Lipid Profile Change after Thyroidectomy

Chih Hao Chu,Soo Young Kim,Yong Sang Lee,Hang-Seok Chang 대한갑상선-내분비외과학회 2020 The Koreran journal of Endocrine Surgery Vol.20 No.3

Purpose: Thyroid diseases and lipid metabolic abnormalities have been reported to be correlated. In patients with thyroid cancer, thyroid stimulating hormone levels are suppressed to prevent recurrence. Many studies have reported dyslipidemia associated with thyroid function, although its extent before and after thyroidectomy remains to be studied. This study aimed to determine the lipid levels for administering accurate lipid treatment in thyroid cancer patients post thyroidectomy. Methods: In total, 1,203 patients with thyroid cancer who underwent thyroidectomy between June 1, 2016 and December 31, 2016 at the Thyroid Cancer Center, Gangnam Severance Hospital, Yonsei University, were enrolled in the study. Of these, patients aged <19 years and taking medication for dyslipidemia were excluded. Finally, we enrolled 295 thyroid cancer patients who underwent thyroidectomy and whose lipid profiles were confirmed pre- and post-operatively. Results: The total cholesterol levels in the lobectomy group without levothyroxine supplementation were significantly increased 1 year after surgery than those before surgery (168.17±29.19 mg/dL vs. 182.50±34.03 mg/dL, P=0.003). Additionally, the triglyceride (TG) levels were significantly decreased in the lobectomy with levothyroxine supplementation and total thyroidectomy groups, whereas cholesterol and low-density lipoprotein-cholesterol (LDL-C) levels showed no significant change. No significant changes in the levels of cholesterol, LDL-C, and TG were observed in all the 3 groups. Conclusion: Extent of surgery and levothyroxine supplementation had an insignificant impact on the levels of cholesterol, LDL-C, TG, and high-density lipoprotein-cholesterol compared pre- and post-operatively.

中國의 食糧流通 體系 改革에 관한 硏究

金映秀,金活,曺彰浣 全南大學校 農業科學技術硏究所 1999 農業科學技術硏究 Vol.34 No.-

Chinese government has declared that China solved the "problem of food subsistency" by 1984, Which means China solved the food problem by mid 1980s. The potentially unemployed labor forces in Chinese rural area were estimated as much as 173 million as of 1996. Thereforce, food is really serious in China, Where seasonality lack of food is very important in China. Chinese food marketing system developed 3rd step. But the effects of food system were miners because of increasing food price and monetery in urban.

Cytotoxic anthraquinone dimers from Melandrium firmum

Chang Hao Zhang,Da Lei Yao,Cheng-Shen Li,Jie Luo,Mei Jin,Ming-Shan Zheng,Zhen-Hua Lin,Tie-Feng Jin,Gao Li 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.6

Two new anthraquinone dimers, melrubiellin A(1) and melrubiellin B (2), were isolated from the aerialpart of Melandrium firmum Rohrbach, along with sevenknown compounds (3–9). The structures of these compoundswere elucidated by spectral analyses, including 1Dand 2D NMR (COSY, HMQC, HMBC and NOESY)experiments. Compound 1 and 2 exhibited significantcytotoxicity towards HeLa, NCI-H460, Hep G2, Hep 3Band MKN-28 cell lines with IC50 values ranging from 5.26to 81.16 lM.

Enzymatic Biotransformation of Ginsenoside Rb1 and Gypenoside XVII into Ginsenosides Rd and F2 by Recombinant β-glucosidase from F lavobacterium johnsoniae

Hao Hong,Chang-Hao Cui,Jin-Kwang Kim,Feng-Xie Jin,Sun-Chang Kim,Wan-Taek Im 고려인삼학회 2012 Journal of Ginseng Research Vol.36 No.4

This study focused on the enzymatic biotransformation of the major ginsenoside Rb1 into Rd for the mass production of minor ginsenosides using a novel recombinant β-glucosidase from Flavobacterium johnsoniae. The gene (bglF3) consisting of 2,235 bp (744 amino acid residues) was cloned and the recombinant enzyme overexpressed in Escherichia coli BL21(DE3) was characterized. This enzyme could transform ginsenoside Rb1 and gypenoside XVII to the ginsenosides Rd and F2, respectively. The glutathione S-transferase (GST) fused BglF3 was purifi ed with GST-bind agarose resin and characterized. The kinetic parameters for β-glucosidase had apparent Km values of 0.91±0.02 and 2.84±0.05 mM and Vmax values of 5.75±0.12 and 0.71±0.01 μmol·min-1·mg of protein-1 against p-nitrophenyl-β-D-glucopyranoside and Rb1, respectively. At optimal conditions of pH 6.0 and 37°C, BglF3 could only hydrolyze the outer glucose moiety of ginsenoside Rb1 and gypenoside XVII at the C-20 position of aglycon into ginsenosides Rd and F2, respectively. These results indicate that the recombinant BglF3 could be useful for the mass production of ginsenosides Rd and F2 in the pharmaceutical or cosmetic industry.

Modeling and Implementation of Fixed Switching Frequency Sliding Mode Control to Two-Stage DC-DC Converter

Chang-hao Piao,Chao Jiang,Hongtao Qiao,조종두,Sheng Lu 제어·로봇·시스템학회 2014 International Journal of Control, Automation, and Vol.12 No.6

A fixed switching frequency sliding mode (FSFSM) controller for two-stage DC-DC converter is proposed. Owing to the time-varying switched mode operation, the dynamic performance of two-stage converter becomes high order and non-linear. For designing the FSFSM controller, the state-space average model is made, and then the three conditions of sliding mode (SM) control, namely, hitting, existence and stability condition are analyzed. A conventional linear controller (Lag) for two-stage converter is designed as a comparison to validate the good robustness and dynamic response of the FSFSM controller. At last, a series of simulation and experimental results are presented to demonstrate the feasibility of the designed FSFSM controller.

