Antiangiogenic-Like Properties of Fermented Extracts of Ayurvedic Medicinal Plants

Che´rif Rabhi,Guillaume Arcile,Le´on Cariel,Christine Lenoir,Je´rome Bignon,Joanna Wdzieczak-Bakala,Jamal Ouazzani 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.9

The three ayurvedic medicinal plants, Withania somnifera, Emblica officinalis, and Bacopa monnieri, were extracted by high-pressure static extraction using the Zippertex® technology. The extracts were mixed to reach quantifiable amounts of active compounds identified by high-pressure liquid chromatography-mass spectrometry (HPLC-MS) analysis. The mixture of extracts was incubated with resting cells of the fungus Beauveria bassiana ATCC 7159. The fermentation promoted the fluidization of the starting dense mixture, while HPLC monitoring evidenced the disappearance of glucogallin from E. officinalis extract and the concomitant increase in gallic acid content. Topical exposure of the chick embryo chorioallantoic membrane (CAM) to the nonfermented extract led to the extensive necrosis and destruction of the treated membrane. However, the fermented extract was shown to be free of any toxicity. Furthermore, compared with the untreated CAM, the fermented sample reduced CAM vascularization, suggesting its antiangiogenic potency. The innocuity of the fermented extract was demonstrated using the in vivo LD50 test, the morphological examination of internal organs of treated rats, as well as the evaluation of blood biomarkers of liver damage (aspartate aminotransferase and alanine aminotransferase). The fermented extract was developed as a nutraceutical antiangiogenic treatment of age-related macular degeneration and commercialized in an oral form named Ethnodyne-Visio™.

제주 우수 육상경기 선수들의 년중 훈련효과 분석 및 처방

김철원,임상용,김승곤,오만원,김성찬,이창준,남사웅,이세형,류재청 濟州大學敎 體育科學硏究所 1996 체육과학연구 Vol.2 No.-

The study was undertaken to analysis, evaluate, and prescribe t h e annual effect of training of periodically anaerobic and aerobic motor ability for Che-Ju representive team of elementary, middle and high school athletes. first. the performance can be obtained when it was prescribed proper training after analysis of physical fitness by each events. second, individually fitness. scientific analysis. prescription. proper management of athlete will be necessary to apply. In addition to physiology aspect, it is essential to consider sport biomechanics. sport psychology when we prescribe specific events and necessary approach in demension coach-athlete-researcher for individual.

제주 우수 수영 선수들의 년중 훈련효과 분석 및 처방

김철원,임상용,김승곤,오만원,김성찬,이창준,남사웅,이세형,류재청 濟州大學敎 體育科學硏究所 1996 체육과학연구 Vol.2 No.-

The study was undertaken to analysis, evaluate, and prescribe the annual effect of training of periodically anaerobic and erobic motor ability for Che-Ju representive team of elementary, middle and high school athletes, first the performance can be obtained when it was prescribed proper training after analysis of physical fitness by each events, second individually fitness scientific analysis. prescription. proper management of athlete will be necessary to apply.

의료소비자의 관계혜태 지각이 관계의 질 및 행동의도에 미치는 영향

허철선(Che이-Seon Heo),유광우(Kwang-Woo Yoo) 한국무역연구원 2014 무역연구 Vol.10 No.1

Medical institutions are important to develop and maintain enduring relationship with medical service conswners. So, this research aims to find out the effect of medical service conswners perception of relational benefits on relationship quality and behavioral intention. On the basis of the literature review, the research model is established. This research has been done through the survey utilizing medical service consumers in Gangwondo, and the effective 368 questionnaires are tested for the research model. The main findings are as follows. First, among 5 key dimensions of relational benefits, psychological, customization, economic, and information benefits except social benefits have significant effects on relationship satisfaction. Also, medical institutions type and medical service consumers type as moderating variables are included concurrently, and the significant differences are found in other 4 benefits except relationship between social benefits and relationship satisfaction. Second, relationship satisfaction relates positively to relationship commitment and behavioral intention. But the normative commitment, one of 3 key dimensions of relationship commitment, has no significant effects on recommendation to others. Third, the revisit intention has significant effect on recommendation to others. Finally, the findings reveal that the overall goodness fit index of the model is comparatively good and model set in this research is significant. At the end of the research, managerial implications, limitations and future research directions are suggested.

