Daily Serum Collection after Acellular Dermal Matrix-Assisted Breast Reconstruction

Caputo, Glenda Giorgia,Franchini, Zeno,Maritan, Monia,Pozza, Edoardo Dalla,Vigato, Enrico,Tedeschi, Umberto,Governa, Maurizio Korean Society of Plastic and Reconstructive Surge 2015 Archives of Plastic Surgery Vol.42 No.3

Background The acellular dermal matrix (ADM)-assisted breast reconstruction technique is widely known, but discouraging results due to early postoperative complications have been reported. As the literature identifies seroma as the most common issue after breast surgery without identifying its pathogenesis, we aimed to report the trend of postoperative daily serum collection after ADM-assisted breast reconstruction and compare it with data in the literature in order to discover more about this little-known topic. Methods A retrospective study on 28 consecutive patients who received ADM-assisted breast reconstruction between February 2013 and February 2014 was performed. In order to reduce the number of variables that could affect serum production, only one brand of ADM was used and all tissues were handled gently and precisely. The daily drainage volume was recorded per patient during the first four days of hospitalization. Likewise, postoperative complications were noted during routine follow-up. Results In total, five (17.9%) bilateral and 23 (82.1%) unilateral ADM-assisted breast reconstructions (33 implants) were performed. The mean age, body mass index, and length of hospital stay were 53.6 years, $21.3kg/m^2$, and 4.5 days, respectively. One major complication led to implant loss (3.0%), and nine minor complications were successfully treated with ambulatory surgery (27.3%). Serum collection linearly decreased after 24 hours postoperatively. Conclusions Daily drainage decreased following the theoretical decline of acute inflammation. In concordance with the literature, daily serum production may not be related to the use of ADM.

Analytical model of the drain current in amorphous silicon junction field effect transistors

Caputo Domenico,Lovecchio Nicola,Di Laurenzio Sara,de Cesare Giampiero 한국물리학회 2022 Current Applied Physics Vol.41 No.-

This paper presents an analytical model of a hydrogenated amorphous silicon (a-Si:H) junction field effect transistor (JFET) based on a p-type/intrinsic/n-type stacked structure. The p-doped layer is connected to the transistor gate electrode, while the n-layer acts as the device channel. The analysis shows the effect of the geometrical and physical parameters of the intrinsic and n-doped layers on the transistor characteristics. In particular, the intrinsic layer thickness plays a central role in determining the depletion region of the n-channel and, as a consequence, the device threshold voltage. The drain current behavior achieved with a modeled parametric analysis is in very good agreement with the experimental drain current measured on fabricated JFET, both in triode and pinch-off regions. This demonstrates the model feasibility as an effective tool to design thin film electronic circuit as a sensor signal amplifier based on a-Si:H p-i-n junction.

Daily Serum Collection after Acellular Dermal Matrix-Assisted Breast Reconstruction

Glenda Giorgia Caputo,Zeno Franchini,Monia Maritan,Edoardo Dalla Pozza,Enrico Vigato,Umberto Tedeschi,Maurizio Governa 대한성형외과학회 2015 Archives of Plastic Surgery Vol.42 No.3

Background The acellular dermal matrix (ADM)-assisted breast reconstruction technique is widely known, but discouraging results due to early postoperative complications have been reported. As the literature identifies seroma as the most common issue after breast surgery without identifying its pathogenesis, we aimed to report the trend of postoperative daily serum collection after ADM-assisted breast reconstruction and compare it with data in the literature in order to discover more about this little-known topic. Methods A retrospective study on 28 consecutive patients who received ADM-assisted breast reconstruction between February 2013 and February 2014 was performed. In order to reduce the number of variables that could affect serum production, only one brand of ADM was used and all tissues were handled gently and precisely. The daily drainage volume was recorded per patient during the first four days of hospitalization. Likewise, postoperative complications were noted during routine follow-up. Results In total, five (17.9%) bilateral and 23 (82.1%) unilateral ADM-assisted breast reconstructions (33 implants) were performed. The mean age, body mass index, and length of hospital stay were 53.6 years, 21.3 kg/m2, and 4.5 days, respectively. One major complication led to implant loss (3.0%), and nine minor complications were successfully treated with ambulatory surgery (27.3%). Serum collection linearly decreased after 24 hours postoperatively. Conclusions Daily drainage decreased following the theoretical decline of acute inflammation. In concordance with the literature, daily serum production may not be related to the use of ADM.

