Impacts and Countermeasures of Climate Change on Food Supply

Kim Chang-gil,Jeong Hak-kyun,Han Suk-ho,Kim Jeong-seung,Moon Dong-hyun 한국농촌경제연구원 2013 한국농촌경제연구원 기본연구보고서 Vol.- No.-

Climate change has become a megatrend that will lead to significant changes in future society. Korean and overseas agencies specializing in climate forecasts predict that average global temperatures will continue to rise. While climate change may potentially have certain positive impacts for crop yields, the overall impact is predicted to be negative for environment and food security. In this context, our study aims to suggest a plan for systematically establishing a stable food supply system in Korea in respose to climate change. Various analytical models were employed, including: a response analysis based on questionnaire for farmers, panel-based analysis of the causes of pests and diseases in rice production, a random-effects model for panel data of extreme weather impact, and an analysis of food supply effects using the Simulation Model for Climate-Agriculture Relations (SIMCAR) integrated model in conjunction with the Crop Estimation through Resource and Environment Synthesis (CERES) model of the Korea Agricultural Simulation Model (KASMO). An analysis was made of major grain yields by means of the KREI-KASMO. This revealed reduced yields and area in comparison with the baseline in 2050, resulting in a reduction of rice production by 17.8%p in the RCP8.5 scenario, and reduction of soybean by 21.2%p and reduction of barley by 13.7%p in the A2 scenario. Self-sufficiency ratio of major grains in 2050 drawn from the SIMCAR revealed that the climate change scenario for rice showed 55.0% to be reduced by 18.3% in comparison with the baseline. It is predicted that selfsufficiency ratio in rice will drop to 50% which means a half of consumed rice should be imported. Key tasks for building a stable food supply system to cope with climate change were developed based on the domestic production capacity, the buffering capacity to climate change, import capacity from other countries, and policy performance capacity with reference to the empirical analysis. First, the suggested key tasks for improving the domestic production capacity include developing and disseminating adaptation technology, conserving farmland and expanding arable land, practicing climate-smart agriculture by using fusion technology, and modernizing infrastructure for agriculture. Second, key tasks for improving buffering capacity to climate change are improving resilience and biodiversity, building a risk management system, and further improving storage of food in Korea and other countries. Third, major tasks for improving the import capacity from other countries are constructing overseas food bases, effectively using the international grain market, and enhancing international cooperation with relevant countries. Finally, key tasks for improving policy performance capacity are refining and applying the climate change impact analysis model with respect to policies, expanding investments in research and development, building a vulnerability assessment system, enhancing education and training, and installing Climate Change Response Center for Agriculture (tentative). In this study, several key challenges were presented in the four different areas related to building a stable food supply system which can help overcome the challenges of climate change. It is expected that the nature of the policies that need to be prioritized and promoted, given the constraints of budget, organization and information will be addressed in future research. Also, in order for the solutions for key challenges to work properly in the field such that policy outcomes will be maximized, a consortium of research bodies in the related fields of agriculture, agricultural meteorology and agricultural economics should be created. As preparation for specific action programs. Furthermore, follow-up studies should be conducted to verify the expenses required for developing reliable climate change impact assessment models and the effectiveness of the enforced policies. Such fie

Development of a multimedia model (IIAQ-CC) to assess climate change influences on volatile and semi-volatile organic compounds in indoor environments

Chang, Lia,Lee, Yunah,Kim, Chan-Kook,Lee, Dong Soo Elsevier 2018 Building and Environment Vol.143 No.-