의료 화상을 위한 전처리 필터들의 특성에 관한 연구

강명아,최종주,정종필,정채영,정남채 조선대학교 기초과학연구소 1997 自然科學硏究 Vol.20 No.1

There has been no fixed rule of pre-processing course required to do image processing that it was barely possible to find the proper pre-processing course, only to process with experience till now. In this paper, lots of application method of pre-processing algorithm, only available by the non-typified and experiential method, shall quantify and the algorithm method of algorithm according to the rule shall calculate the frequency of the value of each pixel gray level and the histogrm of the image. And then average it to all pixel number and finally set a high-ranking or optional % standardized by the average value in teh standard value. The result of a experiment showed the Median filter is superior to the Mean filter in all image of the smoothing filter. The sobel filter extracted feature. The laplacian filter presented sectional feature which not showed in original image.

군산시 지하수의 특성에 대한 연구

장재철,성금수,김동원 군산대학교 기초과학연구소 2000 基礎科學硏究 Vol.15 No.-

The purpose of this study is to investigate the pollution characteristics of groundwaters in Kansan city. Volatile organic compounds such as TCE(tri-choroethylene), PCE(tetruchloroethylene), 1,1,1-trichloroethane, THM(trihalo-methane), dichloromethane, pesticides such as diazinon, parathion, malathion, toxic inoganic matters such as As, Hg, Se, Cd, Al, Cr6+, oder, taste and phenol were not detected in the groundwaters. Mean values of groundwater pollution indicators were bellow drinking-water standards, but Bacteria, Total Coliforms, Pb, Mn, NO3-N and NH3-N, total solid and pH exceeded a little in some samples.

해조류 에탄올 농도별 추출물의 항돌연변이원성 및 항균성

박제석,오명철,오창경,현재석,김봉오,김수현 濟州大學校工科大學産業技術硏究所 1996 尖端技術硏究所論文集 Vol.7 No.2

톳. 미역 및 다시마의 에탄올 농도별 추출물이 MMS. ICR191 및 sodium azide에 의해 유도되는 돌연변이원성의 억제효과 및 E. coli, B. subtilis 및 S. serevisiae에 대한 항균효과를 검정하였다. 톳의 90% 에탄올 추출물은 MMS와 ICR191에 대한 항돌연변이 원성이 각각 70 및 95% 이상으로 매우 높았으나, sodium azide에 대한 항돌연변이원성은 없었다. 미역의 에탄올 농도별 추출물은 30∼90% 에탄올 추출물에서 50% 이상의 항돌연변이 효과를 보았으나 MMS와 sodium azide에 대한 항돌연변이 효과는 없었다. 다시마의 30∼90% 에탄올 추출물의 ICR191에 대한 항돌연변이 효과는 70% 이상이었으나, MMS와 sodium azide에 대한 효과는 없었다. 에탄올 농도별 톳의 추출물들에 대한 항균성 검색 결과 70과 90% 추출물들이 E. coli와 B. subtilis에 대하여 뚜렷한 항균효과는 미역 추출물 보다 다시마의 추출물이 더욱 요과적이었다. 미역 추출물은 50% 추출물만이 S. cerevisiae에 대한 성장저지효과를 나타낸 반면, 다시마 추출물은 90% 에탄올 추출물에서는 시험된 모든 공시균주에 대하여, 그리고 70% 에탄올 추출물에서는 E. coli와 B. sutilis에 대하여 높은 성장저지효과를 나타내었다. Desmutagenic against MMS-, ICR191- and sodium azide-induced mutations, and antimicrobial effects against Escherichia coli, Bacillus subtilis and Saccharomyces cerevisiae by the extracts from Hizikia fusiforme. Laminaria japonica and Undaria pinnatifida with ethanol of a different concentrations were investigated. Desmutagenic effects against MMS and ICR191 of 90% ethanol extracts from Hizikia fusiforme were up 70 and 95%. respectively. no against sodium azide. Desmutagenic effects against ICR191 of 30∼90% ethanol extracts from Undaria pinnatifida and Laminaria japonica were up to 50 and 70%. respectively. but no against sodium azide and MMS. Antimicrobial effect of 70 and 90% ethanol extracts from Hizikia fusiforme had potent antimicrobial activities against E. coli and B. subtilis. Ethanol extracts from Laminaria japonica showed more effective antimicrobial effects than those from Undaria pinnatifida. Only 50% ethanol extract from Undaria pinnatifida showed growth inhibition effect against S. cerevisiae. Seventy percent ethanol extract from Laminaria japonica showed growth inhibition effect against all strains tested. while 90% ethanol extract showed against E. coli and B. subtilis.

