植物凝集素 Terminalis chebula R.C. 및 토끼赤血球에 의한 사람 血淸型에 關한 硏究

張丙錡,文國鎭 고려대학교 의과대학 1985 고려대 의대 잡지 Vol.22 No.3

Plant extracts have variable biological activities, as phytagglutinins, mitogens, lymphocytotoxins, anticancer substances, sperm agglutinins and so on. So they have been used extensively in medical field, including medicolegal part. In medicolegal part, plant extracts, as phytagglutinins (PHA), were mainly used for classification of new human red blood cell types and for detection of new lectins up to date. But recently some investigators attempted to classify human sera by their inhibition properties on PHA. For the purpose of new classification of human serum, the author used Terminalis chebula R.C. extracts, which act as panphytagglutinin to rabbit red blood cells, by use of inhibition property of fresh human serum, blood stains, whole blood stains and various blood type to PHA. The results of this study could be summerized as follows; 1. Human sera could be classified into two groups. One was possessed of certain substance which inhibit the agglutination activity of Terminalis chebula R.C. extracts on rabbit RBC and the other was not. 2. The frequency of the former was 15% and the latter was 85% respectively. 3. The agglutination inhibition phanomena of Terminalis chebula R.C. extracts on rabbit RBC by human sera showed no relation with ABO, Cl, H, ab.C, CCI, PVI, Cea, WCea, and Hp blood types respectively. 4. This serum type may be available for classification of blood stains.

텅스텐인산으로 개질된 SBA-15 촉매 상에서 아세트산의 탈수반응

우창수,He, Nong-Yue,김현국,이호인 한국공업화학회 2004 응용화학 Vol.8 No.1

TPA (tungstophosphoric acid), a typical heteropoly acid, was impregnated on SBA-15 to modify the acidic property of the mesoporous catalyst. The TPA was highly dispersed on the SBA-15 which has large surface area confirming by nitrogen adsorption, X-ray diffraction, and infrared spectroscopy. According to the result of in-situ FTIR spectroscopy using pyridine as a probe molecule, it was revealed that silanol group was gradually decreased with increasing the loading amount of TPA, and that new acidic site different from that of pure TPA was generated resulting in the enhancement of catalytic activity. TPA could act as a promoter when loaded on SBA-15 by relatively small amount, but the catalytic activity was greatly decreased due to the loss of silanol group as an active site when a large amount of TPA was loaded.

종합병원 입원 환자에서의 불면증의 임상적 특징

이종국,유태혁,한창환 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.1

The purpose of this study is to investigate the clinical characteristics of insomnia in 300 new inpatients of general hospital with semistructured interview and questionaires. Among 4 clinical groups-129 noninsomniacs, 171 insomniacs (100 insomniacs with past insomnia history and 71 without past history), we compared the following variables ; age, sex, associated significant diseases, usual life habits, environmental variables influencing sleep pattern, types of insomnia, causes of insomnia, coping methods with insomnia, and usage of hypnotics. In insomniacs we also compared the changes of types and causes of insomnia, coping methods with insomnia after admission. The prevalence of insomnia was significantly increased after admission, and was higher in female patients but not significantly different in age. The frequencies of associated significant disease(angina, arrhythmia, asthma, duodenal ulcer etc.), naps, smoking, alcohol and coffee drinking showed no difference between insomniacs and noninsomniacs. Among environmental variables, “apprehension about illness”, “noise”, “nurse's visit”, and “bed discomfort”were significantly more frequent in insomniacs. Presence or absence of past insomnia history gave no significant effect on the types, causes of insomnia and coping methods with insomnia. Difficulty in maintaining sleep(DMS) was significantly increased after admission but difficulty in falling asleep(DFA) was decreased. The causes of insomnia were physical illness, sleep environmental variables, and psychological variables in order ; first two of these were significantly increased after admission. After admission as well as before admission, the most coping method with insomnia was “effort to forget problems”. Among the methods, “exercise or walking” was significantly increased after admission. Afterwards the study on the psychopathology and characteristics of personality which related with insomnia will be needed to broaden our understanding about insomnia and to establish proper management plan of insomnia.

