered to be a novel, potent and AR-specific antagonist for treating prostate cancer. Thus, our study successfully applied molecular modeling and bioisosteric replacement for hit optimization. The methods here provide a guide for future development of drug candidates through structure-based drug discovery and chemical Modifications. ⓒ 2015 Elsevier Ltd. All rights reserved.

Antimicrobial Constituents from Fruits of Ailanthus Altissima SWINGLE

Zhao Chun-Chao,Shao Jian-Hua,Li Xian,Xu Jing,Zhang Peng The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.10

A new naturally occurring sterol, compound 5, and six known stigmasterols were isolated from fruits of Ailanthus altissima Swingle by repeated column chromatography and RP-HPLC. Their structures were identified as, 5${\alpha}$-stigmastane-3,6-dione (1), 3${\beta}$-hydroxystigmast-5-en-7-one (2), stigmast-5-ene-3${\beta}$, 7${\alpha}$-diol (3), 6${\alpha}$-hydroxystigmast-4-en-3-one (4), 5${\alpha}$-stigmastane-3${\beta}$, 6${\beta}$-diol (5), stigmast-4-ene-3${\beta}$, 6${\alpha}$-diol (6), stigmast-5-ene-3${\beta}$, 7${\alpha}$, 20$\xi$-triol (7) by spectral analysis and comparison with the published data. These compounds have not been reported from genus Ailanthus, whereas compound 7 was identified by NMR for the first time. In addition, the $95\%$ ethanol extract and compounds from the fruits of Ailanthus altissima SWINGLE were assayed for in vitro antimicrobial activity. The extract was potent active against the assayed bacteria while compounds 3 and 7 exhibited moderate activity.

Feasibility study of buckling-restrained braces with PM-35 steel core

Chao Zhao,Qianqian Chen,Xingu Zhong,Tianyu Zhang,Zhiwen Chen 국제구조공학회 2021 Structural Engineering and Mechanics, An Int'l Jou Vol.79 No.2

The energy dissipation characteristics of core materials greatly influence the working performance of bucklingrestrained braces (BRBs), so it is a vital work to develop more excellent energy dissipation core materials. In this research, a series of experimental studies are conducted, including the mechanical properties of PM-35 steels and the working performance of PM-35 BRB specimens, which serve to investigate the feasibility of PM-35 steel as core materials of BRBs. In addition, the analysis of variance (ANOVA) has been conducted to study the sensitivity factors of energy dissipation of PM-35 BRB specimens, especially the pre-force applied on the BRB specimens. According to the results of this research, it can be concluded that the energy absorption efficiency of PM-35 BRBs specimens is much higher than that of BRB specimens with ordinary core materials; the internal pores greatly weaken the yield strength of PM-35 steel and obviously improve the plastic deformation capacity, which makes that PM-35 core materials are able to absorb energy in a lower stress level; pre-force applied on core materials is the key factor governing the energy absorption, and can significantly improve the working performance of BRB specimens with PM-35 core materials.

Production of Transgenic Pigs with an Introduced Missense Mutation of the Bone Morphogenetic Protein Receptor Type IB Gene Related to Prolificacy

Zhao, Xueyan,Yang, Qiang,Zhao, Kewei,Jiang, Chao,Ren, Dongren,Xu, Pan,He, Xiaofang,Liao, Rongrong,Jiang, Kai,Ma, Junwu,Xiao, Shijun,Ren, Jun,Xing, Yuyun Asian Australasian Association of Animal Productio 2016 Animal Bioscience Vol.29 No.7

