임신마우스에서 수용성카이토산에 의한 태아의 방사성스트론튬 오염 억제

채기문,최근희,양광희,범희승,김지열,김광윤 대한방사선 방어학회 1994 방사선방어학회지 Vol.19 No.3

핵분열생성물중의 하나인 방사성스트론튬은 임신한 쥐에서 태반을 빠르게 통과하여 태아를 오염시킨다. 독성이 적은 천연착화제로서 마우스체내의 방사성스트론튬(Sr-85)의 제거에 효과적인 것으로 알려진 카이토산을 이용하여 Sr-85의 태반오염억제에 관한 연구를 하였다. 실험군은 일반식이를 공급한 대조군과 임신 17일째에 수용성카이토산을 피하(1% 카이토산), 구강(10% 카이토산), 복강(0.3% 카이토산)으로 주사한 카이토산군으로 분류하였다. 피하주사군은 Sr-85 오염후 카이토산을 주사한 군이며 복강과 구강주사군은 Sr-85 오염젼 15일간 카이토산을 공급한 군이었다. 출산과 동시에 어린마우스의 전신을 측정한 겨러과 출생후 7일째에 대조군이 2.8 ±0.3%의 전신축적율을 나타낸 반면 피하, 구강, 복강, 주사군은 각각 1.2 ±0.1%, 1.4 ±0.1%, 1.6 ±0.2%로 나타났다. 결과적으로 임신한 마우스에서 수용성카이토산은 방사성스트론튬의 태반오염을 유의하게 억제하는 것으로 사료된다. Radiostrontium passes the placental barrier in pregnant rodents very well. Chitosan, a natural nontoxic chelator, was reported to reduce whole body retention of radiostrontium in mice. The aim of the present study was to evaluate water soluble chitosan as a blocking agent of transplacental transfer of radiostrontium in pregnant mice. Twenty pregnant mice wre divided into four groups : control and three groups of chitosan treatment(groups 1 to 3). Sr-85(15KBq in 0.2ml saline) was subcutaneously injected into pregnant mice at the 17th day of pregnancy. In control mice, 0.2ml saline was given 5 hours after the injection of Sr-85. In group 1.1% water soluble chitosan was given subcutanously for two days, twice daily after the injection of Sr-85. In group 2, 10% water soluble chitosan was given orally for 15 days before conception. In group 3, 0.3% water soluble chitosan was injected intravenously for 15 days, once daily before conception. Gamma counting of newborns were done at days 0, 2 and 7 after their births. Whole body retention of Sr-85 in newborns of control mice at days 0, 2, 7 were 3.1 ±0.3%, 2.9 ±0.3%, 2.8 ±0.3% respectively. In experimental groups, whole body retention of Sr-85 was significantly lower thanthat of control(p<0.01) and no statistical difference was noted between them. In group 1, the values were 2.1 ±0.3%, 1.4 ±0.1%, 1.4 ±0.1%, respectively. In group 3, they were 2.1 ± 0.2%, 1.7 ± 0.2%, 1.6 ± 0.2%, respectively. In conclusion, the water soluble chitosan reduced transplacental contamination of radiostrontium in pregnant mice.

췌장염에 의한 가성낭종내에 생긴 가성동맥류 : 1례 보고

오연희,이채경,김승현,이성우,양창현,이정호,이영현 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

만성 췌장염의 합병증으로 생긴 가성동맥류는 드문질환으로, 반복적으로 다량의 출혈을 일으킬 수 있으며, 치료를 하지 않을 경우 사망율이 높기 때문에, 조기 진단과 치료가 필수적이다. 저자들은 38세 남자 환자에서 췌장염의 합병증으로 생긴 가성낭종내에서 발생한 가성동맥류 1예를 경험하였기에 보고하는 바이다. 가성 동맥류의 색혈류도플러상 낭종내에 양방향 흐름의 와류를 볼 수 있었다. Pancreatic Pseudoaneurysm within Pseudocyst from Pancreatitis: 1 Case Department of Diagnostic Radiology and Internal Medicine, College of Medicine,DongGuk University Yeon Hee OH M.D., Chae Kyeong Lee M.D., Seoung Hyeon Kim M.D., Sung Woo Lee M.D., Chang Heon Yang M.D., Jung Ho Lee M.D., Young Hyun Lee M.D. Pseudoaneurysm from pancreatitis is uncommon, but it can cause recurrent and massive hemorrhage. Because of high morbidity and mortality, early detection and treatment of the pseudoaneurysm is needed. We report a case of pseudoaneurysm within pseudocyst from pancreatitis. Color-flow Doppler sonography shows bidirectional flow and turbulent arterial flow, within anechoic mass.

