Japan-South Korea Security Cooperation: Sisyphus Getting Muscles?

( Celine Pajon ),( Remy Hemez ) 한국국방연구원 2018 The Korean Journal of Defense Analysis Vol.30 No.2

This article aims to assess the progress of the ROK-Japan security cooperation in recent years, both in the bilateral and trilateral framework involving the United States. It argues that the unprecedented progress in North Korea’s nuclear program, along with a constant U.S. persuasion, led to a certain political convergence to allow and accompany the security cooperation. This said, political mistrust, asymmetric expectations and diverging perspectives still persist, explaining why the cooperation is mainly taking place within the trilateral framework. Nevertheless, the latest set of dialogue, exchanges and joint exercises did build up confidence and highlighted the benefit of an expanded cooperation while pushing the two countries to seriously consider the concrete issues, conditions and implications of such cooperation. The paper concludes that the recent progress in the security cooperation is still fragile and dependent on external factors, even if it is pointing to a greater understanding.

Photo-triggered Theranostic Nanoparticles in Cancer Therapy

Celine DG. Abueva 대한의학레이저학회 2021 MEDICAL LASERS Vol.10 No.1

In cancer therapy, it is often desirable to use precision medicine that involves treatments of high specificity. One such treatment is the use of photo-triggered theranostic nanoparticles. These nanoparticles make it possible to visualize and treat tumors specifically in a controlled manner with a single injection. Several novel and powerful photo-triggered theranostic nanoparticles have been developed. These range from small organic dyes, semiconducting and biopolymers, to inorganic nanomaterials such as iron-oxide or gold nanoparticles, carbon nanotubes, and upconversion nanoparticles. Using photo-triggered theranostic nanoparticles and localized irradiation, complete tumor ablation can be achieved without causing significant toxicity to normal tissue. Given the great advances and promising future of theranostic nanoparticles, this review highlights the progress that has been made in the past couple of years, the current challenges faced and offers a future perspective.

기획번역 : 도시의 인간화

( Celine Sachs Jeantet ),조은숙(역) 한국도시연구소 1996 도시와 빈곤 Vol.24 No.-

Photobiomodulation Therapy in the Treatment of Salivary Dysfunction

Celine DG. Abueva 대한의학레이저학회 2022 MEDICAL LASERS Vol.11 No.1

Photobiomodulation therapy, owing to its photobiological anti-inflam-matory and wound healing effects, has been suggested as a non-invasive, safe, and effective approach in treating salivary dysfunctions. Xerostomia or dry mouth and hyposalivation are challenging conditions, and patients suffer oral problems and a poor quality of life. Several studies have demonstrated the potential of photobiomodulation in reducing xerosto-mia and hyposalivation. However, there is a lack of synthesis of available evidence to establish whether it is an efficient, safe, and cost-effective method. In addition, the challenges include the lack of consensus on the optimal PBM dosage, as well as the variability of the findings in published studies.

Enhancement of cutaneous immune response to bacterial infection after low-level light therapy with 1072nm infrared light: A preliminary study

Celine Lee, S.Y.,Seong, I.W.,Kim, J.S.,Cheon, K.A.,Gu, S.H.,Kim, H.H.,Park, K.H. Elsevier Sequoia 2011 Journal of photochemistry and photobiology. B, Bio Vol.105 No.3

We investigated the photobiomodulation effects of 1072nm infrared light on the natural immune response involved in anti-bacterial and wound healing processes. Thirty mice infected with MRSA on the skin were divided into two groups. The experimental group was treated with 1072nm infrared light (irradiance: 20mW/cm<SUP>2</SUP>, fluence: 12J/cm<SUP>2</SUP> for 10min) at 2, 4, 8, 12, 24h, 3 and 5days after inoculation and the control group with sham light. Serial changes of the mRNA levels of TLR2, IL-1β, TNF-α, IL-6, iNOS, MCP-1, TGF-β, bFGF and VEGF were studied by real time RT-PCR and those of the expression level of VEGF, bFGF, TGF-β and NF-κB by immunohistochemistry. The mRNA levels of the cytokines involved in the early phase of anti-bacterial immune response (IL-1β, TNF-α, IL-6, MCP-1) increased significantly in the 1072nm group, peaking between 12 and 24h post-inoculation. These levels normalized after 3-5days. Immunohistochemistry revealed a notably stronger expression of VEGF in the 1072nm group from 8-h post-inoculation to 5-day post-inoculation. We concluded that 1072nm infrared light had a photobiomodulation effect which resulted in an enhanced biological immune response to the bacterial infection by MRSA and also increased the expression of VEGF to a significant level.