順氣活血湯 및 加味順氣活血湯이 瘀血病態模型에 미치는 影響

朴昌國 동서의학사 1998 동서의학 Vol.23 No.2

약물을 이용한 의식진정시 발생한 부작용에 대한 치험례

한국재,이창섭,이상호,김현식 大韓小兒齒科學會 1997 大韓小兒齒科學會誌 Vol.24 No.4

The patients visiting pediatric dental office have been being younger than the previous, and they were often combined with systemic disease. But, we aren't able to perform the verbal communication, because of their impediment and youthfullness. And, we can't carry out the behavior control via physical restraint, as the developed social structure and the attitude of children and their parents. So, the importance and concerning of conscious sedation using sedative medicine are increased by time and time. Among the various conscious sedation, Chloral Hydrate and Nitrous Oxide inhalation are most popularly used, and barbiturates, benzodiazepine, opioids and hydroxyzine are used often. But, these medications have some side-effects and adverse reactions, may be failed to sedate the children. And limited use of medically compromised patients, especially for ASA class Ⅲ, Ⅳ or more dangerous patients. We, the Department of Pediatric Dentistry, Chosun University have met some dangerous situation due to unfavorable pharmacogenic reactions, but we can control the situation and get well healed results. The below results are common situations and their solutions during conscious sedation. 1. By the intravenous administration, thrombophlebitis is the most common side-effects, but it may be healed with time without any special treatment. 2. Under the definitive guidelines about conscious-sedation, we can perform a safe conscious sedation for ASA class Ⅲ patients. 3. When adversed reaction of Benzodiazepine is occured, it could be cared effectively with benzodiazepine antagonist, named Flumazenil.

알루미늄과 헤테로폴리산으로 개질된 메조포러스 실리카 상에서의 AKD 합성

김현국,우창수,최재석,박민태,이병민,이호인 한국공업화학회 2003 응용화학 Vol.7 No.1

AKD(alkyl ketene dimer) used widely as a neutral sizing agent is produced industrially by halogenization of stearic acid followed by dimerization of alkyl ketene. In the present work, to suppress the byproduct of hydrochloric acid and to improve reaction pathway. AKD was prepared through of ketene intermediate by dehydration of stearic acid in gas phase using reaction with silanol on silica as active sites of the catalyst SBA-15 showed the highest activity due to the large and open tubular pores. It was found that main products were dimer and trimer. Our goal of the present work was to increase of the selectivity for the dimer.

21世紀를 향한 公州市 開發方向에 관한 硏究

林國澤,崔昌喜 公州大學校 地域開發硏究所 1992 地域開發硏究論叢 Vol.1 No.1

For the development of Kong-Ju city, there should be strategic transformation. Since the promotion of Dae-Jun city as a directly governed city on Jan 1, 1989, Chung-Nam Province had made various functional changes for its administration, but still depends on Dae-Jun city for its proper administrative function. However for the realistic development of Chung-Nam Province, Kong-Ju city should be developed to be the transportation center along the 3rd comprehensive national-land development plan and 7th development plan of economy & society. Furthermore there should be mid, or long-term plan for the development of Kong-Ju city as the center of local administration, transportation & culture, by the comprehensive plan of Baik-Je cultural zone in order to revitalize the traditional education center to produce a large number of talented men. Currently proceeding systematic development through the functional allocation of four regions should be an effective promotional policy of local development for the expansion-basis of city growth. And through expanding the city plan region for the industrial-tour development & through inducing movement of many manufacturers in the "Gum-Sang farming & industrial complex", there should be established balanced development & self-financing through industrial restructuring & revitalization of local economy. Additionally there needs early establishment of cooperative atmosphere for democratic administration ,between local assembly & local government to split up the responsibility for citizens' harmonization & local development, between two two bodies, and when voluntary cooperation is established for the assembly activities, local residents will trust & help the local government & assembly. Furthermore ,by satisfying local residents' desire which increased suddenly & by establishing reliable financial source with such current planning & proceeding as enforced investigation of individual tax payers, internal revenue search,construction of farming & industrial complexes,restructuring of industries, specialized development of industrial region, development of tour-resources through building resort complex & expansion of its facilities, collecting construction material from rivers,increasing revenue with the income from garden-cemeteries and making realistic adjustment of charges & entrance fees, Kong-Ju city could become realistic center of administration,transportation,culture & education for Chung-Nam Province.

구조물의 강성구조에 따른 파동 전파 특성의 이해(Ⅰ)

조미라,홍창국,김기봉 중앙대학교 건설환경연구소 2001 環境科學硏究 Vol.12 No.2

본 연구에서는 뛰어난 현장 적용성으로 구조물의 비파괴 건전도 평가 방법으로 주목받고 있는 충격반향기법의 신뢰성 향상과 정확도 개선을 위하여 콘크리트 구조물에서 전파되는 탄성파의 전파특성을 연구하였다. 이를 위하여 유한 요소해석기법과 동강성행렬법을 도입하여 수치실험을 수행하였다. 또한 이로써 기존에 보고되고 있는 총격반향기법의 수정이론을 검증하고 구조물의 전단강성구조에 따른 P파와 SH파의 전파 특성 등에 의한 평가방법이 미치는 영향을 평가하였으며 이를 바탕으로 충격반향기법의 실험자료 분석 및 해석에 있어서 보다 신뢰성 있는 결과를 도출할 수 있었다. The propagation of the elastic waves transmitting concrete structures was investigated to improve the reliability of the impact echo test, which is recognized as an excellent nondestructive method for the assessment of structural integrity. The finite element analysis and the analytical method of the dynamic stiffness matrix method were introduced for the investigation of the wave propagation, The study was first dedicated to the verification of the modified impact echo test (Kim, et at.,2001 ; Cho,2001), and then to the effects of factors such as stiffness structure and wane type (P-wave and SH-wave). This research enabled the impact echo test to be more reliable in the interpretation and analysis of the measurements.