<P><B>Abstract</B></P> <P>An indoor air quality model (IIAQ-CC) was developed to assess climate change (CC) influences on indoor level of volatile or semi-volatile organic compounds. With IIAQ-CC, the CC influences is predicted in integrated manners by factors including fate/transport properties of pollutants, building characteristics, occupant behaviors, indoor emission sources, and outdoor air quality. IIAQ-CC was evaluated for the temperature sensitivity of indoor formaldehyde (FA) concentration at outdoor temperature below 20 °C. No significant difference (<I>t</I>-test, <I>p</I> < 0.05) was found between the predicted (3.9 ± 1.0%/<SUP>o</SUP>C) and the measured (5.0%/<SUP>o</SUP>C with a 95% confidence interval (3.7%/<SUP>o</SUP>C to 6.4%/<SUP>o</SUP>C)), demonstrating that IIAQ-CC can successfully predict CC influences driven by temperature change on VOCs of indoor environmental concern. IIAQ-CC predicts that the long-term FA concentration may slowly rise due to increase in the outdoor concentration or may decrease in the presence of strong indoor sources in RCP8.5 conditions of South Korea. In either case, the long-term change does not exceed 12% of the average FA concentration of the base period. Over a shorter period (e.g., a month), the FA level may noticeably rise (by about 4 times) when windows are closed due to exceedingly hot or cold weather. The FA concentration change is primarily governed by duration of windows kept open, which depends on outdoor temperature. That is, temperature manifests its effects on the indoor air quality essentially by change in window opening behavior rather than by changes in kinetics or equilibrium processes such as photo-degradation and sorption/desorption onto/from walls and floor.</P> <P><B>Highlights</B></P> <P> <UL> <LI> IIAQ-CC was developed to assess climate change impacts on indoor pollution level. </LI> <LI> IIAQ-CC predicts well temperature dependence of formaldehyde concentration change. </LI> <LI> Long-term formaldehyde levels digress within 12% of that in base period. </LI> <LI> Monthly mean formaldehyde levels increase up to 4 times under RCP8.5 conditions. </LI> <LI> Window opening behavior in response to temperature governs the indoor air quality. </LI> </UL> </P>

주택시장구조 변화에 대한 실증 분석

장용동(Chang, Young–,Dong) 한국주거환경학회 2009 주거환경(한국주거환경학회논문집) Vol.7 No.2

Korea is known to have the market structure changes around the time of the construction of 2 million houses and IMF foreign exchange crisis. This paper tries to verify the existence of structure changes and the change time points. First we carried the estimation of housing price equation which is believed to represent the market structure. The housing price equation fully contains the information of housing market even in the reduced form. We used the housing price as dependant variable and the Chonsei price, the GDP, the interest rate of corporate bond, the mortgage loans and the approved residential construction area as independent variables. The estimation shows the proper fitness with a good result of autocorrelation. Given with the estimated housing price equation we carried the statistical test for the structural changes of housing market. We used the three tests (Chow Test, Chow's Forecast Test, N-Step Forecast Test) and the results of all three tests indicate that the housing market experienced the market changes in 1991 and 1999(or 2000, 2001). These results are fully matched to the presumptions on the market structural changes. Also These findings imply that the policy makers must consider the market changes before they manipulate the market variables. Since there are market changes even the same policy tools could give the different results. It should give more uncertainty to the market instead of the stability. The statistical resutls show that there were market changes after IMF foreign crisis which means that the policy makers should select different set of policy tools different from those applied in the IMF foreign crisis. The proper and precise analysis of market movement must be done before the housing policy is adopted.