What Matters for Innovation and Leadership in Women eBusiness? : A research on women-led enterprise In China

Shen, Celine Yi,Ge, Jianqiao Asian pacific women's information network center 2006 APWIN Vol.8 No.-

To explore the strategy of women enterprises for making more effective performance in the digital economy, people first characterize those who have done better than the others. In this paper we introduce one of our research area which focus on the eBusiness usage index (with 5 sub-categories) and demonstrate that the women enterprises whose leaders have higher educated are more involved in the digital economy. This result is tested by a statistical test (two sample t-test) as well as simple comparison by average scores. Detailed studies show that education makes more significant impacts on two categories of the. eBusiness usage index. The research suggests that women entrepreneurs could make their eBusiness more competitive by enhancing and enriching their knowledge-based background.

Photoresponsive Hydrogels as Drug Delivery Systems

ABUEVA CELINE,Phil-Sang Chung,류현석,So-Young Park,우승훈 대한의학레이저학회 2020 MEDICAL LASERS Vol.9 No.1

Hydrogels have been developed and used in tissue engineering and regenerative medicine to deliver therapeutics to injured or diseased tissue because of their versatility and properties that can be tailored to match the natural extracellular matrix. Hydrogels can be made with a variety of physical and chemical properties combined with light responsiveness ideal for applications in different fields of medicine that require the spatiotemporal control of therapeutics. Light, as a stimulus, is relatively inexpensive, contact-free, noninvasive with high spatial resolution and temporal control, convenient and easy to use, and allows deep tissue penetration that is relatively harmless. Photoresponsive hydrogels are ideal candidates for on-demand drug delivery systems that are capable of sustained and controlled drug release, minimizing the side effects, and ensuring the activity and efficient delivery of drugs to the target tissue.

What Matters for Innovation and Leadership in Women eBusiness?

Shen, Celine Yi;Ge, Jianqiao Asian Pacific Women's Information Network Center t 2006 APWIN Vol.8 No.-

Scientific Analysis of Pigments in 20th Century Paintings for Selected Historical Churches of the Bohol, Philippines

Gracile Celine Roxas,Min Su Han,Dong Hyeok Moon 한국문화재보존과학회 2017 보존과학회지 Vol.33 No.6

Through a combination of scientific analytical methods, the coloring materials used in 20th century paintings in historical churches of Baclayon, Dauis and Loay, which are municipalities in Bohol, Philippines, were studied. Inorganic pigments were identified using SEM-EDS and XRD. Iron-based pigments were commonly found in the paintings, yielding dark yellow and brown colors. Zinc oxide was identified as the white pigment in the ceiling paintings of Dauis Church and Loay Church, while titanium dioxide was detected in the column painting in Baclayon Church. Organic analysis showed the presence of Pigment Yellow 3, a synthetic organic pigment. Paint layers, as well as other components of the samples such as grounds and metal leaves, were examined microscopically. It was observed that different types of grounds were applied on different types of surfaces. Moreover, organic pigments were found in combination with white extender materials. Microscopic examination also revealed alterations in the artworks, such as the overpaint layer found in the samples from Baclayon Church cornice and the imitation metal leaf layers applied over the original gilt surface in the Loay Church retablo.

Multi-channel biphasic calcium phosphate granules as cell carrier capable of supporting osteogenic priming of mesenchymal stem cells

Abueva, Celine D.G.,Park, Chan Mi,Kim, Boram,Lee, Byong-Taek Elsevier 2018 Materials & Design Vol.141 No.-

<P><B>Abstract</B></P> <P>Advances in bone tissue engineering include versatile and intricate biomaterial scaffolds in combination with stem cells for enhanced bone regeneration. In this study, a unique scaffold with multi-channels designed to allow cell infiltration within its pores was investigated for its capability to serve as a stable platform for adhesion and osteogenic priming of mesenchymal stem cells. The biphasic calcium phosphate multi-channel granule consisted of 60% hydroxyapatite and 40% β-tricalcium phosphate. Successful loading and retention of isolated and expanded rat bone marrow-derived mesenchymal stem cells (rBMSCs) were observed. The cells proliferated within the micro-channels starting from the surface then into the channels. The multi-channel granules were also able to support osteogenic priming of rBMSCs in 2D culture without the aid of a growth factor. Alkaline phosphatase, type I collagen, and runt-related transcription factor 2 expressions were detected with high osteopontin marker expression in as early as 7days, which persisted for 14days of culture under osteogenic condition. Results confirmed commitment towards osteogenic lineage of rBMSCs that have attached and grown onto the surface of the multi-channel granules and thus have high potential as a cell-scaffold based approach in bone regenerative medicine.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Multi-channel BCP granule fabricated by multi-extrusion process successfully served as cell platform for MSCs. </LI> <LI> MSCs attached well on the granule’s surface, while the micro-channel design allowed cell infiltration within the granules. </LI> <LI> Expression of osteogenic markers (ALP, OPN, COL-1 & RUNX 2) confirm successful priming of MSCs and lineage commitment. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>