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Anders Larsson,Elin Nilsson,Hans Kollberg,Marie Johannesson,Per-Erik Wej?ker,David Carlander 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.2
Immunotherapy with specific antibodies is an alternative to antibiotics for the prevention of infections in hu-mans and animals. We have used orally administered immunoglobulin Y (IgY) preparations, purified from eggs of hens im-munized with Pseudomonas aeruginosabacteria, to prevent pulmonary P. aeruginosainfections in a group of patients withcystic fibrosis (CF). Respiratory infections are major problems for CF patients because of the thick mucus in the airways, andchronic P. aeruginosalung infections occur in virtually all CF patients and cause morbidity and mortality. The IgY-treatedgroup had only 2.5 P. aeruginosa-positive sputum cultures per 100 months, and none of the IgY-treated patients becamechronically colonized with P. aeruginosa. In the control group, 13.7 of the cultures per 100 months were positive for P. aerug-inosa, and 24% of patients became chronically colonized with P. aeruginosa. The first enrolled patient in this study has nowbeen treated continuously for more than 10 years. During the first 8 years she only had four P. aeruginosa-positive cultures.After 8 years she became chronically infected, but still after 10 years the bacteria have not turned mucoid. No negative sideeffects of IgY treatment have been noted during these 10 years. To our knowledge this is the longest treatment with specificyolk antibodies for therapeutic purposes.
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