청소년기 태권도 수련생들의 체격 및 체력 요인별 발달 비교

김동제,권창기,가경환 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.2

This study was intended to investigate changes in the physique and fitness by age in adolescence. For this purpose, it attempted to make the first measurement in June, 2001 and the second measurement in 2002 for a total of 15 persons(seven middle school students aged 13 to 14 years and 8 high school students aged 16 to 17 years) practicing Taekwondo at 'S' and 'C' Drill Centers located in South Kyungsang Province. Both measures were conducted over the 2-day period. An attempt was made to compare and analyze the growth rate of physique and fitness factors by age based on data from measurement. As a result, the following conclusion was drawn: First, it was found that there was a statistically significant difference in the change of height, weight and body fat percent before and after measurement in order to investigate the change of physique(P<.05). Among other things, it was found that there was a statistically significant difference in the change of height, weight between the period of middle school days(13 to 14 years old) and the period of high school days(16 to 17 years old)(P<.05). It was found that Taekwondo trainees grew more over the period of middle school days(13 to 14 years old) than over the period of high school days(16 to 17 years old). But it was found that there was not a statistically significant difference in body fat percent between both groups(P<.05). But body fat percent reduced over the period of middle school days{13 to 14 years old) but did remain almost unchanged. Second, an attempt was made to measure power(high jump test), agility(side step test), muscular endurance(sit-up) and cardiopulmonary endurance(1500-meter run) to investigate the change of physique. It was found that there was not a statistically significant difference in the change of power(high jump test) and muscular endurance(sit-up) before and after measurement(P<.05). But it was found that there was a statistically significant difference on agility(side-step test) and cardiopulmonary(1500-meter run)(P<.05). It was found that there was a statistically significant difference in agility(side-step test), muscular endurance(sit-up) and cardiopulmonary endurance(1500-meter run) except power(high jump test) between he period of middle school days(13 to 14 years old) and the period of high school days(16 to 17 years old)(P<.05). The high jump test was conducted to investigate the change of power. As a result, it was found that power increase the period of middle school days(13 to 14 years old), whereas it decrease over the period of high school days(16 to 17 years old). On the other hand, the side-step test was conducted to investigate the change of agility. It was found that agility increased in Tawekwondo trainees over both the period of middle school days(13 to 14 years old) and the period of high school daysd(16 to 17 years old), the latter of which it was more or less improved. This study conducted the sit-up test to investigate the change of muscular endurance and the 1500-meter run test to investigate the change of cardiopulmonary endurance. In case of the 1500-meter run, cardiopulmonary endurance decreased over the period of middle school days(13 to 14 years old) but increased over the period of high school days(16 to 17 years old).

아세틸 콜린 유발 검사시 허혈성 심전도 변화와 흉통의 발생이 내피세포 기능장애에 미치는 영향

최철웅(Cheol Ung Choi),나승운(Seung-Woon Rha),김선원(Sun Won Kim),나진오(Jin Oh Na),임홍의(Hong Euy Lim),김진원(Jin Won Kim),김응주(Eung Ju Kim),한성우(Seong Woo Han),박창규(Chang Gyu Park),서홍석(Hong Seog Seo),오동주(Dong Joo Oh) 대한임상노인의학회 2010 대한임상노인의학회지 Vol.11 No.4

