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Chae, Yoon‐,Jee,Lee, Kyeong‐,Ryoon,Noh, Chi‐,Kyung,Chong, Saeho,Kim, Dae‐,Duk,Shim, Chang‐,Koo,Chung, Suk‐,Jae Wiley Subscription Services, Inc., A Wiley Company 2012 Journal of Pharmaceutical Sciences Vol.101 No.3
<P><B>Abstract</B></P><P>The objectives of this study were to investigate the allele frequencies and linkage disequilibrium (LD) in the organic anion transporting polypeptide 1B3 (OATP1B3) in the Korean population and to examine the functional consequences. Using samples from 48 Koreans, direct sequencing was carried out to determine the allele frequencies and LD of OATP1B3 in a representative Korean population. Thirty‐six genetic variations in the transporter were found in Koreans; among them, five undocumented variations (i.e.,−6436G>C in the 5′‐upstream region, 26A>C and 586A>G in the protein coding region, and IVS6‐72A>T and IVS12‐80A>T in intron regions) were identified. In the upstream region, −5035G>A was found to have lowered gene expression, as determined by a reporter gene assay, suggesting that this variation reduces the expression of OATP1B3 in humans. The functional relevance of the genetic variations in the protein coding region was determined by an uptake study involving representative substrates in human embryonic kidney 293 cells expressing wild type or variant forms. Variations involving 699G>A showed a reduced uptake activity for testosterone, but not for estradiol 17β‐<SMALL>d</SMALL>‐glucuronide or methotrexate, indicating that the functional impact of the variations is substrate specific. Considering the kinetic relevance of OATP1B3, the functionally affected variations may be therapeutically important. © 2011 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 101:1302–1313, 2012</P>
Memory and Loss in Friel’s “Self-Portrait” and Dancing at Lughnasa
( Chaeyoon Park ) 한국영미문학페미니즘학회 2020 영미문학페미니즘 Vol.28 No.2
This article strives to bring critical attention to the relationships between memory, memory loss, and imminent adversity in Brian Friel’s Dancing at Lughnasa (1990) through examinations of often-overlooked scenes and “Self-Portrait” (1972). This work of prose that predates the play by eighteen years portrays memory as a contradictory “fact” and “fiction” and conveys a disinclination to write “a play ‘about the trouble[s] in the North’” (39, 46). By examining Maggie’s demonstration of sensory experiences that are “all in your mind” and Chris’s collaborative and subjective recollections, this essay departs from existing studies that generally focus on Michael’s recollections or Father Jack’s memory loss (15). What Michael, Father Jack, Chris, and Maggie remembers or forgets highlights their anguish and isolation. The retroactive interference account of forgetting provides insight into whether learning the language and culture of Africa prevents the former missionary priest from recalling information related to his old life in Ireland; his memory loss, in turn, presents novel interpretations on the role of memory and its relationship with revelations on imminent losses caused by poverty, unemployment, and mechanization.
Language Barriers and Asian American Students in The Woman Warrior
( Chaeyoon Park ) 한국영미문학페미니즘학회 2021 영미문학페미니즘 Vol.29 No.2
Overcoming language barriers and unfavorable learning experiences appear in Shang-Chi and the Legend of the Ten Rings (2021), Marvel Studio’s first Asian superhero film, as well as in novels and essays by Asian American writers. The Woman Warrior: Memoirs of a Girlhood Among Ghosts (1976), one of the most influential works of Chinese American fiction, is frequently taught and read as delineating the narrator’s discovery of her voice through acceptance of her mother’s conservative “talk-stories” and her Chinese heritage. Attributing the narrator’s silence as symptomatic of “being a Chinese girl,” however, does not account for how her communication skills sporadically deteriorate and how several bicultural women’s voices become inaudible at school and after graduation (166). This paper demonstrates that Maxine Hong Kingston’s novel questions conventional associations between learning English and becoming American through comparisons with the essays about adapting to new environments after immigrating from China, Hong Kong, and Vietnam: Binh Ha Hong’s “Reflections on Becoming American” (1999), Jubilee Lau’s “Chinese and Proud of It” (1996), and Amy Tan’s “Mother Tongue” (1990). Whereas these essays extol the American-educated daughters’ adjustments through allusions to their parents’ lack of English skills and its impact on the family’s socio-economic status, the frustrating experiences of students, parents, teachers in The Woman Warrior reveal that language barriers at elementary schools cause unresolved communication problems for multiple Chinese Americans.