酸棗仁이 CT105에 의한 신경세포 상해 및 白鼠의 기억에 미치는 영향

정정욱,박창국,박치상,이소연,윤현덕,신오철 대한본초학회 2005 大韓本草學會誌 Vol.20 No.1

Objective: This study was designed to research whether demonstrate neuroprotective and memory enhancing effects of Z1BU, suggesting its beneficial actions for the treatment of AD. Methods: The present study investigated effects of the dichloromethane extract of Semen Zizyphi Spinosae(ZIBU) on neurotoxicity and reactive oxygen species(ROS) and nitric oxide(NO) formation in PC 12 cell line overexpressed with carboxyl-terminal 105 amino acid peptide fragment of amyloid precursor protein(CT105). In addition, the present study evaluated its radical scavenging activity and effects on acetylcholinesterase(AChE) activity. Furthermore, effects on neuronal loss in CAl area and cognitive deficits induced by scopolamine treatment were also evaluated in rats. Result: we found in this study that ZIBU significantly inhibited apoptotic neuronal death induced by CT105 overexpression in PC12 cells, with the IC_(50) value of 23 ㎍/ml. Based on phase-contrast and fluorescence microscopic examinations, ZIBU reversed morphological changes of CT105-expressed PC-12 cells. It was also found that Z1BU significantly induced neurite outgrowth and inhibited formation of ROS and NO.Z1BU scavenged DPPH radicals and inhibited AChE activity. Furthermore, it attenuated memory impairment induced by the injection of scopolamine in rats, based on passive avoidance test. Crystal violet staining of rat brain slices exhibited increase in the viability of pyramidal neurons in hippocampal CAI area. Conclusion: these results demonstrate neuroprotective and memory enhancing effects of ZIBU, suggesting its beneficial actions for the treatment of AD.

한국 연안 퇴적물에서 ^137Cs, ^90Sr 및 Pu 동위원소의 분포

최석원,진현국,김철수,노정환,김창규,노병환 대한방사선 방어학회 2002 방사선방어학회지 Vol.27 No.2

한국 주변 연안 15개 정점의 퇴적물(0∼20 cm)에서 ^137Cs, ^90Sr, ^239+240Pu 의 농도와 농도비를 조사했다. ^137Cs, ^90Sr, ^238Pu 및^239+240Pu의 평균 방사능 농도는 각각 2.24±0.79 Bq·kg^-1-dry, 0.20±0.04 Bq·kg^-1-dry, 0.009±0.005 Bq·kg^-1-dry 및 0.27±0.17 Bq·kg^-1-dry이다. ^137Cs/^90Sr, ^239+240Pu/^137Cs 및 ^238Pu/229+240Pu의 평균 농도 비와 ^239Pu/240의 평균 원자 비는 각각 11.2±2.9, 0.123±0.053, 0.033±0.01 및 0.218±0.036이다. 퇴적물에서 핵종의 농도 범위와 핵종간의 농도 비는 그 동안 주변국가의 퇴적물에서 조사한 값과 비슷하였다. 퇴적물에서 ^137Cs과 ^239+240Pu의 상관계수는 0.80이다. ^137Cs과 SOM, ^239+240Pu과 점토 함량과의 상관계수는 각각 0.69, 0.67 이다. The concentrations and activity ratios of ^137Cs, ^90Sr, ^238Pu and ^239+240Pu in sediment(0∼20 cm) at 15 coastal stations of Korea were determined. The mean concentrations of ^137Cs, ^90Sr, ^238Pu and ^239+240Pu are 2.24±0.79 Bq·kg^-1-dry, 0.20±0.04 Bq·kg^-1-dry, 0.009±0.005 Bq·kg^-1-dry and 0.27±0.17 Bq·kg^-1-dry, respectively. The mean activity ratios of ^137Cs/^90Sr, ^239+240Pu/^137Cs and ^238Pu/^229+240Pu and atomic ratio of ^240Pu/^239Pu are 11.2±2.9, 0.123±0.053 and 0.033±0.017 and 0.218±0.036, respectively. The concentrations and activity ratios in sediment samples are similar to those reported from neighbouring country in the northern hemisphere. The correlation coefficient of ^137Cs and ^239+240Pu is 0.80. The correlation coefficient of ^137Cs and soil organic matter(SOM), and ^239+240Pu and clay content are 0.69 and 0.67, respectively.