A Case of Moderate Hidradenitis Suppurativa and Psoriasis Treated with Secukinumab

( Pistone Giuseppe ),( Pardo Nicola ),( Caputo Valentina ),( Castelli Elena ),( Curiale Salvatrice ),( Gurreri Rosario ),( Bongiorno Maria Rita ) 대한피부과학회 2018 Annals of Dermatology Vol.30 No.4

Hidradenitis suppurativa (HS) is a disorder of the apocrine gland causing a chronic, recurrent and painful inflammation. It is a disabilitating condition and, though many therapeutic options are available, the response is often ineffective in most cases and patients can present many recurrences with physical and psychological sequelae. Recent data had shown increased interleukin (IL)-17 serum levels in patients with HS. Psoriasis is a chronic immune-mediated inflammatory disorder and new evidences have shown the role of Th17 cells in its pathogenesis and the therapeutic efficacy of anti-IL-17 antibodies. We present a case of a patient suffering from psoriasis and HS successfully treated with anti-IL-17 antibodies for both conditions. This is the first case report of HS treated with secukinumab. (Ann Dermatol 30(4) 462∼464, 2018)

Alcohol use disorder and liver transplant: new perspectives and critical issues

Stefano Gitto,Silvia Aspite,Lucia Golfieri,Fabio Caputo,Francesco Vizzutti,Silvana Grandi,Valentino Patussi,Fabio Marra 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.4

Alcoholic liver disease is a consolidated indication for liver transplantation, but many unsolved issues can be highlighted. Patients with alcohol use disorder develop peculiar comorbidities that can become contraindications for transplantation. Moreover, a number of social and psychological patterns should be evaluated to select candidates with a low risk of alcohol relapse and adequate post-transplant adherence. In this context, the 6-month rule is too rigid to be widely applied. A short period of abstinence (1 to 3 months) is useful to estimate recovery of liver function and, possibly to avoid transplant. Cardiovascular disorders and extra-hepatic malignancies represent the main clinical issues after transplant. Patients transplanted due to alcoholic disease are a major risk for other liver diseases. Severe corticosteroid-resistant alcoholic acute hepatitis is a debated indication for transplant. However, available data indicate that well-selected patients have excellent post-transplant outcomes. Behavioral therapy, continued psychological support and a multidisciplinary team are essential to achieve and maintain complete alcohol abstinence during the transplant process. Alcoholic liver disease is an excellent indication for a liver transplant but patients with alcohol use disorder deserve a personalized approach and dedicated resources.

Endurance and Strength Athlete’s Heart: Analysis of Myocardial Deformation by Speckle Tracking Echocardiography

Amato Santoro,Federico Alvino,Giovanni Antonelli,Maria Caputo,Margherita Padeletti,Matteo Lisi,Sergio Mondillo 한국심초음파학회 2014 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.22 No.4

Background: Intensive training induces two morphological myocardial typologies of athlete’s heart. Endurance training (ET)induces eccentric remodeling, bradycardia and better diastolic filling. Strength training (ST) determines concentric chamberremodelling maintaining a normal heart rate (HR). Aim of the study was to compare ET and ST athletes’ heart using speckletracking echocardiography (STE). Methods: 33 professional ET, 36 ST athletes, and 17 healthy controls (CT) were enrolled. All subjects underwent standardtransthoracic echocardiography at rest and STE. Results: In ET group, HR was lower than ST group and CT group (p < 0.001; p < 0.01). ET group had higher E/A ratio thanST group and CT group (p < 0.01; p < 0.001). The left ventricular apical circumferential strain in ET group was lower than STgroup and CT group (-21.6 ± 4.1% vs. -26.8 ± 7.7%, p < 0.05; vs. -27.8 ± 5.6%, p < 0.01). ET group had lower left ventriculartwist (LVT) and untwisting (UTW) than ST group (6.2 ± 0.1° vs. 12.0 ± 0.1°, p < 0.01; -67.3 ± 22.9°/s vs. -122.5 ± 52.8°/s, p< 0.01) and CT group (10.0 ± 0.1°, p < 0.01; -103.3 ± 29.3°/s, p < 0.01). The univariate analysis showed significant correlationbetween E/A ratio and HR (r = -0.54; p < 0.001), LVT (r = -0.45; p < 0.01), UTW (r = 0.24; p < 0.05). At the multivariateanalysis only HR was confirmed as independent predictor of diastolic function in all groups (Beta -0.52; p < 0.001). Conclusion: In ET there was a better global systolic and diastolic functional reserve at rest observed with strain analysis and itmaybe depended on autonomic modulation.

Back-analysis of a Large Landslide in a Heterogeneous Rock Mass

( Matteo Berti ),( Anna Rita Bernardi ),( Giuseppe Caputo ) 대한지질공학회 2019 대한지질공학회 학술발표회논문집 Vol.2019 No.2

