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Anti-tumor activity of retinoic acid-incorporated glycol chitosan nanoparticles
Cy-Hyun Kim,Do-Hyung Kim,Hye-Myung Lee,Tae-Won Kwak,Young-IL Jeong,Chung-Wook Chung,Dae-Hwan Kang 한국당과학회 2012 한국당과학회 학술대회 Vol.2012 No.1
Nanoparticles have been extensively investigated for targeted delivery of anticancer drug. Especially, chitosan based nanoparticles is believed as a promising carriers for cancer chemotherapy and imaging. Due to superior biocompatibility, non-cytotoxic, and biologically active properties, chitosan is frequently used as a biomedical materials and drug carriers. Furthermore, chitosan is regarded as an ideal vehicle for delivery of anionic drug or DNA drug due to its positive ionic proeprties. Chitosan is used to make polyion complexes with anionic drug such as all-trans retinoic acid (RA) and these ionic complexes can form nanoparticles in aqueous media We prepared RA-incorporated glycol chitosan (GC) nanoparticles by simple mixing RA into the GC aqueous solution through ion complex formation between RA and GC. Particle sizes of RA-incorporated GC nanoparticles were approximately 300~500 nm. Lyophilized nanoparticles were simply reconstituted into aqueous solution in spite of absence of cryoprotectants. RA-incorporated GC nanoparticles showed similar cytotoxicity against cholangiocarcinoma cells. Furthermore, RA-incorporated GC nanoparticles showed enhanced anti-invasive capacity and anti-migration capacity against HuCC-T1 cholangiocarcinoma cells. We suggest that RA-incorporated GC nanoparticles are promising vehicles for antitumor drug delivery.
김창이(CY Kim),황세영(SY Hwang),최진주(JJ Choi),김윤호(YH Kim) 대한산부인과학회 1973 Obstetrics & Gynecology Science Vol.16 No.1
자궁탈을 동반한 과립 난포막 세포종 1예 A case of granulosa theca cell tumor combiend with uterine prolapse in a 57 year old postmenopausal woman was presented and a brief review of literature on granulosa theca cell tumor was made.
김철영(CY Kim) 대한산부인과학회 1970 Obstetrics & Gynecology Science Vol.13 No.1
It has been known for long that the fetal glucose is related closely to that of mother during normal pregnancy, and the former is lower than the letter. The transport of blood glucose across the placenta is directly by maternal blood glucose level. The fetal blood glucose level is infruenced by endogenouse and exogenous factors of the mother, and the infant born with hypoglycemia is in an unfavorable condition during the neonatal period because glucose is only source of energy to feetus. The feral hypoglycemia is due to 1)the rapid utilization by the fetal tissue and 2)the placental extraction of glucose. Eastman et al(1936)described that metabolic acidosis during labor is caused by hypoxia with abnormal changes in electrolytes such as hyperkalemia, low blood PH and high PCO. Paterson (1967)reported that the administration of glucose with bicarbonate improved metabolic acidosis of the newborn. This experiment was carried out to learn the effect of 5% dextrose in water during labor on the mother and fetus. The blood glucose from the mother and fetus was evaluated in relation to the length of labor, presence of toxemia of pregnancy, protein-uria, gestation week and fetal weight. The blood glucose from the maternal vein and umbilical vein was measured by Folin-Wu`s method. The following results were obtained from the experiment: 1. Mean values of the fetal blood glucose in 106 patients were 124.9 and 92.3mg% respectively with significant difference.(P<0.001) 2. Blood glucose level of both the mother and fetus given glucose solution intravenously was significantly higher than in control group.(P<0.001, P<0.001) 3. The glucose level in the blood of the mother was not changed by the duration of labor, however, that of the fetus had a tendency to rise upto 20 hours and decreased after this time. 4. Blood glucose level of toxemic mothers and their fetuses who were given glucose were fairly higher than the mean values of nomal cases given glucose. Blood glucose level of mothers with proteinuria showed a tendency to be hogher, and also was related to the degree of proteinuria in the mother. The values being higher with increased proteinuria. 5. The maternal and fetal blood glucose level maintained a same values by the length of gestation and birth weight. The results suggest that the infusion of 5% dextrose in water during labor elevates the maternal blood glucose as well as fetal blood particularly in primigravid, and it can help to improve fetal condition particularly in prolonged labor.