Effect of sodium sulfite, tartaric acid, tannin, and glucose on rheological properties, release of aroma compounds, and color characteristics of red wine

Hao Wang,Zhi-Jing Ni,Wen-Ping Ma,Chang-Bing Song,Jian-Guo Zhang,Kiran Thakur,Zhao-Jun Wei 한국식품과학회 2019 Food Science and Biotechnology Vol.28 No.2

In this study, we evaluated the effect of additionof non-volatile compounds (sodium sulfite, tartaric acid,tannin, and glucose) on the rheological properties, releaseof aroma compounds, and color of the red wine. Whiledetermining the rheological properties of the supplementedsamples, non-Newtonian fluidic and shear-thinningbehavior of samples was noticed. The viscosity of thesesamples was found in negative correlation with the dose ofaddition of various non-volatile substances. The aromaprofile of red wine after additions showed the change in therelease of the nine key aroma compounds. Among themethyl hexanoate, phenylethyl alcohol, octanoic acid, diethylsuccinate, and ethyl octanoate were profoundly increased. Further, the color of red wines was improved in the presenceof tartaric acid and tannin. Overall, supplementationof various substances during storage period of three differentwines could enormously affect the sensory characteristicsin a dose dependent manner.

Expression Profiling of Lipopolysaccharide Target Genes in RAW264.7 Cells by Oligonucleotide Microarray Analyses

Hao Huang,Cheol Kyu Park,Ji Yoon Ryu,Eun-Ju Chang,Youngkyun Lee,강삼식,김홍희 대한약학회 2006 Archives of Pharmacal Research Vol.29 No.10

In inflammatory responses, induction of cytokines and other immune regulator genes in macrophages by pathogen-associated signal such as lipopolysaccharide (LPS) plays a crucial role. In this study, the gene expression profile changes by LPS treatment in the macrophage/monocyte lineage cell line RAW264.7 was investigated. A 60-mer oligonucleotide microarray of which probes target 32381 mouse genes was used. A reverse transcription-in vitro translation labeling protocol and a chemileuminescence detection system were employed. The mRNA expression levels in RAW264.7 cells treated for 6 h with LPS and the control vehicle were compared. 747 genes were up-regulated and 523 genes were down-regulated by more than 2 folds. 320 genes showing more than 4-fold change by LPS treatment were further classified for the biological process, molecular function, and signaling pathway. The biological process categories that showed high number of increased genes include the immunity and defense, the nucleic acid metabolism, the protein metabolism and modification, and the signal transduction process. The chemokine-cytokine signaling, interleukin signaling, Toll receptor signaling, and apoptosis signaling pathways involved high number of genes differentially expressed in response to LPS. These expression profile data provide more comprehensive information on LPS-target genes in RAW264.7 cells, which will be useful in comparing gene expression changes induced by extracts and compounds from anti-inflammatory medicinal herbs.

A Novel Battery State of Health Estimation Method Based on Outlier Detection Algorithm

Chang-hao Piao,Zi-hao Hu,Ling Su,Jian-fei Zhao 대한전기학회 2016 Journal of Electrical Engineering & Technology Vol.11 No.6

A novel battery SOH estimation algorithm based on outlier detection has been presented. The Battery state of health (SOH) is one of the most important parameters that describes the usability state of the power battery system. Firstly, a battery system model with lifetime fading characteristic was established, and the battery characteristic parameters were acquired from the lifetime fading process. Then, the outlier detection method based on angular distribution was used to identify the outliers among the battery behaviors. Lastly, the functional relationship between battery SOH and the outlier distribution was obtained by polynomial fitting method. The experimental results show that the algorithm can identify the outliers accurately, and the absolute error between the SOH estimation value and true value is less than 3%.

Chemical constituents from the aerial parts of Melandrium firmum

Chang Hao Zhang,Gao Li,Jie Luo,Tian Li,Yong Cui,Mei Jin,Da Lei Yao,Ming Shan Zheng,Zhen-Hua Lin,Jiong Mo Cui 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.10

Two new anthraquinones, melrubiellin C (1) andmelrubiellin D (2), were isolated from the aerial parts of Melandriumfirmum Rohrbach, together with eight known compounds(3–10). The structures of these compounds wereelucidated using 1Dand 2DNMR(COSY,HMQC,HMBCandNOESY) experiments. All isolated compounds were tested fortheir cytotoxicity against NCI-H460, Hep G2, MKN-28 andA-549 cells.Of these 10 compounds,1 and 2 exhibitedmoderatecytotoxicity with IC50 values ranging from 9.54 to 32.41 lM.

From Housewives to Activists : Lived Experiences of Mothers for Disability Rights in Taiwan

Chang, Heng Hao Ewha Womans University Press 2009 Asian Journal of Women's Studies(AJWS) Vol.15 No.3

When a family has a disabled child, the mother usually takes on the caretaker role and also carries the social stigma associated with disability. Based on participant observation and in-depth interviews with members of the Parents Association for Persons with Intellectual Disabilities (PAPID), this article explores the meanings of activism for parents who participate in the disability rights movement. First, it shows the impact of disability stigma on family members, especially the mothers of disabled persons. Second, the study shows that the participants of this movement, mainly the mothers of intellectually disabled children, not only promote the welfare of their children but they also learn to confront social stigma and renegotiate their gender roles. Parents’ associations have become an important public space for these mothers to escape home confinement and enjoy civic life. In contrast, the fathers who were interviewed saw activism as an obligation and were less likely to show emotional attachment to the civic organizations.