Flysch is a sedimentary rock consisting of a rhythmic alternation of hard (limestone, sandstone, siltstone) and weak (marl, mudstone, claystone) layers. Because of the presence of layers with different physical properties the mechanical characterization of heterogeneous rock masses such as flysch is a real challenge. Different methods have been proposed in the literature to characterize flysch, combining empirical classification indexes with laboratory tests. Most of these methods, however, were specifically designed for tunneling and underground excavations and their applicability to slope stability problems is not yet fully investigated. In this study, we analyze a large landslide in a cretaceous flysch rock in order to compare the mobilized strength at failure with those predicted by the modified GSI method (Marinos and Hoek, 2001). The landslide occurred in the Savena River basin (Northern Apennines of Italy) on April 6, 2013 with a volume of about 3 million cubic meters. Soon after the failure, geological, geotechnical, and geophysical investigations were carried out to detect the failure mechanism and define the landslide geometry. Back-analyses of the failed slope were performed using both limit equilibrium and finite difference methods to estimate the in situ strength of the flysch. The results show that the mobilized rock mass cohesion is very low and that the GSI method can predict the in situ strength only assuming a very high disturbance factor. Moreover, the analysis shows that the linearization criteria proposed in literature to compute the equivalent Mohr-Coulomb parameters remarkably overestimate the rock mass strength.

Comment on “A stepwise approach to fine needle aspiration cytology of lymph nodes”

Elisabetta Maffei,Valeria Ciliberti,Pio Zeppa,Alessandro Caputo 대한병리학회 2024 Journal of Pathology and Translational Medicine Vol.58 No.1

Effect of Auriculotherapy on the Plasma Concentration of Biomarkers in Individuals with Knee Osteoarthritis

Rebeca Grac¸a Costa-Cavalcanti,Danu´bia da Cunha de Sa´-Caputo,Eloa´ Moreira-Marconi,Cristiane Ribeiro Ku¨ter,Samuel Branda˜o-Sobrinho-Neto,Laisa Liane Paineiras-Domingos,Marcia Cristina Moura-Fernand 사단법인약침학회 2018 Journal of Acupuncture & Meridian Studies Vol.11 No.4

Knee osteoarthritis (KOA) is one of the most frequent noncommunicable diseases with pain associated symptoms and affects the musculoskeletal system. Various forms of treatment can be indicated, and nonpharmacological treatment is also an available option for the management of KOA individuals. For instance, auriculotherapy (AT) is one possible procedure associated with the Traditional Chinese Medicine for dealing with KOA. It is believed that the concentration of certain biomarkers could be altered in individuals with KOA after AT. The aim of this study was to evaluate the effect of AT on plasma concentration of biomarkers in KOA individuals. This intervention is a controlled trial. Twentyone subjects were grouped in two groups and submitted to AT with the stimulation of the Shen Men, kidney, and knee points in the treatment group or different points in the control group, once a week for 5 weeks. Blood was collected before the beginning of protocols and a week after the last session. KolmogoroveSmirnov and Wilcoxon tests were performed, and a p 0.05 was considered statistically significant. Hematological parameters did not show any significant variation between the control group and treated group. Concerning the biochemical parameters, a significant reduction of direct bilirubin (from 43.31 Æ 22.10 to 21.21 Æ 5.30 mmol/L, p Z 0.003), aspartate aminotransferase (from 0.48 Æ 0.16 to 0.38 Æ 0.09 mKat/L, p Z 0.010), and triglycerides (from 7.04 Æ 2.90 to 5.45 Æ 2.57 mmol/L, p Z 0.008) in the treated group was obtained. In conclusion, the analysis of results suggests that AT might be a useful intervention for the management of KOA individuals.

Role of adjuvant chemotherapy in the management of non-granulosa cell ovarian sex cord-stromal tumors

Dimitrios Nasioudis,Theofano Orfanelli,Melissa K. Frey,Eloise Chapman-Davis,Thomas A. Caputo,Steven S. Witkin,Kevin Holcomb 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.2

Objective: To investigate the role of adjuvant chemotherapy (CT) in the management of ovarian non-granulosa cell (GC) sex cord-stromal tumors (SCSTs). Methods: The National Cancer Database was accessed and patients diagnosed between 2004 and 2013 with a malignant non-GC SCST were selected. Overall survival (OS) was evaluated with Kaplan-Meier curves and compared with the log-rank test. Multivariate survival analysis was performed with Cox regression. Factors associated with the administration of CT were evaluated with the chi-square test and binary logistic regression. Results: A total of 391 patients were identified. The majority had a Sertoli-Leydig cell tumor (SLCT) (73.2%) and early stage disease (84.8%). A total of 203 (51.9%) patients received CT. Advanced disease stage, younger age, high-grade histology, White race, large tumor size and SLCT histology were associated with administration of CT. For patients with early stage disease, there was no difference in OS between those who did (n=134) and did not receive CT (n=157), p=0.40; 5-year OS rates were 81.7% and 84.6%, respectively. No mortality benefit was observed (hazard ratio=0.73; 95% confidence interval=0.38–1.4) after controlling for tumor histology. Median OS of women with advanced stage disease who received CT (n=41) was 34.96 months compared to 15.51 months for those who did not (n=11), p=0.013. Conclusion: Adjuvant CT was associated with improved survival for patients with advanced stage non-GC SCSTs. No clear benefit was found for those with early stage disease.