특수체육지도자의 스페셜올림픽 참여경험과 교육신념에 관한 연구

채규연 ( Kyu Yeon Chae ),조영희 ( Young Hee Cho ) 한국특수체육학회 2010 한국특수체육학회지 Vol.18 No.3

본 연구의 목적은 특수체육지도자들의 스페셜올림픽 참여경험이 교육신념에 영향을 미치는지를 규명하는데 있다. 특수학급 교사, 사회복지기관의 특수체육 담당교사와 지도자 300명을 대상으로 설문 중 참여자 108부, 비참여자 111부, 총 219부 설문지를 분석하여 자료처리 하였다. 본 연구에서 사용된 조사도구는 Spodek(1985)의 신념분류기준과 Peters 등(1985)이 제시한 신념측정도구(Beliefs Test Inventory)와 최선미(2001)와 임종미(2005)의 교육신념에 관한 연구에서 사용된 설문지를 중심으로 본 연구의 목적에 알맞게 수정, 보완하여 사용하였다. 자료 분석 방법으로 수집된 자료의 통계처리는 SPSS 12.0 Version을 활용하여 빈도분석, 독립표본 t-test, 일원변량분석을 실시하였다. 연구결과는 다음과 같다. 첫째, 특수체육지도자의 스페셜올림픽 참여에 따른 교육신념은 스페셜올림픽에 참여한 집단이 비참여 집단에 비해 교육신념이 높게 나타났고, 하위요인은 성숙, 행동, 상호작용 순으로 높게 나타났다(p<.001). 둘째, 스페셜올림픽에 참여한 특수체육지도자의 일반적 특성에 따른 교육신념을 살펴보면, 성별에 따른 교육신념은 남자가 여자에 비해 높게 나타났고, 하위요인 중 행동주의에서만 유의한 차이가 나타났다(p<.05). 특수체육 전공유무에 따른 교육신념은 특수체육 전공한 지도자가 비전공자에 비해 높게 나타났고, 하위요인 중 상호작용에서만 유의한 차이가 나타났다(p<.01). 지도경력에 따라서는 3년 이하-5년 이하의 경우 교육신념의 정도가 높게 나타났으나 5년 이상에서 낮아졌다. 근무시설에 따른 교육신념에서는 특수학교가 사회복지시설, 일반학교 특수학급에 비해 높은 교육신념을 나타냈다(p<.05).셋째, 특수체육지도자의 스페셜올림픽 참여횟수가 많을수록 교육신념이 높은 것을 알 수 있었으며(p<.05), 하위요인별로는 성숙과 행동주의적 교육신념에서 6회 이상 참여한 특수체육지도자의 교육신념이 가장 높게 나타났다(p<.01). 또한 스페셜올림픽에 참여한 특수체육지도자의 대회규모에 따른 교육신념에서는 국내, 국제대회에 모두 참여한 특수체육지도자들의 교육신념이 가장 높게 나타났고, 교육신념의 하위요인별로는 성숙과 행동주의적 교육신념에서 또한 국내, 국제대회에 모두 참여한 특수체육지도자들의 교육신념이 높게 나타났다(p<.01). The purposes of this study was to investigate how adapted physical education teachers and instructors` participation in Special Olympics influences their educational faith. The subjects of this study were 219 adapted physical education teachers and instructors of special school, special class and welfare center, including 108 who participated in special olympics and 111 who did not. The research tools employed by this study include Spodek(1985)`s categorization of beliefs, the Beliefs Test Inventory by Peters(1985), and the questionnaire used in Choi Seon-mi`s 2001 study, modified from the original questionnaire used in some past studies on educational faith (Oh Chae-seon, 1990; Han Ji-hye, 1992; Heo Hye-gyeong, 1994; etc.) to suit adapted physical education instructors. For statistical analysis of the collected data, the SPSS 12.0 statistical package was used for frequency analysis, independent sample t-test and one-way ANOVA. The results of the analysis were as follows; First, those who had participated in Special Olympics showed a higher level of educational faith than those who had not. Among the sub-factors of educational faith, maturity, behavior, and interaction were found to be relevant, with a statistically significant difference (p<.001). Second, no significant differences were observed among the Special Olympics-experienced adapted physical education instructors with respect to age. As for the college major of the participant, those who majored in adapted physical education exhibited a higher level of educational faith, but the difference was not statistically significant. Among the sub-factors of the educational faith, only interaction was found to be statistically significant (p<.01). With respect to the length of experience, the participants with 1 to 5 year experience showed an increase in their educational faith, but the level of faith was found to decrease after 5 years. In regard to the facility type, those working at special schools showed a higher level of educational faith than those working at welfare facilities or those teaching special classes within regular schools, with a statistically significant difference (p<.05). Third, the analysis revealed a statistically significant increase (p<.05) in educational faith proportional to the number of times each instructor had participated in Special Olympics. As for the sub-factors of educational faith, a significant difference was observed in maturity and behavior of those who had participated in Special Olympics 6 times or more (p<.01). There was no significant difference in interaction. As for the size of the event, those who had participated in both domestic and international events demonstrated a higher level of educational faith while those who had participated only in international events were found to have the lowest level of educational faith (p<.01). The instructors with both domestic and international Special Olympics experiences were also found to be higher in educational faith in terms of maturity and behavior (p<.01) while no significant difference was found in terms of interaction.

