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Ling‑Hong Miao,Wen‑Jing Pan,Yan Lin,Bo Liu,Ming‑Chun Ren,Qun‑Lan Zhou,Xian‑Ping Ge 한국유전학회 2017 Genes & Genomics Vol.39 No.12
The objective of this study was to analyze the target genes and regulatory function of miR-34a in Megalobrama amblycephala using second-generation highthroughput sequencing and bioinformatic tools. Functional enrichment analysis was performed by gene ontology. MiR- 34a and target gene expression levels were measured in M. amblycephala fed normal and high-carbohydrate diets. The results revealed that miR-34a was highly conserved in several species, and miR-34a of M. amblycephala has a close evolutionary relationship to that of zebrafish and common carp. miRanda, TargetScan, RNAhybrid predicted 5,185, 6,282 and 2,168 target genes, respectively, and 645 target genes were in common. According to annotation information, the target genes were enriched in phosphate metabolism, glycerophospholipid metabolism, Golgi vesicle transport, cell division, and other biological processes (P < 0.05). Pathway enrichment analysis revealed that these target genes were mainly enriched in alpha-linolenic acid and linoleic acid metabolism, ether lipid metabolism, VEGF signaling pathway, Fc epsilon RI signaling pathway, GnRH signaling pathway, and MAPK signaling pathway (P < 0.05). The regulatory role of miR-34a was more significant in the liver than in the brain of M. amblycephala. MiR-34a regulates glucose lipid homeostasis induced by high glucose diets by upregulating hepatic PI3K/Akt, FOXO, and TOR signaling pathways.
Relationship between the FRAX® score and falls in community-dwelling middle-aged and elderly people
Ling-Chun Ou,Yin-Fan Chang,Chin-Sung Chang,Ting-Hsing Chao,Ruey-Mo Lin,Zih-Jie Sun,Chih-Hsing Wu 대한골다공증학회 2016 Osteoporosis and Sarcopenia Vol.2 No.4
Objectives: Falls is a risk factor for fracture. The FRAX® predicts fractures. Whether the FRAX® is associated with fall in both gender is inconclusive. The aim of our study is to evaluate the association between FRAX scores and falls. Methods: The cross-sectional study set from 2009 to 2010 included 1200 community-dwelling people who were systematically sampled in central Taiwan. The 1200 participants (men: 524; women: 676; ?40 years old) completed questionnaires about socioeconomic status; lifestyle; medical and fall history were completed. FRAX scores with and without bone mineral density (BMD) were calculated by using the Taiwan calculator. Results: A total of 19.8% participants fell down. Binary regression models showed that diabetes mellitus history (OR: 1.61; 95% CI: 1.03e2.52), the FRAX without BMD in a continuous major score (OR: 1.06; 95% CI: 1.03e1.09), continuous hip score (OR: 1.11; 95% CI: 1.05e1.16), categorical major score ? 10% (OR: 1.81; 95% CI: 1.25e2.61), and categorical hip score ? 3% (OR: 1.80; 95% CI: 1.30e2.50) were independent risk factors for falls. FRAX with BMD in a continuous major score (OR: 1.04; 95% CI: 1.02e1.06), continuous hip score (OR: 1.06; 95% CI: 1.02e1.09), categorical major score ? 10% (OR: 1.52; 95% CI: 1.09e2.12), and categorical hip score ? 3% (OR: 1.53; 95% CI: 1.13e2.09) were also independent risk factors. Conclusions: We concluded that FRAX® scores with and without BMD were unanimously correlated with falls in community-dwelling middleaged and elderly males and females.
Chun-Yu Liu,Tzu-Ting Huang,Pei-Yi Chu,Chun-Teng Huang,Chia-Han Lee,Wan-Lun Wang,Ka-Yi Lau,Wen-Chun Tsai,Tzu-I Chao,Jung-Chen Su,Ming-Huang Chen,Chung-Wai Shiau,Ling-Ming Tseng,Kuen-Feng Chen 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Triple-negative breast cancer (TNBC) remains difficult to treat and urgently needs new therapeutic options. Nintedanib, a multikinase inhibitor, has exhibited efficacy in early clinical trials for HER2-negative breast cancer. In this study, we examined a new molecular mechanism of nintedanib in TNBC. The results demonstrated that nintedanib enhanced TNBC cell apoptosis, which was accompanied by a reduction of p-STAT3 and its downstream proteins. STAT3 overexpression suppressed nintedanib-mediated apoptosis and further increased the activity of purified SHP-1 protein. Moreover, treatment with either a specific inhibitor of SHP-1 or SHP-1-targeted siRNA reduced the apoptotic effects of nintedanib, which validates the role of SHP-1 in nintedanib-mediated apoptosis. Furthermore, nintedanib-induced apoptosis was attenuated in TNBC cells expressing SHP-1 mutants with constantly open conformations, suggesting that the autoinhibitory mechanism of SHP-1 attenuated the effects of nintedanib. Importantly, nintedanib significantly inhibited tumor growth via the SHP-1/p-STAT3 pathway. Clinically, SHP-1 levels were downregulated, whereas p-STAT3 was upregulated in tumor tissues, and SHP-1 transcripts were associated with improved disease-free survival in TNBC patients. Our findings revealed that nintedanib induces TNBC apoptosis by acting as a SHP-1 agonist, suggesting that targeting STAT3 by enhancing SHP-1 expression could be a viable therapeutic strategy against TNBC.