Kim, Cy Hyun,Chung, Chung-Wook,Lee, Hye Myeong,Kim, Do Hyung,Kwak, Tae Won,Jeong, Young-IL,Kang, Dae Hwan Dove Medical Press 2013 International journal of nanomedicine Vol.8 No.-
<P>5-Aminolevulinic acid (ALA)-based photodynamic therapy (PDT) has the potential to kill cancer cells via apoptotic or necrotic signals that are dependent on the generation of intracellular reactive oxygen species (ROS). Celecoxib is an anti-inflammatory drug that induces intracellular ROS generation. We investigated whether the combined application of celecoxib and ALA-PDT improved the efficacy of PDT in human cholangiocarcinoma cells and in tumor bearing mice. In vitro, combined treatment of celecoxib and ALA-PDT increased phototoxicity and intracellular ROS levels after irradiation with 0.75 J/cm<SUP>2</SUP> when compared to ALA-PDT alone. Even though ROS levels increased with 0.25 J/cm<SUP>2</SUP> of irradiation, it did not influence phototoxicity. When heme oxygenase-1, a defensive protein induced by oxidative stress, was inhibited in the combined treatment group, phototoxicity was increased at both 0.25 J/cm<SUP>2</SUP> and 0.75 J/cm<SUP>2</SUP> of irradiation. We identified the combined effect of ALA-PDT and celecoxib through the increase of oxidative stress such as ROS. In vivo, about 40% tumor growth inhibition was observed with combined application of ALA-PDT and celecoxib when compared to ALA-PDT alone. The combined application of ALA-PDT and celecoxib could be an effective therapy for human cholangiocarcinoma. Moreover, use of a heme oxygenase-1 inhibitor with PDT could play an important role for management of various tumors involving oxidative stress.</P>
Ahn, CY,Bae, SK,Bae, SH,Kim, T,Jung, YS,Kim, YC,Lee, MG,Shin, WG Wiley (Blackwell Publishing) 2009 British journal of pharmacology Vol.156 No.6
<P>BACKGROUND AND PURPOSE: The incidence of diabetes mellitus is increased in patients with liver cirrhosis. Oltipraz is currently in trials to treat patients with liver fibrosis and cirrhosis induced by chronic hepatitis types B and C and is primarily metabolized via hepatic cytochrome P450 isozymes CYP1A1/2, 2B1/2, 2C11, 2D1 and 3A1/2 in rats. We have studied the influence of diabetes mellitus on pharmacokinetics of oltipraz and on expression of hepatic, CYP1A, 2B1/2, 2C11, 2D and 3A in rats with experimental liver cirrhosis. EXPERIMENTAL APPROACH: Oltipraz was given intravenously (10 mg x kg(-1)) or orally (30 mg x kg(-1)) to rats with liver cirrhosis induced by N-dimethylnitrosamine (LC rats) or with diabetes, induced by streptozotocin (DM rats) or to rats with both liver cirrhosis and diabetes (LCD rats) and to control rats, and pharmacokinetic variables measured. Protein expression of hepatic CYP1A, 2B1/2, 2C11, 2D and 3A was measured using Western blot analysis. KEY RESULTS: After i.v. or p.o. administration of oltipraz to LC and DM rats, the AUC was significantly greater and smaller, respectively, than that in control rats. In LCD rats, the AUC was that of LC and DM rats (partially restored towards control rats). Compared with control rats, the protein expression of hepatic CYP1A increased, that of CYP2C11 and 3A decreased, but that of CYP2B1/2 and 2D was not altered in LCD rats. CONCLUSIONS AND IMPLICATIONS: In rats with diabetes and liver cirrhosis, the AUC of oltipraz was partially restored towards that of control rats.</P>