연구배경: 아세틸 콜린 유발 검사시 발생하는 흉통과 허혈성 심전도 변화가 아세틸 콜린에 의해 발생하는 관상동맥의 내피세포 기능에 어떤 영향을 주는지 알아보고자 했다. 방법: 흉통으로 내원하여 관상동맥 조영술과 아세틸 콜린 유발검사를 시행받은 1,085명의 환자를 대상으로 하였다. 아세틸 콜린 유발 검사를 하는 동안 허혈성 심전도 변화 및 흉통의 발생 유무에 따른 관상동맥 내피세포 기능의 특징을 비교하였다. 결과: 539명의 환자에서 아세틸 콜린 검사시 내피세포 기능 장애가 발생 하였다. 허혈성 심전도 변화가 있었던 그룹이 심전도 변화가 없었던 그룹보다 흉통이 더 많았고(78.1% vs. 60.8%, P=0.007), 관상동맥 조영술상 다발성 관상동맥 경련이 빈번하였고(59.4% vs. 40.6%, P=0.004), 관상동맥의 경련 정도도 더 심하였다(64.1% vs. 46.5%, P=0.006). 흉통이 있었던 그룹이 흉통이 없었던 그룹보다 허혈성 심전도 변화의 빈도가 더 높았다(14.7% vs. 7.5%, P=0.007). 또한 흉통이 있었던 그룹이 관상동맥 경련이 다발성으로 발생하는 경우가 많았고 (50.7% vs. 29.5%, P<0.001), 미만성으로 발생하는 경우가 많았고(87.1% vs. 75%, P<0.001), 관상동맥의 경련의 정도도 더 심하였다(51.6% vs. 43.5%, P=0.041). 결론: 아세틸 콜린 유발검사시 발생하는 허혈성 심전도 변화와 흉통은 관상동맥 경련의 정도와 경련이 발생하는 관상동맥 개수와 연관이 있다. Background: ECG changes and chest pain during acetylcholine (Ach) provocation tests may constitute important clinical parameters for Ach-induced endothelial dysfunction. We investigated the association between ischemic ECG changes and chest pain during the Ach-provocation test and angiographic characteristics of Ach-induced endothelial dysfunction. Methods: A total of 1,085 patients with anginal symptoms underwent diagnostic coronary angiography (CAG) and Ach-provocation tests. We compared angiographic characteristics of Ach-induced endothelial dysfunction according to the presence of ECG change and chest pain. Results: A total of 539 patients experienced Ach-induced endothelial dysfunction. Patients who experienced ECG change group suffered more frequent chest pain (78.1% vs. 60.8%, P=0.007), angiographically more frequent multiple coronary artery spasm (59.4% vs. 40.6%, P=0.004), and more severe coronary artery spasm (64.1% vs. 46.5%, P=0.006) than patients without ECG change. However, there was no difference in the length of endothelial dysfunction between the groups. The incidence of ischemic ECG changes in patients with chest pain was higher than in patients without chest pain (14.7% vs. 7.5%, P=0.007). Patients who experienced chest pain more often experienced multiple (50.7% vs. 29.5%, P<0.001), diffuse (87.1% vs. 75%, P<0.001), and severe coronary artery spasm (51.6% vs. 43.5%, P=0.041) than patients without chest pain. Conclusion: Ischemic ECG changes and chest pain during the Ach-provocation test are associated with multi-vessel involvement and severe coronary artery spasm. Chest pain is associated with the length of endothelial dysfunction, but ischemic ECG change is not.