부하수준에 따른 보행양상과 일치도에 관한 연구

류재청,김철원 제주대학교 1994 논문집 Vol.39 No.-

동작의 일치하는 정도를 분석하기 위해 적용된 동작은 정상보행동작이었고, 이 때 부하는 체중에 대해 0%BW, 20%BW, 40%BW의 부하를 달리하여 정상보행의 양상과 운동학적 변인간의 인지계수(Recoginition coefficient; Mallwain J.S. 등, 1985)를 구하기 위해 실험 및 분석한 결과 다음과 같은 결론을 얻었다. 부하의 종류가 0%BW, 20%BW일 때 정상보행동안 다른 운동학적 변인간의 인지능력에는 큰 차이를 보이지 않지만 부하가 40%BW이상 및 특수상황과 과부하 보행시에는 인지능력이 감소하여 일치도가 떨어졌다. 동일한 운동학적 변인에서 부하를 달리했을 때 히프각과 무릎각은 부하조건에 상관없이 높은 부하일수록 높은 인지능력을 보였고, 동작의 일치도가 높았다. 히프각속도와 무릎각속도는 부하를 하였을 때 일치감소하였고, 부하조건 간에는 일치도가 매우 높고, 인지능력은 증가했다. 신체중심변위의 경우 부하 및 무부하간의 일치하는 정도는 다소 높은 것으로 나타났고, 부하의 종류에 따라 큰 영향을 받지 않았지만, 신체중심속도는 부하의 종류에 따라 일치도는 감소하여 동작의 인지능력은 적었다. The study was undertaken to investigate congruity of kinematic variables on a kind of load level(%BW) during normal gait with packback system, and the congruity degree was represented with recognition coefficient. The difference of recognition ability between 0%BW and 20%BW was little, but was not in 40%BW, over load situation and grately dropped congruity among other kinematic during variable normal gait. The congruity of hip & knee angle was shown high regardless of loaded conditions in the same kinematic variables, was reduced in hip & knee angular velocity loaded and was shown high between loaded conditions, recognition ability was increased. The congruity degree of COG displacement was rather high in all load level, and was not influenced by load levels, but was decresed according to load levels in COG velocity.

방언 연구의 의의에 대하여

정제문 順天大學校 師範大學 附屬 科學敎育硏究所 1996 科學과 敎育 Vol.4 No.-

In introductory remarks, we seldom meet with argumentations about the purpose of dialectology. They are usually centered upon the usefulness of dialect data for the description of language development from the viewpoint of the historical comparative linguistics. Aside from the topics so far, the writer in this paper aims to discuss the significance of studying dialects in the age of local autonomy especially from an epistemological point of view. As a result of his investigation over dialect phenomena, he insists that dialects should be educated as a means of expelling the evil motto of 'both-sides wrong' from our society.

만경강하구역에 서식하는 풀망둑어(Acanthogobius hasta)중의 중금속함량에 관한 연구

장재철,권용훈,김경현 群山大學校 1997 論文集 Vol.24 No.-

만경강 하구에 서식하는 풀망둑어(Acanthogobius hasta)를 기관별(지느러미, 아가미, 뼈, 폐 근육, 머리)로 7가지의 중금속을 분석하였다. 그 결과 Cd, Cr, Cu, Zn, Mn, As 등이 지느러미>아가미>뼈>폐>머리>근육 순으로 높게 나타났고, 반면 7가지의 중금속중에 Pb Hg 미검출 되었다. Cd, Cu, Zn, As Cr은 지느러미 뼈 머리 부위에서, 폐 아가미부위에 비해 전반적으로 높게 나타났다. 모든 중금속들은 다른 기관보다도 지느러미와 뼈에 많은 량을 함유하고 있음을 알았다. The concentration of 7 heavy metals(Pb, Hg, Cu, Cr, Zn, Mn, Cd, and As)were measured in the tisseus(head, bone, muscle, lung, gill, pinna)of the Acanthogobius hasta of Man-kyung estuary. The order of mean value of cadimium, copper, zinc and manganese content in the five parts were shown as pinna>gill>bone>lung>head respectively. The other side among the seven heavy metal contents did not show lead and mercury. Cd, Cu, Zn, As, Cr, Mn were detected higher in the part of pinna, bone and head than lung, gill.