소규모사업장 용접근로자들의 소음·용접흄·망간 노출에 관한 연구

김동구,문덕환,이채관,박명희,함성애,손병철,김대환,이창희,김휘동,이채언 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5

Objective : This study was conducted for the purpose of investigating the level exposure of welders to noise, welding fume and Manganese(Mn) related to this process. Methods and Material : All subjects in this study were welders engaged in CO2 arc and coated arc welding process especially in small-scale enterprises classified by type of manufacture of ship building, repairing and of other fabricated metal products, which is located in Gimhae and Milyang of Kyeongsang province in south Korea. Air sampling of welding fume was measured, shipped and analyzed on the basis of national institute for occupational safety and health(NIOSH) method in U.S. and work environment measurement method established in south Korea. To measure Noise in the work environment, Noise dosimeter was used on the basis of work environment measurement method established in south Korea. Result : This study was performed during a period from January, 2000 to December, 2001 and Results were as follows: 1. Noise level measured in this work environment was higher than national criteria for permissible exposure limit on health examinations related to hearing loss. 2. The concentration of welding fume and Mn in manufacture of ship building and repairing was higher than those in manufacture of other fabricated metal products. 3. In conditions of existing in ventilation system installed and operated, the concentration of welding fume and Mn was slightly lower than those of not existing. 4. In conditions of existing in sufficient air supply from out door into the work place relied on natural exhaust system, the concentration of welding fume and Mn was slightly lower than those of in not sufficient. 5. In all subjects, a rate of wearing ear plug and respiratory mask for dust and fume was lower than that of not wearing. Conclusion : According to above results, this study suggests that more positive work environment managements such as the use of portable local ventilation system, the supply of highly qualified personal protective equipment, and consecutive education and training related to health protection should be need to acquire suitable health protection program for welders engaged in small-scale enterprises in Korea.

카이토산을 이용한 방사성스트론튬 오염의 치료

김지열,송호천,양광희,최근희,채기문,범희승,김광윤 대한방사선 방어학회 1994 방사선방어학회지 Vol.19 No.3

본 연구에서는 마우스에 이미 오염된 방사성스트론튬(Sr-85)을 제거하는데 수용성카이토산이 어느정도 효과가 있는지 알아보고자 하였다. Sr-85를 정맥주사한 경우 주사후 1일째의 체내 잔류량은 72.9 ±5.7%, 5일째는 57.7 ±1.9%, 7일째는 54.2 ±1.4%로 서서히 감소하였으며, Sr-85를 복강내 주사한 경우는 주사후 5일째 54.4 ±1.2%, 15일째 50.6 ±0.8%로 정맥주사에 비해 낮은 잔류량을 보였다(5일째 잔류량의 비교, P<0.05), 0.3% 수용성카이토산을 1회 정맥주사해준 제21군 및 10% 수용성카이토산을 식이중에 섞어 먹인 제5군은 각각의 대조군에 비해 체내 잔류방사능의 차이가 없었으나 (P>0.05), 0.3% 수용성카이토산을 3일간 정맥주사한 제3군과 3% 수용성카이토산을 이틀 간격으로 15일간 복강내 주사한 제6군에서는 각각의 대조군에 비해 낮은 잔류방사능을 보였다. (P<0.01). 결론적으로 수용성카이토산을 연속적으로 정맥투여하거나 복강내 투여하는 경우에는 스트론튬의 골대사촉진 또는 골중의 스트론튬과의 반응등을 통해 그 배출을 촉진시킬 것으로 사료되었다. The aim of the present study was to elucidate the effect of the water soluble chitosans on the removal of contaminated radiostrontium(Sr-85) from the bone of mice. The remaining radioactivities in intravenously injected controls(group 1) were higher than in intraperitoneally injected controls (group 4, P<0.01). The % retention at day 5 were 57.7 ±1.9%, 54.4 ±1.2%, respectively. Single intravenous injection of 0.3% water soluble chitosan and continuous oral ingestion of 10% water soluble chitosan for 15 days were ineffective on the removal of contaminated radiostrontiums. Multiple intravenous or intraperitoneal injections of water soluble chitosan effectively removed contaminated radiostrontiums (P<0.01 vs controls). In conclusion, water soluble chitosan might remove once incorporated radiostrontium from bones of mice. further studies were needed to elucidate the mechanism of the removal.