대학수학능력시험 도입후의 고교교육 변화에 관한 연구

박병량,변영계,한대동,성병창 교육연구소 1994 敎育硏究 Vol.4 No.1

Under the current school system in which secondary schools aim at the preparation for college entrance, the college entrance examination has a crucial impact on high school education. The former college entrance examination has been accused of causing many problems in high school education such as training students, in a recital mode, by giving fragmentary knowledges and skills picked up by teachers largely for the college entrance emanination. Under the examination system students were not recommended either in school or at home to pursue their own interests and concerns which are supposed to enhance higher order thinking including creativity. In order to reform this change-resisting high school education a new type of college entrance examination called College Scholastic Aptitude Test (CSAT, hereafter) replaced the former one in 1990 in the worldwide tide of educational reform toward the quality education. This study is to examine whether and/or to what extent the newly introduced CSAT has brougght changes to high school education. This study began with two concrete research problems. First, to what degree did the CSAT affect high school students particularly in the areas of attitudes toward school, classroom learning and instruction, and study habits? This refers to personal effects separated from school education. Second, to what extent did the CSAT make changes in high school education? This refers to institutional effects. As a survey, this study collected questionnaire data from 1,600 male and female high school third graders from 33 high schools locatedin Pusan City and its surrounding KyungNam-Do province. The CSAT was firstly introduced in 1990 when the survey respondents were then high school freshmen. The sample method is a systematic cluster random sample. After schools had been randomly selected about 60 students(2 classes) were sampled from each school. The questionnaire consisted of questions asking largely whether any changes were made in the areas such as individual student's studying strategies and their perceptions of schooling. The students' responses were analyzed according to concrete research problems using appropriate statistical methods. The research results are summarized as follows. First, according to students' responses they evaluated that CSAT was somewhat successful in measuring higher order thinking and somewhat conducive to lessening social problems cuased by excessively competitive high-cost private lessons. The new exam, however, unexpectedly did not have affirmative effects on such areas as: undesirable operation of high school; measurement of learning ability; selection of college qualifiers; and test item difficulty and discrimination. Second, the effects of CSAT on school-based tests were found to be both slightly positive and negative. For the positive side of the effects, the test content was not confined to textbooks but taken either from other non-text sources or from what was taught in classrooms beside textbooks; in solving the test questions not only correct answers were not required but also the problem-solving processess were also emphasized in schools. In following areas, however, there were almost no changes made: the dominance of multiple-choice test items; anxiety of testers; the utilization of test results for own learning improvement; and the frequent school testing. Third, since the introduction of CSAT there have been almost no improvements in school organizational practices, management, and climates such as; extracurricular activities, communications with teachers, guidance and discipline, teachers' expectations of students, grouping of students according to ability and talent, and friendship among classmates. One exception was that classroom climate has become somewhat open and democratic than before. Fourth, with regard to classroom activities some improvements have been detected. The classroom instruction has been somewhat changed into one emphasizing higher order thinking. It was revealed through teachers' efforts to employ new teaching methods and to carry out curriculum in a regular basis, to try to upgrade expectations of students, and to make classroom learning more explorative. On the other hand, in other areas of classroom activities it was hard to find any noticeable improvements. Finally, it was the area of individual student's studying methods and attitudes that the most noticeable changes were found since the introduction of CSAT. To mention some of them, the dependency on private lessons and private academic institutes was much lessened; the learning materials were varied beside school textbooks; the students' autonomy has been increased in the area of learning need and motivations, studying strategy from memorizing to understanding, and selecting educational or occupational careers based on one's own character and talent. As a result, the introduction of CSAT seems to give student more confidence in studying and learning. Compared to these changes in individual-based studying attitudes, perceptions and learning methods connected to schooling did not change noticeably. This contrasting finding is in a sense a main point of this study. All in all, and in short, the introduction of the new College Scholastic Aptitude Test (CSAT) were somewhat effective in changing individual students' studying or learning attitudes, methods, and strategies in preparation for college entrance, but it was found to be unexpectedly ineffective in improving institutionally school organizational practices, instructional methods, guidance and disciplines, curricular implementation, and other school management and operations. This result reminds us a fact that and educational policy could not be easily rooted in the practical soil.

Causes and Predictive Factors Associated with “Diagnosis Changed” Outcomes in Patients Notified as Tuberculosis Cases in a Private Tertiary Hospital

( Byung Ju Kang ),( Kyung Wook Jo ),( Tai Sun Park ),( Jung Wan Yoo ),( Sei Won Lee ),( Chang Min Choi ),( Yeon Mok Oh ),( Sang Do Lee ),( Woo Sung Kim ),( Dong Soon Kim ),( Tae Sun Shim ) 대한결핵 및 호흡기학회 2013 Tuberculosis and Respiratory Diseases Vol.75 No.6