In the last few decades, transgenic animal technology has witnessed an increasingly wide application in animal breeding. Reproductive traits are economically important to the pig industry. It has been shown that the bone morphogenetic protein receptor type IB (BMPR1B) A746G polymorphism is responsible for the fertility in sheep. However, this causal mutation exits exclusively in sheep and goat. In this study, we attempted to create transgenic pigs by introducing this mutation with the aim to improve reproductive traits in pigs. We successfully constructed a vector containing porcine BMPR1B coding sequence (CDS) with the mutant G allele of A746G mutation. In total, we obtained 24 cloned male piglets using handmade cloning (HMC) technique, and 12 individuals survived till maturation. A set of polymerase chain reactions indicated that 11 of 12 matured boars were transgene-positive individuals, and that the transgenic vector was most likely disrupted during cloning. Of 11 positive pigs, one (No. 11) lost a part of the terminator region but had the intact promoter and the CDS regions. cDNA sequencing showed that the introduced allele (746G) was expressed in multiple tissues of transgene-positive offspring of No.11. Western blot analysis revealed that BMPR1B protein expression in multiple tissues of transgene-positive $F_1$ piglets was 0.5 to 2-fold higher than that in the transgene-negative siblings. The No. 11 boar showed normal litter size performance as normal pigs from the same breed. Transgene-positive $F_1$ boars produced by No. 11 had higher semen volume, sperm concentration and total sperm per ejaculate than the negative siblings, although the differences did not reached statistical significance. Transgene-positive $F_1$ sows had similar litter size performance to the negative siblings, and more data are needed to adequately assess the litter size performance. In conclusion, we obtained 24 cloned transgenic pigs with the modified porcine BMPR1B CDS using HMC. cDNA sequencing and western blot indicated that the exogenous BMPR1B CDS was successfully expressed in host pigs. The transgenic pigs showed normal litter size performance. However, no significant differences in litter size were found between transgene-positive and negative sows. Our study provides new insight into producing cloned transgenic livestock related to reproductive traits.

Right-to-Left Displacement of an Airgun Lead Bullet after Transorbital Entry into the Skull Complicated by Posttraumatic Epilepsy : A Case Report

Chao-bin Wang,Hui Wang,Jun-shuang Zhao,Ze-jun Wu,Hao-dong Liu,Chao-jia Wang,An-rong Li,Dawei Wang,Juntao Hu 대한신경외과학회 2023 Journal of Korean neurosurgical society Vol.66 No.5

Penetrating head injury is a serious open cranial injury. In civilians, it is often caused by non-missile, low velocity flying objects that penetrate the skull through a weak cranial structure, forming intracranial foreign bodies. The intracranial foreign body can be displaced due to its special quality, shape, and location. In this paper, we report a rare case of right-to-left displacement of an airgun lead bullet after transorbital entry into the skull complicated by posttraumatic epilepsy, as a reminder to colleagues that intracranial metal foreign bodies maybe displaced intraoperatively. In addition, we have found that the presence of intracranial metallic foreign bodies may be a factor for the posttraumatic epilepsy, and their timely removal appears to be beneficial for epilepsy control.

Comparison of the Wave Model Experiments around Japan Island Using WAModel and JWA3G Model and JMA Buoy Data

Zhao, Chao Fang,Komine, H.,Akiyama, M.,Sugimori, Y.,Matsuura, N. 대한원격탐사학회 1996 International Symposium on Remote Sensing Vol.12 No.1

The WAM (WAve Modeling) model, as one of the best wave models used in the world, has been used for wave data assimilation, SAR data verification and wave forecasting on global and regional scales. In this study, an experiment of the wave model comparison is carried out around Japan Island by using WAM wave model and Japan Meteorological Agency wave model (JWA3G). Both of these two model results are compared with the Ocean Buoy Station around Japan, which are operated by Japan Meteorological Agency. Compared with WAM model, wind input and dissipation have been modified in JWA3G model. Wind input data used in both wave model are the interpolated result with 0.5x0.5 degree grid by using ECMWF wind data with spatial resolution of 2.5x2.5 degree. The main results can be summaried as follows, (I). Compared with buoy data, the predicted wave height from both models are delayed several hours in typhoon period. This result is consistent with wind data difference between buoy data and the predicted wind data by ECMWF. (2). The predicted wave height by both models give a consistent result around typhoon period. (3). In low sea state, the result from WAM model gives a much better result than that from JWA3G model by comparing with buoy data.