Hepatic Cirrhosis Occurring in a Young Woodchuck(Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus(WHV)

Kyu-shik Jeong,정원일,Jae-yong Chung,Mi-young An,Chae-yong Jung,Gyoung-jae Lee,Jong-soo Kang,Byeong-cheol Kang,Young-heun Jee,Bruce H Williams,Young-oh Kwon,Da-hee Jeong 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

Cirrhosis Occurring in a Young Woodchuck (Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus (WHV)Da-hee Jeong, Won-il Jeong, Jae-yong Chung, Mi-young An, Chae-yong Jung, Gyoung-jae Lee1, Jong-soo Kang1, Byeong-cheol Kang2, Young-heun Jee3, Bruce H Williams4, Young-oh Kwon5 and Kyu-shik Jeong*College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea1Shinwon Scientific Co., LTD, Research Institute, Suwon, Korea2Clinical Research Institute, Seoul National University, Seoul 110-744, Korea3College of Veterinary Medicine, Jeju National University, Jeju 690-756, Korea

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

도시와 농촌주부의 가사노동시간 비교

채옥희,오희정 圓光大學校 1995 論文集 Vol.29 No.2

This paper attempts to examine how urban and rural homemaker spend their time on household affairs, whether there is some difference between the two according to the constituent family members and economic causesm nd how their consciouness of housekeeping affects the time. The findings are follows. 1.The average household time of an urban homemaker are seven hours and forth one minutes on weekdays, and eight hours and twenty nine minutes on holidays. In case of a rural homemaker, they are sever hours and twenty nine minutes on weekdays, and eight hours and thirty three minutes on holidays, which shows that the household time of a rural homemaker are closely connected with farm labor. 2.As the youngest child is at an age, the total household time of a homemaker are most affected and increased. The working time spent in cooking are affected according to the academic background and monthly income. Those spent on clothing are affected in the order of the youngest child's age, the number of family, and the academic background. When the house is a korea-style one, the working time on the house are most affected, and they are also affected by the homemaker age and the number of the childern, etc. The working time spent in taking care of the family and buying something are affected according to the youngest child's age, the number of the children, and the homemaker's age, etc. As mentioned above, the younger the youngest child is, the younger a homemaker is, the more a homemaker has a brilliant acedemic career, the higher the monthly income is, and the more the number of childern is, the more the household time of a homemaker are affected by the constituent family members and economic causes. 3.The homemaker's conciousness of the household time is almost similar to one another irrespective of the region. Almost all urban and rural homemakers think that making efficient use of time is necessary, but that it is very hard to put it into practice. The homemakers usually do the household chores all alone they consider them rewarding but hard.

해군장병의 여가조건과 직무만족의 관계

채한승,정희석 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.6

The purpose of this study was to examine the relations between the leisure condition of the military personnel in the Korean Navy and the duty stress of them. The subjects are present on duty military personnel in the navy and they are selected by the stratified random sampling. Among 950 subjects, 933 responded the questionnaire. The number of 913 subjects are finally accepted as insincere or insufficient questionnaire are eliminated among 933. Data have been processed by SPSS and especially the frequencies, the one and two way ANOVA, Duncan analysis are used as tools for this study. After the procedures, through the methods and analysis, the results are followed by; First, after the analysis of the differences among the duty satisfaction according to the population-socialistic traits of navy personnel, the duty satisfaction by the age, the rank, the education level, the health condition, the household income and the number of vacation days have the significant difference statistically. But the duty satisfaction by the duty area do not have the significant difference statistically. Second, after the analysis of the differences of the duty satisfaction by the leisure condition of the navy personnel, there is a significant effect statistically on the duty satisfaction by the weekday leisure time. Also, the differences of the duty satisfaction by the leisure cost have the significant effect statistically.

프랜차이즈 便宜店 事業者와 加盟店의 利益葛藤關係에 관한 實證硏究

채희용 慶南大學校 産業經營硏究所 1997 産業經營 Vol.20 No.-