Background: The aim of our study was to evaluate the “diagnosis changed” rate in patients notified as tuberculosis (TB) on the Korean TB surveillance system (KTBS). Methods: A total of 1,273 patients notified as TB cases on the KTBS in one private tertiary hospital in 2011 were enrolled in the present study. Patients were classified into three groups: “diagnosis maintained”, “diagnosis changed” (initially notified as TB, but ultimately diagnosed as non-TB), and “administrative error” (notified as TB due to administrative errors). Results: Excluding 17 patients in the “administrative error” group, the “diagnosis maintained” and “diagnosis changed” groups included 1,097 (87.3%) and 159 patients (12.7%), respectively. Common causes of “diagnosis changed” were nontuberculous mycobacterial (NTM) disease (51.7%, 61/118), and pneumonia (17.8%) in cases notified as pulmonary TB, and meningitis (19.5%, 8/41) and Crohn`s disease (12.2%) in cases notified as extrapulmonary TB. Being older than 35 years of age (odds ratio [OR], 2.18) and a positive acid-fast bacilli stain (OR, 1.58) were positive predictors and a TB-related radiological finding (OR, 0.42) was a negative predictor for a “diagnosis changed” result via multivariate logistic regression analysis in pulmonary TB cases. Conclusion: Because of a high “diagnosis changed” rate in TB notifications to the KTBS, the TB incidence rate measured by the KTBS may be overestimated. Considering the worldwide trend toward increased NTM disease, the “diagnosis changed” rate may increase over time. Thus, when reporting the annual TB notification rate in Korea, the exclusion of “diagnosis changed” cases is desirable.

선천눈꺼풀처짐 교정술 후 발생한 난시변화

이동섭,김준모,우경인,장혜란,Dong Sub Lee,Joon Mo Kim,Kyung In Woo,Hae Ran Chang 대한안과학회 2006 대한안과학회지 Vol.47 No.9

Purpose: To determine postoperative astigmatic changes after surgery for congenital ptosis and the astigmatic changes depending on surgical method and to discern cases of postoperatively developed anisometropia or amblyopia. Methods: Fifty-one patients who underwent surgery due to congenital ptosis were reviewed. Refraction or cycloplegic refraction was conducted preoperatively and 3 to 6 months after surgery to measure astigmatic changes. Astigmatic changes in operated eyes were compared to control eyes. Astigmatic changes were compared depending on surgical method. Results: The mean astigmatism was 1.33±1.29D preoperatively and 1.48±1.13D postoperatively (P=0.10) and the mean astigmatic change in the ptotic and control eye was an increase in cylinder +0.56±0.55D and +0.68±0.72D (P=0.37). The mean astigmatic change of patients receiving frontalis sling was +0.57±0.67D which was similar to those who received levator resection (+0.56±0.50D). Newly developed anisometropia was found in three patients postoperatively due to an increase in astigmatism, but newly developed amblyopia was not found. Conclusions: The increase of astigmatism by ptosis surgery was not statistically significant and there was no statistically significant difference when accounting for surgical method. However, it is necessary to monitor refractive error carefully in younger patients to prevent amblyopia because postoperative increase of astigmatism can cause anisometropia.

肉鷄後期飼料의 給與時期가 鷄肉의 理化學的 性質에 미치는 影響 : 貯藏期間別에 따른 pH, 保水性 및 軟度의 變化 Changes in PH, Water Holding Capacity and Tendness