Chun Ling Zhao,Guang Ping Zhang,Zheng Zheng Xiao,Zhi Kun Ma,Cai Peng Lei,Shi Yuan Song,Ying Ying Feng,Ya Chao Zhao,Xiao Shan Feng 한국유방암학회 2015 Journal of breast cancer Vol.18 No.2
Purpose: We investigated whether recombinant human granulocyte colony-stimulating factor (rhG-CSF) could promote the development of preinvasive and invasive breast cancer in mouse mammary tumor virus (MMTV-erbB2) mice with estrogen receptor- positive tumors. Methods: MMTV-erbB2 mice were randomly divided into three experimental groups with 20 mice in each group. MMTV-erbB2 mice were treated with daily subcutaneous injections of vehicle or rhG-CSF (low-rhG-CSF group, rhG-CSF 0.125 μg; vehicle-rhG-CSF group, normal saline 0.25 μg; and high-rhG-CSF group, rhG-CSF 0.25 μg) at 3 months of age. Cellular and molecular mechanisms of G-CSF action in mammary glands were investigated via immunohistochemistry and reverse transcription polymerase chain reaction. Results: Low, but not high, rhG-CSF doses significantly accelerated mammary tumorigenesis in MMTV-erbB2 mice. Short-term treatment with rhG-CSF could significantly promote the development of preinvasive mammary lesions. The cancer prevention effect was associated with reduced expression of proliferating cell nuclear antigen, cluster of differentiation 34, and signal transducers and activators of transcription 3 in mammary glands by >80%. Conclusion: We found that G-CSF was regulated by rhG-CSF both in vitro and in vivo. Identification of G-CSF genes helped us further understand the mechanism by which G-CSF promotes cancer. Low doses of rhG-CSF could significantly increase tumor latency and increase tumor multiplicity and burden. Moreover, rhG-CSF effectively promotes development of both malignant and premalignant mammary lesions in MMTV-erbB2 mice.
Chun-Ling Song,Lin Xie,Zun-Quan Xia 한국전산응용수학회 2004 Journal of applied mathematics & informatics Vol.15 No.-
A new topology in terms of order on fuzzy sets, revealing betterthe relationship between smooth topology and Chang’s fuzzy topology, ispresented in the paper. Some basic properties are discussed.
RELATION BETWEEN DEMYANOV DIFFERENCE ANDMINKOWSKI DIFFERENCE OF CONVEX COMPACTSUBSETS IN R2
CHUN-LING SONG,ZUN-QUAN XIA,LI-WEI ZHANG,SHU-YANG LI 한국전산응용수학회 2007 Journal of applied mathematics & informatics Vol.23 No.1
A necessary and sufficient condition for Demyanov difference and Minkowski difference of compact convex subsets in R2 being equal is given in this paper. Several examples are computed by Matlab to test our result. The necessary and sufficient condition makes us to compute Clarke subdifferential by quasidifferential for a special of Lipschitz functions.
APPLICATION OF FUZZY LOGIC IN THE CLASSICAL CELLULAR AUTOMATA MODEL
Chang, Chun-Ling,Zhang, Yun-Jie,Dong, Yun-Ying 한국전산응용수학회 2006 Journal of applied mathematics & informatics Vol.20 No.1
In [1], they build two populations' cellular automata model with predation based on the Penna model. In this paper, uncertain aspects and problems of imprecise and vague data are considered in this model. A fuzzy cellular automata model containing movable wolves and sheep has been built. The results show that the fuzzy cellular automata can simulate the classical CA model and can deal with imprecise and vague data.
맹춘영 ( Chun Ling Meng ) 한국중국언어학회 2011 중국언어연구 Vol.0 No.34
韓國學生在習得中文時所造的中文句子旣不屬於他們的母語――韓國語, 也不屬於目的語――漢語, 而屬於他們自己所建立的一個動態的語法體系, 卽中介語。 中介語中存在正確的句子, 也存在有偏誤的句子, 卽病句。 本稿就中介語中的病句建立了一個修改模型, 該修改模型由兩個階段的操作構成, 第一階段爲結合造句者的母語特征, 將有偏誤的中介語還原成他們的母語, 還原以後的母語句子要最大限度地反映出造句者的思考方式或交際意圖。 第二階段是根據最佳關聯性, 將還原後的母語句子再重新飜譯成目的語句子, 在此過程中, 所選擇的目的語信息結構要盡量與有偏誤的的中介語信息結構保持一致或相似。