Establishment of Potent Neutralizing Antibodies against SARS-CoV-2
Chaeyoon HA,Minjung CHOI,Se-ho PARK 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
SARS-CoV-2 is infected through the interaction between the spike protein of the virus and human angiotensin-converting enzyme 2 (hACE2), the receptor molecule of the host cell. Thus, most therapeutic antibodies have been developed to prevent the interaction between these two molecules. Despite the continuous development of therapeutic antibodies, there are only a few antibodies that effectively inhibit SARS-CoV-2 infection. In this study, we developed spike protein-specific antibodies to make effective SARS-CoV-2 therapeutic antibodies. We selected several hybridomas which are specific for Spike S1 protein. Then, potential clones were chosen by comparing S1 protein-specific affinity levels between selected hybridomas. To confirm whether these clones work as neutralizing antibodies, we tested the blocking effect by using SARS-CoV-2 pseudovirus to infect hACE2 expressing cells. As a result, total of 7 potent anti-S1 antibodies were obtained. Consequently, we expect these 7 clones to serve as therapeutic antibodies. To find whether it can inhibit infection in response to authentic SARS-CoV-2, in vitro and in vivo experiments are planned as further experiments.
Desire, Disguise, and Disguised Desires in William Shakespeare’s Twelfth Night
Chaeyoon Park(박채윤) 한국셰익스피어학회 2019 셰익스피어 비평 Vol.55 No.4
This paper explores the relationship between desire and gender in William Shakespeare’s Twelfth Night (1601-1602) through an analysis of the complex desires that Viola’s disguise activates. The treatment of disguise on the early modern stage contrasts with records from the Court of Aldermen and from the Court at Bridewell Hospital that equate cross-dressing with illicit sexuality. Whereas previous studies on Twelfth Night generally discuss gender in terms of binaries and subversions or see the play as disciplining Countess Olivia and Malvolio for being transgressive, this paper will examine how Viola’s disguise as Cesario obscures conventional boundaries of gender. The mockery of Malvolio’s aspirations to wed Olivia to acquire wealth and status through her exemplifies suppressing class mobility, especially one that involves women of higher status. By comparison, Twelfth Night portrays Olivia and Viola as desiring subjects, yet their desires are not exclusively heterosexual in light of Viola’s disguise and the early modern playhouses’ use of male actors.
시각장애인 온라인 쇼핑 도움 어플리케이션 설계 및 구현
김채윤 ( Chaeyoon Kim ),김지선 ( Jiseon Kim ),천명희 ( Myeonghui Cheon ) 한국정보처리학회 2019 한국정보처리학회 학술대회논문집 Vol.26 No.2
스마트폰의 대중화로 인터넷 이용률이 증가함에 따라 온라인 쇼핑 시장의 규모가 커지는 반면 대부분의 온라인 쇼핑몰은 시각장애인의 접근성이 미흡하여 온라인 쇼핑의 어려움을 겪고 있다. 그 불편함은 ‘정보화 사회에서의 소외감’ 이라는 정신적 피해로 이어지고 있는 심각한 상황이다. 따라서 이 불편함을 해소하고 정보 접근의 격차를 줄이고자 <쇼움이>를 설계, 구현하게 되었다. <쇼움이>는 챗봇을 활용하여 일문일답으로 입력 받아 시각장애인들이 쉽고 편리하게 상품을 검색/파악할 수 있도록 설계, 구현되었으며, 시각장애인들이 파악하지 못했던 이미지 내의 상품 정보를 분석하여 텍스트와 음성으로 안내한다. 또 관심 상품 등록, 상품 링크 공유 기능을 구현하였다. 또한 사용자의 편리성 확보를 위해 버튼을 포함한 모든 항목이 안드로이드의 voice-assistant 로 읽히도록 설계, 구현하였다.