尹東根,鄭場龍,張判亨,朴久富 진주산업대학교 1985 論文集 Vol.23 No.-

後期飼料를 3주령부터 조기에 급여한 broiler肉의 흉심부, 대퇴부 및 근위를 냉장온도(4℃)에서 저장한 후 저장시간의 경과(0,8,48,96,168시간)에 따른 pH, 보수성 및 軟度의 變化를 경시적으로 分析한 結果는 다음과 같다. 1. pH의 變化를 보면 各 시험구의 部位間에는 통계적인 유의성이 없었고 저장시간의 경과에 따른 경시적인 차이를 보면 도살직후 6.68~6.77로 나타났으나 저장후 8시간이 경과될 때 pH가 5.67~5.76으로 급격히 저하되었으며 48시간이 경과되면서 부터 상승하여 이후는 서서히 회복되었다. 2. 保水性의 變化를 보면 各 시험구의 부위간에는 통계적인 유의성이 없었고 저장시간의 경과에 따른 경시적인 차이를 보면 도살직후 65.9~67.4%로 나타났으며 저장후 8시간이 경과될 때 흉심, 대퇴, 근위 모두 급격히 감소되었으나 48시간이 경과되면서 부터 증가되어 168시간 이후부터는 서서히 회복되었다. 3. 軟度의 變化는 흉심과 대퇴部位 근육에 비하여 근위가 매우 낮았고 저장기간의 경과에 따른 變化는 도살직후에 비하여 8시간이 경과될때 현저히 낮아진 후 48시간까지는 서서히 감소된후 168시간 부터는 회복되는 결과였다. 4. pH, 保水性 및 軟度等의 물리적인 性質을 究明한 바 각 처리區間에 통계적인 유의성은 인정되지 않았으며 3주령 부터 후기사료를 급여한 결과 pH, 보수성 및 연도 等에 영향을 미치지 않았다. This experiment was conducted to investigate the changes in pH, water holding capacity and tenderness as the passage of storing time(0,8,48 168 hr) after storing at 4℃ the meat cut 3 parts of leg, breast and gizzard of broiler-Hubbard at 9weeks fed early finisher diet from 3 weeks. The results obtained were summarized as follows: 1. In the pH changes during postmorterm storage, there were nonsignificant differences(p>0.05) between treatments. In the pH changes as storage time passed, pH immediately after slaughtering was 6.68 to 6.77 and the lowest with 5.67 to 5.76 when storage time passed 8hours and pH was again high after storage time passed 48 hours. 2. Though the changes in water holding capacity were nonsignificant differences(p>0.05) between leg, breast and gizzard meat. There was lightly difference as the storage time passed, pH immediately after slaughtering was 65.9 to 67.4%, pH of leg, breast and gizzard was decreased as the storage time passed 8 hours, but was increased as the storage time passed 48 hours. 3. The changes in tenderness were lower in gizzard in leg than breast. It was lower in the storage of 8 hours than immediately after slaughtering. After pH was gradually decreased to the storage of 48 hours, again increased from the storage of 168 hours. 4.PH, water holding capacity and tenderness analyzed in this experiment were non significant differences(p>0.05) between treatments and there was not the effect of finisher diet on the physical properties.

Dipyridamole 부하 심근 SPECT에서 Dipyridamole의 작용과 부작용

고창순(Chang Soon Koh),이명철(Myung Chul Lee),정준기(June Key Chung),이동수(Dong Soo Lee),최창운(Chang Woon Choi),배상균(Sang Kyun Bae),양형인(Hyung In Yang),여정석(Jeong Suk Yeo) 대한핵의학회 1993 핵의학 분자영상 Vol.27 No.2

N/A Dipyridamole is an agent that may be used to noninvasively evaluate coronary artery disease. The effect of dipyridamole infusion its generally related to its induced peripheral vasodilatory effect. In normal person, heart rate is generally increased slightly while blood pressure decrease, but the achieved double product and related myocardial oxygen consumption have no significant change. The purpose of this study is to examine the effect and side effect of dipyridamole, and to compare different response to dipyridamole among the patients. We evaluated 847 patients who underwent dipyridamole stress myocardial SPECT. 93.6% of them had induced hypotension 0.9% showed no change of blood pressure, 5.5% had increased blood pressure 8.3% had no change of pulse rate more than 10% of basal pulse rate. Among diabetes, 16.9% was not change of pulse rate, 6.7% in non-diabetes. There was no significant correlation between age and rate pressure product rest(RPPr), in patients without perfusion defects on SPECT(y=7.1x+48.4r=0.13 p>0.01). As increasing age, RPPs/RPPr was declined(y=-11.6x+68.9 r=0.17 p〈0.01), similar results were obtained in patients with perfusion defect. The size of perfusion defect on myocardial SPECT have no correlation between RPPr and RPPs/RPPr. The side effects of dipyridamole included chest pain and chest tightness, headache, abdominal pain, dizzness, nausea, and dyspnea. As increasing age, dipyridamole-induced cardiac work at rest was increased, cardiac response to dipyridamole was decreased.