최종열(CY Choi),신재진(JJ Shin),이명우(MW Lee),오원섭(WS O) 대한산부인과학회 1982 Obstetrics & Gynecology Science Vol.25 No.6
저자들은 1975년 1월부터 1980년 8월까지 5년 8개월 동안 본 한강성심병원 산부인과에서 치험한 자궁파열 33예에 대하여 임상적으로 분석을 하여 다음과 같은 결과를 얻었다. 1. 총분만수 10509예중 자궁파열이 33예로서 발생빈도는 1:318이었다. 2. 연령분포는 30-34세군에서 42.4%로 분만회수는 1-2회에서 82%로 가장 많았다. 3. 자궁파열의 종류별 빈도는 기왕제왕절개반흔파열이 21예로 64% 자연자궁파열이 7예로 21% 가해자궁파열이 5예로 15%이었다. 4. 파열장소는 원의가 31에로 94% 원내가 2예로 6%였다. 5. 임신주수별 자궁파열은 대부분이 만삭임신이었다. 6. 가해자궁파열의 원인적 요소는 자궁수축제의 남용이 가장 많았다. 7. 자궁파열의 부위는 자궁체부가 49% 자궁하절부가 21% 자궁측벽이 30%였으며 자궁체부파열은 대부분이 반흔파열이었고 자연자궁파열과 가해자궁파열은 대부분이 측벽파열이었다. 8. 치료는 원칙적으로 전자궁적출술(67%)을 했으며 그의 환자의 상태 파열부위 및 정도에 따라 단순봉합 자궁경상부적출술을 하였다. 수혈량은 평균 6.2pints이었다. 9. 모체사망율은 9% 태아사망율은 52%이었다. This report concerns 33 cases of uterine rupture diagnosed among 10509 obstetric deliveries at Han Gang Heart Hospital in Seoul from Jan. 1975 through Aug. 1980. The results are summerized as follows. 1. There were 33 cases of uterine rupture among 10509 deliveries, an incidence of 1 in 318 deliveries. 2. The age distribution was from 29 to 39 years of age and about 82% of cases were in 25 to 34 years of age. According to parity, 82% of cases were in para 1 and 2.3. The incidence depending on the classification of rupture, 21 cases (64%) were ruptured previous Cesarean section scars, 7 cases (21%) were spotaneous rupture, 5 cases(15%) were traumatic rupture. 4. The place of rupture were 31 cases of extramural (94%) and 2 cases of intramural (6%). 5. According to gestational age, about 27 cases (82%) were over 38 weeks. 6. The major etiologic factor associated with traumatic rupture of the uterus noted to be the abuse of oxytocic drug. 7. The sites of rupure were composed of 7 cases (21%) in loxer uterine segment, 10(30%) in the lateral wall of uterus, and 16(49%) in the other sites of corpus. Corpus ruptures were largely due to ruptured scars, but lateral wall ruptures were almostly spotaneous and traumatic rupture. 8. About surgical management of uterine rupure, we have performed totoal hysterectomy(67%), simple repaire of defect(27%), subtotal hysterectomy(6%), according to suptured site, extensiion, patient`s general condition. During clinical management, the average blood transfusion was 6.2 pints. 9. Maternal mortality was 9% and the fetal mortality 52%.
원창용(CY Won),이우용(WY Lee),박신근(SK Park),배병추(BC Bai) 대한산부인과학회 1978 Obstetrics & Gynecology Science Vol.21 No.3
Congenital anomalies of female genital tract are comparatively rare. Pregnancy in association with anomalies is rarer still. We have experienced a case of lithopedion in rudimentary uterine horn. This paper reports a case of lithopedion in rudimentary uterine horn, Gartners duct cyst in vagina and agenesis of left kidney, and presents with a brief review of the literature concerning the reproductive problem in uterine anomalies.